Strain Name:
C57BL/6J-MtgxR4594Btlr/Mmmh
Stock Number:
041810-MU
Citation ID:
RRID:MMRRC_041810-MU
Other Names:
R4594 (G1), C57BL/6J-MtgxR4594Btlr
Major Collection:

Gene Information

Ptk2
Name: PTK2 protein tyrosine kinase 2
Synonyms: Fadk, FAK, FRNK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14083
VEGA: 15
HGNC: HGNC:9611
Homologene: 7314
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Plcb4
Name: phospholipase C, beta 4
Synonyms: C230058B11Rik, A930039J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18798
HGNC: HGNC:9059
Homologene: 8471
Fgfr1
Name: fibroblast growth factor receptor 1
Synonyms: Flt-2, Fgfr-1, Hspy, Eask, FGFR-I, Fr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14182
HGNC: HGNC:3688
Homologene: 69065
Diaph3
Name: diaphanous related formin 3
Synonyms: p134MDia2, mDia2, 4930417P13Rik, Drf3, Diap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 56419
VEGA: 14
Homologene: 84829
Trappc8
Name: trafficking protein particle complex 8
Synonyms: 5033403J15Rik, D030074E01Rik, Trs85
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 75964
VEGA: 18
Homologene: 40993
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70699
Homologene: 45971
Gsk3b
Name: glycogen synthase kinase 3 beta
Synonyms: GSK-3beta, GSK-3, 8430431H08Rik, 7330414F15Rik, GSK3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 56637
HGNC: HGNC:4617
Homologene: 55629
Ints12
Name: integrator complex subunit 12
Synonyms: A230056J18Rik, 4930529N21Rik, 2810027J24Rik, 1110020M19Rik, Phf22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71793
Homologene: 32474
Mcpt1
Name: mast cell protease 1
Synonyms: Mcp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17224
VEGA: 14
Homologene: 137209
Got2
Name: glutamatic-oxaloacetic transaminase 2, mitochondrial
Synonyms: mAspAT, mitochondrial aspartate aminotransferase, FABP-pm, plasma membrane fatty acid binding protein, Kyat4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14719
HGNC: HGNC:4433
Homologene: 1572
Cacna2d3
Name: calcium channel, voltage-dependent, alpha2/delta subunit 3
Synonyms: alpha 2 delta-3, alpha2delta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12294
Homologene: 74929
Nxpe2
Name: neurexophilin and PC-esterase domain family, member 2
Synonyms: 4432416J03Rik, Fam55b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78252
Homologene: 87072
Il17f
Name: interleukin 17F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 257630
Homologene: 17115
H2-M5
Name: histocompatibility 2, M region locus 5
Synonyms: H-2M5, D130003B22Rik, CRW2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240095
Homologene: 128812
Slmap
Name: sarcolemma associated protein
Synonyms: Slap, D330001L02Rik, Miranda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 83997
Homologene: 31428
Rexo2
Name: RNA exonuclease 2
Synonyms: 1810038D15Rik, Sfn, Smfn, Rex2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 104444
VEGA: 9
Homologene: 6447
Rasef
Name: RAS and EF hand domain containing
Synonyms: RAB45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242505
Homologene: 28424
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Olfr639
Name: olfactory receptor 639
Synonyms: GA_x6K02T2PBJ9-6747143-6746193, MOR12-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259088
Homologene: 17497
Dscam
Name: DS cell adhesion molecule
Synonyms: 4932410A21Rik, Down syndrome cell adhesion molecule
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Tmem132e
Name: transmembrane protein 132E
Synonyms: LOC270893
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 270893
Homologene: 41524
Auh
Name: AU RNA binding protein/enoyl-coenzyme A hydratase
Synonyms: W91705
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 11992
HGNC: HGNC:890
Homologene: 1284
Nek11
Name: NIMA (never in mitosis gene a)-related expressed kinase 11
Synonyms: 4932416N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208583
Homologene: 57008
Ccdc54
Name: coiled-coil domain containing 54
Synonyms: 1700007N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 69339
VEGA: 16
Homologene: 49871
Rskr
Name: ribosomal protein S6 kinase related
Synonyms: BC030499
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216976
Homologene: 79669
