Strain Name:
C57BL/6J-MtgxR5016Btlr/Mmmh
Stock Number:
042607-MU
Citation ID:
RRID:MMRRC_042607-MU
Other Names:
R5016 (G1), C57BL/6J-MtgxR5016Btlr
Major Collection:

Gene Information

Slc12a6
Name: solute carrier family 12, member 6
Synonyms: gaxp, KCC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 107723
Homologene: 21069
Gpr19
Name: G protein-coupled receptor 19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 14760
HGNC: HGNC:4473
Homologene: 4476
Llgl2
Name: LLGL2 scribble cell polarity complex component
Synonyms: 9130006H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217325
HGNC: HGNC:6629
Homologene: 3323
Ltbp4
Name: latent transforming growth factor beta binding protein 4
Synonyms: 2310046A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 108075
HGNC: HGNC:6717
Homologene: 2645
Luc7l2
Name: LUC7-like 2 (S. cerevisiae)
Synonyms: CGI-74, 4930471C18Rik, CGI-59
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 192196
Homologene: 56737
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 9030205D12Rik, 1810014J18Rik, AD013, A330063D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 109151
Homologene: 11844
Coro1c
Name: coronin, actin binding protein 1C
Synonyms: CRN2, coronin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 23790
HGNC: HGNC:2254
Homologene: 56537
Wdr3
Name: WD repeat domain 3
Synonyms: D030020G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 269470
Homologene: 4937
Ezh1
Name: enhancer of zeste 1 polycomb repressive complex 2 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14055
HGNC: HGNC:3526
Homologene: 20458
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: E430018P19Rik, 8030453L17Rik, KMT2H, chromatin remodeling factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 192195
Homologene: 10225
Sp2
Name: Sp2 transcription factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 78912
Homologene: 2340
Gprc5c
Name: G protein-coupled receptor, family C, group 5, member C
Synonyms: 1110028I06Rik, 3200002M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 70355
Homologene: 11099
Drd3
Name: dopamine receptor D3
Synonyms: D3R, D3 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 13490
VEGA: 16
HGNC: HGNC:3024
Homologene: 623
Igsf9
Name: immunoglobulin superfamily, member 9
Synonyms: Dasm1, NRT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 93842
Homologene: 10815
Ptprs
Name: protein tyrosine phosphatase, receptor type, S
Synonyms: PTP-NU3, PTPsigma, Ptpt9, RPTPsigma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 19280
HGNC: HGNC:9681
Homologene: 20626
Bach1
Name: BTB and CNC homology 1, basic leucine zipper transcription factor 1
Synonyms: 6230421P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 12013
HGNC: HGNC:935
Homologene: 916
Mcm6
Name: minichromosome maintenance complex component 6
Synonyms: Mcmd6, D1Wsu22e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 17219
HGNC: HGNC:6949
Homologene: 4322
Hnrnpul2
Name: heterogeneous nuclear ribonucleoprotein U-like 2
Synonyms: 1110031M08Rik, Hnrpul2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 68693
VEGA: 19
Homologene: 28583
Nadk
Name: NAD kinase
Synonyms: 4432404C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 192185
Homologene: 49724
Ksr2
Name: kinase suppressor of ras 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 333050
Homologene: 45469
Wdr95
Name: WD40 repeat domain 95
Synonyms: 4930434E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 381693
HGNC: null
Homologene: 124480
Miox
Name: myo-inositol oxygenase
Synonyms: RSOR, C85427, Aldrl6, 0610009I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 56727
Homologene: 9732
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Stat4
Name: signal transducer and activator of transcription 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20849
Homologene: 20679
Ephb6
Name: Eph receptor B6
Synonyms: Cekl, Mep
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 13848
HGNC: HGNC:3396
Homologene: 20940
Atp7b
Name: ATPase, Cu++ transporting, beta polypeptide
Synonyms: Wilson protein, WND, Atp7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 11979
HGNC: HGNC:870
Homologene: 20063
Specc1
Name: sperm antigen with calponin homology and coiled-coil domains 1
Synonyms: B230396K10Rik, 2810012G08Rik, Cytsb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 432572
Homologene: 45157
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230622
HGNC: null
Homologene: 135888
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 243369
Homologene: 45453
Vmn2r79
Name: vomeronasal 2, receptor 79
Synonyms: EG621430
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 621430
HGNC: null
Homologene: 115466
St6galnac1
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Synonyms: Siat7a, ST6GalNAc I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20445
Homologene: 7937
Col16a1
Name: collagen, type XVI, alpha 1
Synonyms: [a]1 (XVI) collagen, 2700007F12Rik, A530052M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 107581
HGNC: HGNC:2193
Homologene: 1397
Vmn2r91
Name: vomeronasal 2, receptor 91
Synonyms: EG665210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 665210
HGNC: null
Homologene: 115024
Ankzf1
Name: ankyrin repeat and zinc finger domain containing 1
Synonyms: D1Ertd161e, 1300008P06Rik, 2810025E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 52231
Homologene: 41225
Ccdc158
Name: coiled-coil domain containing 158
Synonyms: 4932413O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 320696
