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Strain Name:
C57BL/6J-MtgxR4810Btlr/Mmmh
Stock Number:
042429-MU
Citation ID:
RRID:MMRRC_042429-MU
Other Names:
R4810 (G1), C57BL/6J-MtgxR4810Btlr
Major Collection:

Strain Information

Zmpste24
Name: zinc metallopeptidase, STE24
Synonyms: A530043O15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230709
Homologene: 4277
Mtmr3
Name: myotubularin related protein 3
Synonyms: FYVE-DSP1, 1700092A20Rik, ZFYVE10
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74302
HGNC: HGNC:7451
Homologene: 23662
Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, Grm1, Gprc1a, nmf373, rcw, 4930455H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Plekha7
Name: pleckstrin homology domain containing, family A member 7
Synonyms: A430081P20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233765
Homologene: 52172
Fam91a1
Name: family with sequence similarity 91, member A1
Synonyms: D15Ertd621e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 210998
VEGA: 15
Homologene: 13388
Trim36
Name: tripartite motif-containing 36
Synonyms: D18Wsu100e, Haprin
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 28105
VEGA: 18
Homologene: 10275
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 54,735,143 bp
  • T to C, chromosome 1 at 71,303,612 bp
  • A to G, chromosome 1 at 72,298,152 bp
  • T to C, chromosome 1 at 87,047,574 bp
  • T to C, chromosome 1 at 98,423,254 bp
  • C to A, chromosome 1 at 190,808,963 bp
  • C to T, chromosome 1 at 191,356,392 bp
  • T to C, chromosome 2 at 77,045,755 bp
  • A to C, chromosome 2 at 122,059,796 bp
  • A to G, chromosome 2 at 125,987,939 bp
  • A to T, chromosome 2 at 149,405,543 bp
  • A to G, chromosome 2 at 152,945,454 bp
  • A to G, chromosome 2 at 164,772,562 bp
  • A to G, chromosome 3 at 37,092,034 bp
  • G to T, chromosome 3 at 57,796,272 bp
  • T to A, chromosome 3 at 64,137,462 bp
  • C to T, chromosome 3 at 96,136,607 bp
  • T to A, chromosome 3 at 108,470,011 bp
  • T to C, chromosome 4 at 59,351,653 bp
  • T to C, chromosome 4 at 105,039,814 bp
  • T to A, chromosome 4 at 121,061,054 bp
  • T to C, chromosome 4 at 128,755,563 bp
  • C to T, chromosome 4 at 131,900,102 bp
  • T to C, chromosome 4 at 148,156,446 bp
  • G to T, chromosome 5 at 65,091,447 bp
  • T to C, chromosome 5 at 71,623,982 bp
  • C to T, chromosome 5 at 84,105,891 bp
  • T to A, chromosome 5 at 92,414,249 bp
  • A to G, chromosome 5 at 115,480,449 bp
  • T to C, chromosome 6 at 27,761,296 bp
  • T to C, chromosome 6 at 90,363,153 bp
  • C to A, chromosome 6 at 106,655,611 bp
  • G to A, chromosome 6 at 118,429,846 bp
  • G to T, chromosome 7 at 7,182,847 bp
  • T to C, chromosome 7 at 25,015,497 bp
  • A to T, chromosome 7 at 25,474,520 bp
  • A to C, chromosome 7 at 26,378,177 bp
  • A to G, chromosome 7 at 38,099,593 bp
  • T to C, chromosome 7 at 43,532,710 bp
  • T to C, chromosome 7 at 97,714,017 bp
  • C to A, chromosome 7 at 112,841,866 bp
  • A to T, chromosome 7 at 116,144,938 bp
  • A to G, chromosome 8 at 75,888,653 bp
  • T to C, chromosome 8 at 82,990,362 bp
  • T to C, chromosome 8 at 86,560,842 bp
  • T to A, chromosome 8 at 93,208,631 bp
  • A to G, chromosome 9 at 38,330,394 bp
  • C to A, chromosome 9 at 38,499,324 bp
  • A to G, chromosome 9 at 44,508,353 bp
  • A to G, chromosome 9 at 46,287,978 bp
  • A to G, chromosome 9 at 92,354,630 bp
  • A to G, chromosome 9 at 110,389,136 bp
  • A to T, chromosome 9 at 123,810,162 bp
  • C to G, chromosome 10 at 10,782,694 bp
  • T to C, chromosome 10 at 39,823,725 bp
  • T to A, chromosome 10 at 62,411,525 bp
  • CACTCGTCATACT to CACT, chromosome 10 at 89,430,958 bp
  • A to G, chromosome 10 at 106,915,690 bp
  • A to T, chromosome 11 at 4,498,046 bp
  • A to T, chromosome 11 at 29,755,011 bp
  • A to G, chromosome 11 at 41,971,839 bp
  • A to G, chromosome 11 at 53,534,589 bp
  • G to A, chromosome 11 at 59,031,591 bp
  • G to A, chromosome 11 at 78,167,803 bp
  • G to A, chromosome 11 at 97,240,933 bp
  • A to G, chromosome 11 at 115,488,961 bp
  • T to A, chromosome 12 at 11,457,405 bp
  • A to G, chromosome 12 at 55,794,993 bp
  • T to C, chromosome 12 at 71,189,442 bp
  • A to T, chromosome 12 at 76,623,197 bp
  • A to G, chromosome 13 at 9,158,591 bp
  • A to G, chromosome 13 at 49,289,650 bp
  • A to T, chromosome 13 at 96,483,495 bp
  • A to G, chromosome 13 at 100,481,002 bp
  • A to G, chromosome 14 at 48,472,473 bp
  • A to C, chromosome 14 at 119,013,521 bp
  • C to T, chromosome 15 at 43,169,820 bp
  • T to A, chromosome 15 at 50,822,296 bp
  • T to A, chromosome 15 at 58,434,740 bp
  • G to T, chromosome 16 at 19,028,331 bp
  • T to C, chromosome 16 at 44,451,535 bp
  • T to A, chromosome 17 at 6,991,768 bp
  • T to C, chromosome 17 at 25,163,498 bp
  • T to C, chromosome 17 at 25,265,147 bp
  • C to T, chromosome 17 at 34,057,112 bp
  • G to A, chromosome 17 at 52,905,220 bp
  • C to T, chromosome 17 at 65,722,003 bp
  • T to C, chromosome 17 at 73,512,121 bp
  • G to A, chromosome 18 at 37,738,548 bp
  • G to T, chromosome 18 at 46,172,469 bp
  • C to A, chromosome 18 at 52,907,199 bp
  • T to A, chromosome 19 at 18,639,909 bp
  • G to T, chromosome 19 at 37,439,655 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4810 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042429-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.