Strain Name:
C57BL/6J-MtgxR4826Btlr/Mmmh
Stock Number:
042442-MU
Citation ID:
RRID:MMRRC_042442-MU
Other Names:
R4826 (G1), C57BL/6J-MtgxR4826Btlr
Major Collection:

Gene Information

Myh9
Name: myosin, heavy polypeptide 9, non-muscle
Synonyms: D0Jmb2, E030044M24Rik, NMHC II-A, Myhn1, Myhn-1, myosin IIA, Fltn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17886
HGNC: HGNC:7579
Homologene: 129835
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Dnajc11
Name: DnaJ heat shock protein family (Hsp40) member C11
Synonyms: E030019A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230935
Homologene: 14558
Slc37a1
Name: solute carrier family 37 (glycerol-3-phosphate transporter), member 1
Synonyms: G3PP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224674
VEGA: 17
Homologene: 70486
Eif4g3
Name: eukaryotic translation initiation factor 4 gamma, 3
Synonyms: eIF4GII, 1500002J22Rik, 4930523M17Rik, G1-419-52, repro8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230861
HGNC: HGNC:3298
Homologene: 2789
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: GCN1L, G431004K08Rik, Gcn1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Dip2b
Name: disco interacting protein 2 homolog B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239667
Homologene: 72227
Pkn2
Name: protein kinase N2
Synonyms: PRK2, 6030436C20Rik, Stk7, Prkcl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109333
HGNC: HGNC:9406
Homologene: 2054
Iqgap2
Name: IQ motif containing GTPase activating protein 2
Synonyms: 4933417J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 544963
VEGA: 13
HGNC: HGNC:6111
Homologene: 101543
Acin1
Name: apoptotic chromatin condensation inducer 1
Synonyms: 2610510L13Rik, 2610036I19Rik, Acinus
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 56215
Homologene: 22853
Icam5
Name: intercellular adhesion molecule 5, telencephalin
Synonyms: CD50, Tlcn, TLN, Icam3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15898
VEGA: 9
HGNC: HGNC:5348
Homologene: 2447
Fam193a
Name: family with sequence homology 193, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231128
Homologene: 2746
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: per, Pcn, Plc, perlecan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: Mpr300, CI-MPR, IGF-II/CI-MPR, M6P/IGF2R, CD222, mannose-6-phosphate receptor, cation independent
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Itgb1
Name: integrin beta 1 (fibronectin receptor beta)
Synonyms: CD29, beta1 integrin, 4633401G24Rik, Fnrb, Gm9863
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16412
HGNC: HGNC:6153
Homologene: 22999
Ext2
Name: exostosin glycosyltransferase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14043
HGNC: HGNC:3513
Homologene: 345
Ap1b1
Name: adaptor protein complex AP-1, beta 1 subunit
Synonyms: beta-prime adaptin, Adtb1, b2b1660Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11764
HGNC: HGNC:554
Homologene: 21972
Ints7
Name: integrator complex subunit 7
Synonyms: 5930412E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77065
Homologene: 9136
Tcerg1
Name: transcription elongation regulator 1 (CA150)
Synonyms: p144, ca150, Taf2s, 2410022J09Rik, 2900090C16Rik, Fbp28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 56070
Homologene: 4879
Dusp4
Name: dual specificity phosphatase 4
Synonyms: E130306H24Rik, 2700078F24Rik, MKP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319520
HGNC: HGNC:3070
Homologene: 1065
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, ALS2CR17, A530083I02Rik, 2310076G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269198
Homologene: 16453
Rad54b
Name: RAD54 homolog B (S. cerevisiae)
Synonyms: E130016E03Rik, E130016E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 623474
Homologene: 8240
Slamf9
Name: SLAM family member 9
Synonyms: CD2F-10, SF2001, CD84-H1, 2310026I04Rik, Cd2f10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98365
Homologene: 12642
Gm7102
Name: predicted gene 7102
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 633057
Pde4a
Name: phosphodiesterase 4A, cAMP specific
Synonyms: dunce, Dpde2, D9Ertd60e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18577
HGNC: HGNC:8780
Homologene: 4520
Prkg1
Name: protein kinase, cGMP-dependent, type I
Synonyms: Prkgr1b, Prkg1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19091
