Strain Name:
C57BL/6J-MtgxR4575Btlr/Mmmh
Stock Number:
041798-MU
Citation ID:
RRID:MMRRC_041798-MU
Other Names:
R4575 (G1), C57BL/6J-MtgxR4575Btlr
Major Collection:

Gene Information

Sf1
Name: splicing factor 1
Synonyms: WBP4, MZFM, CW17R, Zfp162
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 22668
Homologene: 134065
Ide
Name: insulin degrading enzyme
Synonyms: 1300012G03Rik, 4833415K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 15925
HGNC: HGNC:5381
Homologene: 3645
Hgf
Name: hepatocyte growth factor
Synonyms: scatter factor, NK1, SF/HGF, HGF/SF, NK2, C230052L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15234
HGNC: HGNC:4893
Homologene: 503
Ppp1r14c
Name: protein phosphatase 1, regulatory inhibitor subunit 14C
Synonyms: 6330514J04Rik, KEPI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76142
VEGA: 10
Homologene: 12805
Hdac1
Name: histone deacetylase 1
Synonyms: RPD3, HD1, MommeD5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 433759
HGNC: HGNC:4852
Homologene: 68426
Fgd4
Name: FYVE, RhoGEF and PH domain containing 4
Synonyms: Frabin-gamma, Frabin-beta, Frabin-alpha, Frabin, 9330209B17Rik, ZFYVE6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224014
Homologene: 26727
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: U5-200KD, HELIC2, A330064G03Rik, Ascc3l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320632
Homologene: 5859
Erp44
Name: endoplasmic reticulum protein 44
Synonyms: 1110001E24Rik, Txndc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76299
Homologene: 12638
Auts2
Name: autism susceptibility candidate 2
Synonyms: D830032G16Rik, A730011F23Rik, 2700063G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319974
Homologene: 22907
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208628
Homologene: 32227
Ago3
Name: argonaute RISC catalytic subunit 3
Synonyms: argonaute 3, eIF2C3, C130014L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 214150
Homologene: 49799
2310057M21Rik
Name: RIKEN cDNA 2310057M21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68277
Homologene: 11793
Uhrf1bp1
Name: UHRF1 (ICBP90) binding protein 1
Synonyms: 1110020K19Rik, F830021D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224648
Homologene: 9816
Ep300
Name: E1A binding protein p300
Synonyms: p300, KAT3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 328572
HGNC: HGNC:3373
Homologene: 1094
Nol6
Name: nucleolar protein family 6 (RNA-associated)
Synonyms: Nrap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230082
Homologene: 41505
Prr14l
Name: proline rich 14-like
Synonyms: 6030436E02Rik, C330019G07Rik, Prl14l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 215476
Homologene: 65866
Adgrf3
Name: adhesion G protein-coupled receptor F3
Synonyms: LOC381628, PGR23, Gpr113
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381628
Homologene: 17826
Klk12
Name: kallikrein related-peptidase 12
Synonyms: KLK-L5, 2310008B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69511
HGNC: HGNC:6360
Homologene: 44690
Lnx1
Name: ligand of numb-protein X 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16924
HGNC: HGNC:6657
Homologene: 7819
Rpn2
Name: ribophorin II
Synonyms: Rpn-2, 1300012C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20014
Homologene: 2214
Srpr
Name: signal recognition particle receptor ('docking protein')
Synonyms: 1300011P19Rik, D11Mgi27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67398
Homologene: 2364
Haus8
Name: 4HAUS augmin-like complex, subunit 8
Synonyms: 2410004L22Rik, Hice1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76478
Homologene: 12644
Thsd1
Name: thrombospondin, type I, domain 1
Synonyms: 4833423O18Rik, Tmtsp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56229
Homologene: 10264
Elfn1
Name: leucine rich repeat and fibronectin type III, extracellular 1
Synonyms: A930017N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243312
Homologene: 18465
Otop1
Name: otopetrin 1
Synonyms: A530025J20Rik, tlt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21906
Homologene: 35244
Nlgn1
Name: neuroligin 1
Synonyms: 6330415N05Rik, NL1, Nlg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 192167
Homologene: 56690
Clec4b2
Name: C-type lectin domain family 4, member b2
