Strain Name:
C57BL/6J-MtgxR5012Btlr/Mmmh
Stock Number:
042603-MU
Citation ID:
RRID:MMRRC_042603-MU
Other Names:
R5012 (G1), C57BL/6J-MtgxR5012Btlr
Major Collection:

Gene Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: Mll3, E330008K23Rik, HALR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231051
Homologene: 46480
Septin4
Name: septin 4
Synonyms: Bh5, cell division control-related protein 2b, Pnutl2, septin H5, Sept4, ARTS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18952
HGNC: HGNC:9165
Homologene: 6107
Emx1
Name: empty spiracles homeobox 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13796
HGNC: HGNC:3340
Homologene: 55799
Elf1
Name: E74 like ETS transcription factor 1
Synonyms: Elf-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13709
VEGA: 14
HGNC: HGNC:3316
Homologene: 7303
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224273
Homologene: 28544
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, XRCC7, DNA-PK, dxnph, DNAPDcs, DOXNPH, slip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Mcm7
Name: minichromosome maintenance complex component 7
Synonyms: mCDC47, Mcmd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17220
HGNC: HGNC:6950
Homologene: 4323
Paip1
Name: polyadenylate binding protein-interacting protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218693
Homologene: 4709
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: Lrrc16a, Carmil, 1110037D04Rik, Lrrc16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68732
Homologene: 9757
9530068E07Rik
Name: RIKEN cDNA 9530068E07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 213673
Homologene: 10620
Aftph
Name: aftiphilin
Synonyms: 9130023F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216549
Homologene: 9764
Itgb3bp
Name: integrin beta 3 binding protein (beta3-endonexin)
Synonyms: 4930471O16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67733
HGNC: HGNC:6157
Homologene: 8617
Yars2
Name: tyrosyl-tRNA synthetase 2 (mitochondrial)
Synonyms: 2210023C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70120
Homologene: 7097
Steap2
Name: six transmembrane epithelial antigen of prostate 2
Synonyms: 4921538B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74051
Homologene: 17682
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: Ta3, talpid3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76967
Homologene: 8839
Zfp386
Name: zinc finger protein 386 (Kruppel-like)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56220
Homologene: 51668
Zfp988
Name: zinc finger protein 988
Synonyms: Gm13151
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Ttll5
Name: tubulin tyrosine ligase-like family, member 5
Synonyms: 1700048H13Rik, 2310009M18Rik, D630041K24Rik, STAMP, 4930556H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320244
Homologene: 9013
Grn
Name: granulin
Synonyms: acrogranulin, PC cell-derived growth factor, epithelin, Pgrn, progranulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14824
HGNC: HGNC:4601
Homologene: 1577
Fastkd2
Name: FAST kinase domains 2
Synonyms: 2810421I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75619
Homologene: 8957
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Pcdhb11
Name: protocadherin beta 11
Synonyms: PcdhbK, Pcdhb5E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93882
Homologene: 62178
Magi2
Name: membrane associated guanylate kinase, WW and PDZ domain containing 2
Synonyms: Acvrinp1, Magi-2, S-SCAM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 50791
Homologene: 8189
Acsl1
Name: acyl-CoA synthetase long-chain family member 1
Synonyms: Facl2, Acas1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14081
HGNC: HGNC:3569
Homologene: 37561
Plcb1
Name: phospholipase C, beta 1
Synonyms: 3110043I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18795
Homologene: 22876
Ankrd34c
Name: ankyrin repeat domain 34C
Synonyms: LOC330998, B230218L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330998
Homologene: 19814
Vipr1
Name: vasoactive intestinal peptide receptor 1
Synonyms: VPAC1, VIP receptor subtype 1, VIP-R1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22354
Homologene: 3399
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: Adlican2, CMF608, 6530405F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242050
