Strain Detail Sheet

Strain Name:
B6;129-Scml2tm1Jw/Mmmh
Stock Number:
041874-MU
Citation ID:
RRID:MMRRC_041874-MU
Other Names:
Scml2-fl/fl

Strain Information

Gene Details

Scml2tm1Jw
Name:
Type: Allele
Species: Mus musculus (mouse)
Chromosome:
Scml2
Name: Scm polycomb group protein like 2
Synonyms: 4932420G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 107815
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Genetic Alterations
Two loxp sites were inserted in introns 10 and 11 using hybrid V6.5 ES cells (C57BL/6 × 129/sv)
Genotype Determination
ES Cell Line
v6.5 derived from (C57BL/6 x 129S4/SvJae)F1

Strain Description

Phenotype

Homozygous: Same as wild-type

Heterozygous: Same as wild-type

Cre-excised: Mice are expected to be sub-fertile and produce fewer sperm.

MeSH Terms
  • Animals
  • Apoptosis/genetics
  • Chromatin/genetics
  • Epigenesis, Genetic/genetics
  • Gene Silencing
  • Histones/genetics
  • Male
  • Meiosis/genetics
  • Mice
  • Multiprotein Complexes/genetics
  • Polycomb-Group Proteins/genetics
  • Spermatogenesis/genetics
  • Testis/growth & development
  • Testis/metabolism
  • Ubiquitin-Specific Peptidase 7
  • Ubiquitin-Specific Proteases/genetics
  • Ubiquitin-Specific Proteases/metabolism
  • X Chromosome/genetics
  • Y Chromosome/genetics
Strain Development
Mice were bred with C57BL/6J.
Suggested Control Mice
Wild-type littermates

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.

Research Applications

  • Neurobiology
  • Reproduction

Strain Origin

Donor
P. Jeremy Wang, Ph.D., University of Pennsylvania.
Primary Reference

Luo M, Zhou J, Leu NA, Abreu CM, Wang J, Anguera MC, de Rooij DG, Jasin M, Wang P. Polycomb Protein SCML2 Associates with USP7 and Counteracts Histone H2A Ubiquitination in the XY Chromatin during Male Meiosis. PLoS Genet. 2015 Jan 29. (Medline PMID: 25634095)

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
agouti

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
  • Wild-type female x Heterozygous male from the colony or reciprocal mating
  • Heterozygous female x Heterozygous male from the colony
  • Homozygous female x Homozygous male from the colony
Overall Breeding Performance
Excellent

Reproductive Statistics

NOTE: "Hemizygote" as used here refers to males carrying a mutation on the X Chromosome or mice of either sex carrying an inserted transgene with no homologous allele on the other chromosome.
Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Hetero/Hemizygotes are fertile: Yes Yes
Age Reproductive Decline: > 12 months > 12 months
Average litter size
5-9
Recommended wean age
3 weeks

Order Request Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Fees

- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.
To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.