Strain Name:
C57BL/6J-MtgxR5048Btlr/Mmmh
Stock Number:
042638-MU
Citation ID:
RRID:MMRRC_042638-MU
Other Names:
R5048 (G1), C57BL/6J-MtgxR5048Btlr
Major Collection:

Gene Information

Zfp143
Name: zinc finger protein 143
Synonyms: D7Ertd805e, pHZ-1, KRAB14, Zfp79, Zfp80-rs1, Staf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20841
Homologene: 56444
Slit3
Name: slit guidance ligand 3
Synonyms: Slit1, b2b2362.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20564
Homologene: 2303
Clasp1
Name: CLIP associating protein 1
Synonyms: 5730583A19Rik, 1700030C23Rik, mCLASP1, CLASP1alpha, CLASP1, B130045P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76707
Homologene: 41024
St13
Name: suppression of tumorigenicity 13
Synonyms: PRO0786, HSPABP1, SNC6, p48, Hsp70 interacting protein, 3110002K08Rik, 1110007I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70356
Homologene: 2921
Pitpnb
Name: phosphatidylinositol transfer protein, beta
Synonyms: Pitp beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56305
HGNC: HGNC:9002
Homologene: 4533
Msh2
Name: mutS homolog 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17685
HGNC: HGNC:7325
Homologene: 210
Iars
Name: isoleucine-tRNA synthetase
Synonyms: E430001P04Rik, 2510016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105148
HGNC: HGNC:5330
Homologene: 5325
Rab11fip3
Name: RAB11 family interacting protein 3 (class II)
Synonyms: Rab11-FIP3, D030060O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 215445
Homologene: 49396
Pdcd11
Name: programmed cell death 11
Synonyms: ALG-4, 1110021I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18572
VEGA: 19
Homologene: 74968
Slc30a5
Name: solute carrier family 30 (zinc transporter), member 5
Synonyms: Zntl1, ZnT-5, ZTL1, 1810010K08Rik, Znt5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69048
VEGA: 13
Homologene: 41503
Psmg1
Name: proteasome (prosome, macropain) assembly chaperone 1
Synonyms: Dscr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 56088
HGNC: HGNC:3043
Homologene: 2759
Abhd5
Name: abhydrolase domain containing 5
Synonyms: NCIE2, IECN5, 1300003D03Rik, 2010002J10Rik, CGI-58
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67469
Homologene: 41088
Foxi2
Name: forkhead box I2
Synonyms: B130055A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 270004
Homologene: 18838
Gprc5c
Name: G protein-coupled receptor, family C, group 5, member C
Synonyms: 1110028I06Rik, 3200002M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70355
Homologene: 11099
Nxpe2
Name: neurexophilin and PC-esterase domain family, member 2
Synonyms: 4432416J03Rik, Fam55b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78252
Homologene: 87072
Amotl2
Name: angiomotin-like 2
Synonyms: Lccp, MASCOT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56332
Homologene: 9420
Tmtc1
Name: transmembrane and tetratricopeptide repeat containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387314
Homologene: 65299
Ccdc85c
Name: coiled-coil domain containing 85C
Synonyms: Gm9010, hhy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 668158
VEGA: 12
Homologene: 82238
Uncx
Name: UNC homeobox
Synonyms: Chx4, Uncx4.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22255
Homologene: 56598
Mfng
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Synonyms: manic fringe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17305
HGNC: HGNC:7038
Homologene: 1803
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77505
Homologene: 131117
Zfp287
Name: zinc finger protein 287
Synonyms: SKAT-2, B230333C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 170740
Homologene: 23244
Itga4
Name: integrin alpha 4
Synonyms: VLA-4 receptor, alpha 4 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16401
HGNC: HGNC:6140
Homologene: 37364
Emilin2
