Strain Name:
C57BL/6J-MtgxR4830Btlr/Mmmh
Stock Number:
042446-MU
Citation ID:
RRID:MMRRC_042446-MU
Other Names:
R4830 (G1), C57BL/6J-MtgxR4830Btlr
Major Collection:

Gene Information

Dst
Name: dystonin
Synonyms: 2310001O04Rik, ah, bullous pemphigoid antigen 1, Bpag, nmf339, BPAG1-n, nmf203, athetoid, bullous pemphigoid antigen 1, Macf2, BPAG1, Bpag1, A830042E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Slc25a12
Name: solute carrier family 25 (mitochondrial carrier, Aralar), member 12
Synonyms: B230107K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78830
Homologene: 48235
Tnpo3
Name: transportin 3
Synonyms: D6Ertd313e, C430013M08Rik, 5730544L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320938
Homologene: 40848
Zic1
Name: zinc finger protein of the cerebellum 1
Synonyms: odd-paired homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22771
Homologene: 2562
Grhl2
Name: grainyhead like transcription factor 2
Synonyms: BOM, 0610015A08Rik, grainyheadlike, clft3, Tcfcp2l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 252973
HGNC: HGNC:2799
Homologene: 32616
Ltn1
Name: listerin E3 ubiquitin protein ligase 1
Synonyms: Rnf160, 4930528H02Rik, Zfp294, Listerin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 78913
VEGA: 16
Homologene: 32272
Ankle2
Name: ankyrin repeat and LEM domain containing 2
Synonyms: D5Ertd585e, 1110001J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71782
Homologene: 35424
Ccnt1
Name: cyclin T1
Synonyms: CycT1, 2810478G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12455
HGNC: HGNC:1599
Homologene: 947
Nedd1
Name: neural precursor cell expressed, developmentally down-regulated gene 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17997
VEGA: 10
HGNC: HGNC:7723
Homologene: 7439
Exd1
Name: exonuclease 3'-5' domain containing 1
Synonyms: 4932702D22Rik, Exdl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241624
Homologene: 17627
Slc43a2
Name: solute carrier family 43, member 2
Synonyms: 7630402D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 215113
Homologene: 17555
Trf
Name: transferrin
Synonyms: HP, Tfn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22041
Homologene: 68153
Dsp
Name: desmoplakin
Synonyms: rul, 2300002E22Rik, DP, 5730453H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Pirb
Name: paired Ig-like receptor B
Synonyms: Gp91, Lilrb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18733
HGNC: HGNC:6607
Homologene: 134028
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: Coh1, C330002D13Rik, 2310042E16Rik, 1810042B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Abcd3
Name: ATP-binding cassette, sub-family D (ALD), member 3
Synonyms: PMP70, Pxmp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19299
HGNC: HGNC:67
Homologene: 2140
Gm3604
Name: predicted gene 3604
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100041979
Homologene: 136271
Adamtsl1
Name: ADAMTS-like 1
Synonyms: 5930437A14Rik, punctin-1, 6720426B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77739
Homologene: 64642
Boc
Name: biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 117606
Homologene: 32819
Cuzd1
Name: CUB and zona pellucida-like domains 1
Synonyms: UTCZP, Itmap1, UO-44, ERG-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16433
Homologene: 7389
Rbl1
Name: RB transcriptional corepressor like 1
Synonyms: p107, retinoblastoma-like 1 (p107)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19650
HGNC: HGNC:9893
Homologene: 2172
Inpp4a
Name: inositol polyphosphate-4-phosphatase, type I
Synonyms: 107kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269180
HGNC: HGNC:6074
Homologene: 2871
Patl1
Name: protein associated with topoisomerase II homolog 1 (yeast)
Synonyms: Pat1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225929
VEGA: 19
Homologene: 82269
Nop53
Name: NOP53 ribosome biogenesis factor
Synonyms: 9430097C02Rik, Gltscr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68077
HGNC: HGNC:4333
Homologene: 44130
Klhl20
Name: kelch-like 20
