Strain Name:
C57BL/6J-MtgxR4819Btlr/Mmmh
Stock Number:
042000-MU
Citation ID:
RRID:MMRRC_042000-MU
Other Names:
R4819 (G1), C57BL/6J-MtgxR4819Btlr
Major Collection:

Strain Information

Pax6
Name: paired box 6
Synonyms: Pax-6, Gsfaey11, Dey, AEY11, Dickie's small eye, 1500038E17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18508
HGNC: HGNC:8620
Homologene: 1212
Plin2
Name: perilipin 2
Synonyms: adipophilin, ADPH, Adrp, Adfp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11520
HGNC: HGNC:248
Homologene: 872
Dst
Name: dystonin
Synonyms: Bpag, Macf2, A830042E19Rik, nmf339, 2310001O04Rik, BPAG1, BPAG1-n, bullous pemphigoid antigen 1, bullous pemphigoid antigen 1, athetoid, nmf203, Bpag1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Med1
Name: mediator complex subunit 1
Synonyms: Pparbp, TRAP 220, DRIP205, CRSP210, l11Jus15, PBP, TRAP220
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19014
HGNC: HGNC:9234
Homologene: 21002
Mapk1
Name: mitogen-activated protein kinase 1
Synonyms: 9030612K14Rik, Erk2, Prkm1, MAPK2, p42mapk
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 26413
HGNC: HGNC:6871
Homologene: 37670
Dctn1
Name: dynactin 1
Synonyms: p150glued, p150, Glued
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13191
HGNC: HGNC:2711
Homologene: 3011
Ttc17
Name: tetratricopeptide repeat domain 17
Synonyms: 9130020K17Rik, D2Bwg1005e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74569
Homologene: 10100
Zfp462
Name: zinc finger protein 462
Synonyms: Zfpip, 9430078C22Rik, Gt4-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242466
Homologene: 41430
Pop1
Name: processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
Synonyms: 4932434G09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67724
Homologene: 41000
Kif18a
Name: kinesin family member 18A
Synonyms: gcd2, B130001M12Rik, N-8 kinesin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228421
Homologene: 41820
Trim66
Name: tripartite motif-containing 66
Synonyms: Tif1d, D7H11orf29
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330627
Homologene: 28044
Zfp281
Name: zinc finger protein 281
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226442
Homologene: 8270
Efs
Name: embryonal Fyn-associated substrate
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13644
VEGA: 14
Homologene: 4284
Arhgef1
Name: Rho guanine nucleotide exchange factor 1
Synonyms: Lbcl2, Lsc
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16801
HGNC: HGNC:681
Homologene: 3454
Ik
Name: IK cytokine
Synonyms: MuRED
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 24010
VEGA: 18
HGNC: HGNC:5958
Homologene: 36193
Oas1d
Name: 2'-5' oligoadenylate synthetase 1D
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100535
HGNC: HGNC:8086
Homologene: 110815
Lig4
Name: ligase IV, DNA, ATP-dependent
Synonyms: DNA ligase IV, tiny, 5830471N16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319583
HGNC: HGNC:6601
Homologene: 1736
Adgrf3
Name: adhesion G protein-coupled receptor F3
Synonyms: PGR23, LOC381628, Gpr113
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381628
Homologene: 17826
Hspa9
Name: heat shock protein 9
Synonyms: C3H-specific antigen, Hsp74a, mortalin, Hsp74, Hspa9a, mot-2, mthsp70, GRP75, PBP74, CSA, Hsc74
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15526
HGNC: HGNC:5244
Homologene: 39452
Khsrp
Name: KH-type splicing regulatory protein
Synonyms: 6330409F21Rik, KSRP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16549
VEGA: 17
HGNC: HGNC:6316
Homologene: 2734
Mkln1
Name: muskelin 1, intracellular mediator containing kelch motifs
Synonyms: A130067F06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27418
HGNC: HGNC:7109
Homologene: 8305
Akap8
Name: A kinase anchor protein 8
Synonyms: 1200016A02Rik, AKAP95
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56399
