Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR4690Btlr/Mmmh
Stock Number:
041941-MU
Citation ID:
RRID:MMRRC_041941-MU
Other Names:
R4690 (G1), C57BL/6J-MtgxR4690Btlr
Major Collection:

Strain Information

Itpk1
Name: inositol 1,3,4-triphosphate 5/6 kinase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217837
HGNC: HGNC:6177
Homologene: 8588
Myo5a
Name: myosin VA
Synonyms: MVa, MyoVA, Myo5, flail, 9630007J19Rik, Dbv
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17918
HGNC: HGNC:7602
Homologene: 20100
Slc6a1
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Synonyms: XT-1, Gabt, Xtrp1, Gat1, Gabt1, GAT-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232333
Homologene: 2290
Cd40
Name: CD40 antigen
Synonyms: Cd40, Bp50, p50, Tnfrsf5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21939
Homologene: 954
Fiz1
Name: Flt3 interacting zinc finger protein 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23877
Homologene: 22663
Mga
Name: MAX gene associated
Synonyms: Mga, Mad5, C130042M01Rik, D030062C11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Pfdn1
Name: prefoldin 1
Synonyms: 2700086I23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67199
VEGA: 18
HGNC: HGNC:8866
Homologene: 37644
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 24,224,706 bp
  • C to T, chromosome 1 at 39,577,214 bp
  • A to G, chromosome 1 at 91,520,112 bp
  • A to T, chromosome 1 at 97,269,499 bp
  • C to T, chromosome 1 at 106,982,844 bp
  • T to A, chromosome 2 at 52,244,075 bp
  • T to A, chromosome 2 at 86,046,898 bp
  • T to C, chromosome 2 at 119,923,585 bp
  • T to C, chromosome 2 at 131,274,025 bp
  • C to T, chromosome 2 at 155,635,133 bp
  • T to C, chromosome 2 at 165,069,695 bp
  • C to A, chromosome 3 at 30,238,310 bp
  • C to T, chromosome 3 at 51,247,879 bp
  • G to C, chromosome 3 at 90,221,023 bp
  • A to G, chromosome 3 at 93,323,652 bp
  • A to G, chromosome 3 at 138,326,171 bp
  • T to A, chromosome 4 at 42,873,032 bp
  • G to A, chromosome 4 at 45,046,369 bp
  • G to A, chromosome 4 at 45,372,769 bp
  • G to A, chromosome 4 at 62,486,525 bp
  • A to T, chromosome 4 at 111,774,826 bp
  • T to A, chromosome 4 at 116,155,510 bp
  • A to T, chromosome 4 at 120,717,011 bp
  • T to C, chromosome 4 at 123,323,043 bp
  • A to T, chromosome 4 at 148,612,621 bp
  • C to T, chromosome 4 at 154,287,963 bp
  • A to G, chromosome 5 at 32,844,156 bp
  • A to G, chromosome 5 at 73,100,293 bp
  • G to A, chromosome 5 at 105,907,076 bp
  • A to C, chromosome 5 at 139,805,622 bp
  • T to G, chromosome 6 at 40,245,613 bp
  • A to T, chromosome 6 at 57,926,025 bp
  • A to G, chromosome 6 at 113,302,055 bp
  • A to G, chromosome 6 at 114,302,831 bp
  • A to T, chromosome 6 at 116,423,189 bp
  • A to T, chromosome 6 at 122,036,296 bp
  • A to G, chromosome 7 at 5,009,168 bp
  • T to A, chromosome 7 at 10,719,203 bp
  • T to A, chromosome 7 at 26,939,209 bp
  • A to G, chromosome 7 at 102,447,879 bp
  • A to T, chromosome 7 at 126,575,393 bp
  • G to A, chromosome 7 at 127,538,014 bp
  • G to A, chromosome 7 at 141,842,294 bp
  • A to G, chromosome 8 at 25,793,680 bp
  • T to C, chromosome 8 at 84,082,745 bp
  • C to T, chromosome 8 at 112,002,584 bp
  • A to T, chromosome 9 at 53,622,871 bp
  • T to C, chromosome 9 at 75,153,823 bp
  • T to C, chromosome 10 at 58,813,704 bp
  • A to G, chromosome 10 at 79,675,401 bp
  • C to T, chromosome 10 at 80,546,421 bp
  • C to A, chromosome 10 at 80,786,182 bp
  • G to A, chromosome 10 at 94,545,557 bp
  • A to G, chromosome 10 at 127,030,678 bp
  • A to G, chromosome 10 at 127,091,375 bp
  • A to G, chromosome 11 at 53,465,722 bp
  • A to T, chromosome 11 at 77,455,205 bp
  • A to T, chromosome 11 at 96,284,460 bp
  • A to G, chromosome 11 at 110,148,880 bp
  • A to T, chromosome 11 at 116,816,252 bp
  • C to T, chromosome 12 at 24,655,072 bp
  • A to T, chromosome 12 at 102,606,175 bp
  • A to G, chromosome 12 at 103,732,380 bp
  • A to G, chromosome 12 at 111,445,248 bp
  • T to A, chromosome 12 at 111,832,558 bp
  • T to C, chromosome 13 at 99,431,068 bp
  • G to T, chromosome 14 at 3,964,471 bp
  • A to T, chromosome 14 at 24,464,281 bp
  • A to T, chromosome 14 at 61,611,727 bp
  • A to G, chromosome 14 at 66,173,300 bp
  • G to T, chromosome 14 at 68,642,048 bp
  • T to C, chromosome 14 at 79,345,057 bp
  • T to C, chromosome 15 at 76,174,256 bp
  • A to T, chromosome 15 at 77,967,316 bp
  • A to G, chromosome 15 at 86,311,836 bp
  • T to C, chromosome 16 at 4,716,341 bp
  • T to A, chromosome 16 at 18,218,295 bp
  • T to C, chromosome 16 at 18,226,741 bp
  • T to C, chromosome 16 at 19,957,284 bp
  • G to A, chromosome 16 at 58,613,970 bp
  • A to C, chromosome 17 at 28,351,837 bp
  • A to T, chromosome 17 at 90,037,081 bp
  • A to T, chromosome 18 at 6,216,759 bp
  • A to T, chromosome 18 at 36,451,080 bp
  • T to A, chromosome 18 at 38,203,475 bp
  • A to T, chromosome 18 at 74,722,462 bp
  • A to C, chromosome 19 at 13,234,768 bp
  • C to A, chromosome 19 at 47,747,859 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4690 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041941-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.