Strain Name:
C57BL/6J-MtgxR4955Btlr/Mmmh
Stock Number:
042552-MU
Citation ID:
RRID:MMRRC_042552-MU
Other Names:
R4955 (G1), C57BL/6J-MtgxR4955Btlr
Major Collection:

Gene Information

Utrn
Name: utrophin
Synonyms: Dmdl, G-utrophin, DRP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Ing4
Name: inhibitor of growth family, member 4
Synonyms: D6Xrf92, p29ING4, D6Wsu147e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 28019
Homologene: 22952
Rcan2
Name: regulator of calcineurin 2
Synonyms: MCIP2, Dscr1l1, Csp2, ZAKI-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 53901
VEGA: 17
HGNC: HGNC:3041
Homologene: 130985
Prkd3
Name: protein kinase D3
Synonyms: 5730497N19Rik, Prkcn, 4930557O20Rik, PKD3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75292
HGNC: HGNC:9408
Homologene: 2055
Rab3gap2
Name: RAB3 GTPase activating protein subunit 2
Synonyms: 1110059F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98732
Homologene: 40842
Zfp341
Name: zinc finger protein 341
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228807
Homologene: 13127
Mgrn1
Name: mahogunin, ring finger 1
Synonyms: 2610042J20Rik, nc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17237
VEGA: 16
Homologene: 41020
Naca
Name: nascent polypeptide-associated complex alpha polypeptide
Synonyms: LOC380777, skNAC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17938
VEGA: 10
HGNC: HGNC:7629
Homologene: 136025
Dusp27
Name: dual specificity phosphatase 27 (putative)
Synonyms: C130085G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240892
Homologene: 18949
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213262
Homologene: 10584
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: Shn-2, Schnurri-2, MIBP1, Gm20114
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Fbn2
Name: fibrillin 2
Synonyms: sy, Sne, Fib-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Cfap44
Name: cilia and flagella associated protein 44
Synonyms: D16Ertd642e, 6330444M21Rik, Wdr52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 212517
Homologene: 75085
3110009E18Rik
Name: RIKEN cDNA 3110009E18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 73103
Homologene: 41754
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Kif21a
Name: kinesin family member 21A
Synonyms: N-5 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16564
VEGA: 15
Homologene: 56761
Abca8a
Name: ATP-binding cassette, sub-family A (ABC1), member 8a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217258
HGNC: HGNC:38
Homologene: 131160
Opn5
Name: opsin 5
Synonyms: Neuropsin, PGR12, Gpr136, TMEM13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 353344
VEGA: 17
Homologene: 72341
Mettl2
Name: methyltransferase like 2
Synonyms: PSENIP1, 2810438F06Rik, D11Ertd768e, C130031G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52686
Homologene: 10174
Gm9839
Name: predicted gene 9839
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 408192
Homologene: 130042
Palmd
Name: palmdelphin
Synonyms: PALML, 4631423C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 114301
Homologene: 9804
Tecpr1
Name: tectonin beta-propeller repeat containing 1
Synonyms: 2210010N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70381
Homologene: 9120
Slc5a1
Name: solute carrier family 5 (sodium/glucose cotransporter), member 1
Synonyms: sodium glucose cotransporter 1, Sglt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20537
Homologene: 55456
Cdh20
Name: cadherin 20
Synonyms: Cdh7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 23836
HGNC: HGNC:1760
Homologene: 8015
Prex1
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Synonyms: P-REX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 277360
Homologene: 10821
Ttll6
Name: tubulin tyrosine ligase-like family, member 6
Synonyms: t8130b59, D11Moh43e, 4932418K24Rik, D11Moh44e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237930
Homologene: 18229
4933407L21Rik
Name: RIKEN cDNA 4933407L21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71141
Olfr1287
Name: olfactory receptor 1287
Synonyms: GA_x6K02T2Q125-72500603-72501520, MOR248-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257935
Plekhd1
Name: pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
Synonyms: 3830431G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217682
Homologene: 15090
Ninj2
