Strain Name:
C57BL/6J-MtgxR4910Btlr/Mmmh
Stock Number:
042512-MU
Citation ID:
RRID:MMRRC_042512-MU
Other Names:
R4910 (G1), C57BL/6J-MtgxR4910Btlr
Major Collection:

Gene Information

Gene Symbol: Pkd1 [MGI:97603] (Mus musculus (mouse))
Name: polycystin 1, transient receptor poteintial channel interacting
Synonyms: PC1, PC-1, polycystin-1
Chromosome: 17
Alteration at locus: Chemically Induced
Gene Symbol: Card11 [MGI:1916978] (Mus musculus (mouse))
Name: caspase recruitment domain family, member 11
Synonyms: 0610008L17Rik, BIMP3, 2410011D02Rik, CARMA1
Chromosome: 5
Alteration at locus: Chemically Induced
Gene Symbol: Slc17a6 [MGI:2156052] (Mus musculus (mouse))
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
Synonyms: VGLUT2, 2900073D12Rik
Chromosome: 7
Alteration at locus: Chemically Induced
Gene Symbol: Snta1 [MGI:101772] (Mus musculus (mouse))
Name: syntrophin, acidic 1
Synonyms: alpha1-syntrophin, Snt1
Chromosome: 2
Alteration at locus: Chemically Induced
Gene Symbol: Slit3 [MGI:1315202] (Mus musculus (mouse))
Name: slit guidance ligand 3
Synonyms: Slit1, b2b2362.1Clo
Chromosome: 11
Alteration at locus: Chemically Induced
Gene Symbol: Wdr73 [MGI:1919218] (Mus musculus (mouse))
Name: WD repeat domain 73
Synonyms: 1200011I23Rik, 2410008B13Rik
Chromosome: 7
Alteration at locus: Chemically Induced
Gene Symbol: Cnot7 [MGI:1298230] (Mus musculus (mouse))
Name: CCR4-NOT transcription complex, subunit 7
Synonyms: Caf1
Chromosome: 8
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 3,680,941 bp
  • C to T, chromosome 1 at 80,290,089 bp
  • C to A, chromosome 1 at 82,672,679 bp
  • C to T, chromosome 1 at 88,215,123 bp
  • T to C, chromosome 1 at 93,135,714 bp
  • A to T, chromosome 1 at 134,541,864 bp
  • A to G, chromosome 1 at 139,491,543 bp
  • T to G, chromosome 1 at 139,774,563 bp
  • T to A, chromosome 1 at 150,455,823 bp
  • T to A, chromosome 1 at 159,168,359 bp
  • T to A, chromosome 1 at 174,217,863 bp
  • C to T, chromosome 1 at 176,782,263 bp
  • A to T, chromosome 1 at 183,135,463 bp
  • C to A, chromosome 1 at 187,194,011 bp
  • G to A, chromosome 2 at 73,367,538 bp
  • A to G, chromosome 2 at 106,365,550 bp
  • A to T, chromosome 2 at 111,945,078 bp
  • G to T, chromosome 2 at 121,806,828 bp
  • T to A, chromosome 2 at 150,117,952 bp
  • C to A, chromosome 2 at 154,377,018 bp
  • A to T, chromosome 2 at 167,036,804 bp
  • G to T, chromosome 2 at 167,037,482 bp
  • A to T, chromosome 2 at 178,358,224 bp
  • T to C, chromosome 2 at 181,308,837 bp
  • A to T, chromosome 2 at 181,515,212 bp
  • T to A, chromosome 3 at 19,989,224 bp
  • C to A, chromosome 3 at 36,998,199 bp
  • T to A, chromosome 3 at 59,869,014 bp
  • T to A, chromosome 3 at 87,939,263 bp
  • T to A, chromosome 3 at 100,993,889 bp
  • T to A, chromosome 3 at 108,781,252 bp
  • T to C, chromosome 4 at 58,096,276 bp
  • G to T, chromosome 4 at 82,820,331 bp
  • T to C, chromosome 4 at 99,963,527 bp
  • T to C, chromosome 4 at 106,709,955 bp
  • T to C, chromosome 4 at 132,338,213 bp
  • C to T, chromosome 5 at 6,770,540 bp
  • A to G, chromosome 5 at 65,091,462 bp
  • T to G, chromosome 5 at 88,502,314 bp
  • G to T, chromosome 5 at 118,056,466 bp
  • G to T, chromosome 5 at 118,125,027 bp
  • A to G, chromosome 5 at 120,556,519 bp
  • C to G, chromosome 5 at 140,874,414 bp
  • T to C, chromosome 5 at 151,062,527 bp
  • A to T, chromosome 6 at 25,746,021 bp
  • A to T, chromosome 6 at 36,524,233 bp
  • A to G, chromosome 6 at 41,955,444 bp
  • A to G, chromosome 6 at 43,272,828 bp
  • C to A, chromosome 6 at 47,931,499 bp
  • A to G, chromosome 6 at 57,691,948 bp
  • A to C, chromosome 6 at 67,720,926 bp
