Strain Name:
C57BL/6J-MtgxR4596Btlr/Mmmh
Stock Number:
041812-MU
Citation ID:
RRID:MMRRC_041812-MU
Other Names:
R4596 (G1), C57BL/6J-MtgxR4596Btlr
Major Collection:

Strain Information

Nfat5
Name: nuclear factor of activated T cells 5
Synonyms: B130038B15Rik, TonEBP, nfatz, OREBP
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54446
HGNC: HGNC:7774
Homologene: 4811
Nedd4
Name: neural precursor cell expressed, developmentally down-regulated 4
Synonyms: E430025J12Rik, Nedd4-1, Nedd4, Nedd4a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17999
HGNC: HGNC:7727
Homologene: 134533
Fasl
Name: Fas ligand
Synonyms: CD178, Tnfsf6, Fas-L, APT1LG1, Fasl, CD95L
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14103
Homologene: 533
Gria2
Name: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Synonyms: GluA2, Glur2, GluR2, GluR-B, Glur-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14800
HGNC: HGNC:4572
Homologene: 20225
Aopep
Name: aminopeptidase O
Synonyms: ApO, 2010111I01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72061
HGNC: HGNC:1361
Homologene: 66273
Gmps
Name: guanine monophosphate synthetase
Synonyms: Gm9479
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229363
HGNC: HGNC:4378
Homologene: 68367
U2surp
Name: U2 snRNP-associated SURP domain containing
Synonyms: 2610101N10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67958
Homologene: 13964
Wdr3
Name: WD repeat domain 3
Synonyms: D030020G18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269470
Homologene: 4937
Ift80
Name: intraflagellar transport 80
Synonyms: Wdr56, 4921524P20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68259
Homologene: 12253
Thbs1
Name: thrombospondin 1
Synonyms: TSP1, tbsp1, TSP-1, Thbs-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21825
Homologene: 31142
Bcam
Name: basal cell adhesion molecule
Synonyms: 1200005K12Rik, Lu, B-CAM
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57278
HGNC: HGNC:6722
Homologene: 21149
Prr14l
Name: proline rich 14-like
Synonyms: 6030436E02Rik, C330019G07Rik, Prl14l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215476
Homologene: 65866
Nsd2
Name: nuclear receptor binding SET domain protein 2
Synonyms: 9430010A17Rik, 5830445G22Rik, Whsc1, D030027O06Rik, C130020C13Rik, D930023B08Rik, Whsc1l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 107823
Homologene: 26175
Jak3
Name: Janus kinase 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16453
HGNC: HGNC:6193
Homologene: 181
Anxa6
Name: annexin A6
Synonyms: Annexin VI, Cabm, Anx6, AnxVI, Camb
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11749
HGNC: HGNC:544
Homologene: 55558
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: Dnchc2, m152Asp, m407Asp, b2b414Clo, D030010H02Rik, D330044F14Rik, 4432416O06Rik, DHC1b, DHC2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Tia1
Name: cytotoxic granule-associated RNA binding protein 1
Synonyms: 2310050N03Rik, mTIA-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21841
Homologene: 20692
Eif2a
Name: eukaryotic translation initiation factor 2A
Synonyms: D3Ertd194e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229317
HGNC: HGNC:3254
Homologene: 5969
Hspa13
Name: heat shock protein 70 family, member 13
Synonyms: 1600002I10Rik, 60kDa, Stch, B230217N24Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110920
Homologene: 5062
Paxbp1
Name: PAX3 and PAX7 binding protein 1
Synonyms: Pax3/7bp, 1810007M14Rik, Gcfc1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67367
Homologene: 9604
Tvp23b
Name: trans-golgi network vesicle protein 23B
Synonyms: 1810036I24Rik, Fam18b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67510
Homologene: 128511
Cipc
Name: CLOCK interacting protein, circadian
Synonyms: 2310044G17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217732
Homologene: 14124
1700017B05Rik
