Strain Name:
C57BL/6J-MtgxR4587Btlr/Mmmh
Stock Number:
042006-MU
Citation ID:
RRID:MMRRC_042006-MU
Other Names:
R4587 (G1), C57BL/6J-MtgxR4587Btlr
Major Collection:

Gene Information

Zic1
Name: zinc finger protein of the cerebellum 1
Synonyms: odd-paired homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 22771
Homologene: 2562
Wnt7a
Name: wingless-type MMTV integration site family, member 7A
Synonyms: tw, Wnt-7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 22421
Homologene: 20969
Adsl
Name: adenylosuccinate lyase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 11564
HGNC: HGNC:291
Homologene: 12
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Nf-1, Mhdadsk9, Dsk9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 9030205D12Rik, 1810014J18Rik, AD013, A330063D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 109151
Homologene: 11844
Tbcd
Name: tubulin-specific chaperone d
Synonyms: 2310057L06Rik, A030005L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 108903
Homologene: 4368
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: Grit, 3426406O18Rik, PX-RICS, GC-GAP, p200RhoGAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 330914
Homologene: 8812
Zfp617
Name: zinc finger protein 617
Synonyms: Zfps11-6, Zinc finger protein s11-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 170938
Homologene: 135689
Tle3
Name: transducin-like enhancer of split 3
Synonyms: Grg3a, 2610103N05Rik, Grg3b, ESG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 21887
Homologene: 21059
Kif22
Name: kinesin family member 22
Synonyms: Kif22a, Kid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 110033
HGNC: HGNC:6391
Homologene: 32011
Mapk8ip3
Name: mitogen-activated protein kinase 8 interacting protein 3
Synonyms: Syd2, c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1, JSAP1a, JSAP1b, JSAP1c, JSAP1d, JUN/SAPK-associated protein 1, Jip3, JNK-interacting protein 3, JSAP1, D17Wsu15e, sunday driver 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 30957
HGNC: HGNC:6884
Homologene: 22790
Ckap2
Name: cytoskeleton associated protein 2
Synonyms: LB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 80986
HGNC: HGNC:1990
Homologene: 10070
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930543C13Rik, 4930516E05Rik, D330038K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Ric3
Name: RIC3 acetylcholine receptor chaperone
Synonyms: E130307J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 320360
Homologene: 49772
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1537Clo, b2b1565Clo, b2b3491Clo, b2b1154Clo, Mdnah5, Dnahc5, b2b1134Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: Hug, Jbts17, b2b012Clo, 2410089E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 73692
Homologene: 11315
Chrd
Name: chordin
Synonyms: Chd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 12667
HGNC: HGNC:1949
Homologene: 2774
Cd244a
Name: CD244 molecule A
Synonyms: Cd244, F730046O15Rik, 2B4, Nmrk, C9.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18106
Homologene: 9493
Atp11b
Name: ATPase, class VI, type 11B
Synonyms: 1110019I14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 76295
Homologene: 32919
Trim30a
Name: tripartite motif-containing 30A
Synonyms: Trim30, Rpt1, Rpt-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20128
Homologene: 114426
Myt1l
Name: myelin transcription factor 1-like
Synonyms: 2900093J19Rik, Pmng1, Nztf1, Png-1, 2900046C06Rik, C630034G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 17933
VEGA: 12
HGNC: HGNC:7623
Homologene: 7435
Gm5155
Name: predicted gene 5155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 381852
Homologene: 115938
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: Cryabp1, alphaA-CRYBP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Vmn2r59
Name: vomeronasal 2, receptor 59
Synonyms: EG628444
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 628444
Homologene: 129683
Sobp
Name: sine oculis binding protein
Synonyms: jc, Jxc1, 5330439J01Rik, 2900009C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 109205
Homologene: 41216
Taar7f
Name: trace amine-associated receptor 7F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 435207
Homologene: 134040
Col15a1
Name: collagen, type XV, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12819
HGNC: HGNC:2192
Homologene: 1396
Tecpr1
Name: tectonin beta-propeller repeat containing 1
Synonyms: 2210010N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 70381
Homologene: 9120
