Strain Name:
C57BL/6J-MtgxR4984Btlr/Mmmh
Stock Number:
042578-MU
Citation ID:
RRID:MMRRC_042578-MU
Other Names:
R4984 (G1), C57BL/6J-MtgxR4984Btlr
Major Collection:

Strain Information

Ubp1
Name: upstream binding protein 1
Synonyms: NF2d9, LBP-1b, LBP-1a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22221
VEGA: 9
Homologene: 8435
Adra2a
Name: adrenergic receptor, alpha 2a
Synonyms: alpha2A-AR, alpha2A, alpha2A-adrenergic receptor, alpha(2A)AR, Adra-2, Adra-2a
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11551
VEGA: 19
HGNC: HGNC:281
Homologene: 47944
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: Alfy, Bchs, Ggtb3, Bwf1, D5Ertd66e, 2610509D04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72145
Homologene: 22855
Ttc39b
Name: tetratricopeptide repeat domain 39B
Synonyms: 1810054D07Rik, 9130422G05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69863
Homologene: 25228
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: Loa, dynein heavy chain, retrograde transport, Dnchc1, Swl, MAP1C, 9930018I23Rik, Dnec1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Nubp1
Name: nucleotide binding protein 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 26425
HGNC: HGNC:8041
Homologene: 1857
Pou4f1
Name: POU domain, class 4, transcription factor 1
Synonyms: Brn-3.0, Brn3, Brn3a, E130119J07Rik, Brn-3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18996
HGNC: HGNC:9218
Homologene: 21255
Cdc42bpg
Name: CDC42 binding protein kinase gamma
Synonyms: MRCKgamma
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240505
Homologene: 28384
Cftr
Name: cystic fibrosis transmembrane conductance regulator
Synonyms: Abcc7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12638
HGNC: HGNC:1884
Homologene: 55465
Gpr89
Name: G protein-coupled receptor 89
Synonyms: 4933412D19Rik, SH120
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67549
Homologene: 9475
Muc15
Name: mucin 15
Synonyms: D730046L02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269328
Homologene: 51680
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: 2900010L19Rik, mSorLA, LR11, Sorla
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20660
Homologene: 2336
Zfp644
Name: zinc finger protein 644
Synonyms: 1110068L01Rik, BM-005, Zep-2, D5Ertd689e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52397
Homologene: 12971
Taf4b
Name: TATA-box binding protein associated factor 4b
Synonyms: 105kDa, 4932409F03Rik, Taf2c2, TAFII105, 2610524B04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72504
VEGA: 18
Homologene: 28266
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: Dpde3, 9630011N22Rik, dunce
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238871
HGNC: HGNC:8783
Or52h9
Name: olfactory receptor family 52 subfamily H member 9
Synonyms: Olfr651, GA_x6K02T2PBJ9-7179540-7180481, MOR31-11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258809
Homologene: 64922
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Cd109
Name: CD109 antigen
Synonyms: Gov platelet alloantigens, 9930012E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235505
Homologene: 25183
Vmn2r93
Name: vomeronasal 2, receptor 93
Synonyms: EG627132
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627132
Homologene: 129750
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17836
HGNC: HGNC:9750
Homologene: 136663
Cpb1
Name: carboxypeptidase B1
Synonyms: 0910001A18Rik, 1810063F02Rik, 2210008M23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76703
HGNC: HGNC:2299
Homologene: 68127
Phldb2
Name: pleckstrin homology like domain, family B, member 2
Synonyms: LL5b, C820004H04Rik, LL5beta
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208177
Homologene: 17100
Crocc
Name: ciliary rootlet coiled-coil, rootletin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230872
Homologene: 16811
Kcnh8
Name: potassium voltage-gated channel, subfamily H (eag-related), member 8
