Strain Detail Sheet

Strain Name:
FVB-Tg(IGHM-Csnk2a1)CKADcs/Mmmh
Stock Number:
041879-MU
Citation ID:
RRID:MMRRC_041879-MU
Other Names:
transgenic CK2alpha driven by the immunoglobin promoter and enhancer, TG.CKA, EμPμ-CK2α

Strain Information

Gene Details

Csnk2a1
Name: casein kinase 2, alpha 1 polypeptide
Synonyms: CK2, Csnk2a1-rs4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12995
Homologene: 90874
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Tg(IGHM-Csnk2a1)CKADcs
Name:
Type: Transgene
Species: Mus musculus (mouse)
Chromosome:
Genetic Alterations
The Csnk2a1 cDNA was subcloned into a vector with human immunoglobulin promoter (human) and enhancer (human/mouse) sequences as well as simian virus 40 intron and polyadenylate (SV40pA) sequences. 
Genotype Determination

Strain Description

Phenotype

Homozygous: Development of stochastic lymphoma with a 6 to 15% penetrance and disease onset at 6.5 months. (median 9 months)

Hemizygous: Not characterized

MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Casein Kinase II
  • Cattle
  • Cell Transformation, Neoplastic
  • Cloning, Molecular
  • Gene Expression Regulation, Enzymologic
  • Gene Rearrangement, T-Lymphocyte
  • Genes, myc
  • Leukemia/etiology
  • Lymphocytes/enzymology
  • Lymphoma/enzymology
  • Lymphoma/etiology
  • Lymphoma/genetics
  • Mice
  • Mice, Transgenic
  • Molecular Sequence Data
  • Protein-Serine-Threonine Kinases/genetics
  • Protein-Serine-Threonine Kinases/metabolism
  • Theileriasis/enzymology
  • Up-Regulation
  • Basic Helix-Loop-Helix Transcription Factors
  • DNA-Binding Proteins/genetics
  • DNA-Binding Proteins/metabolism
  • DNA-Binding Proteins/physiology
  • Disease Models, Animal
  • Humans
  • Immunophenotyping
  • Leukemia-Lymphoma, Adult T-Cell/etiology
  • Leukemia-Lymphoma, Adult T-Cell/pathology
  • Oncogenes/genetics
  • Phosphorylation
  • Protein-Serine-Threonine Kinases/physiology
  • Proto-Oncogene Proteins/genetics
  • Proto-Oncogene Proteins/metabolism
  • Proto-Oncogene Proteins/physiology
  • RNA, Messenger/analysis
  • RNA, Neoplasm/analysis
  • T-Cell Acute Lymphocytic Leukemia Protein 1
  • Thymoma/chemistry
  • Thymoma/etiology
  • Thymoma/pathology
  • Thymus Gland/chemistry
  • Thymus Neoplasms/chemistry
  • Thymus Neoplasms/etiology
  • Thymus Neoplasms/pathology
  • Transcription Factors
  • Transgenes/genetics
  • Autoimmune Diseases/genetics
  • Autoimmune Diseases/immunology
  • Autoimmune Diseases/pathology
  • CD4 Antigens/analysis
  • CD8 Antigens/analysis
  • Gene Expression Regulation/immunology
  • Heterozygote
  • Homozygote
  • Leukocyte Common Antigens/analysis
  • Lymphatic Diseases/genetics
  • Lymphatic Diseases/immunology
  • Lymphoproliferative Disorders/genetics
  • Lymphoproliferative Disorders/immunology
  • Lymphoproliferative Disorders/pathology
  • Mice, Inbred MRL lpr
  • Mice, Knockout
  • Protein-Serine-Threonine Kinases/immunology
  • Splenomegaly/genetics
  • Splenomegaly/immunology
  • T-Lymphocyte Subsets/immunology
  • Transgenes/immunology
  • Gene Dosage
  • Lymphoma, T-Cell/enzymology
  • Lymphoma, T-Cell/etiology
  • Lymphoma, T-Cell/genetics
  • Lymphoma, T-Cell/pathology
  • Mutagenesis
  • Thymus Gland/pathology
  • Thymus Neoplasms/enzymology
  • Thymus Neoplasms/genetics
  • Tumor Suppressor Protein p53/genetics
  • Tumor Suppressor Protein p53/physiology
Strain Development
The vector was injected into FVB/N fertilized oocytes. The strain has been maintained on the FVB/N background. 
Suggested Control Mice
Wild-type littermates

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.

Research Applications

  • Apoptosis
  • Cancer
  • Hematology
  • Immunology and Inflammation
  • Models for Human Disease
  • Research Tools

Strain Origin

Donor
David C. Seldin, M.D., Ph.D., Boston University.
Esther Landesman, Ph.D., BU.
Primary Reference

Seldin DC, Leder P. Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle. Science. 1995 Feb 10;267(5199):894-7. (Medline PMID: 7846532)

Kelliher MA, Seldin DC, Leder P. Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha. EMBO J. 1996 Oct 1;15(19):5160-6. (Medline PMID: 8895560)

Rifkin IR, Channavajhala PL, Kiefer HL, Carmack AJ, Landesman-Bollag E, Beaudette BC, Jersky B, Salant DJ, Ju ST, Marshak-Rothstein A, Seldin DC. Acceleration of lpr lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha. J Immunol. 1998 Nov 15;161(10):5164-70. (Medline PMID: 9820486)

Landesman-Bollag E, Channavajhala PL, Cardiff RD, Seldin DC. p53 deficiency and misexpression of protein kinase CK2alpha collaborate in the development of thymic lymphomas in mice. Oncogene. 1998 Jun 11;16(23):2965-74. (Medline PMID: 9662328)

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
White

Breeding

MMRRC Breeding System
Sib-mating
Breeding Scheme(s)
  • Wild-type female x Hemizygous male littermate or reciprocal mating
  • Heterozygous female x Heterozygous male littermate
  • Homozygous female x Homozygous male littermate
Overall Breeding Performance
Excellent

Reproductive Statistics

NOTE: "Hemizygote" as used here refers to males carrying a mutation on the X Chromosome or mice of either sex carrying an inserted transgene with no homologous allele on the other chromosome.
Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Hetero/Hemizygotes are fertile: Yes Yes
Age Reproductive Decline: 6 to 8 months >12 months
Average litter size
5-9
Recommended wean age
3 weeks

Order Request Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.
To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.