  • A to C, chromosome 6 at 69,726,849 bp
  • A to G, chromosome 6 at 77,244,901 bp
  • T to C, chromosome 6 at 137,368,338 bp
  • A to T, chromosome 6 at 145,815,280 bp
  • T to A, chromosome 7 at 10,378,409 bp
  • T to A, chromosome 7 at 12,715,535 bp
  • C to T, chromosome 7 at 12,837,135 bp
  • A to G, chromosome 7 at 25,358,370 bp
  • T to A, chromosome 7 at 41,573,592 bp
  • T to C, chromosome 7 at 42,043,653 bp
  • A to T, chromosome 7 at 46,264,062 bp
  • A to T, chromosome 7 at 46,298,534 bp
  • A to G, chromosome 7 at 47,426,544 bp
  • A to T, chromosome 7 at 51,658,741 bp
  • C to T, chromosome 7 at 65,343,727 bp
  • A to G, chromosome 7 at 80,891,708 bp
  • A to T, chromosome 7 at 83,997,411 bp
  • A to G, chromosome 7 at 102,195,800 bp
  • G to A, chromosome 7 at 104,975,479 bp
  • A to C, chromosome 7 at 107,186,583 bp
  • A to T, chromosome 7 at 123,308,377 bp
  • T to G, chromosome 7 at 128,240,728 bp
  • A to G, chromosome 7 at 141,093,788 bp
  • T to A, chromosome 8 at 24,694,305 bp
  • T to A, chromosome 8 at 40,507,496 bp
  • A to T, chromosome 8 at 95,733,231 bp
  • G to T, chromosome 8 at 121,885,122 bp
  • T to C, chromosome 8 at 123,927,131 bp
  • T to A, chromosome 9 at 38,378,742 bp
  • A to G, chromosome 9 at 54,549,879 bp
  • A to G, chromosome 9 at 79,817,932 bp
  • C to T, chromosome 9 at 86,492,061 bp
  • A to G, chromosome 9 at 89,976,752 bp
  • T to C, chromosome 9 at 121,982,947 bp
  • A to T, chromosome 10 at 18,107,688 bp
  • T to A, chromosome 10 at 20,724,734 bp
  • T to A, chromosome 10 at 80,609,671 bp
  • T to A, chromosome 10 at 88,555,724 bp
  • T to C, chromosome 10 at 107,879,517 bp
  • T to C, chromosome 10 at 129,625,807 bp
  • T to A, chromosome 11 at 8,929,360 bp
  • T to C, chromosome 11 at 35,632,722 bp
  • A to G, chromosome 11 at 53,478,445 bp
  • A to G, chromosome 11 at 60,752,378 bp
  • A to G, chromosome 11 at 70,030,925 bp
  • T to A, chromosome 11 at 71,217,277 bp
  • G to A, chromosome 11 at 97,139,130 bp
  • T to C, chromosome 11 at 100,766,988 bp
  • G to A, chromosome 11 at 115,446,455 bp
  • A to G, chromosome 11 at 121,220,895 bp
  • A to G, chromosome 12 at 8,007,848 bp
  • A to G, chromosome 12 at 89,260,360 bp
  • A to G, chromosome 12 at 102,808,048 bp
  • C to T, chromosome 12 at 103,895,032 bp
  • G to C, chromosome 12 at 114,829,508 bp
  • A to G, chromosome 12 at 115,067,842 bp
  • C to A, chromosome 12 at 117,873,785 bp
  • T to A, chromosome 13 at 77,043,880 bp
  • T to C, chromosome 13 at 90,923,752 bp
  • T to C, chromosome 13 at 93,771,977 bp
  • C to A, chromosome 14 at 50,362,889 bp
  • A to G, chromosome 15 at 37,291,676 bp
  • A to G, chromosome 15 at 88,958,212 bp
  • T to C, chromosome 15 at 100,716,178 bp
  • T to C, chromosome 16 at 19,530,018 bp
  • T to C, chromosome 16 at 37,091,137 bp
  • T to A, chromosome 16 at 58,797,442 bp
  • T to C, chromosome 16 at 73,933,778 bp
  • T to A, chromosome 17 at 5,342,203 bp
  • T to C, chromosome 17 at 15,544,323 bp
  • TC to T, chromosome 17 at 23,479,513 bp
  • T to A, chromosome 17 at 23,815,388 bp
  • T to A, chromosome 17 at 24,572,687 bp
  • T to C, chromosome 17 at 35,061,544 bp
  • T to C, chromosome 17 at 37,170,043 bp
  • T to C, chromosome 17 at 75,327,292 bp
  • A to T, chromosome 18 at 37,485,159 bp
  • T to A, chromosome 18 at 38,993,637 bp
  • T to A, chromosome 18 at 65,266,286 bp
  • G to A, chromosome 19 at 56,798,691 bp
  • C to T, chromosome X at 9,915,602 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4910 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042512-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.