Name: ninjurin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 29862
HGNC: HGNC:7825
Homologene: 9555
Lrfn5
Name: leucine rich repeat and fibronectin type III domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238205
Homologene: 17582
Kcnc3
Name: potassium voltage gated channel, Shaw-related subfamily, member 3
Synonyms: KShIIID, Kv3.3, Kcr2-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16504
HGNC: HGNC:6235
Homologene: 3650
Atp8b2
Name: ATPase, class I, type 8B, member 2
Synonyms: Id
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 54667
Homologene: 23226
Arsj
Name: arylsulfatase J
Synonyms: 9330196J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 271970
Homologene: 35257
H4c9
Name: H4 clustered histone 9
Synonyms: Hist1h4i
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 319158
Homologene: 134468
Stac2
Name: SH3 and cysteine rich domain 2
Synonyms: 24b2/STAC2, 24b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217154
Homologene: 17131
Slc35b3
Name: solute carrier family 35, member B3
Synonyms: 4921526O06Rik, PAPST2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 108652
VEGA: 13
Homologene: 9313
Olfr761
Name: olfactory receptor 761
Synonyms: Olfr1552-ps1, MOR218-12, MOR218-6P, MOR218-5P, GA_x6K02T2PSCP-2403971-2403000, MOR218-6P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258094
Homologene: 134080
Olfr243
Name: olfactory receptor 243
Synonyms: MOR22-4, Olfr627, GA_x6K02T2PBJ9-6440320-6440766, GA_x6K02T2L9TJ-1933-2295
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 436002
Homologene: 8420
Olfr224
Name: olfactory receptor 224
Synonyms: MOR275-3, Olfr327-ps1, GA_x6K02T2NKPP-858022-858862, GA_x6K02T00261-652-347, MOR275-10_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258198
Homologene: 133015
Nqo1
Name: NAD(P)H dehydrogenase, quinone 1
Synonyms: Dia4, NQO1, Nmor1, QR1, NAD(P)H dehydrogenase (quinone), NMO1, Ox1, Ox-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18104
HGNC: HGNC:2874
Homologene: 695
Arl2bp
Name: ADP-ribosylation factor-like 2 binding protein
Synonyms: BART, 1700010P10Rik, 1700027H16Rik, Bart1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 107566
Homologene: 11479
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 32,520,077 bp
  • T to A, chromosome 1 at 85,931,287 bp
  • T to C, chromosome 1 at 104,984,803 bp
  • G to C, chromosome 1 at 120,169,110 bp
  • G to T, chromosome 1 at 120,169,119 bp
  • C to T, chromosome 1 at 120,169,120 bp
  • T to C, chromosome 1 at 166,108,092 bp
  • C to T, chromosome 1 at 185,267,155 bp
  • A to T, chromosome 2 at 111,449,605 bp
  • T to C, chromosome 2 at 154,638,030 bp
  • A to G, chromosome 2 at 166,573,223 bp
  • T to A, chromosome 3 at 76,223,876 bp
  • G to T, chromosome 3 at 89,952,920 bp
  • A to G, chromosome 3 at 116,924,224 bp
  • T to C, chromosome 3 at 126,438,540 bp
  • T to C, chromosome 5 at 33,160,902 bp
  • T to C, chromosome 5 at 144,217,257 bp
  • A to G, chromosome 6 at 120,197,946 bp
  • C to T, chromosome 6 at 125,048,201 bp
  • CTT to CT, chromosome 7 at 44,591,296 bp
  • A to T, chromosome 7 at 103,716,705 bp
  • G to A, chromosome 8 at 94,670,428 bp
  • A to G, chromosome 8 at 107,388,857 bp
  • C to T, chromosome 10 at 12,861,567 bp
  • T to A, chromosome 10 at 14,130,958 bp
  • T to A, chromosome 10 at 128,042,215 bp
  • A to G, chromosome 11 at 58,566,518 bp
  • T to C, chromosome 11 at 59,069,172 bp
  • A to G, chromosome 11 at 96,138,789 bp
  • A to C, chromosome 11 at 98,043,548 bp
  • C to T, chromosome 11 at 105,137,779 bp
  • T to G, chromosome 11 at 110,036,512 bp
  • A to C, chromosome 12 at 61,839,978 bp
  • T to A, chromosome 12 at 80,722,021 bp
  • T to A, chromosome 13 at 22,041,185 bp
  • A to G, chromosome 13 at 38,932,890 bp
  • A to T, chromosome 15 at 48,673,518 bp
  • A to T, chromosome 15 at 90,937,190 bp
  • T to C, chromosome 16 at 4,934,219 bp
  • T to G, chromosome 16 at 37,061,082 bp
  • T to A, chromosome 16 at 44,475,277 bp
  • T to C, chromosome 17 at 37,952,898 bp
  • A to T, chromosome 17 at 42,611,238 bp
  • C to A, chromosome 17 at 44,037,081 bp
  • T to C, chromosome 17 at 78,952,727 bp
  • T to C, chromosome 18 at 58,058,383 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4955 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042552-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.