Strain Name:
C57BL/6J-MtgxR4954Btlr/Mmmh
Stock Number:
042551-MU
Citation ID:
RRID:MMRRC_042551-MU
Other Names:
R4954 (G1), C57BL/6J-MtgxR4954Btlr
Major Collection:

Gene Information

Ext1
Name: exostosin glycosyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957
Sema7a
Name: sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
Synonyms: Semaphorin K1, CDw108, Semal, 2900057C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20361
VEGA: 9
Homologene: 2678
Lgi1
Name: leucine-rich repeat LGI family, member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56839
HGNC: HGNC:6572
Homologene: 3737
Ncoa3
Name: nuclear receptor coactivator 3
Synonyms: pCIP, TRAM-1, AIB1, RAC3, Src3, TRAM1, 2010305B15Rik, KAT13B, bHLHe42
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17979
HGNC: HGNC:7670
Homologene: 4764
Phf14
Name: PHD finger protein 14
Synonyms: 1110001C23Rik, 4932409F11Rik, 5730446A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 75725
Homologene: 8775
Rps6ka2
Name: ribosomal protein S6 kinase, polypeptide 2
Synonyms: Rsk3, Rps6ka-rs1, 90kDa, p90rsk, pp90rsk, D17Wsu134e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20112
VEGA: 17
Homologene: 100680
Usp5
Name: ubiquitin specific peptidase 5 (isopeptidase T)
Synonyms: Ucht
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22225
Homologene: 55758
Nbea
Name: neurobeachin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Stk4
Name: serine/threonine kinase 4
Synonyms: Ysk3, Kas-2, Mst1, sterile 20-like kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 58231
Homologene: 55965
Usp15
Name: ubiquitin specific peptidase 15
Synonyms: Gcap18, 4921514G19Rik, E430033I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14479
VEGA: 10
Homologene: 101542
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, Bruce, A430032G04Rik, D630005A10Rik, A430040A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12211
Homologene: 7248
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 217995
VEGA: 13
Homologene: 34562
Kpna1
Name: karyopherin (importin) alpha 1
Synonyms: mSRP1, m-importin-alpha-S1, Rch2, NPI1, importin alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16646
HGNC: HGNC:6394
Homologene: 55642
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: MAP1C, dynein heavy chain, retrograde transport, Dnec1, Loa, 9930018I23Rik, Dnchc1, Swl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Ate1
Name: arginyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11907
HGNC: HGNC:782
Homologene: 31420
Cep128
Name: centrosomal protein 128
Synonyms: 5430424K18Rik, 4930534B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 75216
Homologene: 35315
Dennd1b
Name: DENN/MADD domain containing 1B
Synonyms: F730008N07Rik, 4632404N19Rik, 4930467M19Rik, 6820401H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329260
Homologene: 11739
Cir1
Name: corepressor interacting with RBPJ, 1
Synonyms: 2810021A19Rik, CIR, 1700023B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66935
Homologene: 3589
Rbm33
Name: RNA binding motif protein 33
Synonyms: 6430512A10Rik, 3200001K10Rik, Prr8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381626
Homologene: 137386
Eps15
Name: epidermal growth factor receptor pathway substrate 15
Synonyms: 2410112D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13858
HGNC: HGNC:3419
Homologene: 128359
Dnajb6
Name: DnaJ heat shock protein family (Hsp40) member B6
Synonyms: Mrj, mDj4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 23950
Homologene: 38058
Arhgap28
Name: Rho GTPase activating protein 28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268970
Homologene: 18264
Dync2i1
Name: dynein 2 intermediate chain 1
Synonyms: D430033N04Rik, Wdr60, Dync2l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217935
VEGA: 12
Homologene: 23067
Galnt3
Name: polypeptide N-acetylgalactosaminyltransferase 3
Synonyms: ppGaNTase-T3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14425
HGNC: HGNC:4125
Homologene: 55827
H2-T22
Name: histocompatibility 2, T region locus 22
Synonyms: H-2T22, H-2T17, H2-T17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15039
