Strain Name:
C57BL/6J-MtgxR5035Btlr/Mmmh
Stock Number:
042626-MU
Citation ID:
RRID:MMRRC_042626-MU
Other Names:
R5035 (G1), C57BL/6J-MtgxR5035Btlr
Major Collection:

Gene Information

Ptprz1
Name: protein tyrosine phosphatase, receptor type Z, polypeptide 1
Synonyms: PTPbeta, DSD-1-PG, Ptprz, Ptpz, Rptpbeta, PTPzeta, RPTPz, phosphacan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Clcnka
Name: chloride channel, voltage-sensitive Ka
Synonyms: CLC-K1, Clcnk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12733
Homologene: 65
Apbb2
Name: amyloid beta (A4) precursor protein-binding, family B, member 2
Synonyms: TR2L, Zfra, Rirl1, 2310007D03Rik, FE65L1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 11787
HGNC: HGNC:582
Homologene: 32079
Dab2ip
Name: disabled 2 interacting protein
Synonyms: 2310011D08Rik, AIP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 69601
Homologene: 13058
Gse1
Name: genetic suppressor element 1, coiled-coil protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 382034
Homologene: 40964
Mcm3
Name: minichromosome maintenance complex component 3
Synonyms: P1, p1.m, Mcmd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 17215
HGNC: HGNC:6945
Homologene: 1791
Lin9
Name: lin-9 homolog (C. elegans)
Synonyms: 2700022J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 72568
Homologene: 35252
Cdc40
Name: cell division cycle 40
Synonyms: PRP17, 1200003H23Rik, EHB3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 71713
VEGA: 10
Homologene: 5716
Bcas3
Name: breast carcinoma amplified sequence 3
Synonyms: 1500019F07Rik, K20D4, rudhira, 2610028P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192197
Homologene: 9778
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 21819
Homologene: 2430
Fubp1
Name: far upstream element (FUSE) binding protein 1
Synonyms: FBP, Fubp4, Fubp, 9530027K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 51886
HGNC: HGNC:4004
Homologene: 48253
Osbpl9
Name: oxysterol binding protein-like 9
Synonyms: ORP-9, 2600011I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100273
Homologene: 69380
Creb3l1
Name: cAMP responsive element binding protein 3-like 1
Synonyms: Oasis, BBF-2 (drosophila) homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 26427
Homologene: 8058
Dbx1
Name: developing brain homeobox 1
Synonyms: Mmox C, Dbx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13172
Homologene: 19002
Glmp
Name: glycosylated lysosomal membrane protein
Synonyms: 0610031J06Rik, NCU-G1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56700
Homologene: 10562
Rnf4
Name: ring finger protein 4
Synonyms: Gtrgeo8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19822
Homologene: 37711
Bicra
Name: BRD4 interacting chromatin remodeling complex associated protein
Synonyms: Gltscr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243842
HGNC: HGNC:4332
Homologene: 9250
Dock8
Name: dedicator of cytokinesis 8
Synonyms: A130095G14Rik, 1200017A24Rik, 5830472H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 76088
VEGA: 19
Homologene: 52414
Ush2a
Name: usherin
Synonyms: Ush2a, Ushrn, MUSH2A, A930037M10Rik, A930011D15Rik, LOC269160, LOC381317
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22283
Homologene: 66151
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: PKHDL1, fibrocystin L, D86 mRNA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 192190
Homologene: 16332
Afp
Name: alpha fetoprotein
Synonyms: alpha-foetoprotein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 11576
HGNC: HGNC:317
Homologene: 36278
Slc24a2
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
Synonyms: 6330417K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 76376
Homologene: 10669
Cdk5rap3
Name: CDK5 regulatory subunit associated protein 3
Synonyms: 1810007E24Rik, IC53, HSF-27, MST016, C53, OK/SW-cl.114
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 80280
Homologene: 12718
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239420
Homologene: 65982
Rabgap1l
Name: RAB GTPase activating protein 1-like
Synonyms: 5830411O09Rik, 8430421H08Rik, Hh1, 9630005B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 29809
Homologene: 8143
Speer2
Name: spermatogenesis associated glutamate (E)-rich protein 2
Synonyms: SPEER-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224318
Homologene: 69402
Map3k13
Name: mitogen-activated protein kinase kinase kinase 13
Synonyms: C130026N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 71751
VEGA: 16
HGNC: HGNC:6852
Homologene: 37958
Tns1
Name: tensin 1
Synonyms: 1200014E20Rik, E030037J05Rik, 1110018I21Rik, Tns, E030018G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 21961
Homologene: 11219
