Strain Name:
C57BL/6J-MtgxR5043Btlr/Mmmh
Stock Number:
042633-MU
Citation ID:
RRID:MMRRC_042633-MU
Other Names:
R5043 (G1), C57BL/6J-MtgxR5043Btlr
Major Collection:

Gene Information

Snx1
Name: sorting nexin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 56440
Homologene: 99716
Utp20
Name: UTP20 small subunit processome component
Synonyms: DRIM, 3830408P06Rik, mDRIM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 70683
VEGA: 10
Homologene: 38373
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 208440
Homologene: 40996
Nisch
Name: nischarin
Synonyms: 1200007D05Rik, 3202002H23Rik, edsn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 64652
Homologene: 136161
Zfp609
Name: zinc finger protein 609
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 214812
Homologene: 72220
Yeats2
Name: YEATS domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 208146
VEGA: 16
Homologene: 9967
Skil
Name: SKI-like
Synonyms: sno-dE3, SnoN, Skir, 9130011J04Rik, SnoN2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20482
Homologene: 3948
Cct6a
Name: chaperonin containing Tcp1, subunit 6a (zeta)
Synonyms: Cct6, chaperonin containing TCP-1, Cctz-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12466
HGNC: HGNC:1620
Homologene: 1336
Akap12
Name: A kinase (PRKA) anchor protein (gravin) 12
Synonyms: Srcs5, SSeCKS, Tsga12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 83397
VEGA: 10
HGNC: HGNC:370
Homologene: 3740
Smg6
Name: Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 103677
Homologene: 23024
Rasa3
Name: RAS p21 protein activator 3
Synonyms: R-Ras gap, GAPIII activator 3, hlb381, GAPIII, Ras GTPase-activating protein III, scat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 19414
Homologene: 7217
Glmp
Name: glycosylated lysosomal membrane protein
Synonyms: 0610031J06Rik, NCU-G1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56700
Homologene: 10562
Srpk2
Name: serine/arginine-rich protein specific kinase 2
Synonyms: mSRPK2, WBP6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 20817
Homologene: 101663
Cp
Name: ceruloplasmin
Synonyms: D3Ertd555e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12870
HGNC: HGNC:2295
Homologene: 75
Capg
Name: capping protein (actin filament), gelsolin-like
Synonyms: mbh1, gCap39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12332
HGNC: HGNC:1474
Homologene: 37523
Olfr354
Name: olfactory receptor 354
Synonyms: MOR127-4, GA_x6K02T2NLDC-33601476-33602429
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258941
Homologene: 17443
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Dnahc12, HL-19, DLP12, HL19, DHC3, 4921531P07Rik, Hdhc3, Dnahc7l, LOC380889
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Art3
Name: ADP-ribosyltransferase 3
Synonyms: 4930569O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 109979
HGNC: HGNC:725
Homologene: 911
Arhgap29
Name: Rho GTPase activating protein 29
Synonyms: Parg1, C76601, B130017I01Rik, 6720461J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 214137
Homologene: 3539
Gm12794
Name: predicted gene 12794
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 332923
Slc7a14
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 241919
Homologene: 76320
Ifi206
Name: interferon activated gene 206
Synonyms: Pyblhin-C, Gm4955
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 102639543
HGNC: HGNC:5395
Homologene: 115929
Ugt2b37
Name: UDP glucuronosyltransferase 2 family, polypeptide B37
Synonyms: 0610033E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 112417
Homologene: 137225
Klra2
Name: killer cell lectin-like receptor, subfamily A, member 2
Synonyms: Ly49b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16633
Homologene: 133782
Topaz1
Name: testis and ovary specific PAZ domain containing 1
Synonyms: Gm9524
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 671232
VEGA: 9
Homologene: 19835
Myo5b
Name: myosin VB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Emcn
Name: endomucin
Synonyms: 0610012K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 59308
Homologene: 9438
Dennd3
Name: DENN/MADD domain containing 3
Synonyms: E030003N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105841
