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Strain Name:
C57BL/6J-MtgxR4784Btlr/Mmmh
Stock Number:
041994-MU
Citation ID:
RRID:MMRRC_041994-MU
Other Names:
R4784 (G1), C57BL/6J-MtgxR4784Btlr
Major Collection:

Strain Information

Kcnc1
Name: potassium voltage gated channel, Shaw-related subfamily, member 1
Synonyms: Kv3.1, KV4, NGK2, KShIIIB, Kcr2-1, Shaw, C230009H10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16502
HGNC: HGNC:6233
Homologene: 68134
Elf1
Name: E74 like ETS transcription factor 1
Synonyms: Elf-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13709
VEGA: 14
HGNC: HGNC:3316
Homologene: 7303
Mga
Name: MAX gene associated
Synonyms: Mga, Mad5, C130042M01Rik, D030062C11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Dnajc17
Name: DnaJ heat shock protein family (Hsp40) member C17
Synonyms: D9Bwg1371e, 1700025B16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69408
Homologene: 49527
Slc37a3
Name: solute carrier family 37 (glycerol-3-phosphate transporter), member 3
Synonyms: 2610507O21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72144
Homologene: 41740
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 36,632,415 bp
  • A to G, chromosome 1 at 40,450,188 bp
  • G to A, chromosome 1 at 54,259,995 bp
  • A to G, chromosome 1 at 59,215,313 bp
  • A to G, chromosome 1 at 65,267,846 bp
  • A to T, chromosome 1 at 74,679,007 bp
  • T to C, chromosome 1 at 134,541,325 bp
  • A to G, chromosome 1 at 135,458,739 bp
  • T to C, chromosome 1 at 153,231,740 bp
  • T to C, chromosome 1 at 188,974,468 bp
  • T to A, chromosome 2 at 25,292,381 bp
  • T to A, chromosome 2 at 32,297,156 bp
  • A to G, chromosome 2 at 52,620,126 bp
  • T to A, chromosome 2 at 80,506,934 bp
  • A to T, chromosome 2 at 111,873,050 bp
  • G to A, chromosome 2 at 112,248,936 bp
  • T to C, chromosome 2 at 119,179,428 bp
  • C to T, chromosome 2 at 119,903,057 bp
  • A to T, chromosome 2 at 121,008,522 bp
  • A to T, chromosome 2 at 125,324,919 bp
  • T to C, chromosome 2 at 156,096,564 bp
  • T to C, chromosome 3 at 75,085,041 bp
  • T to C, chromosome 3 at 121,527,074 bp
  • G to T, chromosome 3 at 127,687,592 bp
  • A to T, chromosome 4 at 43,356,980 bp
  • A to C, chromosome 4 at 43,568,315 bp
  • T to C, chromosome 4 at 91,254,142 bp
  • A to T, chromosome 4 at 126,368,503 bp
  • A to T, chromosome 4 at 132,902,117 bp
  • A to G, chromosome 4 at 132,916,190 bp
  • A to T, chromosome 4 at 136,933,322 bp
  • G to A, chromosome 4 at 137,007,097 bp
  • G to T, chromosome 4 at 139,300,001 bp
  • A to G, chromosome 4 at 152,287,832 bp
  • G to A, chromosome 4 at 152,554,546 bp
  • T to A, chromosome 5 at 73,420,111 bp
  • C to T, chromosome 5 at 86,306,281 bp
  • A to G, chromosome 5 at 100,459,738 bp
  • T to A, chromosome 5 at 103,847,039 bp
  • A to G, chromosome 5 at 114,360,599 bp
  • T to C, chromosome 5 at 123,579,293 bp
  • T to G, chromosome 5 at 123,816,762 bp
  • C to G, chromosome 5 at 123,864,450 bp
  • T to A, chromosome 5 at 125,848,713 bp
  • T to G, chromosome 5 at 135,217,413 bp
  • T to G, chromosome 6 at 7,678,029 bp