Homologene: 18560
Olfr155
Name: olfactory receptor 155
Synonyms: mOR37a, Olfr37a, OR37A, GA_x6K02T2N78B-16092200-16091241, MOR262-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 29845
HGNC: HGNC:8276
Homologene: 84331
Slc22a19
Name: solute carrier family 22 (organic anion transporter), member 19
Synonyms: D630043A20Rik, Slc22a9, Oat5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 207151
Homologene: 133125
Pdss2
Name: prenyl (solanesyl) diphosphate synthase, subunit 2
Synonyms: 5430420P03Rik, mDLP1, kd, PLMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 71365
Homologene: 56885
Serpinb3a
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A
Synonyms: Sqn5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20248
Homologene: 76659
Steap4
Name: STEAP family member 4
Synonyms: Tiarp, Tnfaip9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 117167
Homologene: 36422
Abi3bp
Name: ABI gene family, member 3 (NESH) binding protein
Synonyms: TARSH, eratin, D930038M13Rik, 5033411B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 320712
VEGA: 16
Homologene: 134172
Ptpn22
Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Synonyms: Ptpn8, 70zpep
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 19260
HGNC: HGNC:9652
Homologene: 7498
Vmn1r202
Name: vomeronasal 1 receptor 202
Synonyms: V1ri7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 171258
HGNC: null
Homologene: 110880
Nxpe4
Name: neurexophilin and PC-esterase domain family, member 4
Synonyms: D930028F11Rik, Fam55d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244853
VEGA: 9
Homologene: 83471
Olfr811
Name: olfactory receptor 811
Synonyms: MOR110-6, GA_x6K02T2PULF-11481207-11480248
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258545
HGNC: null
Homologene: 133725
Gpr61
Name: G protein-coupled receptor 61
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229714
Homologene: 12910
Nudt18
Name: nudix (nucleoside diphosphate linked moiety X)-type motif 18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 213484
VEGA: 14
Homologene: 32604
Slc27a5
Name: solute carrier family 27 (fatty acid transporter), member 5
Synonyms: FACVL3, FATP5, VLCSH2, VLCS-H2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 26459
Homologene: 7596
Olfr1089
Name: olfactory receptor 1089
Synonyms: GA_x6K02T2Q125-48226321-48225386, MOR193-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 257933
HGNC: null
Homologene: 79354
Cygb
Name: cytoglobin
Synonyms: Staap, 3110001K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 114886
Homologene: 12706
Rasd2
Name: RASD family, member 2
Synonyms: TEM-2, TEM2, 4930526B11Rik, Rhes
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 75141
Homologene: 8628
Ugt1a5
Name: UDP glucuronosyltransferase 1 family, polypeptide A5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 394433
Homologene: 88621
Gm14007
Name: predicted gene 14007
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 102640103
HGNC: null
Homologene: null
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 52,105,728 bp
  • C to A, chromosome 1 at 75,195,978 bp
  • C to G, chromosome 1 at 88,166,241 bp
  • A to G, chromosome 1 at 107,046,330 bp
  • G to A, chromosome 1 at 128,343,427 bp
  • A to C, chromosome 1 at 172,490,712 bp
  • T to G, chromosome 2 at 86,732,746 bp
  • C to T, chromosome 2 at 112,356,627 bp
  • A to T, chromosome 2 at 128,607,175 bp
  • A to G, chromosome 3 at 88,982,323 bp
  • A to T, chromosome 3 at 100,141,620 bp
  • T to A, chromosome 3 at 103,886,355 bp
  • A to G, chromosome 3 at 108,150,667 bp
  • T to C, chromosome 4 at 43,854,596 bp
  • T to A, chromosome 4 at 113,171,533 bp
  • C to T, chromosome 4 at 130,079,195 bp
  • G to A, chromosome 4 at 155,588,633 bp
  • C to T, chromosome 5 at 7,976,699 bp
  • A to G, chromosome 5 at 92,657,892 bp
  • G to A, chromosome 5 at 113,882,117 bp
  • A to G, chromosome 5 at 117,500,792 bp
  • T to C, chromosome 5 at 149,544,801 bp
  • A to G, chromosome 6 at 38,585,101 bp
  • G to A, chromosome 6 at 41,618,107 bp
  • C to T, chromosome 6 at 48,452,280 bp
  • T to A, chromosome 6 at 134,869,917 bp
  • C to G, chromosome 7 at 12,996,424 bp
  • GT to G, chromosome 7 at 27,327,685 bp
  • T to C, chromosome 7 at 87,037,340 bp
  • T to C, chromosome 8 at 22,015,869 bp
  • C to A, chromosome 8 at 75,221,975 bp
  • T to A, chromosome 8 at 91,006,626 bp
  • A to G, chromosome 9 at 48,392,885 bp
  • G to T, chromosome 10 at 43,222,005 bp
  • A to G, chromosome 10 at 129,801,793 bp
  • A to G, chromosome 11 at 62,118,957 bp
  • A to T, chromosome 11 at 96,955,832 bp
  • G to A, chromosome 11 at 101,199,237 bp
  • G to T, chromosome 11 at 114,864,267 bp
  • A to G, chromosome 11 at 115,853,424 bp
  • A to G, chromosome 11 at 116,650,014 bp
  • A to T, chromosome 11 at 116,765,880 bp
  • G to C, chromosome 11 at 118,080,766 bp
  • A to T, chromosome 13 at 22,502,205 bp
  • T to C, chromosome 14 at 70,579,463 bp
  • A to G, chromosome 15 at 89,335,564 bp
  • C to A, chromosome 16 at 43,762,246 bp
  • C to T, chromosome 16 at 56,671,268 bp
  • T to A, chromosome 16 at 87,719,318 bp
  • C to A, chromosome 17 at 18,110,060 bp
  • T to C, chromosome 17 at 56,419,070 bp
  • G to A, chromosome 19 at 7,674,372 bp
  • A to G, chromosome 19 at 8,822,825 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5016 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042607-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.