Homologene: 28254
Tecpr1
Name: tectonin beta-propeller repeat containing 1
Synonyms: 2210010N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 70381
Homologene: 9120
Ugt2b1
Name: UDP glucuronosyltransferase 2 family, polypeptide B1
Synonyms: 1300012D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71773
Homologene: 68144
Iqcc
Name: IQ motif containing C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230767
Homologene: 49526
Serpinb11
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11
Synonyms: 2310046M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 66957
Homologene: 41653
1700061G19Rik
Name: RIKEN cDNA 1700061G19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 78625
Homologene: 28378
Gabrp
Name: gamma-aminobutyric acid (GABA) A receptor, pi
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216643
HGNC: HGNC:4089
Homologene: 22798
Cntnap3
Name: contactin associated protein-like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 238680
VEGA: 13
Homologene: 129602
Fnip2
Name: folliculin interacting protein 2
Synonyms: D630023B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 329679
Homologene: 46417
Nlrp4c
Name: NLR family, pyrin domain containing 4C
Synonyms: Nalp-alpha, Rnh2, Nalp4c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 83564
Homologene: 75315
1700018F24Rik
Name: RIKEN cDNA 1700018F24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 69396
Homologene: 86127
Gm6483
Name: predicted gene 6483
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 624198
Phlda1
Name: pleckstrin homology like domain, family A, member 1
Synonyms: DT1P1B11, TDAG51, Tdag
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 21664
HGNC: HGNC:8933
Homologene: 7203
Rab36
Name: RAB36, member RAS oncogene family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 76877
HGNC: HGNC:9775
Homologene: 3610
Olfr913
Name: olfactory receptor 913
Synonyms: MOR165-9P, MOR165-10, GA_x6K02T2PVTD-32296575-32297513
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258225
VEGA: 9
Homologene: 79398
Gm5921
Name: predicted gene 5921
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 546164
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 107,369,465 bp
  • A to T, chromosome 1 at 173,486,718 bp
  • A to C, chromosome 2 at 36,906,965 bp
  • T to C, chromosome 3 at 19,973,917 bp
  • C to T, chromosome 3 at 31,097,603 bp
  • T to G, chromosome 3 at 31,237,466 bp
  • A to T, chromosome 3 at 79,492,867 bp
  • T to G, chromosome 3 at 88,326,676 bp
  • A to G, chromosome 3 at 121,974,004 bp
  • A to G, chromosome 3 at 137,391,601 bp
  • T to C, chromosome 4 at 101,940,524 bp
  • T to C, chromosome 4 at 129,618,277 bp
  • T to C, chromosome 5 at 23,524,517 bp
  • C to G, chromosome 5 at 86,917,644 bp
  • C to T, chromosome 5 at 87,251,860 bp
  • T to C, chromosome 5 at 92,363,152 bp
  • T to C, chromosome 5 at 129,845,020 bp
  • T to C, chromosome 5 at 144,197,854 bp
  • T to A, chromosome 5 at 145,044,100 bp
  • T to A, chromosome 6 at 72,558,254 bp
  • T to A, chromosome 6 at 131,220,172 bp
  • A to G, chromosome 7 at 6,066,825 bp
  • G to A, chromosome 8 at 13,570,368 bp
  • A to G, chromosome 8 at 19,693,670 bp
  • A to G, chromosome 9 at 38,594,841 bp
  • T to C, chromosome 9 at 65,700,827 bp
  • C to T, chromosome 9 at 66,097,436 bp
  • C to T, chromosome 9 at 115,438,019 bp
  • A to T, chromosome 9 at 122,748,404 bp
  • G to C, chromosome 10 at 4,355,047 bp
  • G to A, chromosome 10 at 75,051,005 bp
  • A to T, chromosome 10 at 88,798,746 bp
  • T to A, chromosome 10 at 111,507,291 bp
  • T to C, chromosome 11 at 33,568,072 bp
  • T to C, chromosome 11 at 74,929,895 bp
  • G to T, chromosome 13 at 9,551,827 bp
  • A to T, chromosome 13 at 64,794,348 bp
  • C to T, chromosome 14 at 26,884,190 bp
  • A to G, chromosome 14 at 31,176,465 bp
  • T to C, chromosome 15 at 73,527,936 bp
  • A to T, chromosome 16 at 20,208,465 bp
  • A to G, chromosome 17 at 56,885,198 bp
  • T to C, chromosome 18 at 74,638,153 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5043 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042633-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.