Homologene: 79525
Cox5b
Name: cytochrome c oxidase subunit 5B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12859
HGNC: HGNC:2269
Homologene: 133751
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: D330014H01Rik, 2900022L05Rik, Dnhd3, Dnahc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Enpep
Name: glutamyl aminopeptidase
Synonyms: Bp-1/6C3, APA, Ly51, Ly-51, 6030431M22Rik, aminopeptidase-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Pkdrej
Name: polycystin (PKD) family receptor for egg jelly
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18766
VEGA: 15
HGNC: HGNC:9015
Homologene: 4427
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Vmn2r2
Name: vomeronasal 2, receptor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100125586
Homologene: 129753
Zcchc4
Name: zinc finger, CCHC domain containing 4
Synonyms: 4930449I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 78796
Homologene: 14632
Abcb5
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 5
Synonyms: 9230106F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 77706
HGNC: HGNC:46
Homologene: 83488
Olfr628
Name: olfactory receptor 628
Synonyms: GA_x6K02T2PBJ9-6457667-6458617, MOR22-4P, MOR22-1, MOR22-4P, Olfr1526-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259159
Homologene: 8420
Cyp3a57
Name: cytochrome P450, family 3, subfamily a, polypeptide 57
Synonyms: EG622127
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 622127
Homologene: 135775
Alk
Name: anaplastic lymphoma kinase
Synonyms: Tcrz, CD246
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 11682
VEGA: 17
HGNC: HGNC:427
Homologene: 68387
Tas2r104
Name: taste receptor, type 2, member 104
Synonyms: Tas2r4, T2R04, mGR04, mt2r45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387340
Homologene: 130072
Mogat2
Name: monoacylglycerol O-acyltransferase 2
Synonyms: Mgat2, DGAT2L5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233549
Homologene: 57020
Myorg
Name: myogenesis regulating glycosidase (putative)
Synonyms: NET37, AI464131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329828
Homologene: 19853
Arhgap26
Name: Rho GTPase activating protein 26
Synonyms: 1810044B20Rik, 2610010G17Rik, 4933432P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 71302
Homologene: 36349
Bmp2k
Name: BMP2 inducible kinase
Synonyms: BIKE, 4933417M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 140780
Homologene: 34134
Hspa4l
Name: heat shock protein 4 like
Synonyms: APG-1, 94kDa, Osp94
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18415
Homologene: 22610
Scn11a
Name: sodium channel, voltage-gated, type XI, alpha
Synonyms: SNS2, NaN, NaT, NSS2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 24046
VEGA: 9
Homologene: 8041
Ankrd6
Name: ankyrin repeat domain 6
Synonyms: diversin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 140577
Homologene: 8967
Olfr309
Name: olfactory receptor 309
Synonyms: GA_x6K02T2NHDJ-9801340-9802266, MOR251-4P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258196
Homologene: 47595
Musk
Name: muscle, skeletal, receptor tyrosine kinase
Synonyms: MDK4, Nsk1, Nsk2, Nsk3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18198
HGNC: HGNC:7525
Homologene: 4084
Nlrp4e
Name: NLR family, pyrin domain containing 4E
Synonyms: Nalp-epsilon, Nalp4e, 4930406H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 446099
Homologene: 75315
Aoc3
Name: amine oxidase, copper containing 3
Synonyms: SSAO, semicarbazide-sensitive amine oxidase, VAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11754
HGNC: HGNC:550
Homologene: 2770
Kcnc3
Name: potassium voltage gated channel, Shaw-related subfamily, member 3
Synonyms: Kv3.3, KShIIID, Kcr2-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16504
HGNC: HGNC:6235
Homologene: 3650
Oog2
Name: oogenesin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381570
Homologene: 77858
Psmc3
Name: proteasome (prosome, macropain) 26S subunit, ATPase 3
Synonyms: Tat binding protein 1, TBP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19182