Synonyms: C130090D05Rik, ELK1, Kv12.1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 211468
Homologene: 14332
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101100
Homologene: 134361
Or4p19
Name: olfactory receptor family 4 subfamily P member 19
Synonyms: MOR225-1, Olfr1180, GA_x6K02T2Q125-49900552-49899623
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258920
Homologene: 74240
Or8g2
Name: olfactory receptor family 8 subfamily G member 2
Synonyms: MOR171-14, GA_x6K02T02EEW-227-373, GA_x6K02T2PVTD-33608180-33608971, Olfr229, Olfr973
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258606
VEGA: 9
Homologene: 115513
Or4k40
Name: olfactory receptor family 4 subfamily K member 40
Synonyms: GA_x6K02T2Q125-72472405-72471488, MOR248-21, Olfr1286
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277562
Homologene: 73992
Mipep
Name: mitochondrial intermediate peptidase
Synonyms: 5730405E07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70478
VEGA: 14
HGNC: HGNC:7104
Homologene: 4337
Ppl
Name: periplakin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
Pdcd5
Name: programmed cell death 5
Synonyms: Tfar19, 2200003D22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56330
HGNC: HGNC:8764
Homologene: 10506
Or4a47
Name: olfactory receptor family 4 subfamily A member 47
Synonyms: Olfr1256, MOR231-1, GA_x6K02T2Q125-51276848-51275928
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258985
Homologene: 128157
Kbtbd7
Name: kelch repeat and BTB (POZ) domain containing 7
Synonyms: LOC211255, 1110008P08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211255
VEGA: 14
Homologene: 41849
Tox3
Name: TOX high mobility group box family member 3
Synonyms: Tnrc9, 500-9, CAGF9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244579
Homologene: 18257
E230001N04Rik
Name: RIKEN cDNA E230001N04 gene
Synonyms: Lnc956
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 320187
Vmn2r-ps36
Name: vomeronasal 2, receptor, pseudogene 36
Synonyms: EG665442
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 665442
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 2 at 88,412,577 bp
  • A to T, chromosome 2 at 89,835,813 bp
  • C to T, chromosome 2 at 110,731,573 bp
  • A to T, chromosome 2 at 111,420,847 bp
  • GTTT to GTT, chromosome 3 at 20,270,352 bp
  • T to A, chromosome 3 at 96,905,196 bp
  • A to T, chromosome 4 at 83,242,209 bp
  • G to C, chromosome 4 at 101,835,599 bp
  • T to C, chromosome 4 at 141,034,452 bp
  • C to T, chromosome 5 at 101,943,119 bp
  • A to T, chromosome 5 at 106,636,917 bp
  • A to G, chromosome 6 at 18,235,199 bp
  • A to G, chromosome 6 at 113,412,940 bp
  • T to C, chromosome 6 at 121,838,617 bp
  • A to T, chromosome 7 at 7,417,750 bp
  • A to C, chromosome 7 at 35,642,685 bp
  • T to G, chromosome 7 at 104,553,021 bp
  • C to T, chromosome 7 at 119,928,779 bp
  • TCTGCTGCTGCTGCTGCTG to TCTGCTGCTGCTGCTG, chromosome 8 at 90,248,642 bp
  • A to G, chromosome 9 at 39,910,610 bp
  • C to A, chromosome 9 at 41,991,342 bp
  • T to C, chromosome 9 at 78,634,677 bp
  • T to A, chromosome 9 at 113,959,392 bp
  • C to A, chromosome 12 at 110,658,126 bp
  • T to C, chromosome 13 at 109,740,464 bp
  • A to G, chromosome 14 at 60,788,182 bp
  • T to C, chromosome 14 at 79,427,162 bp
  • T to C, chromosome 14 at 104,466,183 bp
  • T to C, chromosome 16 at 5,087,641 bp
  • T to A, chromosome 16 at 10,421,244 bp
  • T to C, chromosome 16 at 45,825,633 bp
  • T to A, chromosome 17 at 18,313,127 bp
  • T to C, chromosome 17 at 28,523,806 bp
  • T to A, chromosome 17 at 52,877,967 bp
  • T to C, chromosome 18 at 14,835,816 bp
  • T to A, chromosome 19 at 6,316,223 bp
  • T to C, chromosome 19 at 54,046,639 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4984 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042578-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.