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Strain Name:
C57BL/6J-MtgxR4808Btlr/Mmmh
Stock Number:
042427-MU
Citation ID:
RRID:MMRRC_042427-MU
Other Names:
R4808 (G1), C57BL/6J-MtgxR4808Btlr
Major Collection:

Strain Information

Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Snap25
Name: synaptosomal-associated protein 25
Synonyms: sp, SNAP-25, GENA 70, Bdr
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20614
Homologene: 13311
Adora2a
Name: adenosine A2a receptor
Synonyms: A2aR, A2AAR, AA2AR, A2a, Rs, ARA2A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11540
VEGA: 10
HGNC: HGNC:263
Homologene: 20166
Zmynd8
Name: zinc finger, MYND-type containing 8
Synonyms: 1110013E22Rik, 2010005I16Rik, ZMYND8, RACK7, 3632413B07Rik, Prkcbp1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228880
HGNC: HGNC:9397
Homologene: 32679
Rpl23
Name: ribosomal protein L23
Synonyms: 2810009A01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 65019
Homologene: 68103
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Fam53a
Name: family with sequence similarity 53, member A
Synonyms: 5430419M09Rik, DNTNP, 2410018C17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74504
Homologene: 18660
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to C, chromosome 1 at 88,277,215 bp
  • C to T, chromosome 1 at 135,455,204 bp
  • T to C, chromosome 1 at 162,657,040 bp
  • A to G, chromosome 2 at 25,362,085 bp
  • G to A, chromosome 2 at 30,090,081 bp
  • T to C, chromosome 2 at 30,410,021 bp
  • G to T, chromosome 2 at 32,303,214 bp
  • G to A, chromosome 2 at 34,597,422 bp
  • A to G, chromosome 2 at 35,003,346 bp
  • T to C, chromosome 2 at 103,981,062 bp
  • A to C, chromosome 2 at 104,201,110 bp
  • A to G, chromosome 2 at 136,770,102 bp
  • A to T, chromosome 2 at 142,857,358 bp
  • A to G, chromosome 2 at 165,852,099 bp
  • T to C, chromosome 2 at 178,393,961 bp
  • A to G, chromosome 3 at 94,958,280 bp
  • T to G, chromosome 3 at 96,270,013 bp
  • G to A, chromosome 3 at 98,806,285 bp
  • T to A, chromosome 3 at 102,818,787 bp
  • G to T, chromosome 4 at 87,032,238 bp
  • C to T, chromosome 4 at 99,273,244 bp
  • A to T, chromosome 4 at 129,592,064 bp
  • G to A, chromosome 4 at 132,117,394 bp
  • G to A, chromosome 4 at 144,272,755 bp
  • C to T, chromosome 5 at 3,559,731 bp
  • G to T, chromosome 5 at 5,738,829 bp
  • T to C, chromosome 5 at 24,501,245 bp
  • C to T, chromosome 5 at 26,054,997 bp
  • A to G, chromosome 5 at 33,607,679 bp
  • G to A, chromosome 5 at 62,730,641 bp
  • A to G, chromosome 5 at 63,927,138 bp
  • T to A, chromosome 5 at 115,083,426 bp
  • T to C, chromosome 5 at 120,118,774 bp
  • T to G, chromosome 5 at 120,879,322 bp
  • A to G, chromosome 6 at 22,088,757 bp
  • A to G, chromosome 6 at 48,451,161 bp
  • A to C, chromosome 6 at 130,520,621 bp
  • A to T, chromosome 7 at 37,479,305 bp
  • T to C, chromosome 7 at 45,008,639 bp
  • A to G, chromosome 7 at 81,282,931 bp
  • A to G, chromosome 7 at 86,663,938 bp
  • T to C, chromosome 7 at 102,973,911 bp
  • C to T, chromosome 8 at 3,610,604 bp
  • A to G, chromosome 9 at 18,292,413 bp
  • A to T, chromosome 9 at 40,304,349 bp
  • A to G, chromosome 9 at 53,445,495 bp
  • G to T, chromosome 9 at 67,331,733 bp
  • G to A, chromosome 9 at 107,300,606 bp
  • A to G, chromosome 10 at 75,333,446 bp
  • A to T, chromosome 10 at 78,752,864 bp
  • A to G, chromosome 10 at 81,155,840 bp
  • A to G, chromosome 10 at 107,718,507 bp
  • T to A, chromosome 10 at 128,671,889 bp
  • A to T, chromosome 11 at 97,781,458 bp
  • C to T, chromosome 11 at 100,378,192 bp
  • T to A, chromosome 12 at 78,654,880 bp
  • T to A, chromosome 12 at 114,455,721 bp
  • C to T, chromosome 13 at 59,715,721 bp
  • A to T, chromosome 13 at 92,023,682 bp
  • T to C, chromosome 14 at 70,315,801 bp
  • T to C, chromosome 16 at 4,849,672 bp
  • A to G, chromosome 16 at 56,594,516 bp
  • A to G, chromosome 17 at 32,674,275 bp
  • T to C, chromosome 17 at 36,640,792 bp
  • T to A, chromosome 17 at 46,235,970 bp
  • G to A, chromosome 18 at 36,974,228 bp
  • G to A, chromosome 18 at 60,916,651 bp
  • A to G, chromosome 18 at 64,561,711 bp
  • T to A, chromosome 19 at 4,620,928 bp
  • G to A, chromosome 19 at 5,344,136 bp
  • A to G, chromosome 19 at 37,701,125 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4808 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042427-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.