Strain Name:
C57BL/6J-MtgxR4933Btlr/Mmmh
Stock Number:
042533-MU
Citation ID:
RRID:MMRRC_042533-MU
Other Names:
R4933 (G1), C57BL/6J-MtgxR4933Btlr
Major Collection:

Strain Information

Myo10
Name: myosin X
Synonyms: D15Ertd600e, myosin-X
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Fn1
Name: fibronectin 1
Synonyms: Fn, Fn-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Ide
Name: insulin degrading enzyme
Synonyms: 4833415K22Rik, 1300012G03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15925
HGNC: HGNC:5381
Homologene: 3645
Wrn
Name: Werner syndrome RecQ like helicase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22427
Homologene: 6659
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Slit3
Name: slit guidance ligand 3
Synonyms: b2b2362.1Clo, Slit1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20564
Homologene: 2303
Zmynd8
Name: zinc finger, MYND-type containing 8
Synonyms: 2010005I16Rik, ZMYND8, RACK7, 3632413B07Rik, Prkcbp1, 1110013E22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228880
HGNC: HGNC:9397
Homologene: 32679
Pnn
Name: pinin
Synonyms: D12Ertd512e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18949
VEGA: 12
HGNC: HGNC:9162
Homologene: 37656
Hdac5
Name: histone deacetylase 5
Synonyms: mHDA1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15184
Homologene: 3995
2610021A01Rik
Name: RIKEN cDNA 2610021A01 gene
Type: Gene
Species: Mouse
Chromosome: 7
Golph3l
Name: golgi phosphoprotein 3-like
Synonyms: 2010204I15Rik, GPP34R
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229593
Homologene: 23082
Gins4
Name: GINS complex subunit 4
Synonyms: SLD5, 4933405K01Rik, 2810037C03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109145
Homologene: 5759
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Ccp110
Name: centriolar coiled coil protein 110
Synonyms: 6330503K22Rik, CP110
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101565
Homologene: 8810
Kdm3b
Name: KDM3B lysine (K)-specific demethylase 3B
Synonyms: JHDM2B, Jmjd1b, 5830462I21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 277250
VEGA: 18
HGNC: HGNC:1337
Homologene: 41145
Gja8
Name: gap junction protein, alpha 8
Synonyms: connexin 50, alpha 8 connexin, dcm, Lop10, Aey5, Cnx50, Cx50
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14616
HGNC: HGNC:4281
Homologene: 3857
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: M6P/IGF2R, mannose-6-phosphate receptor, cation independent, CD222, CI-MPR, Mpr300, IGF-II/CI-MPR
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Ppp1r21
Name: protein phosphatase 1, regulatory subunit 21
Synonyms: Ccdc128, Klraq1, 1110018J12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73825
Homologene: 44811
Zfp296
Name: zinc finger protein 296
Synonyms: 2210018A16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 63872
Homologene: 11185
Pot1a
Name: protection of telomeres 1A
Synonyms: Pot1, 1500031H18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101185
Homologene: 32263
Agtpbp1
Name: ATP/GTP binding protein 1
Synonyms: Ccp1, atms, Nna1, 5730402G09Rik, 1700020N17Rik, 2900054O13Rik, 4930445M19Rik, 2310001G17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67269
Homologene: 9067
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: Ryr, skrr, calcium release channel isoform 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Rnpep
Name: arginyl aminopeptidase (aminopeptidase B)
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215615
Homologene: 10628
Aoc1l3
Name: amine oxidase copper containing 1-like 3
Synonyms: SVS I, Svs1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243377
HGNC: HGNC:80
Homologene: 18250
Sptbn5
Name: spectrin beta, non-erythrocytic 5
Synonyms: EG640524, Spnb5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 640524
Homologene: 41150
Acot10
Name: acyl-CoA thioesterase 10
Synonyms: p48, MT-ACT48, Acate3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 64833
