Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR4991Btlr/Mmmh
Stock Number:
042585-MU
Citation ID:
RRID:MMRRC_042585-MU
Other Names:
R4991 (G1), C57BL/6J-MtgxR4991Btlr
Major Collection:

Strain Information

Ebf2
Name: early B cell factor 2
Synonyms: O/E-3, D14Ggc1e, Mmot1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13592
Homologene: 56471
Mtmr7
Name: myotubularin related protein 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54384
HGNC: HGNC:7454
Homologene: 99732
Utp20
Name: UTP20 small subunit processome component
Synonyms: mDRIM, DRIM, 3830408P06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Chmp4b
Name: charged multivesicular body protein 4B
Synonyms: 2010012F05Rik, Snf7-2, chromatin modifying protein 4B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75608
Homologene: 57102
Hdac5
Name: histone deacetylase 5
Synonyms: mHDA1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15184
Homologene: 3995
Nkx2-1
Name: NK2 homeobox 1
Synonyms: thyroid-specific enhancer-binding protein, T/EBP, tinman, Ttf-1, thyroid transcription factor-1, Titf1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21869
Homologene: 2488
Tpx2
Name: TPX2, microtubule-associated
Synonyms: REPP86, DIL2, p100, 2610005B21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72119
HGNC: HGNC:1249
Homologene: 8107
Cstf1
Name: cleavage stimulation factor, 3' pre-RNA, subunit 1
Synonyms: 1700057K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67337
HGNC: HGNC:2483
Homologene: 1012
Ube4b
Name: ubiquitination factor E4B
Synonyms: UFD2, 4933406G05Rik, 4930551I19Rik, UFD2a, Ufd2p, D4Bwg0973e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 63958
Homologene: 107623
Als2
Name: alsin Rho guanine nucleotide exchange factor
Synonyms: 3222402C23Rik, Als2cr6, 9430073A21Rik, Alsin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74018
HGNC: HGNC:443
Homologene: 23264
Snap91
Name: synaptosomal-associated protein 91
Synonyms: F1-20, 91kDa, AP180
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20616
Homologene: 8429
Nmnat1
Name: nicotinamide nucleotide adenylyltransferase 1
Synonyms: 5730441G13Rik, D4Cole1e, 2610529L11Rik, nicotinamide mononucleotide adenylyl transferase, nmnat
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66454
Homologene: 39074
Adcy4
Name: adenylate cyclase 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 104110
VEGA: 14
HGNC: HGNC:235
Homologene: 23149
Zfp740
Name: zinc finger protein 740
Synonyms: 1110034O07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68744
Homologene: 129530
Irx4
Name: Iroquois homeobox 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 50916
HGNC: HGNC:6129
Homologene: 9485
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235627
Homologene: 86422
Adgrf3
Name: adhesion G protein-coupled receptor F3
Synonyms: LOC381628, PGR23, Gpr113
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381628
Homologene: 17826
Tmem201
Name: transmembrane protein 201
Synonyms: D4Ertd429e, Samp1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230917
Homologene: 35319
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225115
Homologene: 25090
Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Synonyms: ANKTM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 277328
HGNC: HGNC:497
Homologene: 7189
Zfp268
Name: zinc finger protein 268
Synonyms: Gm13212
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433801
Homologene: 133076
Washc5
Name: WASH complex subunit 5
Synonyms: strumpellin, E430025E21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223593
VEGA: 15
Homologene: 8898
Sv2b
Name: synaptic vesicle glycoprotein 2b
Synonyms: A830038F04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 64176
Homologene: 32236
Samd4
Name: sterile alpha motif domain containing 4
Synonyms: 4933436G17Rik, 1700111L17Rik, 1700024G08Rik, Smaug, sunk
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74480
Homologene: 19167
Dmpk
Name: dystrophia myotonica-protein kinase
Synonyms: DM, Dm15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13400
HGNC: HGNC:2933
Homologene: 3247
Kif1a
Name: kinesin family member 1A
Synonyms: Kns1, ATSV, N-3 kinesin, LOC381283, C630002N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: LOC380658, 4930503E15Rik, Gm1557
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74978
Homologene: 46007
Cstf2t
