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Strain Name:
C57BL/6J-MtgxR4808Btlr/Mmmh
Stock Number:
042427-MU
Citation ID:
RRID:MMRRC_042427-MU
Other Names:
R4808 (G1), C57BL/6J-MtgxR4808Btlr
Major Collection:

Strain Information

Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Snap25
Name: synaptosomal-associated protein 25
Synonyms: sp, SNAP-25, GENA 70, Bdr
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20614
Homologene: 13311
Adora2a
Name: adenosine A2a receptor
Synonyms: A2aR, A2AAR, AA2AR, A2a, Rs, ARA2A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11540
VEGA: 10
HGNC: HGNC:263
Homologene: 20166
Zmynd8
Name: zinc finger, MYND-type containing 8
Synonyms: 1110013E22Rik, 2010005I16Rik, ZMYND8, RACK7, 3632413B07Rik, Prkcbp1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228880
HGNC: HGNC:9397
Homologene: 32679
Rpl23
Name: ribosomal protein L23
Synonyms: 2810009A01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 65019
Homologene: 68103
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Fam53a
Name: family with sequence similarity 53, member A
Synonyms: 5430419M09Rik, DNTNP, 2410018C17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74504
Homologene: 18660
Mapkap1
Name: mitogen-activated protein kinase associated protein 1
Synonyms: D230039K05Rik, Sin1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227743
Homologene: 11473
Kif16b
Name: kinesin family member 16B
Synonyms: N-3 kinesin, 8430434E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16558
Homologene: 135708
Fam133b
Name: family with sequence similarity 133, member B
Synonyms: 2900022K02Rik, 5830415L20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68152
Homologene: 85443
Gphn
Name: gephyrin
Synonyms: geph, 5730552E08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268566
VEGA: 12
Homologene: 10820
Arap2
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms: Centd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212285
Homologene: 9064
Rfx5
Name: regulatory factor X, 5 (influences HLA class II expression)
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53970
HGNC: HGNC:9986
Xpo5
Name: exportin 5
Synonyms: 2410004H11Rik, 2700038C24Rik, Exp5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72322
VEGA: 17
Homologene: 69316
Oprd1
Name: opioid receptor, delta 1
Synonyms: DOR-1, Nbor, mDOR, DOR
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18386
HGNC: HGNC:8153
Homologene: 20252
Slc39a14
Name: solute carrier family 39 (zinc transporter), member 14
Synonyms: G630015O18Rik, Zip14
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 213053
Homologene: 15037
Sppl3
Name: signal peptide peptidase 3
Synonyms: 4833416I09Rik, Usmg3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74585
Homologene: 15563
Pcx
Name: pyruvate carboxylase
Synonyms: Pc
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18563
VEGA: 19
HGNC: HGNC:8636
Homologene: 5422
Jup
Name: junction plakoglobin
Synonyms: PG, plakoglobin, gamma-catenin, D930025P04Rik, Ctnng
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16480
HGNC: HGNC:6207
Homologene: 1680
Hjurp
Name: Holliday junction recognition protein
Synonyms: C330011F01Rik, A730008H23Rik, 6430706D22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381280
Homologene: 10184
Chordc1
Name: cysteine and histidine rich domain containing 1
Synonyms: 1110001O09Rik, Chp-1, morgana
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66917
VEGA: 9
Homologene: 8111
Rbm19
Name: RNA binding motif protein 19
Synonyms: 1200009A02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74111
Homologene: 7158
Pias4
Name: protein inhibitor of activated STAT 4
Synonyms: PIASy
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 59004
Homologene: 104136
Agap3
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
Synonyms: MRIP-1, Crag, Centg3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 213990
Homologene: 23742
Nav1
Name: neuron navigator 1
Synonyms: POMFIL3, 9930003A20Rik, C230080M11Rik, unc53H1, steerin-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215690
Homologene: 10719
Lmo2
Name: LIM domain only 2
Synonyms: Rbtn-2, Rbtn2, Rhom-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16909
HGNC: HGNC:6642
Homologene: 4072
Atp8b1
Name: ATPase, class I, type 8B, member 1
Synonyms: FIC1, Ic
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 54670
VEGA: 18
HGNC: HGNC:3706
Homologene: 21151