VEGA: 17
HGNC: HGNC:378
Homologene: 4278
Amotl2
Name: angiomotin-like 2
Synonyms: Lccp, MASCOT
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56332
Homologene: 9420
Pomgnt1
Name: protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase
Synonyms: 4930467B06Rik, 0610016I07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68273
Homologene: 9806
Ptpn4
Name: protein tyrosine phosphatase, non-receptor type 4
Synonyms: PTPMEG, testis-enriched phosphatase, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte), TEP/mPTPMEG, hPTP-MEG, TEP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19258
HGNC: HGNC:9656
Homologene: 2120
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh-4, Zfh4, C130041O22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80892
Homologene: 23477
Ttn
Name: titin
Synonyms: 2310036G12Rik, 2310057K23Rik, D330041I19Rik, mdm, connectin, D830007G01Rik, 1100001C23Rik, shru, 2310074I15Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Vinac1
Name: vinculin/alpha-catenin family member 1
Synonyms: Gm14025
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668894
Homologene: 86340
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Mgat3
Name: mannoside acetylglucosaminyltransferase 3
Synonyms: 1110038J12Rik, GnT-III
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17309
VEGA: 15
HGNC: HGNC:7046
Homologene: 31088
Heca
Name: hdc homolog, cell cycle regulator
Synonyms: LOC380629
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380629
VEGA: 10
Homologene: 32300
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381157
Homologene: 73393
Pcnx2
Name: pecanex homolog 2
Synonyms: Pcnxl2, E330039K12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Fcrla
Name: Fc receptor-like A
Synonyms: Freb1, FREB, FCRL1, mFcrX, mFREB, Fcrx
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98752
Homologene: 13106
Myo5c
Name: myosin VC
Synonyms: 9130003O20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208943
VEGA: 9
HGNC: HGNC:7604
Homologene: 135711
Iho1
Name: interactor of HORMAD1 1
Synonyms: Iho1, Ccdc36
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 434438
Homologene: 52256
Krt2
Name: keratin 2
Synonyms: Krt2-17, Krt2e, Krt2-2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16681
HGNC: HGNC:6439
Edc3
Name: enhancer of mRNA decapping 3
Synonyms: Lsm16, Yjdc
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 353190
Homologene: 11827
Zdhhc1
Name: zinc finger, DHHC domain containing 1
Synonyms: 4432412D04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70796
Homologene: 36891
Hyal6
Name: hyaluronoglucosaminidase 6
Synonyms: Hyal-ps1, 4932701A20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74409
HGNC: HGNC:5324
Homologene: 78028
Gpam
Name: glycerol-3-phosphate acyltransferase, mitochondrial
Synonyms: GPAT1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14732
Homologene: 7343
Atp6v1e2
Name: ATPase, H+ transporting, lysosomal V1 subunit E2
Synonyms: 4930500C14Rik, lysosomal 31kDa, Atp6e1, E1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74915
VEGA: 17
Homologene: 41770
Cd177
Name: CD177 antigen
Synonyms: Pdp3, 1190003K14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68891
Homologene: 49628
Casd1
Name: CAS1 domain containing 1
Synonyms: Cast1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213819
Homologene: 11287
Derl3
Name: Der1-like domain family, member 3
Synonyms: derlin-3, 1810006I20Rik, 1810063P04Rik, IZP6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70377
VEGA: 10
Homologene: 41566
Tmem59
Name: transmembrane protein 59
Synonyms: 3110046P06Rik, 1110001M20Rik, MTDCF1, D4Ertd20e, thymic dendritic cell-derived factor 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56374
HGNC: HGNC:1239
Homologene: 3583
Bfar
Name: bifunctional apoptosis regulator
Synonyms: RNF47