Name: cleavage stimulation factor, 3' pre-RNA subunit 2, tau
Synonyms: tCstF-64, 64kDa
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83410
VEGA: 19
Homologene: 80230
Vmn2r72
Name: vomeronasal 2, receptor 72
Synonyms: EG244114, Vmn2r72-ps
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244114
Homologene: 115466
Gm16432
Name: predicted gene 16432
Type: Gene
Species: Mouse
Chromosome: 1
Nrxn3
Name: neurexin III
Synonyms: neurexin III beta, neurexin III alpha, neurexin III beta, neurexin III alpha, 9330112C09Rik, D12Bwg0831e, 4933401A11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18191
HGNC: HGNC:8010
Homologene: 83225
Zfp212
Name: Zinc finger protein 212
Synonyms: Znf212
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232784
Homologene: 8170
Osgin1
Name: oxidative stress induced growth inhibitor 1
Synonyms: 1700012B18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71839
Homologene: 16325
Gm19684
Name: predicted gene, 19684
Type: Gene
Species: Mouse
Chromosome: 17
Amer3
Name: APC membrane recruitment 3
Synonyms: Fam123c, 9430069J07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211383
Homologene: 51888
Vmn1r215
Name: vomeronasal 1 receptor 215
Synonyms: V1ri2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171253
Homologene: 110880
Or5af2
Name: olfactory receptor family 5 subfamily AC member 20
Synonyms: GA_x6K02T2NKPP-590035-589109, MOR222-2, Olfr313
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258529
Homologene: 77375
Or5b97
Name: olfactory receptor family 5 subfamily B member 97
Synonyms: GA_x6K02T2RE5P-3231251-3230331, MOR202-3, Olfr1447
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258698
HGNC: HGNC:8324
Homologene: 74233
Or5m8
Name: olfactory receptor family 5 subfamily M member 8
Synonyms: GA_x6K02T2Q125-47470765-47471775, MOR200-1, Olfr1031
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257916
Homologene: 73973
Elmo1
Name: engulfment and cell motility 1
Synonyms: CED-12, C230095H21Rik, 6330578D22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 140580
Homologene: 56685
St3gal4
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Synonyms: ST3Gal IV, Siat4c
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20443
VEGA: 9
Homologene: 4572
Dip2a
Name: disco interacting protein 2 homolog A
Synonyms: Kiaa0184-hp, 4931420H10Rik, Dip2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64451
Homologene: 41012
Klk1b26
Name: kallikrein 1-related petidase b26
Synonyms: PRECE-2, EGF-BP type B, mGK-26, Klk26, Egfbp2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16618
Homologene: 68141
Fbp1
Name: fructose bisphosphatase 1
Synonyms: FBPase brain isoform, FBPase liver, Fbp-2, Fbp3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14121
HGNC: HGNC:3606
Homologene: 55467
Lca5l
Name: Leber congenital amaurosis 5-like
Synonyms: 4921526F01Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 385668
HGNC: HGNC:1255
Homologene: 47978
Kcnh3
Name: potassium voltage-gated channel, subfamily H (eag-related), member 3
Synonyms: ether a go-go like, Elk2, Melk2, C030044P22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16512
VEGA: 15
HGNC: HGNC:6252
Homologene: 32150
Mios
Name: meiosis regulator for oocyte development
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 252875
Homologene: 10371
Zbtb24
Name: zinc finger and BTB domain containing 24
Synonyms: ZNF450
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268294
VEGA: 10
Homologene: 8870
Itgb1bp1
Name: integrin beta 1 binding protein 1
Synonyms: bodenin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16413
Homologene: 3496
Pcsk4
Name: proprotein convertase subtilisin/kexin type 4
Synonyms: PC4, SPC5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18551
HGNC: HGNC:8746
Homologene: 22495
Slc17a2
Name: solute carrier family 17 (sodium phosphate), member 2
Synonyms: NPT3, C730032N17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218103
Homologene: 4260
Cpm
Name: carboxypeptidase M
Synonyms: 5730456K23Rik, 1110060I01Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70574
HGNC: HGNC:2311
Homologene: 35367
Ifitm3
Name: interferon induced transmembrane protein 3
Synonyms: mil-1, 1110004C05Rik, Fgls, IP15, fragilis
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66141
HGNC: HGNC:5414
Homologene: 136199
Asb14
Name: ankyrin repeat and SOCS box-containing 14