Oaz3
Name: ornithine decarboxylase antizyme 3
Synonyms: ornithine decarboxylase antizyme in testis, AZ-3, Oaz-t, antizyme 3, AZ3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 53814
HGNC: HGNC:8097
Homologene: 9410
Cluap1
Name: clusterin associated protein 1
Synonyms: 2310030D15Rik, 2610111M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 76779
Homologene: 14831
Olfr393
Name: olfactory receptor 393
Synonyms: MOR135-7, GA_x6K02T2P1NL-4004140-4003208
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 259010
Homologene: 79335
Lmtk3
Name: lemur tyrosine kinase 3
Synonyms: Aatyk3, AATYK3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 381983
Homologene: 79449
Skint4
Name: selection and upkeep of intraepithelial T cells 4
Synonyms: 9530098N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 320640
Glis1
Name: GLIS family zinc finger 1
Synonyms: GliH1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230587
Homologene: 77390
Ces1a
Name: carboxylesterase 1A
Synonyms: Gm4976
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244595
HGNC: HGNC:1863
Homologene: 134142
Nom1
Name: nucleolar protein with MIF4G domain 1
Synonyms: LOC381627, D5Kng1, Gm1040
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 433864
Homologene: 39776
Zfp977
Name: zinc finger protein 977
Synonyms: Gm7221
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
Abhd16a
Name: abhydrolase domain containing 16A
Synonyms: D17H6S82E, NG26, Bat5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 193742
Homologene: 10904
Smr2
Name: submaxillary gland androgen regulated protein 2
Synonyms: MSG2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 20600
Trim72
Name: tripartite motif-containing 72
Synonyms: mitsugumin 53, MG53
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 434246
Homologene: 66924
Dok6
Name: docking protein 6
Synonyms: Dok-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 623279
Homologene: 45143
Zfp51
Name: zinc finger protein 51
Synonyms: Zfp-51, zfec12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 22709
VEGA: 17
Homologene: 134003
Ptcd1
Name: pentatricopeptide repeat domain 1
Synonyms: 1110069M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71799
Homologene: 33161
Gm17029
Name: predicted gene 17029
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 102635786
Gm16047
Name: predicted gene 16047
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 171,577,879 bp
  • A to G, chromosome 3 at 35,806,872 bp
  • A to G, chromosome 3 at 94,433,582 bp
  • C to T, chromosome 4 at 47,257,184 bp
  • C to A, chromosome 4 at 107,627,543 bp
  • G to A, chromosome 4 at 112,087,024 bp
  • A to G, chromosome 4 at 148,963,564 bp
  • T to C, chromosome 5 at 29,451,165 bp
  • G to A, chromosome 5 at 88,108,772 bp
  • C to G, chromosome 5 at 144,212,590 bp
  • T to C, chromosome 5 at 145,154,721 bp
  • A to T, chromosome 6 at 91,366,342 bp
  • C to T, chromosome 7 at 17,886,224 bp
  • T to A, chromosome 7 at 42,046,224 bp
  • A to T, chromosome 7 at 42,580,190 bp
  • T to C, chromosome 7 at 45,632,735 bp
  • A to G, chromosome 7 at 45,794,080 bp
  • G to A, chromosome 7 at 104,435,644 bp
  • A to T, chromosome 7 at 109,054,363 bp
  • A to T, chromosome 7 at 127,032,880 bp
  • A to G, chromosome 7 at 128,007,992 bp
  • A to G, chromosome 8 at 22,176,976 bp
  • A to T, chromosome 8 at 71,929,159 bp
  • G to T, chromosome 8 at 91,036,506 bp
  • A to G, chromosome 8 at 93,025,304 bp
  • T to C, chromosome 9 at 32,260,945 bp
  • A to G, chromosome 9 at 61,374,013 bp
  • A to G, chromosome 9 at 91,364,822 bp
  • T to A, chromosome 10 at 24,050,575 bp
  • T to C, chromosome 10 at 43,158,024 bp
  • A to G, chromosome 11 at 73,847,219 bp
  • T to A, chromosome 11 at 79,536,037 bp
  • T to C, chromosome 11 at 121,605,271 bp
  • A to G, chromosome 12 at 29,910,801 bp
  • A to G, chromosome 13 at 42,156,228 bp
  • T to C, chromosome 15 at 8,201,152 bp
  • T to C, chromosome 15 at 28,304,599 bp
  • T to C, chromosome 15 at 80,967,767 bp
  • T to A, chromosome 16 at 3,933,816 bp
  • A to G, chromosome 16 at 20,738,575 bp
  • G to C, chromosome 16 at 32,753,919 bp
  • C to T, chromosome 17 at 21,464,916 bp
  • G to A, chromosome 17 at 24,904,787 bp
  • T to C, chromosome 17 at 35,101,087 bp
  • T to C, chromosome 18 at 89,301,196 bp
  • T to C, chromosome 19 at 16,640,039 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4587 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042006-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.