Olfr741
Name: olfactory receptor 741
Synonyms: GA_x6K02T2PMLR-6197851-6198786, MOR106-10, MOR106-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258233
Zmynd15
Name: zinc finger, MYND-type containing 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 574428
Homologene: 12995
4933427I04Rik
Name: Riken cDNA 4933427I04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
VEGA: 4
Kynu
Name: kynureninase
Synonyms: 4432411A05Rik, L-kynurenine hydrolase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70789
HGNC: HGNC:6469
Homologene: 2925
Myom1
Name: myomesin 1
Synonyms: skelemin, D430047A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17929
VEGA: 17
HGNC: HGNC:7613
Homologene: 31196
4933427D14Rik
Name: RIKEN cDNA 4933427D14 gene
Synonyms: Gm43951
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74477
Homologene: 8874
Adamts15
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235130
VEGA: 9
Homologene: 8610
Osgin1
Name: oxidative stress induced growth inhibitor 1
Synonyms: 1700012B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71839
Homologene: 16325
Zbtb6
Name: zinc finger and BTB domain containing 6
Synonyms: A830092L04Rik, Zfp482
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241322
Homologene: 4829
Rad51ap2
Name: RAD51 associated protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 209550
VEGA: 12
Homologene: 85245
Vmn2r99
Name: vomeronasal 2, receptor 99
Synonyms: EG665376
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665376
Homologene: 115024
Olfr231
Name: olfactory receptor 231
Synonyms: GA_x6K02T2P20D-21053942-21054499, GA_x6K02T2LER7-6-623, GA_x6K02T02K39-452-3, MOR105-4, Olfr425, Olfr244
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 404222
Homologene: 17363
Mael
Name: maelstrom spermatogenic transposon silencer
Synonyms: 4933405K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98558
Homologene: 13143
Mx2
Name: MX dynamin-like GTPase 2
Synonyms: Mx-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17858
Olfr1370
Name: olfactory receptor 1370
Synonyms: GA_x6K02T2QHY8-12181473-12182423, MOR256-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 258528
Homologene: 105231
Llgl1
Name: LLGL1 scribble cell polarity complex component
Synonyms: Lgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16897
HGNC: HGNC:6628
Homologene: 31220
Meioc
Name: meiosis specific with coiled-coil domain
Synonyms: LOC268491, LOC380729, Gm1564
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268491
Homologene: 19559
Ctnna3
Name: catenin (cadherin associated protein), alpha 3
Synonyms: Vr22, Catna3, 4930429L08Rik, alphaT-catenin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216033
HGNC: HGNC:2511
Homologene: 56583
Vmn2r124
Name: vomeronasal 2, receptor 124
Synonyms: Gm7196, Vmn2r-ps113
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 637021
Homologene: 115024
Vmn2r12
Name: vomeronasal 2, receptor 12
Synonyms: Gm6769
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 627569
Homologene: 129606
Zfp119a
Name: zinc finger protein 119a
Synonyms: Zfp119, Mzf13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 104349
Alpk1
Name: alpha-kinase 1
Synonyms: 8430410J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71481
Homologene: 11849
Kcnd3
Name: potassium voltage-gated channel, Shal-related family, member 3
Synonyms: potassium channel Kv4.3M, potassium channel Kv4.3L, Kv4.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56543
HGNC: HGNC:6239
Homologene: 21036
Nfe2
Name: nuclear factor, erythroid derived 2
Synonyms: NF-E2, p45, p45nf-e2, p45NFE2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18022
HGNC: HGNC:7780
Homologene: 4491
Dnajb5
Name: DnaJ heat shock protein family (Hsp40) member B5
Synonyms: Hsp40-3, Hsc40, 1110058L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56323
Homologene: 8176
Olfr732
Name: olfactory receptor 732
Synonyms: GA_x6K02T2PMLR-5975274-5974348, MOR241-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258659
Homologene: 72012
Fam8a1
Name: family with sequence similarity 8, member A1
Synonyms: C78339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 97863
Homologene: 32301
Olfr906
Name: olfactory receptor 906