Homologene: 18712
Itgal
Name: integrin alpha L
Synonyms: LFA-1, Ly-15, Cd11a, Ly-21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16408
HGNC: HGNC:6148
Homologene: 1666
Prl8a9
Name: prolactin family8, subfamily a, member 9
Synonyms: PLP-Cbeta, 1600019F10Rik, Prlpc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67310
Homologene: 11344
Scn11a
Name: sodium channel, voltage-gated, type XI, alpha
Synonyms: SNS2, NaN, NSS2, NaT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 24046
VEGA: 9
Homologene: 8041
Slc41a2
Name: solute carrier family 41, member 2
Synonyms: A230035L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 338365
Homologene: 9870
Mau2
Name: MAU2 sister chromatid cohesion factor
Synonyms: A930019L04Rik, 9130404D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74549
Homologene: 12574
Mfsd11
Name: major facilitator superfamily domain containing 11
Synonyms: 2600014M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69900
Homologene: 11517
Rassf2
Name: Ras association (RalGDS/AF-6) domain family member 2
Synonyms: 9030412M04Rik, 3830431H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 215653
HGNC: HGNC:9883
Homologene: 22840
1810055G02Rik
Name: RIKEN cDNA 1810055G02 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72056
VEGA: 19
HGNC: HGNC:1174
Homologene: 11174
Anks1b
Name: ankyrin repeat and sterile alpha motif domain containing 1B
Synonyms: Gm10937, E530015N03Rik, LOC380650, AIDA-1b, C030032C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77531
Homologene: 51570
Psmc2
Name: proteasome (prosome, macropain) 26S subunit, ATPase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19181
HGNC: HGNC:9548
Homologene: 2096
Mitd1
Name: MIT, microtubule interacting and transport, domain containing 1
Synonyms: 1500032H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69028
Homologene: 14787
RP23-357H5.5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Lamtor2
Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
Synonyms: 2010111E04Rik, Mapbpip, Rab25, P14, Robld3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 83409
Homologene: 8518
Igkv6-23
Name: immunoglobulin kappa variable 6-23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 637227
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 37,885,293 bp
  • A to T, chromosome 1 at 63,749,896 bp
  • C to A, chromosome 2 at 132,009,690 bp
  • A to G, chromosome 2 at 135,333,400 bp
  • A to G, chromosome 3 at 59,318,722 bp
  • C to T, chromosome 3 at 88,552,856 bp
  • T to A, chromosome 4 at 99,789,679 bp
  • A to G, chromosome 4 at 147,331,603 bp
  • G to C, chromosome 5 at 5,677,784 bp
  • A to T, chromosome 5 at 20,465,620 bp
  • A to G, chromosome 5 at 21,802,565 bp
  • C to A, chromosome 5 at 25,299,712 bp
  • A to T, chromosome 5 at 138,169,347 bp
  • C to A, chromosome 6 at 70,260,545 bp
  • C to T, chromosome 6 at 85,203,973 bp
  • T to C, chromosome 7 at 127,299,630 bp
  • A to G, chromosome 7 at 141,636,657 bp
  • A to G, chromosome 8 at 46,521,431 bp
  • A to G, chromosome 8 at 70,031,457 bp
  • T to G, chromosome 9 at 89,729,656 bp
  • C to A, chromosome 9 at 109,773,203 bp
  • A to T, chromosome 9 at 119,780,878 bp
  • A to T, chromosome 9 at 121,658,045 bp
  • A to G, chromosome 10 at 83,301,263 bp
  • A to G, chromosome 10 at 90,359,137 bp
  • G to A, chromosome 11 at 20,698,264 bp
  • T to C, chromosome 11 at 52,403,059 bp
  • T to A, chromosome 11 at 87,584,404 bp
  • C to A, chromosome 11 at 102,430,554 bp
  • C to T, chromosome 11 at 116,868,589 bp
  • G to T, chromosome 12 at 71,164,546 bp
  • A to T, chromosome 12 at 71,164,547 bp
  • G to A, chromosome 12 at 85,926,844 bp
  • T to A, chromosome 12 at 116,059,244 bp
  • G to T, chromosome 13 at 24,024,420 bp
  • A to T, chromosome 13 at 27,562,611 bp
  • A to G, chromosome 13 at 119,447,802 bp
  • T to A, chromosome 14 at 79,570,734 bp
  • T to C, chromosome 16 at 15,654,731 bp
  • T to C, chromosome 16 at 16,303,584 bp
  • A to G, chromosome 16 at 59,530,194 bp
  • C to A, chromosome 18 at 37,422,976 bp
  • C to A, chromosome 19 at 3,717,217 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5012 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042603-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.