Strain Name:
C57BL/6J-MtgxR4961Btlr/Mmmh
Stock Number:
042558-MU
Citation ID:
RRID:MMRRC_042558-MU
Other Names:
R4961 (G1), C57BL/6J-MtgxR4961Btlr
Major Collection:

Gene Information

Dst
Name: dystonin
Synonyms: BPAG1, ah, athetoid, bullous pemphigoid antigen 1, Bpag, A830042E19Rik, nmf203, Bpag1, 2310001O04Rik, Macf2, bullous pemphigoid antigen 1, BPAG1-n, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Jam2
Name: junction adhesion molecule 2
Synonyms: 2410030G21Rik, VE-JAM, JAM-2, 2410167M24Rik, Jcam2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67374
Homologene: 10929
Map1b
Name: microtubule-associated protein 1B
Synonyms: Mtap-5, LC1, Mtap5, MAP5, Mtap1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17755
VEGA: 13
HGNC: HGNC:6836
Homologene: 38111
Cd9
Name: CD9 antigen
Synonyms: Tspan29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12527
HGNC: HGNC:1709
Homologene: 20420
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: Depdc2, 6230420N16Rik, C030045D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109294
Homologene: 23523
Ltn1
Name: listerin E3 ubiquitin protein ligase 1
Synonyms: Listerin, Rnf160, 4930528H02Rik, Zfp294
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 78913
VEGA: 16
Homologene: 32272
3110082I17Rik
Name: RIKEN cDNA 3110082I17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 73212
Homologene: 49901
Ipo9
Name: importin 9
Synonyms: 0710008K06Rik, Imp9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226432
Homologene: 5874
Otof
Name: otoferlin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 83762
HGNC: HGNC:8515
Homologene: 12892
Kansl3
Name: KAT8 regulatory NSL complex subunit 3
Synonyms: 4632411B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226976
Homologene: 9949
Acp5
Name: acid phosphatase 5, tartrate resistant
Synonyms: TRAP, TRACP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11433
VEGA: 9
HGNC: HGNC:124
Homologene: 137203
Cdh9
Name: cadherin 9
Synonyms: T1-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12565
HGNC: HGNC:1768
Homologene: 9450
Grhl3
Name: grainyhead like transcription factor 3
Synonyms: Som, Get1, ct
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230824
Homologene: 18864
Zfp644
Name: zinc finger protein 644
Synonyms: BM-005, D5Ertd689e, Zep-2, 1110068L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52397
Homologene: 12971
Tstd2
Name: thiosulfate sulfurtransferase (rhodanese)-like domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 272027
Homologene: 16403
Pgk2
Name: phosphoglycerate kinase 2
Synonyms: Pgk-2, Tcp-2, Tcp-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18663
VEGA: 17
HGNC: HGNC:8898
Homologene: 57138
Amy1
Name: amylase 1, salivary
Synonyms: Amy-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11722
Homologene: 20179
Marveld2
Name: MARVEL (membrane-associating) domain containing 2
Synonyms: Mrvldc2, Tricellulin, Tric-c, Tric-b, Tric-a, Tric
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218518
VEGA: 13
Homologene: 27037
Epha5
Name: Eph receptor A5
Synonyms: bsk, Rek7, Cek7, Els1, Hek7, Ehk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13839
HGNC: HGNC:3389
Homologene: 55824
Ttn
Name: titin
Synonyms: 2310057K23Rik, connectin, D830007G01Rik, D330041I19Rik, L56, shru, 1100001C23Rik, 2310036G12Rik, mdm, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: Piezo2, Fam38b, Fam38b2, 9030411M15Rik, 9430028L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 667742
Homologene: 49695
Olfr1301
Name: olfactory receptor 1301
Synonyms: MOR248-5, GA_x6K02T2Q125-72805651-72806589
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258889
Homologene: 74057
Dock3
Name: dedicator of cyto-kinesis 3
Synonyms: PBP, Moca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208869
HGNC: HGNC:2989
Homologene: 21030
Olfr954
Name: olfactory receptor 954
Synonyms: MOR171-53, GA_x6K02T2PVTD-33158015-33158950, MOR171-42