Synonyms: mDCAR1, F830043G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381809
Homologene: 128249
Dpysl3
Name: dihydropyrimidinase-like 3
Synonyms: Ulip1, Ulip, CRMP-4, TUC4, 9430041P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 22240
HGNC: HGNC:3015
Homologene: 20361
Krt35
Name: keratin 35
Synonyms: Ha5, Krt1-24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53617
HGNC: HGNC:6453
Homologene: 1715
Dscam
Name: DS cell adhesion molecule
Synonyms: 4932410A21Rik, Down syndrome cell adhesion molecule
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Iigp1
Name: interferon inducible GTPase 1
Synonyms: 2900074L10Rik, Irga6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 60440
VEGA: 18
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242627
Homologene: 135888
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, OTTMUSG00000020804, Heatr7b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217843
Homologene: 41397
Impg2
Name: interphotoreceptor matrix proteoglycan 2
Synonyms: PG10.2, IPM200, Spacrcan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224224
Homologene: 9439
Kprp
Name: keratinocyte expressed, proline-rich
Synonyms: 1110001M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 433619
Homologene: 54921
Frmd4a
Name: FERM domain containing 4A
Synonyms: C230040M21Rik, 2700017I06Rik, Gm13190
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209630
Homologene: 9971
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: 6530405F15Rik, CMF608, Adlican2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242050
Homologene: 18712
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 333315
Homologene: 35388
Rfc4
Name: replication factor C (activator 1) 4
Synonyms: RFC37, A1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 106344
HGNC: HGNC:9972
Homologene: 6288
Gm12166
Name: predicted gene 12166
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100039624
Slco6b1
Name: solute carrier organic anion transporter family, member 6b1
Synonyms: 1700022M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67854
Homologene: 12199
Cyp2d22
Name: cytochrome P450, family 2, subfamily d, polypeptide 22
Synonyms: 2D22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 56448
VEGA: 15
Homologene: 75003
Ccdc96
Name: coiled-coil domain containing 96
Synonyms: 4921513E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66717
Homologene: 32639
Gm12790
Name: predicted gene 12790
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Asb10
Name: ankyrin repeat and SOCS box-containing 10
Synonyms: Asb-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 117590
Homologene: 135975
Krt2
Name: keratin 2
Synonyms: Krt2-2, Krt2e, Krt2-17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16681
HGNC: HGNC:6439
Svop
Name: SV2 related protein
Synonyms: 1110030H18Rik, msvop
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68666
Homologene: 41283
Vmn2r16
Name: vomeronasal 2, receptor 16
Synonyms: EG384220
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 384220
Homologene: 104825
Aoc1l1
Name: amine oxidase copper containing 1-like 1
Synonyms: Doxl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243376
Homologene: 19443
Traf3ip2
Name: TRAF3 interacting protein 2
Synonyms: Act1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103213
HGNC: HGNC:1343
Homologene: 15885
Fam166a
Name: family with sequence similarity 166, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68222
Homologene: 12247
Edil3
Name: EGF-like repeats and discoidin I-like domains 3
Synonyms: Del1, developmental endothelial locus-1, Del-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13612
HGNC: HGNC:3173
Homologene: 21166
Olfr834
Name: olfactory receptor 834
Synonyms: GA_x6K02T2PVTD-12724921-12725859, MOR153-2, MOR153-4_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258074
HGNC: HGNC:8467
Homologene: 128143
Cyp2c68
Name: cytochrome P450, family 2, subfamily c, polypeptide 68
Synonyms: 9030012A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 433247
Homologene: 74936
Gm11563
Name: predicted gene 11563
Synonyms: 2310045F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100040248
Homologene: 136093
Sri
Name: sorcin
Synonyms: Sor, 2210417O06Rik, 2900070H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 109552
