Strain Name:
C57BL/6J-MtgxR4552Btlr/Mmmh
Stock Number:
041783-MU
Citation ID:
RRID:MMRRC_041783-MU
Other Names:
R4552 (G1), C57BL/6J-MtgxR4552Btlr
Major Collection:

Gene Information

Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20269
Homologene: 56005
Odf2l
Name: outer dense fiber of sperm tails 2-like
Synonyms: 4733401D09Rik, 9630045K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 52184
Homologene: 12011
Arid1a
Name: AT rich interactive domain 1A (SWI-like)
Synonyms: Osa1, Smarcf1, 1110030E03Rik, BAF250a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 93760
Homologene: 21216
Ddx19a
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 19a
Synonyms: Ddx19, DBP5, Eif4a-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 13680
Homologene: 5240
Tipin
Name: timeless interacting protein
Synonyms: 1110005A05Rik, 1110018P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 66131
VEGA: 9
Homologene: 32373
Rtf1
Name: RTF1, Paf1/RNA polymerase II complex component
Synonyms: Gtl7, 6530416A09Rik, 2900005O08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 76246
Homologene: 133868
Cit
Name: citron
Synonyms: C030025P15Rik, citron kinase, Cit-k, citron-N, CRIK-SK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12704
HGNC: HGNC:1985
Homologene: 21404
Nif3l1
Name: Ngg1 interacting factor 3-like 1 (S. pombe)
Synonyms: 1110030G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 65102
Homologene: 5881
Rrp1b
Name: ribosomal RNA processing 1 homolog B (S. cerevisiae)
Synonyms: 2600005C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 72462
Homologene: 57086
Cep128
Name: centrosomal protein 128
Synonyms: 4930534B04Rik, 5430424K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 75216
Homologene: 35315
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Noct
Name: nocturnin
Synonyms: Ccr4, Ccrn4l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12457
Homologene: 7661
Camta1
Name: calmodulin binding transcription activator 1
Synonyms: 2310058O09Rik, 1810059M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100072
Homologene: 18942
Sema6a
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Synonyms: Sema6A-1, sema, A730020P05Rik, VIa, Semaq
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 20358
Homologene: 32426
Epgn
Name: epithelial mitogen
Synonyms: 2310069M11Rik, epigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71920
Homologene: 19527
Ston2
Name: stonin 2
Synonyms: 4933401N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 108800
Homologene: 84338
Nbas
Name: neuroblastoma amplified sequence
Synonyms: 4933425L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 71169
VEGA: 12
Homologene: 41073
Klk4
Name: kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)
Synonyms: KLK-L1, ESMP1, Prss17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 56640
HGNC: HGNC:6365
Homologene: 55856
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1537Clo, b2b1565Clo, b2b3491Clo, b2b1154Clo, Mdnah5, Dnahc5, b2b1134Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 26875
Homologene: 69111
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Dner
Name: delta/notch-like EGF repeat containing
Synonyms: A930026D19Rik, BET
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227325
Homologene: 26722
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Plcb1
Name: phospholipase C, beta 1
Synonyms: 3110043I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18795
Homologene: 22876
Odf4
Name: outer dense fiber of sperm tails 4
Synonyms: Oppo1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 252868
Homologene: 17099
Ptchd4
Name: patched domain containing 4
Synonyms: 3110082D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 627626
VEGA: 17
Homologene: 78322
Rims1
Name: regulating synaptic membrane exocytosis 1
Synonyms: RIM1alpha, RIM1, C030033M19Rik, RIM1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 116837
Homologene: 128399
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380698
Homologene: 70869
Adamts16
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 271127
Homologene: 15146
Rhpn1
Name: rhophilin, Rho GTPase binding protein 1
Synonyms: Rhophilin, Grbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 14787
Homologene: 7346
Dalrd3
Name: DALR anticodon binding domain containing 3
Synonyms: 6330580J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 67789
Homologene: 32388
Caskin1
Name: CASK interacting protein 1
Synonyms: 3300002N10Rik, C630036E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 268932
VEGA: 17
Homologene: 25873
Vmn2r73
Name: vomeronasal 2, receptor 73
Synonyms: EG620928
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 620928
Homologene: 115466
Igbp1b
Name: immunoglobulin (CD79A) binding protein 1b
Synonyms: alpha4-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 50540
Homologene: 75049
Shcbp1
Name: Shc SH2-domain binding protein 1
Synonyms: mPAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 20419
Homologene: 32123
Olfr45
Name: olfactory receptor 45
Synonyms: IB6, GA_x6K02T2PBJ9-42837030-42837962, MOR253-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18344
Homologene: 79416
Hid1
Name: HID1 domain containing
Synonyms: C630004H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217310
Homologene: 12737
Kif26b
Name: kinesin family member 26B
Synonyms: D230039L06Rik, N-11 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 269152
Homologene: 18623
Parpbp
Name: PARP1 binding protein
Synonyms: 4930547N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 75317