Name: elastin microfibril interfacer 2
Synonyms: basilin, FOAP-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 246707
VEGA: 17
Homologene: 36483
Fhad1
Name: forkhead-associated (FHA) phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329977
Homologene: 77947
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Aste1
Name: asteroid homolog 1
Synonyms: 1100001A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66595
Homologene: 130666
Abcb11
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11
Synonyms: PFIC2, ABC16, PGY4, Lith1, sister of P-glycoprotein, Bsep
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27413
HGNC: HGNC:42
Homologene: 74509
Aox1
Name: aldehyde oxidase 1
Synonyms: retinal oxidase, Aox-1, Aox-2, Aox2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
Vmn2r75
Name: vomeronasal 2, receptor 75
Synonyms: EG546981
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 546981
Homologene: 115466
Atg4b
Name: autophagy related 4B, cysteine peptidase
Synonyms: Apg4b, 2510009N07Rik, autophagin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66615
Homologene: 100868
Megf8
Name: multiple EGF-like-domains 8
Synonyms: Egfl4, b2b288Clo, b2b1702Clo, m687Ddg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269878
HGNC: HGNC:3233
Homologene: 15988
Shkbp1
Name: Sh3kbp1 binding protein 1
Synonyms: SB1, B930062H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 192192
Homologene: 26700
Tns4
Name: tensin 4
Synonyms: 9930017A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217169
Homologene: 13147
Nlrp10
Name: NLR family, pyrin domain containing 10
Synonyms: 6430548I20Rik, Pynod, Nalp10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244202
Homologene: 18468
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
Mgarp
Name: mitochondria localized glutamic acid rich protein
Synonyms: Osap, 4930583H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67749
Homologene: 49858
Msh5
Name: mutS homolog 5
Synonyms: G7, Mut5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17687
HGNC: HGNC:7328
Homologene: 8415
Lilra6
Name: leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
Synonyms: 7M1, Pira3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18726
HGNC: HGNC:6609
Homologene: 134028
Gm9934
Name: predicted gene 9934
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Dok1
Name: docking protein 1
Synonyms: p62DOK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13448
HGNC: HGNC:2990
Homologene: 1057
Majin
Name: membrane anchored junction protein
Synonyms: 1700123I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 622554
Homologene: 78163
Slc6a17
Name: solute carrier family 6 (neurotransmitter transporter), member 17
Synonyms: D130012J15Rik, NTT4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229706
Homologene: 27775
Acadsb
Name: acyl-Coenzyme A dehydrogenase, short/branched chain
Synonyms: 1300003O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66885
HGNC: HGNC:91
Homologene: 1216
Or5w16
Name: olfactory receptor family 5 subfamily W member 16
Synonyms: GA_x6K02T2Q125-49250025-49250960, MOR177-6, Olfr1140
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258635
Homologene: 74081
Stoml3
Name: stomatin (Epb7.2)-like 3
Synonyms: SRO, SLP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229277
Homologene: 16628
Nemp1
Name: nuclear envelope integral membrane protein 1
Synonyms: Tmem194
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 210035
Homologene: 18346
Gje1
Name: gap junction protein, epsilon 1
Synonyms: AEY12, connexin 23, Cx23, D230044M03Rik, Gsfaey12, Gjf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76743
Homologene: 87405
Defb10
Name: defensin beta 10
Synonyms: Defb7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 246085
Or4c106
Name: olfactory receptor family 4 subfamily C member 106