Synonyms: GA_x6K02T2PVTD-32194085-32195020, MOR167-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258799
VEGA: 9
Homologene: 132439
Wdr81
Name: WD repeat domain 81
Synonyms: shakey 5, MGC32441, nur5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192652
Homologene: 13983
Olfr678
Name: olfactory receptor 678
Synonyms: GA_x6K02T2PBJ9-7698491-7699432, MOR32-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258753
Homologene: 27254
Mfsd4b1
Name: major facilitator superfamily domain containing 4B1
Synonyms: AI317395
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215929
Homologene: 77426
Speer3
Name: spermatogenesis associated glutamate (E)-rich protein 3
Synonyms: SPEER-3, 4933405P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71026
Homologene: 69402
1700109H08Rik
Name: RIKEN cDNA 1700109H08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 77036
Homologene: 130776
Rdh14
Name: retinol dehydrogenase 14 (all-trans and 9-cis)
Synonyms: PAN2, 3110030G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 105014
VEGA: 12
Homologene: 75139
Oard1
Name: O-acyl-ADP-ribose deacylase 1
Synonyms: AI314976
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106821
VEGA: 17
Homologene: 17038
Rab15
Name: RAB15, member RAS oncogene family
Synonyms: 2310012G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104886
Homologene: 64471
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 20,777,802 bp
  • T to A, chromosome 1 at 166,235,487 bp
  • G to T, chromosome 1 at 174,117,320 bp
  • A to T, chromosome 2 at 37,429,042 bp
  • T to A, chromosome 2 at 43,679,890 bp
  • A to T, chromosome 2 at 136,002,599 bp
  • C to T, chromosome 3 at 105,658,766 bp
  • G to A, chromosome 3 at 127,683,554 bp
  • A to G, chromosome 3 at 133,108,868 bp
  • A to G, chromosome 4 at 42,950,842 bp
  • T to A, chromosome 4 at 73,780,389 bp
  • A to T, chromosome 4 at 123,860,538 bp
  • A to G, chromosome 5 at 3,575,754 bp
  • C to G, chromosome 5 at 13,796,380 bp
  • A to C, chromosome 5 at 109,086,435 bp
  • T to C, chromosome 6 at 35,196,489 bp
  • T to C, chromosome 7 at 104,012,417 bp
  • T to C, chromosome 7 at 105,069,590 bp
  • G to T, chromosome 7 at 141,638,772 bp
  • T to C, chromosome 8 at 25,573,836 bp
  • T to C, chromosome 8 at 95,872,186 bp
  • C to T, chromosome 8 at 119,445,253 bp
  • A to T, chromosome 9 at 30,921,447 bp
  • A to C, chromosome 9 at 38,488,761 bp
  • T to C, chromosome 9 at 48,319,482 bp
  • A to T, chromosome 9 at 48,480,417 bp
  • A to G, chromosome 9 at 105,392,847 bp
  • A to G, chromosome 10 at 40,007,317 bp
  • G to A, chromosome 10 at 64,586,079 bp
  • T to C, chromosome 11 at 55,284,752 bp
  • C to T, chromosome 11 at 60,706,321 bp
  • T to C, chromosome 11 at 70,464,182 bp
  • T to A, chromosome 11 at 72,198,511 bp
  • T to C, chromosome 11 at 75,445,794 bp
  • T to A, chromosome 11 at 78,291,647 bp
  • T to C, chromosome 11 at 82,435,068 bp
  • G to T, chromosome 11 at 102,674,166 bp
  • T to A, chromosome 12 at 10,394,567 bp
  • T to C, chromosome 12 at 11,457,880 bp
  • G to A, chromosome 12 at 76,800,671 bp
  • C to T, chromosome 13 at 21,072,522 bp
  • T to C, chromosome 13 at 46,671,266 bp
  • T to C, chromosome 13 at 52,912,966 bp
  • A to T, chromosome 14 at 26,465,617 bp
  • A to G, chromosome 14 at 28,982,346 bp
  • G to A, chromosome 14 at 50,281,683 bp
  • A to G, chromosome 14 at 50,486,162 bp
  • A to T, chromosome 14 at 56,018,652 bp
  • C to T, chromosome 14 at 86,986,037 bp
  • G to A, chromosome 15 at 73,206,196 bp
  • A to G, chromosome 15 at 103,248,805 bp
  • A to T, chromosome 16 at 15,767,966 bp
  • G to A, chromosome 16 at 38,170,701 bp
  • G to T, chromosome 16 at 50,590,017 bp
  • A to T, chromosome 16 at 96,717,996 bp
  • C to A, chromosome 16 at 97,547,432 bp
  • T to C, chromosome 17 at 18,073,969 bp
  • A to T, chromosome 17 at 19,393,662 bp
  • T to C, chromosome 17 at 36,987,805 bp
  • T to C, chromosome 17 at 48,415,239 bp
  • G to A, chromosome 17 at 55,866,325 bp
  • A to G, chromosome 17 at 71,100,074 bp
  • A to T, chromosome 18 at 20,836,948 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4594 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041810-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.