Strain Name:
C57BL/6J-MtgxR4882Btlr/Mmmh
Stock Number:
042490-MU
Citation ID:
RRID:MMRRC_042490-MU
Other Names:
R4882 (G1), C57BL/6J-MtgxR4882Btlr
Major Collection:

Strain Information

Snca
Name: synuclein, alpha
Synonyms: alphaSYN, alpha-synuclein, alpha-Syn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20617
Homologene: 293
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 0610038M01Rik, 2610510B01Rik, Dopey2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Phf14
Name: PHD finger protein 14
Synonyms: 1110001C23Rik, 4932409F11Rik, 5730446A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 75725
Homologene: 8775
Sgpl1
Name: sphingosine phosphate lyase 1
Synonyms: D10Xrf456
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20397
Homologene: 2897
Mcm7
Name: minichromosome maintenance complex component 7
Synonyms: mCDC47, Mcmd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17220
HGNC: HGNC:6950
Homologene: 4323
Taok3
Name: TAO kinase 3
Synonyms: A430105I05Rik, 2900006A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330177
Homologene: 83279
Shroom3
Name: shroom family member 3
Synonyms: D5Ertd287e, Shrm, Shrm3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27428
Homologene: 9263
Etaa1
Name: Ewing tumor-associated antigen 1
Synonyms: 5730466H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68145
Homologene: 10369
Usp38
Name: ubiquitin specific peptidase 38
Synonyms: 4631402N15Rik, 4833420O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74841
Homologene: 12367
Baz1b
Name: bromodomain adjacent to zinc finger domain, 1B
Synonyms: Wbscr9, WSTF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22385
HGNC: HGNC:961
Homologene: 22651
Flnb
Name: filamin, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Smchd1
Name: SMC hinge domain containing 1
Synonyms: 4931400A14Rik, MommeD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74355
Homologene: 23665
Mcm3ap
Name: minichromosome maintenance complex component 3 associated protein
Synonyms: GANP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54387
VEGA: 10
HGNC: HGNC:6946
Homologene: 2902
Phf11d
Name: PHD finger protein 11D
Synonyms: D14Ertd668e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219132
Homologene: 87807
Uhrf1
Name: ubiquitin-like, containing PHD and RING finger domains, 1
Synonyms: ICBP90, Np95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18140
Homologene: 7866
Lpin1
Name: lipin 1
Synonyms: Lipin1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 14245
VEGA: 12
Homologene: 9266
Cdk12
Name: cyclin-dependent kinase 12
Synonyms: 1810022J16Rik, Crk7, D11Ertd752e, Crkrs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69131
Homologene: 128632
Aqp4
Name: aquaporin 4
Synonyms: aquaporin-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 11829
VEGA: 18
HGNC: HGNC:637
Homologene: 37507
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22635
Homologene: 124417
Slx4
Name: SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
Synonyms: D16Bwg1016e, Btbd12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 52864
Homologene: 23770
Kdm1b
Name: lysine (K)-specific demethylase 1B
Synonyms: 4632428N09Rik, Aof1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218214
Homologene: 14695
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Caskin1
Name: CASK interacting protein 1
Synonyms: C630036E02Rik, 3300002N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268932
VEGA: 17
Homologene: 25873
Cgnl1
Name: cingulin-like 1
Synonyms: Jacop, 4933421H10Rik, 9930020M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68178
Homologene: 41901
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Sez4, Rev
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Gpr158
Name: G protein-coupled receptor 158
Synonyms: 5330427M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241263
Homologene: 19381
Bap1
Name: Brca1 associated protein 1
Synonyms: 2300006C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 104416
HGNC: HGNC:950
Homologene: 3421
Plekhh3
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217198
Homologene: 11787
Axdnd1
Name: axonemal dynein light chain domain containing 1
Synonyms: LOC381304, 9430070O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77352
Homologene: 52328
Hbb-bh2
Name: hemoglobin beta, bh2
Synonyms: Gm5736
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 436003
Prpf19
Name: pre-mRNA processing factor 19
Synonyms: PSO4, D19Wsu55e, Prp19, Snev
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 28000
Homologene: 6421
Acap3
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
Synonyms: Kiaa1716-hp, Centb5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 140500
Homologene: 23708
Irf9
Name: interferon regulatory factor 9
Synonyms: p48, Irf-9, Isgf3g
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16391
HGNC: HGNC:6131
Homologene: 4436
Nnmt
Name: nicotinamide N-methyltransferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18113
HGNC: HGNC:7861
Homologene: 4496
Zfp759
Name: zinc finger protein 759
