Strain Name:
C57BL/6J-MtgxR4588Btlr/Mmmh
Stock Number:
042007-MU
Citation ID:
RRID:MMRRC_042007-MU
Other Names:
R4588 (G1), C57BL/6J-MtgxR4588Btlr
Major Collection:

Gene Information

Mif4gd
Name: MIF4G domain containing
Synonyms: 1110014L05Rik, 2310075G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69674
Homologene: 41389
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21, 2610202A04Rik, D16Ium21e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 22129
Homologene: 2487
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Ect2
Name: ect2 oncogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13605
HGNC: HGNC:3155
Homologene: 7298
Atf7ip
Name: activating transcription factor 7 interacting protein
Synonyms: ATFa-associated Modulator, AM, 2610204M12Rik, Mcaf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54343
Homologene: 10051
Trim66
Name: tripartite motif-containing 66
Synonyms: D7H11orf29, Tif1d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330627
Homologene: 28044
Mepce
Name: methylphosphate capping enzyme
Synonyms: D5Wsu46e, Bcdin3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231803
Homologene: 32447
Vps50
Name: VPS50 EARP/GARPII complex subunit
Synonyms: 8430415E05Rik, 1700034M03Rik, Ccdc132
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 73288
Homologene: 11498
Adnp2
Name: ADNP homeobox 2
Synonyms: Zfp508, 8430420L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240442
Homologene: 8945
Cyp4x1
Name: cytochrome P450, family 4, subfamily x, polypeptide 1
Synonyms: Cyp4a28-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 81906
Homologene: 75853
Ctsa
Name: cathepsin A
Synonyms: PPCA, Ppgb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19025
HGNC: HGNC:9251
Homologene: 80163
Ptprs
Name: protein tyrosine phosphatase, receptor type, S
Synonyms: PTP-NU3, PTPsigma, RPTPsigma, Ptpt9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19280
HGNC: HGNC:9681
Homologene: 20626
Trmt1
Name: tRNA methyltransferase 1
Synonyms: 6720406L13Rik, D8Ertd812e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212528
Homologene: 5632
Atrip
Name: ATR interacting protein
Synonyms: 6620401K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235610
Homologene: 15601
Fancm
Name: Fanconi anemia, complementation group M
Synonyms: C730036B14Rik, D12Ertd364e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104806
VEGA: 12
Homologene: 35378
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930516E05Rik, D330038K10Rik, 4930543C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Cpne5
Name: copine V
Synonyms: A830083G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240058
HGNC: HGNC:2318
Homologene: 23266
Abcb4
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 4
Synonyms: mdr-2, Mdr2, Pgy-2, Pgy2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18670
HGNC: HGNC:45
Homologene: 136368
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233651
Homologene: 2771
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Gcnt3
Name: glucosaminyl (N-acetyl) transferase 3, mucin type
Synonyms: 2010013H22Rik, 2210021I22Rik, 2210401J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72077
VEGA: 9
HGNC: HGNC:4205
Homologene: 20993
Ermap
Name: erythroblast membrane-associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 27028
Homologene: 22782
Sstr1
Name: somatostatin receptor 1
Synonyms: sst1, Smstr-1, Smstr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20605
Homologene: 820
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: Nav1.2, A230052E19Rik, Scn2a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 110876
Homologene: 75001
Tnn
Name: tenascin N
Synonyms: Tnw, tenascin-W
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329278
Homologene: 18634
Atxn7
Name: ataxin 7
Synonyms: ataxin-7, Sca7, A430107N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 246103
VEGA: 14
Homologene: 30967
Defa21
Name: defensin, alpha, 21
Synonyms: 2010016B13Rik, Defcr21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66298
Homologene: 113382
Mast3
Name: microtubule associated serine/threonine kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 546071
Homologene: 66191
Olfr869
Name: olfactory receptor 869
Synonyms: GA_x6K02T2PVTD-13878275-13879204, MOR145-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258550
Homologene: 138312
Stab1
Name: stabilin 1
Synonyms: MS-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 192187
Homologene: 9035
Vmn2r84
Name: vomeronasal 2, receptor 84
Synonyms: EG625068
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 625068
Homologene: 129606
Cfap65
Name: cilia and flagella associated protein 65
Synonyms: B230363K08Rik, Ccdc108
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241116
Homologene: 28093
Pik3r5
Name: phosphoinositide-3-kinase regulatory subunit 5
Synonyms: Foap2, p101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 320207