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67118
Homologene: 9563
As3mt
Name: arsenite methyltransferase
Synonyms: Cyt19, 2310045H08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 57344
VEGA: 19
Homologene: 10754
Csl
Name: citrate synthase like
Synonyms: 1700007H16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71832
VEGA: 10
HGNC: HGNC:2422
Homologene: 7131
Gm5265
Name: predicted pseudogene 5265
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 383613
Gm26702
Name: predicted gene, 26702
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Ear-ps2
Name: eosinophil-associated, ribonuclease A family, pseudogene 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 93743
Tmem100
Name: transmembrane protein 100
Synonyms: 1810057C19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67888
Homologene: 10110
4933422H20Rik
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Trav21-dv12
Name: T cell receptor alpha variable 21-DV12
Synonyms: Gm13892
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100101940
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 33,968,835 bp
  • G to T, chromosome 1 at 119,659,850 bp
  • A to G, chromosome 1 at 136,625,710 bp
  • T to C, chromosome 1 at 169,453,758 bp
  • T to A, chromosome 1 at 170,920,939 bp
  • G to A, chromosome 2 at 25,577,177 bp
  • A to T, chromosome 2 at 76,791,749 bp
  • A to G, chromosome 2 at 82,988,442 bp
  • G to A, chromosome 2 at 94,364,610 bp
  • G to A, chromosome 2 at 105,692,277 bp
  • A to G, chromosome 2 at 109,292,126 bp
  • G to T, chromosome 2 at 129,040,801 bp
  • C to A, chromosome 3 at 5,403,914 bp
  • G to T, chromosome 4 at 55,060,044 bp
  • A to G, chromosome 4 at 86,658,662 bp
  • C to T, chromosome 4 at 107,187,681 bp
  • T to A, chromosome 4 at 116,159,302 bp
  • T to A, chromosome 5 at 30,198,444 bp
  • A to G, chromosome 5 at 111,419,937 bp
  • T to C, chromosome 5 at 120,915,717 bp
  • C to T, chromosome 6 at 4,621,225 bp
  • T to A, chromosome 6 at 24,734,966 bp
  • A to T, chromosome 6 at 31,474,486 bp
  • G to A, chromosome 6 at 83,190,519 bp
  • A to T, chromosome 7 at 24,752,271 bp
  • A to G, chromosome 7 at 24,912,284 bp
  • G to T, chromosome 7 at 109,457,586 bp
  • A to G, chromosome 8 at 9,971,885 bp
  • CGGGGG to CGGGGGG, chromosome 8 at 105,483,744 bp
  • A to T, chromosome 8 at 125,855,230 bp
  • T to A, chromosome 9 at 57,748,397 bp
  • T to A, chromosome 9 at 75,292,202 bp
  • C to T, chromosome 9 at 102,730,071 bp
  • A to G, chromosome 9 at 108,406,678 bp
  • A to G, chromosome 10 at 17,908,072 bp
  • A to C, chromosome 10 at 74,324,389 bp
  • A to G, chromosome 10 at 75,893,879 bp
  • G to T, chromosome 10 at 92,836,477 bp
  • A to G, chromosome 10 at 99,758,082 bp
  • T to A, chromosome 11 at 9,290,421 bp
  • A to T, chromosome 11 at 59,038,848 bp
  • A to G, chromosome 11 at 90,035,445 bp
  • C to T, chromosome 11 at 98,155,432 bp
  • A to G, chromosome 11 at 115,447,943 bp
  • T to A, chromosome 13 at 62,454,417 bp
  • G to A, chromosome 14 at 44,047,060 bp
  • T to A, chromosome 14 at 53,876,613 bp
  • T to C, chromosome 14 at 54,917,153 bp
  • T to C, chromosome 15 at 34,517,982 bp
  • T to A, chromosome 15 at 80,212,349 bp
  • T to C, chromosome 15 at 101,811,544 bp
  • C to T, chromosome 16 at 13,687,467 bp
  • A to G, chromosome 16 at 17,026,495 bp
  • G to A, chromosome 17 at 32,312,305 bp
  • A to G, chromosome 17 at 57,023,360 bp
  • A to G, chromosome 17 at 86,944,538 bp
  • A to G, chromosome 18 at 10,458,358 bp
  • C to T, chromosome 18 at 34,939,388 bp
  • T to A, chromosome 18 at 36,753,257 bp
  • G to T, chromosome 19 at 46,707,529 bp
  • T to A, chromosome 19 at 55,078,341 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4819 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042000-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.