Homologene: 49519
Slc27a1
Name: solute carrier family 27 (fatty acid transporter), member 1
Synonyms: Fatp, FATP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 26457
Homologene: 8063
Ric8a
Name: RIC8 guanine nucleotide exchange factor A
Synonyms: synembryn, RIC-8, Ric8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 101489
Homologene: 23331
Olfr24
Name: olfactory receptor 24
Synonyms: MOR132-1, GA_x6K02T2PVTD-12498544-12497603, MTPCR51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 18322
HGNC: HGNC:8220
Homologene: 64896
Papolb
Name: poly (A) polymerase beta (testis specific)
Synonyms: Plap-ps, Papt, Papola-ps, TPAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 56522
Homologene: 121622
Kcnab2
Name: potassium voltage-gated channel, shaker-related subfamily, beta member 2
Synonyms: I2rf5, Kcnb3, I2rf5, F5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 16498
HGNC: HGNC:6229
Homologene: 56492
Mrgpra2b
Name: MAS-related GPR, member A2B
Synonyms: Mrgpra2, MrgA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 235712
Homologene: 79615
Olfr1391
Name: olfactory receptor 1391
Synonyms: GA_x6K02T2QP88-6107233-6106298, MOR256-27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 258460
Homologene: 17264
Vmn1r117
Name: vomeronasal 1 receptor 117
Synonyms: Gm8544
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 667262
Homologene: 104166
Mtss2
Name: MTSS I-BAR domain containing 2
Synonyms: ABBA, Mtss1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244654
Homologene: 70926
Chit1
Name: chitinase 1 (chitotriosidase)
Synonyms: 2300002L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 71884
HGNC: HGNC:1936
Homologene: 68318
Olfr815
Name: olfactory receptor 815
Synonyms: GA_x6K02T2PULF-11581263-11580331, MOR113-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258665
C4bp
Name: complement component 4 binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12269
Tulp1
Name: tubby like protein 1
Synonyms: Tulp1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 22157
Homologene: 2491
Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Synonyms: Pgc-1alpha, PPAR Gamma Coactivator-1, Pgc-1alphaa, Pgc1, Pgco1, Gm11133, A830037N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19017
HGNC: HGNC:9237
Homologene: 7485
Lrrc73
Name: leucine rich repeat containing 73
Synonyms: Gm88, LOC224813
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224813
VEGA: 17
Homologene: 19183
Vmn1r57
Name: vomeronasal 1 receptor 57
Synonyms: Gm7519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 665150
Homologene: 41799
Vmn2r-ps41
Name: vomeronasal 2, receptor, pseudogene 41
Synonyms: Gm6845
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 628128
Arhgap33os
Name: Rho GTPase activating protein 33, opposite strand
Synonyms: LOC381868, Gm1082
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 100504207
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 22,373,494 bp
  • C to T, chromosome 1 at 58,449,324 bp
  • T to C, chromosome 1 at 84,383,857 bp
  • A to G, chromosome 1 at 130,636,727 bp
  • A to G, chromosome 1 at 134,144,051 bp
  • T to A, chromosome 1 at 178,884,035 bp
  • T to C, chromosome 2 at 65,524,179 bp
  • T to A, chromosome 2 at 119,730,729 bp
  • T to C, chromosome 2 at 135,335,493 bp
  • T to A, chromosome 3 at 51,250,168 bp
  • A to T, chromosome 3 at 145,151,083 bp
  • A to C, chromosome 4 at 133,695,699 bp
  • T to C, chromosome 4 at 151,792,502 bp
  • C to A, chromosome 4 at 152,396,804 bp
  • T to C, chromosome 5 at 14,669,271 bp
  • C to T, chromosome 5 at 51,463,215 bp
  • A to T, chromosome 5 at 91,027,562 bp
  • G to A, chromosome 5 at 115,981,802 bp
  • T to C, chromosome 5 at 142,529,178 bp
  • T to A, chromosome 6 at 138,658,114 bp
  • A to G, chromosome 7 at 5,220,668 bp
  • A to T, chromosome 7 at 9,177,064 bp
  • A to T, chromosome 7 at 20,883,592 bp
  • A to T, chromosome 7 at 30,519,108 bp
  • C to A, chromosome 7 at 43,884,019 bp
  • C to A, chromosome 7 at 47,464,006 bp
  • T to A, chromosome 7 at 85,875,847 bp
  • A to T, chromosome 7 at 140,691,742 bp
  • G to A, chromosome 7 at 140,861,337 bp
  • A to T, chromosome 8 at 4,749,779 bp
  • A to T, chromosome 8 at 71,580,066 bp
  • A to G, chromosome 8 at 110,738,505 bp
  • G to A, chromosome 8 at 110,978,566 bp
  • A to G, chromosome 9 at 18,755,134 bp
  • T to C, chromosome 9 at 54,451,763 bp
  • T to A, chromosome 9 at 64,288,103 bp
  • A to G, chromosome 9 at 108,572,230 bp
  • T to A, chromosome 10 at 88,093,702 bp
  • T to C, chromosome 10 at 129,902,123 bp
  • A to T, chromosome 11 at 49,327,950 bp
  • T to C, chromosome 11 at 59,131,646 bp
  • T to C, chromosome 11 at 65,841,366 bp
  • C to T, chromosome 11 at 68,922,040 bp
  • G to A, chromosome 11 at 115,358,679 bp
  • T to C, chromosome 11 at 118,052,943 bp
  • T to C, chromosome 12 at 13,335,937 bp
  • T to C, chromosome 12 at 91,294,162 bp
  • C to T, chromosome 12 at 91,641,872 bp
  • G to A, chromosome 13 at 70,779,518 bp
  • T to C, chromosome 15 at 28,397,154 bp
  • G to A, chromosome 15 at 75,714,119 bp
  • G to A, chromosome 17 at 24,506,628 bp
  • A to G, chromosome 17 at 28,363,798 bp
  • G to A, chromosome 17 at 32,056,010 bp
  • A to T, chromosome 17 at 42,502,455 bp
  • A to T, chromosome 17 at 46,260,027 bp
  • A to G, chromosome 18 at 47,291,923 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4552 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041783-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.