Synonyms: Rslcan-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 268670
VEGA: 13
Adgrg6
Name: adhesion G protein-coupled receptor G6
Synonyms: LOC215798, 1190004A11Rik, DREG, Gpr126
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215798
Homologene: 10724
Vmn2r96
Name: vomeronasal 2, receptor 96
Synonyms: EG433070
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 433070
BB014433
Name: expressed sequence BB014433
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 434285
Opcml
Name: opioid binding protein/cell adhesion molecule-like
Synonyms: Obcam, LOC235104, 2900075O15Rik, B930023M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330908
HGNC: HGNC:8143
Homologene: 55663
Dqx1
Name: DEAQ RNA-dependent ATPase
Synonyms: 2310066E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 93838
Homologene: 14143
Cd200
Name: CD200 molecule
Synonyms: MRC OX-2, OX2, Mox2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17470
HGNC: HGNC:7203
Homologene: 4344
H2-Eb2
Name: histocompatibility 2, class II antigen E beta2
Synonyms: H-2Eb2, Ia-5, Ia5, A130038H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381091
Homologene: 128636
Inca1
Name: inhibitor of CDK, cyclin A1 interacting protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103844
Homologene: 19481
Map3k9
Name: mitogen-activated protein kinase kinase kinase 9
Synonyms: Mlk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 338372
VEGA: 12
HGNC: HGNC:6861
Homologene: 76377
Ifna9
Name: interferon alpha 9
Synonyms: Ifa9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15972
Homologene: 68536
Npdc1
Name: neural proliferation, differentiation and control 1
Synonyms: NPDC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18146
HGNC: HGNC:7899
Homologene: 32050
Cacng8
Name: calcium channel, voltage-dependent, gamma subunit 8
Synonyms: TARP gamma 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 81905
Homologene: 12894
Cebpzos
Name: CCAAT/enhancer binding protein (C/EBP), zeta, opposite strand
Synonyms: 1110001A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68554
Mfsd8
Name: major facilitator superfamily domain containing 8
Synonyms: 2810423E13Rik, Cln7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72175
Homologene: 115814
Nppa
Name: natriuretic peptide type A
Synonyms: atrial natriuretic peptide, ANP, natriuretic peptide precursor A, Anf, Pnd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230899
HGNC: HGNC:7939
Homologene: 4498
Ceacam13
Name: CEA cell adhesion molecule 13
Synonyms: Ceacam13-C2, Ceacam13-C1, 1600025J19Rik, 1600012K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69785
Homologene: 135962
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 156,395,559 bp
  • T to A, chromosome 2 at 21,825,248 bp
  • G to A, chromosome 2 at 25,408,945 bp
  • C to T, chromosome 3 at 40,835,242 bp
  • T to A, chromosome 4 at 88,592,303 bp
  • G to T, chromosome 4 at 148,001,087 bp
  • A to G, chromosome 4 at 155,905,655 bp
  • G to T, chromosome 5 at 92,943,086 bp
  • A to T, chromosome 5 at 117,252,630 bp
  • T to C, chromosome 5 at 135,216,895 bp
  • A to G, chromosome 5 at 137,438,448 bp
  • A to T, chromosome 5 at 138,165,911 bp
  • T to A, chromosome 6 at 11,988,757 bp
  • A to G, chromosome 6 at 60,815,735 bp
  • A to G, chromosome 6 at 83,066,088 bp
  • T to C, chromosome 7 at 3,412,153 bp
  • A to G, chromosome 7 at 18,013,072 bp
  • A to T, chromosome 7 at 103,839,248 bp
  • A to G, chromosome 8 at 15,042,016 bp
  • G to A, chromosome 8 at 80,981,977 bp
  • G to A, chromosome 9 at 28,901,590 bp
  • T to C, chromosome 9 at 48,604,869 bp
  • T to A, chromosome 9 at 71,717,401 bp
  • T to A, chromosome 10 at 14,434,337 bp
  • T to A, chromosome 10 at 39,821,460 bp
  • T to C, chromosome 10 at 61,112,265 bp
  • C to T, chromosome 10 at 76,484,661 bp
  • T to C, chromosome 11 at 17,946,174 bp
  • T to C, chromosome 11 at 70,688,740 bp
  • C to T, chromosome 11 at 98,210,446 bp
  • G to A, chromosome 11 at 101,165,183 bp
  • T to A, chromosome 11 at 101,167,938 bp
  • G to C, chromosome 12 at 16,538,536 bp
  • C to T, chromosome 12 at 81,724,162 bp
  • T to A, chromosome 13 at 47,060,893 bp
  • T to A, chromosome 13 at 67,139,290 bp
  • A to G, chromosome 14 at 7,929,936 bp
  • C to T, chromosome 14 at 31,251,721 bp
  • G to T, chromosome 14 at 55,609,039 bp
  • T to C, chromosome 14 at 59,359,569 bp
  • T to C, chromosome 16 at 3,980,996 bp
  • T to C, chromosome 16 at 45,397,017 bp
  • G to T, chromosome 16 at 93,752,914 bp
  • T to A, chromosome 17 at 18,597,604 bp
  • T to C, chromosome 17 at 24,504,415 bp
  • C to T, chromosome 17 at 34,334,256 bp
  • T to C, chromosome 17 at 56,309,401 bp
  • T to A, chromosome 17 at 71,358,239 bp
  • T to C, chromosome 17 at 78,919,791 bp
  • A to G, chromosome 18 at 15,398,254 bp
  • T to A, chromosome 19 at 9,005,897 bp
  • T to C, chromosome 19 at 10,898,959 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4882 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042490-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.