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Catsper1
Name: cation channel, sperm associated 1
Synonyms: KSper
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225865
VEGA: 19
Homologene: 14207
Scaf1
Name: SR-related CTD-associated factor 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233208
Slc24a2
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
Synonyms: 6330417K15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76376
Homologene: 10669
Hc
Name: hemolytic complement
Synonyms: C5a, C5, He, Hfib2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
H2-M9
Name: histocompatibility 2, M region locus 9
Synonyms: M9
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14997
Homologene: 110792
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241589
Homologene: 115928
Sycp1
Name: synaptonemal complex protein 1
Synonyms: SCP1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20957
Homologene: 2389
Cyp4f40
Name: cytochrome P450, family 4, subfamily f, polypeptide 40
Synonyms: EG631304
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 631304
VEGA: 17
Homologene: 117991
Gramd1b
Name: GRAM domain containing 1B
Synonyms: A930008A22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235283
Homologene: 18223
Sycp2
Name: synaptonemal complex protein 2
Synonyms: 3830402K23Rik, 4930518F03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320558
Homologene: 8604
Or14c40
Name: olfactory receptor family 14 subfamily C member 40
Synonyms: GA_x6K02T2NHDJ-9457744-9456734, MOR221-3, Olfr293
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257906
Homologene: 79385
Cped1
Name: cadherin-like and PC-esterase domain containing 1
Synonyms: A430107O13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214642
Homologene: 57014
4930562C15Rik
Name: RIKEN cDNA 4930562C15 gene
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78809
Homologene: 53527
Xab2
Name: XPA binding protein 2
Synonyms: 0610041O14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67439
Homologene: 5738
Pde8a
Name: phosphodiesterase 8A
Synonyms: Pde8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18584
HGNC: HGNC:8793
Homologene: 1957
Steap1
Name: six transmembrane epithelial antigen of the prostate 1
Synonyms: Prss24, 2410007B19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70358
Homologene: 8256
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Tektl1
Name: tektin like 1
Synonyms: 4931413A09Rik, Ccdc105
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70976
VEGA: 10
Homologene: 18299
Crat
Name: carnitine acetyltransferase
Synonyms: CARAT
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12908
HGNC: HGNC:2342
Homologene: 598
Zfp536
Name: zinc finger protein 536
Synonyms: 9630010P11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243937
Homologene: 8813
Cyp26a1
Name: cytochrome P450, family 26, subfamily a, polypeptide 1
Synonyms: P450RAI, P450RA, retinoic acid hydrolase, RAH, Cyp26
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13082
VEGA: 19
HGNC: HGNC:2603
Homologene: 37349
Pkn3
Name: protein kinase N3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 263803
Homologene: 50980
H2bc18
Name: H2B clustered histone 18
Synonyms: H2b-616, Hist2h2bb
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 319189
Homologene: 136264
Oas1g
Name: 2'-5' oligoadenylate synthetase 1G
Synonyms: Mmu-L, Mmu-L2, Oias-1, Oias1, Oas1a, L2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23960
HGNC: HGNC:8086
Homologene: 1903
Abi3bp
Name: ABI family member 3 binding protein
Synonyms: 5033411B22Rik, D930038M13Rik, eratin, TARSH
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320712
VEGA: 16
Homologene: 134172
Suox
Name: sulfite oxidase
Synonyms: SO
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 211389
VEGA: 10
Homologene: 394
Uap1l1
Name: UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
Synonyms: 5730445F03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227620
Homologene: 71313
Rasgrf2
Name: RAS protein-specific guanine nucleotide-releasing factor 2
Synonyms: Grf2, 6330417G04Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19418
HGNC: HGNC:9876
Homologene: 2169
Gm10305
Name: predicted gene 10305
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Eif3i
Name: eukaryotic translation initiation factor 3, subunit I
Synonyms: D4Ertd632e, 36kDa, Eif3s2, TRIP-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54709
HGNC: HGNC:3272
Homologene: 2786
Hsd3b6