HGNC: HGNC:9414
Homologene: 55964
Zbtb7b
Name: zinc finger and BTB domain containing 7B
Synonyms: c-Krox, Zfp67, Thpok
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 22724
Homologene: 7605
Acta2
Name: actin, alpha 2, smooth muscle, aorta
Synonyms: Actvs, a-SMA, 0610041G09Rik, SMalphaA, alphaSMA, SMAalpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 11475
VEGA: 19
HGNC: HGNC:130
Homologene: 133938
Slc7a2
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Synonyms: Tea, Atrc2, Cat2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11988
Homologene: 20659
Clspn
Name: claspin
Synonyms: E130314M08Rik, C85083
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269582
Homologene: 11138
Mgam
Name: maltase-glucoamylase
Synonyms: 6030407P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232714
HGNC: HGNC:7043
Homologene: 130099
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329628
Homologene: 14377
Cyp4a10
Name: cytochrome P450, family 4, subfamily a, polypeptide 10
Synonyms: RP1, Cyp4a, D4Rp1, Msp-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13117
HGNC: HGNC:2642
Homologene: 128044
Ephb3
Name: Eph receptor B3
Synonyms: Sek4, MDK5, HEK2, Etk2, Tyro6, Cek10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13845
HGNC: HGNC:3394
Homologene: 20938
Frmd4a
Name: FERM domain containing 4A
Synonyms: C230040M21Rik, 2700017I06Rik, Gm13190
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209630
Homologene: 9971
Tdrd12
Name: tudor domain containing 12
Synonyms: 2410070K17Rik, G1-476-14, ecat8, 2410004F06Rik, EG434165, repro23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71981
Homologene: 87053
Olfr358
Name: olfactory receptor 358
Synonyms: GA_x6K02T2NLDC-33697309-33696317, MOR159-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227789
Homologene: 74157
Ciao3
Name: cytosolic iron-sulfur assembly component 3
Synonyms: 9030612I22Rik, Narfl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67563
Homologene: 6750
Fam20b
Name: FAM20B, glycosaminoglycan xylosylkinase
Synonyms: C530043G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215015
Homologene: 8909
Abca14
Name: ATP-binding cassette, sub-family A (ABC1), member 14
Synonyms: 1700110B15Rik, 4930539G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67928
Homologene: 86128
Cntln
Name: centlein, centrosomal protein
Synonyms: B430108F07Rik, D530005L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 338349
Homologene: 9805
Rmc1
Name: regulator of MON1-CCZ1
Synonyms: 3110002H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 76482
Homologene: 8341
Slc5a1
Name: solute carrier family 5 (sodium/glucose cotransporter), member 1
Synonyms: Sglt1, sodium glucose cotransporter 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20537
Homologene: 55456
Herc6
Name: hect domain and RLD 6
Synonyms: 4930427L17Rik, 1700121D12Rik, CEB1, 2510038N07Rik, Herc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67138
Homologene: 70768
Rassf8
Name: Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
Synonyms: mHoj-1, 5133400D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 71323
Homologene: 5219
Olfr683
Name: olfactory receptor 683
Synonyms: GA_x6K02T2PBJ9-7773007-7772066, MOR40-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259047
Homologene: 133645
Hyal5
Name: hyaluronoglucosaminidase 5
Synonyms: 4933439A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74468
Homologene: 50610
Pla2g6
Name: phospholipase A2, group VI
Synonyms: iPLA2, iPLA2beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 53357
HGNC: HGNC:9039
Homologene: 2635
Lrrc71
Name: leucine rich repeat containing 71
Synonyms: 4933430H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74485
Homologene: 83646
Gm10549
Name: predicted gene 10549
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 433171
VEGA: 18
Olfr1154
Name: olfactory receptor 1154
Synonyms: GA_x6K02T2Q125-49403456-49402524, MOR173-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258641
Homologene: 74192
Olfr46
Name: olfactory receptor 46
Synonyms: IF5, ID12, IB7, MOR253-8, GA_x6K02T2PBJ9-42759973-42760905
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18345
Homologene: 110491
Arsj
Name: arylsulfatase J
Synonyms: 9330196J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 271970
Homologene: 35257
Clec2d
Name: C-type lectin domain family 2, member d