Name: RIKEN cDNA 1700017B05 gene
Synonyms: D9Ertd278e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74211
VEGA: 9
Homologene: 19283
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: Ta3, talpid3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76967
Homologene: 8839
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: [a]4(IV), E130010M05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Mgat4c
Name: MGAT4 family, member C
Synonyms: 9130411I17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67569
Homologene: 8297
Sox17
Name: SRY (sex determining region Y)-box 17
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20671
Homologene: 7948
Wdr72
Name: WD repeat domain 72
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 546144
Homologene: 52326
Cfi
Name: complement component factor i
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12630
HGNC: HGNC:5394
Homologene: 171
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: PTPL1, PTP-BL, Ptpri
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Adad1
Name: adenosine deaminase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21744
Homologene: 7569
Ptgfr
Name: prostaglandin F receptor
Synonyms: FP, PGF
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19220
HGNC: HGNC:9600
Homologene: 741
Sema3a
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Synonyms: semaphorin III, Semad, collapsin-1, SemD, sema III
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20346
Homologene: 31358
Slc4a10
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms: NCBE
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94229
Homologene: 23340
Or9q2
Name: olfactory receptor family 9 subfamily Q member 2
Synonyms: MOR212-1, Olfr1497, GA_x6K02T2RE5P-4127765-4126821
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258736
Homologene: 17373
Arhgef40
Name: Rho guanine nucleotide exchange factor 40
Synonyms: E130112L23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268739
Homologene: 19560
Or6f1
Name: olfactory receptor family 6 subfamily F member 1
Synonyms: GA_x6K02T2NHDJ-9786435-9787361, MOR104-1, Olfr308
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258614
Homologene: 27225
Slc16a14
Name: solute carrier family 16 (monocarboxylic acid transporters), member 14
Synonyms: 1110004H10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71781
Homologene: 34318
Fhod3
Name: formin homology 2 domain containing 3
Synonyms: A930009H06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225288
VEGA: 18
Homologene: 45323
Asz1
Name: ankyrin repeat, SAM and basic leucine zipper domain containing 1
Synonyms: ORF3, Gasz, 4933400N19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74068
HGNC: HGNC:1350
Homologene: 11374
Msl3l2
Name: MSL3 like 2
Synonyms: 1700060H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 73390
VEGA: 10
Homologene: 128448
Or4c31
Name: olfactory receptor family 4 subfamily C member 31
Synonyms: GA_x6K02T2Q125-49948903-49949814, Olfr1183, MOR230-6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258522
Homologene: 128125
Klhl21
Name: kelch-like 21
Synonyms: 1810045K06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242785
Homologene: 8902
Vmn1r62
Name: vomeronasal 1 receptor 62
Synonyms: V1rd8, V1rd2, V3R2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81016
Homologene: 41799
Ube2i
Name: ubiquitin-conjugating enzyme E2I
Synonyms: 5830467E05Rik, Ubce9, UBC9, Mmubc9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22196
Homologene: 5574
Itgb1bp1
Name: integrin beta 1 binding protein 1
Synonyms: bodenin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16413
Homologene: 3496
Sema6c
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
Synonyms: Sema Y, Semay
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20360
Homologene: 7931
Trim30d
Name: tripartite motif-containing 30D
Synonyms: TRIM30-3, Trim79
