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Strain Name:
C57BL/6J-MtgxR5011Btlr/Mmmh
Stock Number:
042602-MU
Citation ID:
RRID:MMRRC_042602-MU
Other Names:
R5011 (G1), C57BL/6J-MtgxR5011Btlr
Major Collection:

Strain Information

Eya1
Name: EYA transcriptional coactivator and phosphatase 1
Synonyms: bor
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14048
HGNC: HGNC:3519
Homologene: 74943
Card11
Name: caspase recruitment domain family, member 11
Synonyms: CARMA1, BIMP3, 2410011D02Rik, 0610008L17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108723
Homologene: 13024
Tert
Name: telomerase reverse transcriptase
Synonyms: TR
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21752
VEGA: 13
Homologene: 31141
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Draxin
Name: dorsal inhibitory axon guidance protein
Synonyms: Neucrin, 2610109H07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70433
Homologene: 19233
Sin3b
Name: transcriptional regulator, SIN3B (yeast)
Synonyms: 2810430C10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20467
Homologene: 81810
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 14,184,358 bp
  • T to C, chromosome 1 at 34,250,647 bp
  • T to C, chromosome 1 at 58,414,483 bp
  • C to A, chromosome 1 at 87,774,180 bp
  • T to C, chromosome 1 at 93,749,876 bp
  • T to C, chromosome 1 at 133,320,268 bp
  • A to G, chromosome 1 at 143,746,531 bp
  • T to A, chromosome 1 at 151,363,202 bp
  • T to C, chromosome 1 at 160,126,379 bp
  • T to A, chromosome 1 at 171,533,390 bp
  • A to T, chromosome 1 at 179,784,110 bp
  • A to T, chromosome 1 at 181,819,888 bp
  • T to A, chromosome 2 at 25,677,070 bp
  • T to A, chromosome 2 at 35,298,921 bp
  • A to G, chromosome 2 at 37,270,925 bp
  • T to C, chromosome 2 at 38,048,728 bp
  • A to T, chromosome 2 at 86,347,303 bp
  • A to G, chromosome 2 at 118,880,465 bp
  • A to G, chromosome 2 at 120,510,534 bp
  • T to C, chromosome 2 at 122,457,890 bp
  • G to A, chromosome 2 at 126,116,123 bp
  • T to C, chromosome 2 at 156,031,215 bp
  • T to C, chromosome 2 at 158,376,952 bp
  • C to A, chromosome 2 at 181,379,673 bp
  • A to T, chromosome 3 at 51,690,775 bp
  • T to A, chromosome 3 at 94,776,145 bp
  • T to C, chromosome 3 at 100,963,169 bp
  • T to A, chromosome 3 at 106,150,161 bp
  • A to G, chromosome 3 at 129,739,920 bp
  • G to A, chromosome 4 at 48,421,807 bp
  • G to A, chromosome 4 at 49,530,438 bp
  • C to A, chromosome 4 at 148,107,979 bp
  • G to T, chromosome 5 at 35,700,289 bp
  • G to A, chromosome 5 at 122,551,069 bp
  • T to C, chromosome 5 at 128,803,921 bp
  • G to T, chromosome 5 at 134,216,982 bp
  • A to G, chromosome 5 at 138,162,197 bp
  • T to A, chromosome 5 at 139,163,257 bp
  • A to T, chromosome 5 at 140,876,520 bp
  • A to G, chromosome 5 at 142,886,680 bp
  • G to A, chromosome 7 at 6,266,333 bp
  • G to A, chromosome 7 at 29,102,809 bp
  • A to C, chromosome 7 at 43,795,995 bp
  • A to G, chromosome 7 at 44,211,068 bp
  • T to C, chromosome 7 at 84,856,438 bp
  • A to G, chromosome 7 at 105,742,249 bp
  • A to G, chromosome 7 at 109,914,776 bp
  • T to C, chromosome 7 at 127,343,703 bp
  • C to T, chromosome 7 at 139,020,222 bp
  • T to C, chromosome 7 at 141,459,291 bp
  • C to T, chromosome 8 at 23,082,284 bp
  • A to T, chromosome 8 at 45,031,263 bp
  • G to A, chromosome 8 at 71,641,477 bp
  • A to G, chromosome 8 at 72,147,094 bp
  • G to A, chromosome 8 at 72,744,556 bp
  • T to C, chromosome 9 at 36,637,824 bp
  • T to A, chromosome 10 at 58,461,895 bp
  • T to C, chromosome 10 at 81,584,697 bp
  • T to C, chromosome 10 at 86,696,753 bp
  • T to C, chromosome 10 at 103,189,923 bp
  • G to A, chromosome 10 at 128,949,447 bp
  • C to T, chromosome 11 at 48,945,827 bp
  • T to C, chromosome 11 at 59,759,895 bp
  • C to A, chromosome 11 at 67,256,363 bp
  • T to A, chromosome 11 at 73,799,647 bp
  • T to C, chromosome 11 at 107,028,498 bp
  • T to C, chromosome 11 at 115,243,486 bp
  • T to C, chromosome 11 at 120,730,871 bp
  • G to T, chromosome 12 at 71,164,546 bp
  • A to T, chromosome 12 at 71,164,547 bp
  • C to T, chromosome 13 at 9,689,443 bp
  • C to T, chromosome 13 at 22,244,888 bp
  • T to C, chromosome 13 at 23,076,551 bp
  • T to C, chromosome 13 at 45,557,069 bp
  • T to C, chromosome 13 at 46,687,403 bp
  • T to A, chromosome 13 at 49,805,180 bp
  • T to C, chromosome 13 at 73,646,309 bp
  • T to A, chromosome 14 at 20,363,371 bp
  • T to A, chromosome 14 at 26,710,171 bp
  • T to C, chromosome 15 at 9,365,287 bp
  • G to T, chromosome 15 at 99,426,576 bp
  • A to T, chromosome 16 at 5,195,879 bp
  • G to A, chromosome 16 at 13,123,581 bp
  • G to A, chromosome 16 at 20,707,215 bp
  • A to T, chromosome 16 at 29,350,748 bp
  • T to C, chromosome 17 at 20,555,189 bp
  • C to T, chromosome 17 at 28,885,584 bp
  • T to C, chromosome 17 at 29,374,980 bp
  • G to A, chromosome 17 at 30,748,568 bp
  • T to C, chromosome 17 at 33,822,070 bp
  • T to A, chromosome 17 at 34,241,279 bp
  • T to A, chromosome 17 at 34,594,699 bp
  • T to A, chromosome 17 at 57,223,236 bp
  • T to C, chromosome 17 at 58,996,504 bp
  • T to A, chromosome 17 at 75,066,157 bp
  • A to G, chromosome 18 at 36,967,907 bp
  • A to T, chromosome 18 at 44,006,412 bp
  • A to G, chromosome 18 at 44,854,742 bp
  • T to A, chromosome 18 at 45,685,285 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5011 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042602-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.