  • T to G, chromosome 6 at 39,337,223 bp
  • T to C, chromosome 6 at 85,901,499 bp
  • A to G, chromosome 6 at 132,909,903 bp
  • A to C, chromosome 6 at 134,479,539 bp
  • T to A, chromosome 7 at 4,009,732 bp
  • T to C, chromosome 7 at 12,971,306 bp
  • A to T, chromosome 7 at 29,292,061 bp
  • A to G, chromosome 7 at 29,377,641 bp
  • G to A, chromosome 7 at 43,692,077 bp
  • G to T, chromosome 7 at 46,437,287 bp
  • A to G, chromosome 7 at 47,335,470 bp
  • T to A, chromosome 7 at 81,768,415 bp
  • A to C, chromosome 7 at 96,774,046 bp
  • G to A, chromosome 7 at 102,113,219 bp
  • A to C, chromosome 7 at 105,024,530 bp
  • A to G, chromosome 7 at 105,765,926 bp
  • T to C, chromosome 7 at 119,857,664 bp
  • A to G, chromosome 7 at 139,242,698 bp
  • G to A, chromosome 7 at 140,763,908 bp
  • T to A, chromosome 8 at 85,302,950 bp
  • A to G, chromosome 8 at 91,085,568 bp
  • T to C, chromosome 9 at 18,350,918 bp
  • A to G, chromosome 9 at 32,129,653 bp
  • T to C, chromosome 9 at 32,260,780 bp
  • T to C, chromosome 9 at 44,513,341 bp
  • C to A, chromosome 9 at 79,678,494 bp
  • A to G, chromosome 9 at 111,239,798 bp
  • A to G, chromosome 9 at 111,264,894 bp
  • A to G, chromosome 10 at 7,604,201 bp
  • C to T, chromosome 10 at 121,615,063 bp
  • T to C, chromosome 11 at 6,419,118 bp
  • G to A, chromosome 11 at 9,038,266 bp
  • T to C, chromosome 11 at 42,597,642 bp
  • A to C, chromosome 11 at 54,915,539 bp
  • A to C, chromosome 11 at 58,310,171 bp
  • T to C, chromosome 11 at 63,889,260 bp
  • T to A, chromosome 11 at 75,492,505 bp
  • A to T, chromosome 11 at 84,026,664 bp
  • T to C, chromosome 11 at 120,367,987 bp
  • A to T, chromosome 12 at 100,838,664 bp
  • C to T, chromosome 13 at 21,312,264 bp
  • C to G, chromosome 13 at 108,052,780 bp
  • T to C, chromosome 13 at 110,061,900 bp
  • T to A, chromosome 14 at 31,263,479 bp
  • C to T, chromosome 14 at 37,062,236 bp
  • T to A, chromosome 14 at 47,693,496 bp
  • C to A, chromosome 14 at 52,205,368 bp
  • T to C, chromosome 14 at 55,501,321 bp
  • AGAGGAGGAGGAGGAGGA to AGAGGAGGAGGAGGA, chromosome 14 at 55,746,402 bp
  • T to A, chromosome 14 at 66,637,824 bp
  • C to T, chromosome 14 at 70,777,874 bp
  • T to A, chromosome 14 at 79,580,743 bp
  • T to C, chromosome 15 at 3,969,041 bp
  • G to A, chromosome 15 at 75,657,703 bp
  • A to G, chromosome 15 at 75,676,031 bp
  • A to G, chromosome 15 at 101,487,956 bp
  • A to C, chromosome 16 at 14,152,457 bp
  • G to A, chromosome 16 at 18,258,310 bp
  • G to T, chromosome 16 at 58,760,548 bp
  • T to C, chromosome 16 at 93,884,542 bp
  • T to C, chromosome 17 at 34,733,406 bp
  • T to G, chromosome 17 at 35,439,938 bp
  • T to C, chromosome 17 at 46,222,717 bp
  • A to G, chromosome 17 at 87,340,897 bp
  • A to T, chromosome 18 at 12,449,544 bp
  • A to G, chromosome 18 at 50,568,065 bp
  • A to G, chromosome 19 at 57,629,158 bp
  • A to G, chromosome Y at 938,198 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4784 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041994-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.