Homologene: 8627
Olfr307
Name: olfactory receptor 307
Synonyms: GA_x6K02T2NHDJ-9772012-9772953, MOR219-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258610
Lipo4
Name: lipase, member O4
Synonyms: Gm6857
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 628236
Homologene: 103863
Ube2ql1
Name: ubiquitin-conjugating enzyme E2Q family-like 1
Synonyms: 3110006E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76980
VEGA: 13
Homologene: 15975
Slc5a1
Name: solute carrier family 5 (sodium/glucose cotransporter), member 1
Synonyms: Sglt1, sodium glucose cotransporter 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20537
Homologene: 55456
Gys2
Name: glycogen synthase 2
Synonyms: LGS, glycogen synthase, liver
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232493
HGNC: HGNC:4707
Homologene: 56580
Aldh18a1
Name: aldehyde dehydrogenase 18 family, member A1
Synonyms: 2810433K04Rik, Pycs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56454
HGNC: HGNC:9722
Homologene: 2142
Palm3
Name: paralemmin 3
Synonyms: 4432412L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74337
Homologene: 53493
Igtp
Name: interferon gamma induced GTPase
Synonyms: Irgm3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16145
Homologene: 23118
Pde11a
Name: phosphodiesterase 11A
Synonyms: A630086N24Rik, 6330414F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241489
HGNC: HGNC:8773
Homologene: 56763
Slc22a16
Name: solute carrier family 22 (organic cation transporter), member 16
Synonyms: FLIPT2, OKB1, OCT6, CT2, 4921504E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70840
Homologene: 41957
Ddi1
Name: DNA-damage inducible 1
Synonyms: 1700011N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71829
VEGA: 9
Homologene: 100549
Selenoo
Name: selenoprotein O
Synonyms: 1300018J18Rik, Selo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223776
Homologene: 69439
Cnn2
Name: calponin 2
Synonyms: h2-calponin, Calpo2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12798
HGNC: HGNC:2156
Homologene: 3215
Sparc
Name: secreted acidic cysteine rich glycoprotein
Synonyms: osteonectin, BM-40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20692
Homologene: 31132
Rdh8
Name: retinol dehydrogenase 8
Synonyms: LOC235033, prRDH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235033
VEGA: 9
Homologene: 41062
Lzts3
Name: leucine zipper, putative tumor suppressor family member 3
Synonyms: Prosapip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241638
Homologene: 8824
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 20,200,868 bp
  • C to A, chromosome 1 at 74,904,056 bp
  • A to G, chromosome 1 at 160,145,111 bp
  • A to T, chromosome 2 at 65,713,767 bp
  • T to C, chromosome 2 at 76,029,303 bp
  • T to C, chromosome 2 at 130,634,766 bp
  • T to C, chromosome 2 at 164,834,150 bp
  • A to G, chromosome 3 at 27,147,000 bp
  • A to T, chromosome 4 at 115,108,797 bp
  • C to A, chromosome 4 at 119,188,248 bp
  • A to T, chromosome 5 at 8,947,328 bp
  • A to G, chromosome 5 at 33,145,288 bp
  • G to A, chromosome 5 at 137,785,272 bp
  • A to G, chromosome 6 at 3,562,306 bp
  • T to C, chromosome 6 at 136,599,694 bp
  • A to G, chromosome 6 at 142,449,455 bp
  • T to A, chromosome 6 at 146,241,196 bp
  • C to T, chromosome 7 at 86,335,644 bp
  • C to A, chromosome 7 at 105,756,041 bp
  • A to G, chromosome 7 at 109,472,354 bp
  • C to T, chromosome 8 at 21,025,648 bp
  • T to A, chromosome 8 at 70,780,607 bp
  • A to G, chromosome 8 at 84,029,386 bp
  • A to G, chromosome 8 at 84,690,753 bp
  • T to A, chromosome 9 at 6,266,003 bp
  • T to A, chromosome 9 at 20,138,087 bp
  • T to A, chromosome 9 at 20,822,729 bp
  • T to A, chromosome 9 at 70,034,230 bp
  • A to C, chromosome 9 at 95,865,667 bp
  • A to T, chromosome 9 at 109,060,279 bp
  • T to C, chromosome 10 at 40,570,681 bp
  • G to T, chromosome 10 at 79,997,867 bp
  • T to A, chromosome 10 at 130,385,940 bp
  • T to C, chromosome 11 at 55,405,236 bp
  • T to A, chromosome 11 at 58,206,682 bp
  • A to G, chromosome 11 at 68,493,261 bp
  • A to T, chromosome 11 at 115,609,546 bp
  • G to T, chromosome 12 at 58,213,631 bp
  • G to A, chromosome 12 at 65,118,441 bp
  • A to C, chromosome 13 at 69,739,157 bp
  • T to A, chromosome 14 at 14,096,268 bp
  • C to A, chromosome 14 at 31,157,445 bp
  • A to G, chromosome 15 at 89,096,718 bp
  • T to C, chromosome 16 at 94,442,901 bp
  • T to C, chromosome 17 at 29,164,713 bp
  • A to G, chromosome 17 at 56,425,534 bp
  • G to T, chromosome 18 at 80,128,648 bp
  • T to C, chromosome 19 at 16,640,039 bp
  • G to A, chromosome 19 at 33,499,247 bp
  • G to A, chromosome 19 at 40,557,751 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4588 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042007-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.