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Availability & Fees Order this Strain
Homozygous: indistinguishable from wild-type.
Heterozygous: indistinguishable from wild-type.
Cre-excised Phenotype: Mice with this deletion died prematurely following spontaneous generalized tonic-clonic seizures ( 30% of animals remaining after 90 days) and are susceptible to thermal induction of seizures. These mice also have the symptoms of Dravet Syndrome, including autistic-like behaviors, cognitive deficits, and sleep disorder.
Cheah CS, Yu FH, Westenbroek RE, Kalume RH, Oakley JC, Potter GB, Rubenstein JL, Catterall WA. Specific deletion of Nav1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14646-51. Epub 2012 Aug 20. (Medline PMID: 22908258)
Kalume F, Westenbroek RE, Cheah CS, Yu FH, Oakley JC, Scheuer T, Catterall WA. Sudden unexpected death in a mouse model of Dravet Syndrome. J Clin Invest. 2013 Apr;123(4):1798-808. Epub 2013 Mar 25. (Medline PMID: 23524966)
Kalume F, Oakley JC, Westenbroek RE, Gile J, de la Iglesia HO, Scheuer T, Catterall WA. Sleep impairment and reduced interneuron excitability in a mouse model of Dravet syndrome. Neurobiol Dis. 2015 May;77:141-54. Epub 2015 Mar 10. (Medline PMID: 25766678)
Rubinstein M, Han S, Tai C, Westenbroek RE, Hunker A, Scheuer T, and Catterall WA. Dissecting the Phenotypes of Dravet Syndrome by Gene Deletion. Brain. 2015 Aug;138(Pt 8):2219-33. Epub 2015 May 27. (Medline PMID: 26017580)
Colony Surveillance Program and Current Health Reports
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to mmrrc@ucdavis.edu for more information.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
The donor or their institution limits the distribution to non-profit institutions only.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.