VEGA: 15
Homologene: 8206
Crybg1
Name: crystallin beta-gamma domain containing 1
Synonyms: Aim1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11630
HGNC: HGNC:356
Homologene: 18168
Vmn2r63
Name: vomeronasal 2, receptor 63
Synonyms: EG435975
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 435975
Homologene: 104832
Or2h15
Name: olfactory receptor family 2 subfamily H member 15
Synonyms: GA_x6K02T2PSCP-2579687-2578746, MOR256-49, Olfr132
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 257889
Homologene: 46430
Megf8
Name: multiple EGF-like-domains 8
Synonyms: b2b288Clo, b2b1702Clo, m687Ddg, Egfl4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269878
HGNC: HGNC:3233
Homologene: 15988
Map1a
Name: microtubule-associated protein 1 A
Synonyms: Mtap1a, Mtap-1, Mtap1, 6330416M19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Abca2
Name: ATP-binding cassette, sub-family A member 2
Synonyms: Abc2, D2H0S1474E
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11305
HGNC: HGNC:32
Homologene: 55590
Kif21b
Name: kinesin family member 21B
Synonyms: N-5 kinesin, 2610511N21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16565
Homologene: 56868
Aurkb
Name: aurora kinase B
Synonyms: aurora B, Stk5, Aik2, STK-1, IPL1, Stk12, AIRK2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20877
Homologene: 55807
Fndc7
Name: fibronectin type III domain containing 7
Synonyms: E230011A21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320181
Homologene: 18551
Tmem38b
Name: transmembrane protein 38B
Synonyms: D4Ertd89e, TRIC-B, 1600017F22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 52076
Homologene: 10010
Or2a7
Name: olfactory receptor family 2 subfamily A member 7
Synonyms: MOR261-6, Olfr13, GA_x6K02T2P3E9-4384160-4383228
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18310
Homologene: 27232
Stpg1
Name: sperm tail PG rich repeat containing 1
Synonyms: 4930403G18Rik, 4930555I21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 78806
Homologene: 12705
Prr15l
Name: proline rich 15-like
Synonyms: E230006A12Rik, Atad4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217138
Homologene: 11522
St8sia6
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
Synonyms: ST8Sia VI, Siat8f, 1700007J08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241230
Homologene: 17112
Rnf148
Name: ring finger protein 148
Synonyms: 4933432M07Rik, Greul3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71300
Homologene: 82404
Haus6
Name: HAUS augmin-like complex, subunit 6
Synonyms: D4Ertd27e, 6230416J20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230376
Homologene: 9760
Shc3
Name: src homology 2 domain-containing transforming protein C3
Synonyms: ShcC, N-Shc, Rai
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20418
VEGA: 13
Homologene: 7536
Lancl1
Name: LanC (bacterial lantibiotic synthetase component C)-like 1
Synonyms: p40, Gpr69a, LanC-like protein 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14768
HGNC: HGNC:6508
Homologene: 4417
Sult3a1
Name: sulfotransferase family 3A, member 1
Synonyms: Sultx2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 57430
VEGA: 10
Homologene: 111031
Dagla
Name: diacylglycerol lipase, alpha
Synonyms: Nsddr
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 269060
HGNC: HGNC:1165
Homologene: 4468
Cabyr
Name: calcium binding tyrosine phosphorylation regulated
Synonyms: 1700016C01Rik, CBP86, FSP-2, 4933421A18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71132
Homologene: 49299
Zfp764l1
Name: zinc finger protein 764 like 1
Synonyms: E430018J23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101604
Homologene: 138471
Pla2g4f
Name: phospholipase A2, group IVF
Synonyms: 4732472I07Rik, Pla2zeta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 271844
Homologene: 77933
Zswim2
Name: zinc finger SWIM-type containing 2