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258328
VEGA: 9
Homologene: 71961
Adamts7
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7
Synonyms: ADAM-TS7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 108153
HGNC: HGNC:223
Homologene: 22803
Snx25
Name: sorting nexin 25
Synonyms: SBBI31, LOC382008
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102141
Homologene: 23744
Letm2
Name: leucine zipper-EF-hand containing transmembrane protein 2
Synonyms: D030041N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270035
Homologene: 56358
Klhl5
Name: kelch-like 5
Synonyms: 1300013C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71778
HGNC: HGNC:6356
Homologene: 56736
Tns1
Name: tensin 1
Synonyms: 1200014E20Rik, E030018G17Rik, Tns, E030037J05Rik, 1110018I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21961
Homologene: 11219
Rgs1
Name: regulator of G-protein signaling 1
Synonyms: BL34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 50778
HGNC: HGNC:9991
Homologene: 2191
Ofcc1
Name: orofacial cleft 1 candidate 1
Synonyms: ojoplano, Opo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218165
VEGA: 13
Homologene: 125376
Oas1h
Name: 2'-5' oligoadenylate synthetase 1H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 246729
HGNC: HGNC:8086
Homologene: 77345
Col16a1
Name: collagen, type XVI, alpha 1
Synonyms: A530052M23Rik, [a]1 (XVI) collagen, 2700007F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 107581
HGNC: HGNC:2193
Homologene: 1397
Kctd1
Name: potassium channel tetramerisation domain containing 1
Synonyms: 4933402K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 106931
VEGA: 18
Homologene: 65999
Arhgef26
Name: Rho guanine nucleotide exchange factor (GEF) 26
Synonyms: 8430436L14Rik, 4631416L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 622434
Homologene: 9204
Gm5581
Name: predicted gene 5581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Vmn1r185
Name: vomeronasal 1 receptor 185
Synonyms: V1re12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 171265
Homologene: 74353
Rasgrf1
Name: RAS protein-specific guanine nucleotide-releasing factor 1
Synonyms: CDC25, Grfbeta, Grf1, CDC25Mm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19417
HGNC: HGNC:9875
Homologene: 74972
Ano8
Name: anoctamin 8
Synonyms: Tmem16h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382014
Homologene: 124473
Cpne7
Name: copine VII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102278
HGNC: HGNC:2320
Homologene: 65128
Matn1
Name: matrilin 1, cartilage matrix protein
Synonyms: Crtm, Mat1, matrilin-1, CMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17180
HGNC: HGNC:6907
Homologene: 1783
Spon2
Name: spondin 2, extracellular matrix protein
Synonyms: Mindin, M-spondin, 2310045I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100689
Homologene: 40843
Zfp316
Name: zinc finger protein 316
Synonyms: Emzf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 54201
Homologene: 69231
Ankrd44
Name: ankyrin repeat domain 44
Synonyms: E130014H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329154
Homologene: 27547
Klhl30
Name: kelch-like 30
Synonyms: 4631423F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70788
Homologene: 18891
Thrb
Name: thyroid hormone receptor beta
Synonyms: T3R[b], Thrb1, TR beta, c-erbAbeta, Thrb2, T3Rbeta, Nr1a2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21834
Homologene: 36025
Adad2
Name: adenosine deaminase domain containing 2
Synonyms: 4930403J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75773
Homologene: 16392
Anks6
Name: ankyrin repeat and sterile alpha motif domain containing 6
Synonyms: LOC269533, b2b1801.1Clo, SamCystin, 2210417J20Rik, Samd6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 75691
Homologene: 19545
Dcun1d4
Name: DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100737
Homologene: 22867
