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Strain Name:
C57BL/6J-MtgxR4873Btlr/Mmmh
Stock Number:
042483-MU
Citation ID:
RRID:MMRRC_042483-MU
Other Names:
R4873 (G1), C57BL/6J-MtgxR4873Btlr
Major Collection:

Strain Information

Strap
Name: serine/threonine kinase receptor associated protein
Synonyms: C78091, Unrip
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20901
Homologene: 43881
Ndufv1
Name: NADH:ubiquinone oxidoreductase core subunit V1
Synonyms: 24 kDa (FP)
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17995
HGNC: HGNC:7716
Homologene: 5151
Atad5
Name: ATPase family, AAA domain containing 5
Synonyms: LOC237877, C130052G03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237877
Homologene: 32611
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: GCN1L, G431004K08Rik, Gcn1l1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Pcnt
Name: pericentrin (kendrin)
Synonyms: Pcnt2, m275Asp, m239Asp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18541
VEGA: 10
Tpx2
Name: TPX2, microtubule-associated
Synonyms: REPP86, DIL2, p100, 2610005B21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72119
HGNC: HGNC:1249
Homologene: 8107
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 46,688,925 bp
  • G to T, chromosome 1 at 88,254,935 bp
  • T to C, chromosome 1 at 92,916,433 bp
  • G to A, chromosome 1 at 127,469,249 bp
  • A to G, chromosome 1 at 151,455,004 bp
  • T to C, chromosome 1 at 155,705,267 bp
  • T to A, chromosome 1 at 174,175,830 bp
  • A to G, chromosome 1 at 178,915,327 bp
  • A to C, chromosome 1 at 190,162,122 bp
  • T to A, chromosome 2 at 24,441,640 bp
  • A to G, chromosome 2 at 31,036,245 bp
  • A to T, chromosome 2 at 32,631,177 bp
  • T to C, chromosome 2 at 66,328,476 bp
  • T to C, chromosome 2 at 73,273,618 bp
  • T to A, chromosome 2 at 121,184,849 bp
  • A to G, chromosome 2 at 132,056,880 bp
  • C to A, chromosome 2 at 152,893,615 bp
  • T to C, chromosome 2 at 155,969,354 bp
  • A to T, chromosome 2 at 163,865,523 bp
  • T to C, chromosome 2 at 164,168,101 bp
  • A to G, chromosome 2 at 178,033,147 bp
  • A to T, chromosome 2 at 181,997,433 bp
  • C to T, chromosome 3 at 81,942,381 bp
  • G to A, chromosome 3 at 155,087,913 bp
  • A to G, chromosome 4 at 143,794,835 bp
  • G to A, chromosome 4 at 145,702,083 bp
  • T to C, chromosome 4 at 148,444,099 bp
  • T to A, chromosome 5 at 112,309,821 bp
  • T to C, chromosome 5 at 114,970,673 bp
  • T to C, chromosome 5 at 115,576,170 bp
  • A to T, chromosome 5 at 142,765,177 bp
  • C to A, chromosome 5 at 145,452,849 bp
  • A to C, chromosome 6 at 69,016,665 bp
  • C to A, chromosome 6 at 83,061,012 bp
  • G to A, chromosome 6 at 106,437,913 bp
  • A to T, chromosome 6 at 116,413,850 bp
  • T to C, chromosome 6 at 120,750,916 bp
  • T to A, chromosome 6 at 121,226,083 bp
  • ACCTGCCCTCCT to ACCT, chromosome 6 at 137,749,318 bp
  • A to T, chromosome 7 at 3,616,017 bp
  • A to T, chromosome 7 at 4,029,034 bp
  • A to T, chromosome 7 at 5,298,859 bp
  • G to T, chromosome 7 at 5,454,109 bp
  • A to G, chromosome 7 at 28,296,435 bp
  • C to T, chromosome 7 at 44,862,403 bp
  • A to G, chromosome 7 at 55,167,248 bp
  • A to T, chromosome 7 at 108,868,786 bp
  • G to C, chromosome 7 at 116,084,413 bp
  • A to T, chromosome 7 at 139,256,062 bp
  • T to A, chromosome 8 at 3,507,422 bp
  • A to G, chromosome 8 at 18,625,558 bp
  • T to A, chromosome 8 at 22,768,450 bp
  • T to A, chromosome 8 at 79,060,774 bp
  • T to A, chromosome 8 at 104,927,185 bp
  • T to C, chromosome 9 at 22,578,715 bp
  • T to C, chromosome 9 at 49,507,621 bp
  • T to C, chromosome 9 at 73,517,284 bp
  • C to T, chromosome 9 at 107,583,619 bp
  • A to G, chromosome 10 at 58,704,043 bp
  • T to C, chromosome 10 at 76,369,854 bp
  • G to A, chromosome 10 at 79,530,929 bp
  • C to A, chromosome 10 at 128,326,095 bp
  • T to C, chromosome 10 at 130,472,498 bp
  • A to G, chromosome 11 at 22,101,164 bp
  • A to G, chromosome 11 at 54,126,240 bp
  • T to C, chromosome 11 at 80,120,689 bp
  • T to C, chromosome 11 at 100,190,037 bp
  • C to T, chromosome 11 at 106,828,540 bp
  • T to A, chromosome 11 at 107,637,734 bp
  • G to A, chromosome 12 at 65,161,435 bp
  • A to T, chromosome 12 at 101,587,985 bp
  • C to A, chromosome 12 at 110,658,126 bp
  • G to A, chromosome 13 at 12,604,436 bp
  • T to A, chromosome 13 at 21,142,280 bp
  • T to C, chromosome 13 at 27,773,759 bp
  • T to C, chromosome 13 at 120,154,670 bp
  • T to C, chromosome 14 at 70,676,816 bp
  • C to T, chromosome 15 at 63,828,252 bp
  • T to A, chromosome 15 at 90,648,568 bp
  • G to A, chromosome 16 at 33,234,493 bp
  • A to T, chromosome 17 at 5,988,068 bp
  • A to G, chromosome 17 at 31,499,155 bp
  • A to G, chromosome 17 at 40,115,383 bp
  • T to C, chromosome 17 at 56,568,938 bp
  • T to C, chromosome 17 at 71,072,119 bp
  • T to G, chromosome 17 at 73,805,304 bp
  • A to G, chromosome 18 at 46,296,289 bp
  • G to T, chromosome 18 at 46,465,737 bp
  • T to C, chromosome 19 at 4,012,653 bp
  • T to A, chromosome 19 at 13,768,762 bp
  • C to T, chromosome X at 74,277,038 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4873 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042483-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.