Strain Name:
C57BL/6J-MtgxR5018Btlr/Mmmh
Stock Number:
042609-MU
Citation ID:
RRID:MMRRC_042609-MU
Other Names:
R5018 (G1), C57BL/6J-MtgxR5018Btlr
Major Collection:

Gene Information

Sh3gl2
Name: SH3-domain GRB2-like 2
Synonyms: endophilin A1, 9530001L19Rik, Sh3d2a, EEN-B1, endophilin I, B930049H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 20404
Homologene: 20652
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: trabeculin alpha, Acf7, Aclp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11426
Homologene: 136191
Aunip
Name: aurora kinase A and ninein interacting protein
Synonyms: 2610002D18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69885
Homologene: 81895
Polr1c
Name: polymerase (RNA) I polypeptide C
Synonyms: Rpo1-1, 40kDa, RPA40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20016
Homologene: 3586
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: D630005A10Rik, apollon, A430032G04Rik, Bruce, A430040A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12211
Homologene: 7248
Sin3a
Name: transcriptional regulator, SIN3A (yeast)
Synonyms: Sin3, mSin3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20466
Homologene: 32124
Stag1
Name: stromal antigen 1
Synonyms: SA-1, Scc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20842
Homologene: 21191
Ubn1
Name: ubinuclein 1
Synonyms: 1110029L11Rik, 2610108L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 170644
VEGA: 16
Homologene: 9656
Alx4
Name: aristaless-like homeobox 4
Synonyms: Aristaless-like 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11695
HGNC: HGNC:450
Homologene: 7229
Slitrk3
Name: SLIT and NTRK-like family, member 3
Synonyms: ST3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 386750
Homologene: 8955
Fgfr3
Name: fibroblast growth factor receptor 3
Synonyms: Fgfr-3, HBGFR, sam3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14184
HGNC: HGNC:3690
Homologene: 55437
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 319262
Homologene: 14127
Eea1
Name: early endosome antigen 1
Synonyms: A430109M19Rik, ZFYVE2, B230358H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216238
VEGA: 10
HGNC: HGNC:3185
Homologene: 37822
Klhl20
Name: kelch-like 20
Synonyms: D930050H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226541
Homologene: 8699
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: Dnahc11, avc4, b2b598Clo, lrd, b2b1289Clo, b2b1727Clo, b2b1279Clo, b2b1203Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Fyttd1
Name: forty-two-three domain containing 1
Synonyms: 3830421F13Rik, 3830411L18Rik, 2010005M05Rik, 4933423A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 69823
Homologene: 12334
Vmn2r3
Name: vomeronasal 2, receptor 3
Synonyms: EG637004
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 637004
Nr1h5
Name: nuclear receptor subfamily 1, group H, member 5
Synonyms: FXRB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 381463
Homologene: 131277
Nlrc5
Name: NLR family, CARD domain containing 5
Synonyms: AI451557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 434341
Homologene: 88935
Hal
Name: histidine ammonia lyase
Synonyms: histidase, Hsd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15109
HGNC: HGNC:4806
Homologene: 68229
Sspo
Name: SCO-spondin
Synonyms: Scospondin, C79529
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243369
Homologene: 45453
Zfp276
Name: zinc finger protein (C2H2 type) 276
Synonyms: D8Ertd377e, D8Ertd370e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 57247
Homologene: 10731
Bfsp1
Name: beaded filament structural protein 1, in lens-CP94
Synonyms: filensin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12075
HGNC: HGNC:1040
Homologene: 922
Vmn2r27
Name: vomeronasal 2, receptor27
Synonyms: EG232367
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232367
Ugt2b1
Name: UDP glucuronosyltransferase 2 family, polypeptide B1
Synonyms: 1300012D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71773
Homologene: 68144
Hpse2
Name: heparanase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 545291
VEGA: 19
Homologene: 19680
Vmn2r91
Name: vomeronasal 2, receptor 91
Synonyms: EG665210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665210
