Strain Name:
C57BL/6J-MtgxR4582Btlr/Mmmh
Stock Number:
041803-MU
Citation ID:
RRID:MMRRC_041803-MU
Other Names:
R4582 (G1), C57BL/6J-MtgxR4582Btlr
Major Collection:

Gene Information

Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: non-erythrocytic, spectrin G, Spnb-2, Spnb2, beta fodrin, brain spectrin, elf3, elf1, 9930031C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20742
Homologene: 2354
Llgl2
Name: LLGL2 scribble cell polarity complex component
Synonyms: 9130006H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217325
HGNC: HGNC:6629
Homologene: 3323
Vps35l
Name: VPS35 endosomal protein sorting factor like
Synonyms: Vsp35l, 9030624J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71517
Homologene: 10659
Eif4g3
Name: eukaryotic translation initiation factor 4 gamma, 3
Synonyms: eIF4GII, G1-419-52, repro8, 4930523M17Rik, 1500002J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230861
HGNC: HGNC:3298
Homologene: 2789
Lima1
Name: LIM domain and actin binding 1
Synonyms: EPLIN, 3526402A12Rik, 1110021C24Rik, epithelial protein lost in neoplasm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 65970
Homologene: 9484
Ccdc138
Name: coiled-coil domain containing 138
Synonyms: 6230424H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 76138
VEGA: 10
Homologene: 44912
Ndel1
Name: nudE neurodevelopment protein 1 like 1
Synonyms: mNudel, 2600006O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 83431
Homologene: 32567
Zbtb16
Name: zinc finger and BTB domain containing 16
Synonyms: Green's luxoid, Zfp145, PLZF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235320
VEGA: 9
Homologene: 21214
Man2a1
Name: mannosidase 2, alpha 1
Synonyms: Mana-2, Mana2, Map-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 17158
HGNC: HGNC:6824
Homologene: 1777
Pkd2
Name: polycystin 2, transient receptor potential cation channel
Synonyms: polycystin-2, TRPP2, PC2, C030034P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 18764
HGNC: HGNC:9009
Homologene: 20104
Tm9sf3
Name: transmembrane 9 superfamily member 3
Synonyms: Smbp, 1810073M23Rik, 2810031D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 107358
VEGA: 19
Homologene: 10588
Ttc7b
Name: tetratricopeptide repeat domain 7B
Synonyms: Ttc7l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 104718
VEGA: 12
Homologene: 14675
Brd9
Name: bromodomain containing 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 105246
VEGA: 13
Homologene: 82462
Akap11
Name: A kinase (PRKA) anchor protein 11
Synonyms: 6330501D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 219181
HGNC: HGNC:369
Homologene: 8279
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 269700
Homologene: 28297
Slc44a4
Name: solute carrier family 44, member 4
Synonyms: NG22, 2210409B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 70129
Homologene: 11359
Ankrd7
Name: ankyrin repeat domain 7
Synonyms: 4930532L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 75196
Homologene: 35506
Naglu
Name: alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 27419
HGNC: HGNC:7632
Homologene: 222
Slc22a5
Name: solute carrier family 22 (organic cation transporter), member 5
Synonyms: Lstpl, Octn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20520
Homologene: 68295
Olfr1338
Name: olfactory receptor 1338
Synonyms: MOR259-4P, Olfr1524-ps1, MOR259-9, GA_x6K02T2QD9B-18795136-18796077, MOR259-4P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 258259
Homologene: 115537
Lipe
Name: lipase, hormone sensitive
Synonyms: HSL, 4933403G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16890
HGNC: HGNC:6621
Homologene: 3912
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Gm7455, Col6a5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 665033
Homologene: 122792
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 50720
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 21974
Homologene: 134711
Rfx4
Name: regulatory factor X, 4 (influences HLA class II expression)
Synonyms: 4933412G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 71137
HGNC: HGNC:9985
Homologene: 31119
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: flamingo, Fmi1, Adgrc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Lrrc66
Name: leucine rich repeat containing 66
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231296
Homologene: 51944
Cfap45
Name: cilia and flagella associated protein 45
Synonyms: 1700028D05Rik, Ccdc19, Nesg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 71870
Homologene: 71837
Brinp2
Name: bone morphogenic protein/retinoic acid inducible neural-specific 2
Synonyms: Fam5b, 6430517E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240843
Homologene: 10905
Ankle1
Name: ankyrin repeat and LEM domain containing 1
Synonyms: Ankrd41, 8430438L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234396