Jph2
Name: junctophilin 2
Synonyms: JP-2, 1110002E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 59091
Homologene: 10714
Herpud1
Name: homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
Synonyms: Mifl, Herp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 64209
Homologene: 40973
Olfr164
Name: olfactory receptor 164
Synonyms: MOR279-2, GA_x54KRFPKG5P-15738260-15737319
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258443
HGNC: HGNC:8269
Homologene: 51725
Zfp51
Name: zinc finger protein 51
Synonyms: zfec12, Zfp-51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22709
VEGA: 17
Homologene: 134003
Spopfm2
Name: speckle-type BTB/POZ protein family member 2
Synonyms: Gm10696
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100043188
Homologene: 128308
Spata31d1a
Name: spermatogenesis associated 31 subfamily D, member 1A
Synonyms: Fam75d1a, Fam75d3, 1700013B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72219
VEGA: 13
Homologene: 122131
Gm20528
Name: predicted gene 20528
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Trbv19
Name: T cell receptor beta, variable 19
Synonyms: Tcrb-V6, Gm16780
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100124684
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 11,098,481 bp
  • A to G, chromosome 1 at 33,968,823 bp
  • T to A, chromosome 1 at 36,348,683 bp
  • C to T, chromosome 1 at 54,663,912 bp
  • A to G, chromosome 1 at 73,935,915 bp
  • CAGAGAGAGAGAGA to CAGAGAGAGAGA, chromosome 1 at 88,211,984 bp
  • T to A, chromosome 1 at 91,357,384 bp
  • A to G, chromosome 1 at 135,400,073 bp
  • A to T, chromosome 1 at 144,248,571 bp
  • T to A, chromosome 2 at 76,885,402 bp
  • A to T, chromosome 2 at 111,754,405 bp
  • C to G, chromosome 2 at 163,375,748 bp
  • A to G, chromosome 3 at 62,459,625 bp
  • A to T, chromosome 3 at 94,175,534 bp
  • A to G, chromosome 3 at 113,561,849 bp
  • T to C, chromosome 4 at 46,120,467 bp
  • C to T, chromosome 4 at 47,030,795 bp
  • G to A, chromosome 4 at 130,054,479 bp
  • A to G, chromosome 4 at 130,952,923 bp
  • A to G, chromosome 4 at 135,552,607 bp
  • C to A, chromosome 5 at 30,383,493 bp
  • A to T, chromosome 5 at 33,214,552 bp
  • T to C, chromosome 5 at 65,152,690 bp
  • A to T, chromosome 5 at 73,544,120 bp
  • A to T, chromosome 5 at 84,233,643 bp
  • T to C, chromosome 5 at 106,618,215 bp
  • T to C, chromosome 5 at 120,871,096 bp
  • T to C, chromosome 5 at 139,364,100 bp
  • T to C, chromosome 5 at 143,253,414 bp
  • A to T, chromosome 6 at 41,178,772 bp
  • A to T, chromosome 6 at 125,463,740 bp
  • A to T, chromosome 6 at 131,167,227 bp
  • G to A, chromosome 7 at 26,611,291 bp
  • T to C, chromosome 8 at 25,594,092 bp
  • T to C, chromosome 8 at 46,068,192 bp
  • G to C, chromosome 8 at 71,482,996 bp
  • T to C, chromosome 8 at 94,390,826 bp
  • G to A, chromosome 8 at 119,615,658 bp
  • G to A, chromosome 8 at 123,133,759 bp
  • C to A, chromosome 9 at 22,129,937 bp
  • A to G, chromosome 9 at 39,461,887 bp
  • C to T, chromosome 9 at 89,944,869 bp
  • G to T, chromosome 9 at 90,185,740 bp
  • A to G, chromosome 9 at 106,941,316 bp
  • G to T, chromosome 10 at 74,379,417 bp
  • A to G, chromosome 13 at 40,263,559 bp
  • T to A, chromosome 13 at 59,701,902 bp
  • T to C, chromosome 13 at 99,435,653 bp
  • T to C, chromosome 13 at 100,611,923 bp
  • G to A, chromosome 14 at 18,011,076 bp
  • A to G, chromosome 15 at 16,850,828 bp
  • C to A, chromosome 16 at 19,285,976 bp
  • C to T, chromosome 16 at 84,809,547 bp
  • A to T, chromosome 16 at 87,397,791 bp
  • A to G, chromosome 17 at 21,456,353 bp
  • G to A, chromosome 17 at 40,207,521 bp
  • G to A, chromosome 18 at 15,062,523 bp
  • T to C, chromosome 18 at 63,052,961 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4961 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042558-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.