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 209387
Homologene: 114426
Or51h5
Name: olfactory receptor family 51 subfamily H member 5
Synonyms: MOR10-2, Olfr572, GA_x6K02T2PBJ9-5638785-5639741
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259093
Homologene: 131142
Cnksr1
Name: connector enhancer of kinase suppressor of Ras 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 194231
Homologene: 4604
Slc35f6
Name: solute carrier family 35, member F6
Synonyms: p40, 5730478O19Rik, 4930471M23Rik, Tango9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74919
Homologene: 9896
Sec61g
Name: SEC61 translocon subunit gamma
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20335
Homologene: 40767
Echdc3
Name: enoyl Coenzyme A hydratase domain containing 3
Synonyms: 2310005D12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67856
Homologene: 11484
Gm3852
Name: predicted gene 3852
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100042453
Rpl26-ps2
Name: ribosomal protein L26, pseudogene 2
Synonyms: Gm4805
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217600
VEGA: 12
Pcdha8
Name: protocadherin alpha 8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353235
HGNC: HGNC:8675
Homologene: 129614
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 4,492,637 bp
  • T to C, chromosome 1 at 46,011,762 bp
  • G to A, chromosome 1 at 82,471,219 bp
  • T to A, chromosome 1 at 84,929,357 bp
  • T to C, chromosome 1 at 161,788,269 bp
  • A to G, chromosome 2 at 6,195,808 bp
  • A to T, chromosome 2 at 62,296,858 bp
  • A to G, chromosome 2 at 88,462,194 bp
  • A to T, chromosome 2 at 118,114,755 bp
  • T to C, chromosome 3 at 37,065,192 bp
  • T to A, chromosome 3 at 58,548,970 bp
  • G to T, chromosome 3 at 63,993,917 bp
  • A to G, chromosome 3 at 68,990,759 bp
  • G to A, chromosome 3 at 80,709,423 bp
  • A to G, chromosome 3 at 95,168,648 bp
  • G to A, chromosome 3 at 100,152,867 bp
  • T to C, chromosome 3 at 129,868,500 bp
  • A to T, chromosome 3 at 151,801,793 bp
  • A to G, chromosome 4 at 134,233,878 bp
  • G to T, chromosome 4 at 152,012,540 bp
  • G to T, chromosome 5 at 13,570,157 bp
  • T to C, chromosome 5 at 30,648,062 bp
  • T to C, chromosome 5 at 32,829,308 bp
  • A to T, chromosome 5 at 33,882,918 bp
  • A to G, chromosome 5 at 103,523,692 bp
  • A to T, chromosome 6 at 18,103,593 bp
  • A to G, chromosome 6 at 86,420,407 bp
  • A to G, chromosome 7 at 5,675,307 bp
  • T to C, chromosome 7 at 19,764,157 bp
  • A to T, chromosome 7 at 86,321,423 bp
  • A to G, chromosome 7 at 102,928,251 bp
  • A to T, chromosome 7 at 104,472,526 bp
  • T to A, chromosome 8 at 71,684,631 bp
  • A to G, chromosome 8 at 107,351,500 bp
  • C to T, chromosome 9 at 6,992,595 bp
  • T to C, chromosome 9 at 57,257,805 bp
  • A to G, chromosome 9 at 72,742,700 bp
  • A to T, chromosome 9 at 74,151,605 bp
  • C to T, chromosome 9 at 95,485,628 bp
  • T to A, chromosome 10 at 56,115,645 bp
  • T to C, chromosome 10 at 102,388,561 bp
  • A to T, chromosome 11 at 16,508,127 bp
  • G to T, chromosome 11 at 54,994,583 bp
  • G to A, chromosome 11 at 62,883,718 bp
  • C to A, chromosome 12 at 21,272,134 bp
  • T to A, chromosome 12 at 57,632,928 bp
  • G to T, chromosome 12 at 71,164,546 bp
  • A to T, chromosome 12 at 71,164,547 bp
  • A to G, chromosome 12 at 86,961,954 bp
  • T to C, chromosome 13 at 63,068,092 bp
  • T to C, chromosome 14 at 51,987,224 bp
  • C to T, chromosome 16 at 75,758,226 bp
  • T to C, chromosome 16 at 91,030,547 bp
  • T to C, chromosome 17 at 25,265,324 bp
  • A to T, chromosome 18 at 25,115,718 bp
  • A to C, chromosome 18 at 36,993,558 bp
  • G to A, chromosome 19 at 13,794,900 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4596 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041812-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.