Homologene: 17562
Gtpbp10
Name: GTP-binding protein 10 (putative)
Synonyms: 4930545J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 207704
Homologene: 8114
Vmn1r29
Name: vomeronasal 1 receptor 29
Synonyms: V1rc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 113859
Homologene: 123821
Pde6b
Name: phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Synonyms: rd, rd10, r, Pdeb, rd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 18587
HGNC: HGNC:8786
Homologene: 237
Ugt1a10
Name: UDP glycosyltransferase 1 family, polypeptide A10
Synonyms: A13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 394430
Homologene: 133281
Nt5c1b
Name: 5'-nucleotidase, cytosolic IB
Synonyms: CN-IB, 4921514H13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 70881
Homologene: 12370
Vdac3-ps1
Name: voltage-dependent anion channel 3, pseudogene 1
Synonyms: ENSMUSG00000075053
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 22336
VEGA: 13
Olfr768
Name: olfactory receptor 768
Synonyms: MOR114-4, GA_x6K02T2PULF-10779441-10778503
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258863
Homologene: 17159
Eef1akmt1
Name: EEF1A alpha lysine methyltransferase 1
Synonyms: Ayu21-96, Gt(Ayu21)96Imeg, 2510005D08Rik, N6amt2, GtAyu21-96
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 68043
VEGA: 14
Homologene: 5952
Abra
Name: actin-binding Rho activating protein
Synonyms: STARS, C130068O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223513
VEGA: 15
Homologene: 34713
Taf1
Name: TATA-box binding protein associated factor 1
Synonyms: Taf2a, KAT4, B430306D02Rik, Ccg-1, Ccg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 270627
Homologene: 37942
Clec4a1
Name: C-type lectin domain family 4, member a1
Synonyms: mDcir4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 269799
Homologene: 72399
Dcaf15
Name: DDB1 and CUL4 associated factor 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 212123
Homologene: 18182
Dhrs9
Name: dehydrogenase/reductase (SDR family) member 9
Synonyms: Rdh15, C730025I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241452
Homologene: 26079
Pcdha3
Name: protocadherin alpha 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 192163
HGNC: HGNC:8669
Homologene: 129613
Gm6003
Name: predicted gene 6003
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 102637838
Homologene: 141213
Tsga13
Name: testis specific gene A13
Synonyms: 1700023D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 116732
Homologene: 76446
5830432E09Rik
Name: RIKEN cDNA 5830432E09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 67765
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 88,055,741 bp
  • A to G, chromosome 1 at 158,267,938 bp
  • A to G, chromosome 1 at 172,529,912 bp
  • A to T, chromosome 2 at 69,397,653 bp
  • A to T, chromosome 4 at 118,753,893 bp
  • G to A, chromosome 4 at 138,171,245 bp
  • T to C, chromosome 5 at 5,542,395 bp
  • T to C, chromosome 5 at 73,608,237 bp
  • A to T, chromosome 5 at 104,502,344 bp
  • A to T, chromosome 5 at 108,425,231 bp
  • A to G, chromosome 5 at 121,286,419 bp
  • T to A, chromosome 6 at 18,868,021 bp
  • A to T, chromosome 6 at 30,902,363 bp
  • A to C, chromosome 6 at 58,308,032 bp
  • G to T, chromosome 6 at 122,932,191 bp
  • A to G, chromosome 7 at 25,397,702 bp
  • A to C, chromosome 7 at 33,165,586 bp
  • G to T, chromosome 7 at 118,833,897 bp
  • A to G, chromosome 7 at 135,652,024 bp
  • AT to A, chromosome 8 at 71,407,207 bp
  • A to G, chromosome 8 at 84,097,969 bp
  • A to G, chromosome 9 at 48,832,082 bp
  • G to A, chromosome 9 at 105,862,764 bp
  • T to C, chromosome 9 at 108,845,723 bp
  • T to C, chromosome 10 at 58,507,643 bp
  • T to A, chromosome 10 at 84,844,300 bp
  • A to T, chromosome 10 at 129,093,158 bp
  • G to A, chromosome 11 at 30,219,597 bp
  • C to T, chromosome 11 at 53,891,209 bp
  • A to G, chromosome 11 at 68,839,932 bp
  • A to T, chromosome 11 at 101,071,929 bp
  • A to G, chromosome 11 at 115,850,706 bp
  • T to A, chromosome 12 at 10,390,054 bp
  • G to A, chromosome 12 at 100,500,117 bp
  • A to T, chromosome 13 at 18,031,592 bp
  • T to C, chromosome 13 at 73,947,733 bp
  • T to G, chromosome 14 at 16,409,189 bp
  • T to C, chromosome 14 at 57,550,448 bp
  • G to A, chromosome 14 at 61,191,698 bp
  • A to T, chromosome 14 at 78,511,929 bp
  • A to T, chromosome 15 at 41,869,285 bp
  • T to C, chromosome 15 at 99,780,992 bp
  • T to C, chromosome 17 at 34,928,839 bp
  • C to T, chromosome 17 at 64,752,499 bp
  • T to C, chromosome 18 at 36,947,432 bp
  • C to A, chromosome 19 at 41,256,166 bp
  • T to C, chromosome X at 101,593,995 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4582 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041803-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.