Synonyms: D930050H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226541
Homologene: 8699
Kdm6b
Name: KDM1 lysine (K)-specific demethylase 6B
Synonyms: Jmjd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216850
Homologene: 18945
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230676
Homologene: 49413
Lemd3
Name: LEM domain containing 3
Synonyms: Man1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 380664
Homologene: 8633
Gm7102
Name: predicted gene 7102
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 633057
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: CED-5, MBC, Hch
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Macroh2a2
Name: macroH2A.2 histone
Synonyms: H2afy2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 404634
Homologene: 10246
Dmpk
Name: dystrophia myotonica-protein kinase
Synonyms: DM, Dm15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13400
HGNC: HGNC:2933
Homologene: 3247
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Kif1a
Name: kinesin family member 1A
Synonyms: N-3 kinesin, ATSV, C630002N23Rik, Kns1, LOC381283
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Rapgef5
Name: Rap guanine nucleotide exchange factor (GEF) 5
Synonyms: D030051B22Rik, mr-gef
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217944
VEGA: 12
Homologene: 56563
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Mast3
Name: microtubule associated serine/threonine kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 546071
Homologene: 66191
Jakmip2
Name: janus kinase and microtubule interacting protein 2
Synonyms: 6430702L21Rik, D930046L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 76217
VEGA: 18
Homologene: 8866
Vmn1r124
Name: vomeronasal 1 receptor 124
Synonyms: Gm9500
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 670764
Homologene: 104166
Opn5
Name: opsin 5
Synonyms: Neuropsin, PGR12, Gpr136, TMEM13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 353344
VEGA: 17
Homologene: 72341
Cd93
Name: CD93 antigen
Synonyms: C1qr1, AA4.1, C1qrp, 6030404G09Rik, Ly68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17064
Homologene: 7823
Myoz1
Name: myozenin 1
Synonyms: calsarcin-2, FATZ, 2310001N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 59011
VEGA: 14
Homologene: 23311
Notch4
Name: notch 4
Synonyms: N4, Int-3, Int3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18132
HGNC: HGNC:7884
Homologene: 3351
Tgfbr3
Name: transforming growth factor, beta receptor III
Synonyms: betaglycan, 1110036H20Rik, TBRIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21814
Homologene: 2436
Dab2
Name: disabled 2, mitogen-responsive phosphoprotein
Synonyms: D630005B22Rik, p96, 5730435J12Rik, D15Wsu122e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13132
HGNC: HGNC:2662
Homologene: 1026
Rgl1
Name: ral guanine nucleotide dissociation stimulator,-like 1
Synonyms: Rgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19731
Homologene: 9039
Gsto1
Name: glutathione S-transferase omega 1
Synonyms: p28, GSTX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14873
Homologene: 37971
Smtn
Name: smoothelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 29856
Homologene: 8482
Slc22a15
Name: solute carrier family 22 (organic anion/cation transporter), member 15
Synonyms: 2610034P21Rik, A530052I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242126
Homologene: 41263
Lvrn
Name: laeverin
Synonyms: Aqpep, 4833403I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 74574
VEGA: 18
Homologene: 51352
Serpinb3a
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A
Synonyms: Sqn5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20248
Homologene: 76659
Agbl5
Name: ATP/GTP binding protein-like 5
Synonyms: 9430057O19Rik, Ccp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231093
Homologene: 11053
Nlrp4e
Name: NLR family, pyrin domain containing 4E
Synonyms: Nalp4e, Nalp-epsilon, 4930406H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 446099
Homologene: 75315
Itpripl2