Homologene: 37736
Khdc1a
Name: KH domain containing 1A
Synonyms: Ndg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 368204
Homologene: 134524
4930408O17Rik
Name: RIKEN cDNA 4930408O17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Slc2a10
Name: solute carrier family 2 (facilitated glucose transporter), member 10
Synonyms: Glut10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 170441
Homologene: 38551
Olfr553
Name: olfactory receptor 553
Synonyms: GA_x6K02T2PBJ9-5333671-5332712, MOR25-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233578
Homologene: 17194
Gm26749
Name: predicted gene, 26749
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Vmn2r125
Name: vomeronasal 2, receptor 125
Synonyms: Gm20782
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 670059
VEGA: 4
4930444A19Rik
Name: RIKEN cDNA 4930444A19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 73980
Gm10804
Name: predicted gene 10804
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 100038525
Llph-ps2
Name: LLP homolog, pseudogene 2
Synonyms: ENSMUSG00000058791, Gm14535
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 100043002
Homologene: 81946
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 21,350,429 bp
  • C to A, chromosome 1 at 54,766,976 bp
  • A to G, chromosome 1 at 88,258,664 bp
  • T to A, chromosome 1 at 96,988,697 bp
  • C to A, chromosome 2 at 4,603,679 bp
  • T to C, chromosome 2 at 25,220,288 bp
  • C to T, chromosome 2 at 93,468,669 bp
  • T to A, chromosome 2 at 127,235,066 bp
  • C to A, chromosome 2 at 157,295,324 bp
  • C to G, chromosome 2 at 165,516,321 bp
  • A to T, chromosome 3 at 26,331,835 bp
  • G to T, chromosome 3 at 59,330,100 bp
  • T to C, chromosome 3 at 92,823,964 bp
  • T to C, chromosome 4 at 41,120,299 bp
  • T to C, chromosome 4 at 48,194,595 bp
  • T to C, chromosome 4 at 101,968,127 bp
  • T to A, chromosome 4 at 113,667,193 bp
  • T to C, chromosome 4 at 126,346,682 bp
  • T to C, chromosome 4 at 129,524,332 bp
  • T to A, chromosome 4 at 156,349,977 bp
  • G to T, chromosome 5 at 8,063,693 bp
  • T to C, chromosome 5 at 16,572,601 bp
  • C to T, chromosome 5 at 24,540,054 bp
  • T to A, chromosome 5 at 30,202,257 bp
  • T to C, chromosome 5 at 32,793,644 bp
  • T to C, chromosome 5 at 36,486,075 bp
  • T to C, chromosome 5 at 38,299,721 bp
  • T to C, chromosome 5 at 74,685,543 bp
  • A to T, chromosome 5 at 109,363,799 bp
  • C to T, chromosome 5 at 114,065,682 bp
  • T to G, chromosome 5 at 123,765,955 bp
  • C to T, chromosome 5 at 132,258,934 bp
  • T to C, chromosome 5 at 139,972,053 bp
  • C to T, chromosome 6 at 48,977,568 bp
  • T to A, chromosome 6 at 123,173,680 bp
  • A to G, chromosome 7 at 43,773,243 bp
  • A to T, chromosome 7 at 102,614,769 bp
  • C to T, chromosome 7 at 131,362,596 bp
  • A to G, chromosome 8 at 22,258,443 bp
  • A to G, chromosome 8 at 71,263,092 bp
  • A to G, chromosome 8 at 80,616,075 bp
  • C to A, chromosome 9 at 18,988,705 bp
  • T to C, chromosome 9 at 35,214,608 bp
  • G to T, chromosome 10 at 3,366,912 bp
  • A to G, chromosome 10 at 39,634,654 bp
  • T to C, chromosome 11 at 46,051,852 bp
  • T to C, chromosome 11 at 59,122,772 bp
  • G to A, chromosome 11 at 99,658,449 bp
  • A to T, chromosome 11 at 100,095,899 bp
  • T to C, chromosome 12 at 103,001,803 bp
  • C to A, chromosome 12 at 104,871,268 bp
  • T to C, chromosome 13 at 89,319,731 bp
  • T to C, chromosome 15 at 81,649,009 bp
  • G to T, chromosome 15 at 82,371,932 bp
  • T to G, chromosome 15 at 101,814,486 bp
  • T to C, chromosome 16 at 16,437,032 bp
  • T to A, chromosome 16 at 23,114,429 bp
  • A to G, chromosome 16 at 56,261,732 bp
  • A to G, chromosome 16 at 96,825,623 bp
  • T to C, chromosome 17 at 27,887,503 bp
  • A to G, chromosome 17 at 74,609,187 bp
  • T to C, chromosome 18 at 43,342,247 bp
  • A to T, chromosome 18 at 60,390,146 bp
  • T to C, chromosome 19 at 6,375,913 bp
  • G to A, chromosome 19 at 37,272,205 bp
  • T to A, chromosome 19 at 39,734,361 bp
  • A to G, chromosome X at 13,218,451 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4575 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041798-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.