Synonyms: 1700025P14Rik, MEX, 4933437F18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71861
Homologene: 32689
Vmn2r51
Name: vomeronasal 2, receptor 51
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042921
Homologene: 113703
Champ1
Name: chromosome alignment maintaining phosphoprotein 1
Synonyms: D8Ertd569e, Zfp828, D8Ertd457e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 101994
Homologene: 18780
Dkkl1
Name: dickkopf-like 1
Synonyms: Soggy, mSgy, SGY1, SGY-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50722
Homologene: 56674
Spata6l
Name: spermatogenesis associated 6 like
Synonyms: 4430402I18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381218
Homologene: 128454
Akirin1
Name: akirin 1
Synonyms: 6330407G11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68050
Homologene: 11348
Mapk7
Name: mitogen-activated protein kinase 7
Synonyms: big MAP kinase 1, b2b2346Clo, Erk5-T, BMK1, ERK5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23939
HGNC: HGNC:6880
Homologene: 2060
Pcdhgb2
Name: protocadherin gamma subfamily B, 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93700
HGNC: HGNC:8709
Homologene: 49571
Gm11314
Name: predicted gene 11314
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 67,021,034 bp
  • C to A, chromosome 1 at 71,620,761 bp
  • C to A, chromosome 1 at 135,267,026 bp
  • G to A, chromosome 1 at 136,151,325 bp
  • T to C, chromosome 2 at 13,665,442 bp
  • T to C, chromosome 2 at 25,444,827 bp
  • A to G, chromosome 2 at 83,925,227 bp
  • G to A, chromosome 2 at 120,050,120 bp
  • T to A, chromosome 2 at 120,302,848 bp
  • G to A, chromosome 2 at 121,305,905 bp
  • A to G, chromosome 2 at 165,834,951 bp
  • T to A, chromosome 3 at 95,617,423 bp
  • T to A, chromosome 3 at 96,919,035 bp
  • G to T, chromosome 3 at 108,876,670 bp
  • T to A, chromosome 4 at 53,840,694 bp
  • A to C, chromosome 4 at 86,585,287 bp
  • G to A, chromosome 4 at 123,736,858 bp
  • A to T, chromosome 4 at 135,506,416 bp
  • A to G, chromosome 6 at 23,654,340 bp
  • A to G, chromosome 6 at 25,771,541 bp
  • C to T, chromosome 6 at 43,174,321 bp
  • T to C, chromosome 6 at 48,987,492 bp
  • A to T, chromosome 7 at 10,098,320 bp
  • G to T, chromosome 7 at 19,579,712 bp
  • A to G, chromosome 7 at 25,360,705 bp
  • T to C, chromosome 7 at 29,104,298 bp
  • A to G, chromosome 7 at 41,626,802 bp
  • A to T, chromosome 7 at 42,903,978 bp
  • A to T, chromosome 7 at 45,211,525 bp
  • A to G, chromosome 7 at 118,725,319 bp
  • A to G, chromosome 7 at 127,393,349 bp
  • T to A, chromosome 8 at 13,879,137 bp
  • A to T, chromosome 8 at 23,234,780 bp
  • T to C, chromosome 8 at 33,322,343 bp
  • T to A, chromosome 10 at 33,866,554 bp
  • T to A, chromosome 10 at 43,999,213 bp
  • G to T, chromosome 11 at 35,688,593 bp
  • G to T, chromosome 11 at 61,493,908 bp
  • T to C, chromosome 11 at 69,048,144 bp
  • G to A, chromosome 11 at 96,934,762 bp
  • A to G, chromosome 11 at 102,200,563 bp
  • T to A, chromosome 12 at 59,070,227 bp
  • A to T, chromosome 13 at 11,945,945 bp
  • T to A, chromosome 13 at 13,637,764 bp
  • G to A, chromosome 13 at 13,759,378 bp
  • T to G, chromosome 13 at 22,772,788 bp
  • G to T, chromosome 13 at 51,442,769 bp
  • A to T, chromosome 13 at 59,500,572 bp
  • A to T, chromosome 15 at 20,666,330 bp
  • C to A, chromosome 15 at 25,781,118 bp
  • A to G, chromosome 17 at 12,691,877 bp
  • G to A, chromosome 17 at 30,748,568 bp
  • A to G, chromosome 17 at 38,130,550 bp
  • T to A, chromosome 17 at 88,547,621 bp
  • T to C, chromosome 18 at 12,744,492 bp
  • T to C, chromosome 18 at 34,810,393 bp
  • G to A, chromosome 18 at 37,692,214 bp
  • A to T, chromosome 19 at 10,269,715 bp
  • G to T, chromosome 19 at 28,941,775 bp
  • A to G, chromosome 19 at 37,277,756 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4933 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042533-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.