HGNC: HGNC:9549
Homologene: 2097
Otos
Name: otospiralin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 260301
Homologene: 16396
Syf2
Name: SYF2 homolog, RNA splicing factor (S. cerevisiae)
Synonyms: p29, mp29, 1110018L13Rik, D4Bwg1551e, Gcipip, Cbpin, Ntc31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68592
Homologene: 5993
Ccin
Name: calicin
Synonyms: 4933417A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 442829
HGNC: HGNC:1568
Homologene: 4306
Pate12
Name: prostate and testis expressed 12
Synonyms: Gm7257
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 639025
Homologene: 86450
Olfr47
Name: olfactory receptor 47
Synonyms: IB12, MOR261-9, GA_x6K02T2P3E9-4322325-4321360
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18346
Homologene: 133700
Slc2a10
Name: solute carrier family 2 (facilitated glucose transporter), member 10
Synonyms: Glut10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 170441
Homologene: 38551
Oxct2a
Name: 3-oxoacid CoA transferase 2A
Synonyms: Oxct2, Scot-t1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 64059
Homologene: 137359
Gm12883
Name: predicted gene 12883
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Gm9921
Name: predicted gene 9921
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 36,692,456 bp
  • T to C, chromosome 1 at 92,644,445 bp
  • A to G, chromosome 1 at 139,053,386 bp
  • T to C, chromosome 2 at 52,177,518 bp
  • T to G, chromosome 2 at 66,095,876 bp
  • T to A, chromosome 2 at 73,310,504 bp
  • C to T, chromosome 2 at 91,055,629 bp
  • C to A, chromosome 2 at 164,151,681 bp
  • T to A, chromosome 2 at 164,151,682 bp
  • A to T, chromosome 2 at 165,514,755 bp
  • T to C, chromosome 2 at 166,065,786 bp
  • T to A, chromosome 3 at 40,785,400 bp
  • T to G, chromosome 3 at 56,035,958 bp
  • T to A, chromosome 3 at 64,140,484 bp
  • A to T, chromosome 3 at 129,284,180 bp
  • G to A, chromosome 4 at 32,821,284 bp
  • G to A, chromosome 4 at 41,498,241 bp
  • A to T, chromosome 4 at 43,985,077 bp
  • C to T, chromosome 4 at 58,344,222 bp
  • G to A, chromosome 4 at 109,370,678 bp
  • T to C, chromosome 4 at 121,395,001 bp
  • A to T, chromosome 4 at 123,322,459 bp
  • T to A, chromosome 4 at 134,934,972 bp
  • A to T, chromosome 4 at 144,190,732 bp
  • A to T, chromosome 5 at 28,339,276 bp
  • G to T, chromosome 5 at 29,757,681 bp
  • A to T, chromosome 5 at 52,819,217 bp
  • C to T, chromosome 5 at 97,086,764 bp
  • A to T, chromosome 5 at 145,370,955 bp
  • C to A, chromosome 6 at 11,987,620 bp
  • A to G, chromosome 6 at 43,236,384 bp
  • C to G, chromosome 6 at 124,822,630 bp
  • A to T, chromosome 6 at 131,685,005 bp
  • A to T, chromosome 7 at 23,361,893 bp
  • CTT to CT, chromosome 7 at 44,591,296 bp
  • T to C, chromosome 7 at 86,306,601 bp
  • T to C, chromosome 7 at 99,238,517 bp
  • A to G, chromosome 7 at 103,732,207 bp
  • C to T, chromosome 7 at 130,509,018 bp
  • A to T, chromosome 9 at 36,432,860 bp
  • T to C, chromosome 9 at 57,956,380 bp
  • C to T, chromosome 9 at 119,758,659 bp
  • G to T, chromosome 10 at 123,131,398 bp
  • G to A, chromosome 11 at 69,539,496 bp
  • G to A, chromosome 11 at 101,332,099 bp
  • A to G, chromosome 12 at 45,437,600 bp
  • G to A, chromosome 12 at 91,299,036 bp
  • C to A, chromosome 12 at 110,658,126 bp
  • T to C, chromosome 12 at 116,256,025 bp
  • G to A, chromosome 12 at 118,911,434 bp
  • G to A, chromosome 13 at 12,407,516 bp
  • T to C, chromosome 15 at 53,344,492 bp
  • T to A, chromosome 15 at 85,816,401 bp
  • T to C, chromosome 16 at 36,033,326 bp
  • A to G, chromosome 17 at 7,271,604 bp
  • G to A, chromosome 17 at 7,299,286 bp
  • C to A, chromosome 17 at 36,041,959 bp
  • C to A, chromosome 17 at 67,869,013 bp
  • C to T, chromosome 17 at 71,902,692 bp
  • T to A, chromosome 17 at 74,612,031 bp
  • T to A, chromosome 18 at 39,243,641 bp
  • C to T, chromosome 19 at 38,284,157 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4954 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042551-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.