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6
Synonyms: 3beta-HSD VI
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15497
Homologene: 133013
Or51g2
Name: olfactory receptor family 51 subfamily G member 2
Synonyms: GA_x6K02T2PBJ9-5685322-5684384, MOR7-2, Olfr577
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259113
Homologene: 64962
Pcdha7
Name: protocadherin alpha 7
Synonyms: Cnr4, Crnr4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12939
HGNC: HGNC:8673
Homologene: 117962
Gm7347
Name: predicted gene 7347
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 664804
Homologene: 69402
Spata31d1b
Name: spermatogenesis associated 31 subfamily D, member 1B
Synonyms: Fam75d1b, Gm4934
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238662
VEGA: 13
Gm27013
Name: predicted gene, 27013
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Myocos
Name: myocilin opposite strand
Synonyms: 7420461P10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100038657
Gm17041
Name: predicted gene 17041
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Ighv6-7
Name: immunoglobulin heavy variable V6-7
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 432701
HGNC: HGNC:5623
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to C, chromosome 1 at 88,277,215 bp
  • C to T, chromosome 1 at 135,455,204 bp
  • T to C, chromosome 1 at 162,657,040 bp
  • A to G, chromosome 2 at 25,362,085 bp
  • G to A, chromosome 2 at 30,090,081 bp
  • T to C, chromosome 2 at 30,410,021 bp
  • G to T, chromosome 2 at 32,303,214 bp
  • G to A, chromosome 2 at 34,597,422 bp
  • A to G, chromosome 2 at 35,003,346 bp
  • T to C, chromosome 2 at 103,981,062 bp
  • A to C, chromosome 2 at 104,201,110 bp
  • A to G, chromosome 2 at 136,770,102 bp
  • A to T, chromosome 2 at 142,857,358 bp
  • A to G, chromosome 2 at 165,852,099 bp
  • T to C, chromosome 2 at 178,393,961 bp
  • A to G, chromosome 3 at 94,958,280 bp
  • T to G, chromosome 3 at 96,270,013 bp
  • G to A, chromosome 3 at 98,806,285 bp
  • T to A, chromosome 3 at 102,818,787 bp
  • G to T, chromosome 4 at 87,032,238 bp
  • C to T, chromosome 4 at 99,273,244 bp
  • A to T, chromosome 4 at 129,592,064 bp
  • G to A, chromosome 4 at 132,117,394 bp
  • G to A, chromosome 4 at 144,272,755 bp
  • C to T, chromosome 5 at 3,559,731 bp
  • G to T, chromosome 5 at 5,738,829 bp
  • T to C, chromosome 5 at 24,501,245 bp
  • C to T, chromosome 5 at 26,054,997 bp
  • A to G, chromosome 5 at 33,607,679 bp
  • G to A, chromosome 5 at 62,730,641 bp
  • A to G, chromosome 5 at 63,927,138 bp
  • T to A, chromosome 5 at 115,083,426 bp
  • T to C, chromosome 5 at 120,118,774 bp
  • T to G, chromosome 5 at 120,879,322 bp
  • A to G, chromosome 6 at 22,088,757 bp
  • A to G, chromosome 6 at 48,451,161 bp
  • A to C, chromosome 6 at 130,520,621 bp
  • A to T, chromosome 7 at 37,479,305 bp
  • T to C, chromosome 7 at 45,008,639 bp
  • A to G, chromosome 7 at 81,282,931 bp
  • A to G, chromosome 7 at 86,663,938 bp
  • T to C, chromosome 7 at 102,973,911 bp
  • C to T, chromosome 8 at 3,610,604 bp
  • A to G, chromosome 9 at 18,292,413 bp
  • A to T, chromosome 9 at 40,304,349 bp
  • A to G, chromosome 9 at 53,445,495 bp
  • G to T, chromosome 9 at 67,331,733 bp
  • G to A, chromosome 9 at 107,300,606 bp
  • A to G, chromosome 10 at 75,333,446 bp
  • A to T, chromosome 10 at 78,752,864 bp
  • A to G, chromosome 10 at 81,155,840 bp
  • A to G, chromosome 10 at 107,718,507 bp
  • T to A, chromosome 10 at 128,671,889 bp
  • A to T, chromosome 11 at 97,781,458 bp
  • C to T, chromosome 11 at 100,378,192 bp
  • T to A, chromosome 12 at 78,654,880 bp
  • T to A, chromosome 12 at 114,455,721 bp
  • C to T, chromosome 13 at 59,715,721 bp
  • A to T, chromosome 13 at 92,023,682 bp
  • T to C, chromosome 14 at 70,315,801 bp
  • T to C, chromosome 16 at 4,849,672 bp
  • A to G, chromosome 16 at 56,594,516 bp
  • A to G, chromosome 17 at 32,674,275 bp
  • T to C, chromosome 17 at 36,640,792 bp
  • T to A, chromosome 17 at 46,235,970 bp
  • G to A, chromosome 18 at 36,974,228 bp
  • G to A, chromosome 18 at 60,916,651 bp
  • A to G, chromosome 18 at 64,561,711 bp
  • T to A, chromosome 19 at 4,620,928 bp
  • G to A, chromosome 19 at 5,344,136 bp
  • A to G, chromosome 19 at 37,701,125 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4808 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042427-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.