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 333315
Homologene: 35388
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 21974
Homologene: 134711
Olfr1202
Name: olfactory receptor 1202
Synonyms: GA_x6K02T2Q125-50290367-50291296, MOR232-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258454
Homologene: 133021
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: 2900083P10Rik, C230094A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237711
Homologene: 104282
Olfr348
Name: olfactory receptor 348
Synonyms: MOR136-8, GA_x6K02T2NLDC-33481050-33481991
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258946
HGNC: HGNC:8209
Homologene: 105219
Bfsp2
Name: beaded filament structural protein 2, phakinin
Synonyms: CP49
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 107993
HGNC: HGNC:1041
Homologene: 20791
Olfr644
Name: olfactory receptor 644
Synonyms: GA_x6K02T2PBJ9-6803062-6802118, MOR13-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259125
Homologene: 17491
Ugt3a2
Name: UDP glycosyltransferases 3 family, polypeptide A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223337
Homologene: 122787
Acat1
Name: acetyl-Coenzyme A acetyltransferase 1
Synonyms: Acat, 6330585C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 110446
HGNC: HGNC:93
Homologene: 6
Olfr970
Name: olfactory receptor 970
Synonyms: MOR171-16, GA_x6K02T2PVTD-33517322-33518257
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258604
VEGA: 9
Homologene: 121532
Prodh2
Name: proline dehydrogenase (oxidase) 2
Synonyms: POX1, MmPOX1, 2510038B11Rik, 2510028N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 56189
Homologene: 36381
Olfr373
Name: olfactory receptor 373
Synonyms: GA_x6K02T2NUPS-231686-232630, MOR282-2, MOR282-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 258532
Homologene: 17287
Misp
Name: mitotic spindle positioning
Synonyms: 9130017N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 78906
VEGA: 10
Homologene: 49933
Krt28
Name: keratin 28
Synonyms: 4733401L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 70843
Homologene: 124711
Prr23a3
Name: proline rich 23A, member 3
Synonyms: 2410012M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 71979
Homologene: 67036
Tcrg-C4
Name: T cell receptor gamma, constant 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 107576
RP24-537K9.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
Gm20918
Name: predicted gene, 20918
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
Alteration at locus: Chemically Induced
NCBI: 108168642
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 20,803,418 bp
  • G to A, chromosome 1 at 73,953,820 bp
  • A to C, chromosome 1 at 160,724,036 bp
  • T to A, chromosome 1 at 180,669,198 bp
  • G to T, chromosome 1 at 188,910,808 bp
  • A to G, chromosome 2 at 35,709,941 bp
  • A to G, chromosome 2 at 36,786,891 bp
  • A to T, chromosome 2 at 88,818,099 bp
  • T to A, chromosome 2 at 91,987,086 bp
  • T to C, chromosome 3 at 38,107,801 bp
  • G to C, chromosome 3 at 88,326,644 bp
  • A to G, chromosome 3 at 152,214,851 bp
  • G to T, chromosome 4 at 87,011,706 bp
  • A to G, chromosome 4 at 109,066,167 bp
  • A to T, chromosome 4 at 141,395,158 bp
  • A to G, chromosome 5 at 34,351,339 bp
  • G to A, chromosome 5 at 66,364,995 bp
  • A to G, chromosome 5 at 90,507,905 bp
  • A to G, chromosome 6 at 23,016,215 bp
  • C to T, chromosome 7 at 15,979,424 bp
  • A to T, chromosome 7 at 30,506,479 bp
  • T to C, chromosome 7 at 49,632,536 bp
  • G to A, chromosome 7 at 104,068,407 bp
  • T to A, chromosome 8 at 72,100,078 bp
  • T to A, chromosome 8 at 80,615,914 bp
  • G to C, chromosome 8 at 120,572,329 bp
  • G to A, chromosome 9 at 39,820,094 bp
  • T to C, chromosome 9 at 53,583,510 bp
  • G to A, chromosome 9 at 98,865,130 bp
  • T to G, chromosome 9 at 103,479,866 bp
  • G to A, chromosome 10 at 40,849,813 bp
  • T to C, chromosome 10 at 79,827,956 bp
  • T to C, chromosome 11 at 29,854,187 bp
  • C to T, chromosome 11 at 85,543,945 bp
  • T to C, chromosome 11 at 96,916,085 bp
  • T to C, chromosome 11 at 99,366,824 bp
  • G to T, chromosome 13 at 19,352,336 bp
  • G to T, chromosome 14 at 16,409,966 bp
  • G to A, chromosome 15 at 9,361,618 bp
  • A to G, chromosome 15 at 44,568,324 bp
  • T to C, chromosome 15 at 47,590,779 bp
  • C to A, chromosome 15 at 66,681,813 bp
  • T to C, chromosome 16 at 21,921,671 bp
  • A to G, chromosome 16 at 69,857,941 bp
  • C to A, chromosome 19 at 25,086,207 bp
  • A to G, chromosome Y at 5,045,992 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5035 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042626-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.