Homologene: 115024
Dmwd
Name: dystrophia myotonica-containing WD repeat motif
Synonyms: 59, Dm9, DMR-N9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13401
HGNC: HGNC:2936
Homologene: 22559
Kif21b
Name: kinesin family member 21B
Synonyms: N-5 kinesin, 2610511N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16565
Homologene: 56868
Adamdec1
Name: ADAM-like, decysin 1
Synonyms: 2210414L24Rik, Dcsn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 58860
VEGA: 14
Homologene: 8711
Nostrin
Name: nitric oxide synthase trafficker
Synonyms: mDaIP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329416
Homologene: 43142
Ccdc186
Name: coiled-coil domain containing 186
Synonyms: 1810028B20Rik, A630007B06Rik, Otg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 213993
Homologene: 9963
Agbl5
Name: ATP/GTP binding protein-like 5
Synonyms: 9430057O19Rik, Ccp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231093
Homologene: 11053
Hhat
Name: hedgehog acyltransferase
Synonyms: Skn, Tg(TFAP2A-cre)1Will, 2810432O22Rik, AP-2CRE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226861
Homologene: 41232
Apol7b
Name: apolipoprotein L 7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 278679
Homologene: 40940
Flacc1
Name: flagellum associated containing coiled-coil domains 1
Synonyms: 4933425F06Rik, 4933405P16Rik, Als2cr12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108812
Homologene: 51399
Scd4
Name: stearoyl-coenzyme A desaturase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 329065
Homologene: 77322
Olfr1513
Name: olfactory receptor 1513
Synonyms: MOR223-7P, MOR223-10, GA_x6K02T2RJGY-644134-645075
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258008
HGNC: HGNC:8171
Homologene: 79404
Pmm2
Name: phosphomannomutase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 54128
HGNC: HGNC:9115
Homologene: 257
Trat1
Name: T cell receptor associated transmembrane adaptor 1
Synonyms: Trim, Tcrim, C030046M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77647
VEGA: 16
Homologene: 41130
Ugp2
Name: UDP-glucose pyrophosphorylase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216558
Homologene: 121676
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 58,690,950 bp
  • A to G, chromosome 1 at 136,172,234 bp
  • T to C, chromosome 1 at 161,101,586 bp
  • A to T, chromosome 1 at 192,595,038 bp
  • G to A, chromosome 2 at 69,183,883 bp
  • G to T, chromosome 2 at 93,677,419 bp
  • C to A, chromosome 2 at 143,862,882 bp
  • T to C, chromosome 3 at 64,271,353 bp
  • G to A, chromosome 3 at 73,050,512 bp
  • A to G, chromosome 3 at 102,947,795 bp
  • A to G, chromosome 4 at 85,391,054 bp
  • C to T, chromosome 4 at 123,385,599 bp
  • T to A, chromosome 4 at 134,523,617 bp
  • G to A, chromosome 5 at 30,903,059 bp
  • C to T, chromosome 5 at 33,735,238 bp
  • G to T, chromosome 5 at 86,925,962 bp
  • T to C, chromosome 5 at 124,762,196 bp
  • G to A, chromosome 6 at 48,455,700 bp
  • T to A, chromosome 6 at 124,224,182 bp
  • A to G, chromosome 7 at 19,078,119 bp
  • C to T, chromosome 8 at 94,525,452 bp
  • A to G, chromosome 8 at 123,264,977 bp
  • T to A, chromosome 9 at 57,110,891 bp
  • A to G, chromosome 9 at 100,951,619 bp
  • T to G, chromosome 10 at 74,643,775 bp
  • T to C, chromosome 10 at 93,507,551 bp
  • T to C, chromosome 10 at 96,011,037 bp
  • A to G, chromosome 11 at 21,331,052 bp
  • G to T, chromosome 12 at 118,130,728 bp
  • A to C, chromosome 14 at 52,349,279 bp
  • A to T, chromosome 14 at 68,571,779 bp
  • A to G, chromosome 15 at 77,424,716 bp
  • A to G, chromosome 16 at 5,063,725 bp
  • A to G, chromosome 16 at 8,645,433 bp
  • A to G, chromosome 16 at 32,902,417 bp
  • A to T, chromosome 16 at 48,734,805 bp
  • G to T, chromosome 17 at 18,136,438 bp
  • G to T, chromosome 17 at 46,247,709 bp
  • T to A, chromosome 17 at 74,640,059 bp
  • C to T, chromosome 18 at 37,959,873 bp
  • A to G, chromosome 19 at 43,384,824 bp
  • T to A, chromosome 19 at 44,337,609 bp
  • A to G, chromosome 19 at 56,800,198 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5018 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042609-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.