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 142687
Homologene: 15445
Nat8f4
Name: N-acetyltransferase 8 (GCN5-related) family member 4
Synonyms: 1700019G17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75541
Homologene: 136346
Pcdha9
Name: protocadherin alpha 9
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 192161
HGNC: HGNC:8664
Homologene: 130700
Cox6b2
Name: cytochrome c oxidase subunit 6B2
Synonyms: COXVIB2, 1700067P11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 333182
Homologene: 16948
U90926
Name: cDNA sequence U90926
Synonyms: putative TNF-resistance related protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57425
Spata31d1a
Name: spermatogenesis associated 31 subfamily D, member 1A
Synonyms: 1700013B16Rik, Fam75d1a, Fam75d3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72219
VEGA: 13
Homologene: 122131
Igkv4-80
Name: immunoglobulin kappa variable 4-80
Synonyms: Gm16729
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 545848
Gm2423
Name: predicted gene 2423
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100039786
VEGA: 13
Homologene: 132185
Grem2
Name: gremlin 2, DAN family BMP antagonist
Synonyms: Prdc
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23893
Homologene: 8023
Gm22388
Name: predicted gene, 22388
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 14,910,746 bp
  • A to C, chromosome 1 at 34,588,741 bp
  • T to C, chromosome 1 at 59,207,768 bp
  • T to C, chromosome 1 at 93,078,808 bp
  • A to G, chromosome 1 at 174,836,813 bp
  • A to C, chromosome 1 at 178,098,421 bp
  • A to G, chromosome 2 at 85,992,287 bp
  • T to C, chromosome 2 at 152,869,724 bp
  • A to G, chromosome 2 at 154,692,625 bp
  • A to G, chromosome 2 at 172,377,800 bp
  • T to C, chromosome 2 at 177,508,829 bp
  • C to A, chromosome 4 at 145,622,334 bp
  • A to G, chromosome 4 at 149,398,654 bp
  • G to A, chromosome 4 at 149,469,127 bp
  • A to T, chromosome 4 at 149,728,155 bp
  • C to T, chromosome 5 at 30,199,148 bp
  • G to A, chromosome 5 at 30,394,181 bp
  • G to A, chromosome 5 at 92,210,020 bp
  • T to G, chromosome 6 at 8,215,847 bp
  • G to A, chromosome 6 at 47,926,862 bp
  • A to C, chromosome 6 at 69,016,665 bp
  • T to C, chromosome 6 at 85,901,140 bp
  • T to G, chromosome 7 at 3,895,572 bp
  • T to C, chromosome 7 at 4,752,161 bp
  • C to G, chromosome 7 at 19,088,019 bp
  • T to A, chromosome 7 at 44,016,249 bp
  • T to C, chromosome 7 at 75,117,722 bp
  • A to G, chromosome 7 at 85,751,130 bp
  • A to T, chromosome 7 at 141,010,459 bp
  • A to G, chromosome 8 at 40,554,345 bp
  • A to G, chromosome 8 at 119,445,289 bp
  • A to G, chromosome 9 at 35,053,136 bp
  • T to C, chromosome 9 at 86,790,154 bp
  • C to T, chromosome 9 at 110,638,767 bp
  • A to G, chromosome 10 at 41,456,618 bp
  • A to G, chromosome 10 at 76,274,157 bp
  • A to G, chromosome 10 at 80,325,381 bp
  • G to T, chromosome 10 at 88,746,934 bp
  • A to G, chromosome 10 at 103,200,559 bp
  • G to A, chromosome 10 at 117,668,103 bp
  • T to C, chromosome 11 at 58,817,718 bp
  • T to A, chromosome 11 at 102,205,624 bp
  • C to T, chromosome 12 at 21,274,848 bp
  • T to C, chromosome 12 at 56,534,939 bp
  • T to A, chromosome 12 at 89,260,474 bp
  • T to C, chromosome 13 at 13,232,886 bp
  • T to C, chromosome 13 at 20,342,519 bp
  • T to G, chromosome 13 at 23,076,527 bp
  • T to C, chromosome 13 at 23,819,019 bp
  • T to C, chromosome 13 at 59,703,151 bp
  • C to T, chromosome 13 at 62,865,074 bp
  • G to T, chromosome 13 at 73,265,507 bp
  • T to C, chromosome 14 at 26,915,058 bp
  • A to T, chromosome 14 at 47,074,010 bp
  • G to T, chromosome 14 at 55,773,465 bp
  • A to T, chromosome 14 at 67,389,657 bp
  • G to T, chromosome 15 at 48,001,478 bp
  • A to G, chromosome 15 at 59,344,080 bp
  • A to G, chromosome 15 at 99,232,756 bp
  • G to T, chromosome 15 at 102,208,279 bp
  • T to C, chromosome 16 at 96,159,732 bp
  • A to G, chromosome 17 at 36,127,472 bp
  • T to C, chromosome 17 at 37,017,489 bp
  • T to A, chromosome 18 at 5,056,810 bp
  • A to T, chromosome 18 at 36,998,345 bp
  • T to G, chromosome 19 at 12,901,451 bp
  • T to A, chromosome 19 at 31,084,583 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4991 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042585-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.