Synonyms: Clr-b, Clrb, Ocil
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 93694
Homologene: 136309
Gm7337
Name: predicted gene 7337
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 654494
Aifm2
Name: apoptosis-inducing factor, mitochondrion-associated 2
Synonyms: PRG3, D730001I10Rik, 5430437E11Rik, Amid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71361
Homologene: 6862
Olfr43
Name: olfactory receptor 43
Synonyms: MOR125-1, GA_x6K02T2P1NL-4359899-4358958
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258706
HGNC: HGNC:8179
Homologene: 8219
Sapcd2
Name: suppressor APC domain containing 2
Synonyms: 6030458L21Rik, ang, 2010317E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72080
Homologene: 18664
Nt5c1a
Name: 5'-nucleotidase, cytosolic IA
Synonyms: Cn1a, LOC230718
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230718
Homologene: 57173
Nlrp1c-ps
Name: NLR family, pyrin domain containing 1C, pseudogene
Synonyms: Nalp1c, OTTMUSG00000006090
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 627984
Tas2r114
Name: taste receptor, type 2, member 114
Synonyms: Tas2r14, T2R14, mGR14, mt2r46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387346
Homologene: 128355
Nit1
Name: nitrilase 1
Synonyms: ESTM30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 27045
HGNC: HGNC:7828
Homologene: 4091
Rnf113a2
Name: ring finger protein 113A2
Synonyms: 2310020H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66381
Homologene: 133824
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 60,251,342 bp
  • A to C, chromosome 1 at 156,705,925 bp
  • T to C, chromosome 1 at 171,345,598 bp
  • C to A, chromosome 1 at 172,476,441 bp
  • G to A, chromosome 1 at 191,611,906 bp
  • T to C, chromosome 2 at 4,601,297 bp
  • C to T, chromosome 2 at 25,372,756 bp
  • A to G, chromosome 2 at 37,005,333 bp
  • T to A, chromosome 2 at 87,903,349 bp
  • T to C, chromosome 2 at 93,762,630 bp
  • T to A, chromosome 3 at 38,982,957 bp
  • T to C, chromosome 3 at 87,743,308 bp
  • A to G, chromosome 3 at 89,380,773 bp
  • A to G, chromosome 3 at 126,438,802 bp
  • C to A, chromosome 3 at 126,956,001 bp
  • T to C, chromosome 3 at 142,809,509 bp
  • G to T, chromosome 4 at 11,599,753 bp
  • T to G, chromosome 4 at 85,005,044 bp
  • C to T, chromosome 4 at 115,518,344 bp
  • T to C, chromosome 4 at 123,208,572 bp
  • T to A, chromosome 4 at 126,573,287 bp
  • T to C, chromosome 4 at 137,565,395 bp
  • T to C, chromosome 4 at 138,177,945 bp
  • T to C, chromosome 4 at 151,950,435 bp
  • A to G, chromosome 5 at 33,159,150 bp
  • A to G, chromosome 5 at 34,436,531 bp
  • A to C, chromosome 5 at 87,850,966 bp
  • A to G, chromosome 5 at 115,593,693 bp
  • T to C, chromosome 6 at 24,891,576 bp
  • T to C, chromosome 6 at 40,680,648 bp
  • T to A, chromosome 6 at 57,647,087 bp
  • T to C, chromosome 6 at 129,184,159 bp
  • A to T, chromosome 6 at 131,689,837 bp
  • T to A, chromosome 6 at 145,816,550 bp
  • A to C, chromosome 7 at 35,504,157 bp
  • G to T, chromosome 7 at 105,143,968 bp
  • A to T, chromosome 7 at 120,216,247 bp
  • T to A, chromosome 7 at 140,610,319 bp
  • T to A, chromosome 8 at 34,818,517 bp
  • T to A, chromosome 8 at 40,911,046 bp
  • T to A, chromosome 8 at 128,720,308 bp
  • C to T, chromosome 9 at 21,037,803 bp
  • T to A, chromosome 9 at 21,192,380 bp
  • T to C, chromosome 10 at 61,725,989 bp
  • T to C, chromosome 11 at 5,018,043 bp
  • A to G, chromosome 11 at 71,242,517 bp
  • A to G, chromosome 11 at 74,206,331 bp
  • T to A, chromosome 12 at 84,417,614 bp
  • T to A, chromosome 13 at 95,763,275 bp
  • A to G, chromosome 14 at 54,664,617 bp
  • A to T, chromosome 15 at 77,788,946 bp
  • A to G, chromosome 15 at 79,308,679 bp
  • A to G, chromosome 15 at 100,169,281 bp
  • G to A, chromosome 16 at 21,214,995 bp
  • A to T, chromosome 17 at 12,701,353 bp
  • A to G, chromosome 17 at 25,780,332 bp
  • A to G, chromosome 17 at 31,322,173 bp
  • G to T, chromosome 18 at 12,185,779 bp
  • C to A, chromosome 18 at 33,470,785 bp
  • C to T, chromosome 18 at 42,535,115 bp
  • A to G, chromosome 19 at 31,764,606 bp
  • A to T, chromosome 19 at 34,251,823 bp
  • C to T, chromosome 19 at 61,175,926 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4826 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042442-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.