Synonyms: GA_x6K02T2Q125-50322618-50323547, MOR232-6, Olfr1204
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258455
Homologene: 133021
Gm6401
Name: predicted gene 6401
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 115486427
Prox2
Name: prospero homeobox 2
Synonyms: 1700058C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73422
Homologene: 18421
Dhrs9
Name: dehydrogenase/reductase (SDR family) member 9
Synonyms: C730025I08Rik, Rdh15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241452
Homologene: 26079
Pigb
Name: phosphatidylinositol glycan anchor biosynthesis, class B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 55981
HGNC: HGNC:8959
Homologene: 3570
Gm38394
Name: predicted gene, 38394
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Igkv4-79
Name: immunoglobulin kappa variable 4-79
Synonyms: LOC213684, IgVk ae4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 213684
Gm26635
Name: predicted gene, 26635
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Btnl5-ps
Name: butyrophilin-like 5, pseudogene
Synonyms: NG12, ENSMUSG00000073420, Btnl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 81497
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 58,059,482 bp
  • T to C, chromosome 1 at 93,775,658 bp
  • A to G, chromosome 1 at 118,547,610 bp
  • T to C, chromosome 1 at 133,658,724 bp
  • T to C, chromosome 2 at 69,308,506 bp
  • T to C, chromosome 2 at 69,394,400 bp
  • C to A, chromosome 2 at 79,273,034 bp
  • C to A, chromosome 2 at 82,993,150 bp
  • C to A, chromosome 2 at 87,746,319 bp
  • T to C, chromosome 2 at 88,852,463 bp
  • G to A, chromosome 3 at 51,391,286 bp
  • A to C, chromosome 3 at 53,500,792 bp
  • A to T, chromosome 3 at 107,471,437 bp
  • T to C, chromosome 4 at 141,964,676 bp
  • T to C, chromosome 5 at 111,383,003 bp
  • C to T, chromosome 5 at 139,547,119 bp
  • G to A, chromosome 6 at 3,374,157 bp
  • T to C, chromosome 6 at 69,042,987 bp
  • T to A, chromosome 6 at 83,032,106 bp
  • A to T, chromosome 6 at 148,237,846 bp
  • C to T, chromosome 7 at 3,915,441 bp
  • A to G, chromosome 7 at 25,331,092 bp
  • G to A, chromosome 7 at 27,352,096 bp
  • G to A, chromosome 7 at 86,165,527 bp
  • A to G, chromosome 7 at 93,079,939 bp
  • G to C, chromosome 7 at 105,693,697 bp
  • A to T, chromosome 7 at 108,924,565 bp
  • A to G, chromosome 7 at 110,074,118 bp
  • G to A, chromosome 7 at 131,437,469 bp
  • A to G, chromosome 7 at 135,411,635 bp
  • G to A, chromosome 8 at 21,861,871 bp
  • T to C, chromosome 9 at 48,326,088 bp
  • T to A, chromosome 9 at 73,029,708 bp
  • A to G, chromosome 9 at 102,723,798 bp
  • C to T, chromosome 9 at 105,396,989 bp
  • T to C, chromosome 9 at 122,377,903 bp
  • T to C, chromosome 10 at 14,717,277 bp
  • T to C, chromosome 10 at 127,690,935 bp
  • T to C, chromosome 11 at 35,588,985 bp
  • T to C, chromosome 11 at 62,714,951 bp
  • T to G, chromosome 11 at 99,078,779 bp
  • T to C, chromosome 11 at 114,870,351 bp
  • A to T, chromosome 12 at 85,094,341 bp
  • A to G, chromosome 12 at 108,221,707 bp
  • T to A, chromosome 13 at 49,688,237 bp
  • C to A, chromosome 13 at 100,806,741 bp
  • T to C, chromosome 14 at 41,967,767 bp
  • C to T, chromosome 15 at 78,764,388 bp
  • G to C, chromosome 15 at 81,399,585 bp
  • C to A, chromosome 16 at 17,258,472 bp
  • T to A, chromosome 16 at 95,983,971 bp
  • A to G, chromosome 17 at 26,067,580 bp
  • T to A, chromosome 17 at 34,488,723 bp
  • C to T, chromosome 17 at 35,046,027 bp
  • G to A, chromosome 17 at 71,273,967 bp
  • T to C, chromosome 17 at 87,672,768 bp
  • C to A, chromosome 19 at 6,222,654 bp
  • C to A, chromosome 19 at 47,107,115 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5048 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042638-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.