Name: inositol 1,4,5-triphosphate receptor interacting protein-like 2
Synonyms: E030018N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 319622
Homologene: 45882
Lipo1
Name: lipase, member O1
Synonyms: Gm5097
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 329055
Homologene: 86428
Esd
Name: esterase D/formylglutathione hydrolase
Synonyms: Esd, Es-10, Es10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13885
HGNC: HGNC:3465
Homologene: 55623
Cpsf4l
Name: cleavage and polyadenylation specific factor 4-like
Synonyms: 1500000C01Rik, D11Ertd636e, 0610010C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52670
Homologene: 32669
Olfr724
Name: olfactory receptor 724
Synonyms: MOR247-2, GA_x6K02T2PMLR-5645801-5644872
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258485
Homologene: 71986
Phactr3
Name: phosphatase and actin regulator 3
Synonyms: scapinin, 4930415A02Rik, 1500003N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74189
Homologene: 14482
Smim27
Name: small integral membrane protein 27
Synonyms: Toporsos, 2010003O02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100504309
RP23-387P23.4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 34,198,505 bp
  • T to A, chromosome 1 at 37,371,780 bp
  • T to C, chromosome 1 at 93,021,209 bp
  • C to T, chromosome 1 at 107,048,586 bp
  • T to C, chromosome 1 at 152,554,330 bp
  • T to C, chromosome 1 at 161,098,376 bp
  • G to T, chromosome 2 at 52,192,520 bp
  • A to T, chromosome 2 at 71,296,805 bp
  • C to T, chromosome 2 at 119,520,326 bp
  • G to A, chromosome 2 at 148,443,379 bp
  • C to T, chromosome 2 at 157,204,399 bp
  • A to G, chromosome 2 at 178,284,018 bp
  • T to C, chromosome 3 at 101,875,603 bp
  • C to A, chromosome 3 at 121,760,284 bp
  • G to T, chromosome 4 at 40,269,719 bp
  • A to G, chromosome 4 at 86,356,382 bp
  • A to T, chromosome 4 at 118,369,248 bp
  • G to A, chromosome 5 at 30,890,715 bp
  • G to T, chromosome 5 at 107,109,719 bp
  • A to C, chromosome 5 at 110,242,013 bp
  • T to C, chromosome 6 at 29,568,938 bp
  • T to A, chromosome 6 at 73,044,762 bp
  • A to T, chromosome 6 at 127,319,455 bp
  • C to T, chromosome 7 at 3,717,603 bp
  • C to T, chromosome 7 at 15,942,204 bp
  • A to T, chromosome 7 at 19,087,528 bp
  • A to G, chromosome 7 at 21,259,699 bp
  • A to T, chromosome 7 at 23,336,740 bp
  • T to C, chromosome 7 at 118,491,057 bp
  • T to A, chromosome 7 at 131,318,054 bp
  • C to A, chromosome 8 at 70,788,915 bp
  • G to T, chromosome 9 at 91,362,531 bp
  • T to A, chromosome 9 at 103,227,915 bp
  • C to T, chromosome 10 at 61,739,353 bp
  • T to A, chromosome 10 at 92,686,258 bp
  • T to C, chromosome 10 at 120,931,948 bp
  • A to G, chromosome 11 at 3,520,736 bp
  • T to C, chromosome 11 at 34,273,767 bp
  • T to C, chromosome 11 at 59,067,607 bp
  • A to T, chromosome 11 at 69,403,794 bp
  • T to C, chromosome 11 at 75,543,293 bp
  • G to T, chromosome 11 at 113,709,502 bp
  • G to A, chromosome 12 at 117,756,074 bp
  • G to A, chromosome 13 at 38,192,864 bp
  • A to T, chromosome 13 at 62,369,043 bp
  • T to C, chromosome 14 at 20,655,309 bp
  • T to C, chromosome 14 at 49,960,224 bp
  • T to C, chromosome 14 at 74,741,160 bp
  • T to C, chromosome 15 at 6,427,527 bp
  • T to A, chromosome 15 at 35,452,224 bp
  • T to A, chromosome 15 at 37,335,659 bp
  • A to T, chromosome 15 at 98,543,451 bp
  • G to C, chromosome 16 at 32,753,919 bp
  • A to C, chromosome 16 at 44,490,157 bp
  • C to A, chromosome 16 at 87,379,694 bp
  • T to C, chromosome 17 at 34,570,118 bp
  • T to C, chromosome 17 at 42,611,296 bp
  • G to A, chromosome 18 at 43,567,143 bp
  • A to T, chromosome 18 at 46,905,351 bp
  • T to C, chromosome 19 at 11,925,151 bp
  • A to G, chromosome 19 at 33,776,587 bp
  • C to T, chromosome 19 at 47,864,391 bp
  • C to T, chromosome 19 at 61,175,926 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4830 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042446-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.