Strain Name:
C57BL/6J-MtgxR5078Btlr/Mmmh
Stock Number:
042667-MU
Citation ID:
RRID:MMRRC_042667-MU
Other Names:
R5078 (G1), C57BL/6J-MtgxR5078Btlr
Major Collection:

Gene Information

Ank2
Name: ankyrin 2, brain
Synonyms: Ankyrin-2, Gm4392, Ank-2, ankyrin B, Ankyrin-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 109676
HGNC: HGNC:493
Homologene: null
Adcy9
Name: adenylate cyclase 9
Synonyms: ACtp10, D16Wsu65e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 11515
HGNC: HGNC:240
Homologene: 868
Dlg1
Name: discs large MAGUK scaffold protein 1
Synonyms: Dlgh1, B130052P05Rik, SAP97
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 13383
HGNC: HGNC:2900
Homologene: 20869
Cdk19
Name: cyclin-dependent kinase 19
Synonyms: Cdc2l6, 2700084L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 78334
VEGA: 10
Homologene: 22862
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: D230004K18Rik, b2b1625.2Clo, Gp330, Megalin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Chd1
Name: chromodomain helicase DNA binding protein 1
Synonyms: 4930525N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 12648
HGNC: HGNC:1915
Homologene: 68174
Sec24d
Name: Sec24 related gene family, member D (S. cerevisiae)
Synonyms: LOC383951, 2310020L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 69608
Homologene: 40986
Auts2
Name: autism susceptibility candidate 2
Synonyms: 2700063G02Rik, D830032G16Rik, A730011F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 319974
Homologene: 22907
Cabin1
Name: calcineurin binding protein 1
Synonyms: Cain, Ppp3in, A330070M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 104248
VEGA: 10
Homologene: 49307
Helz
Name: helicase with zinc finger domain
Synonyms: 3110078M01Rik, 9430093I07Rik, 9630002H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 78455
Homologene: 8918
Kif18a
Name: kinesin family member 18A
Synonyms: gcd2, B130001M12Rik, N-8 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228421
Homologene: 41820
Rasa2
Name: RAS p21 protein activator 2
Synonyms: 5430433H21Rik, GAP1m
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 114713
HGNC: HGNC:9872
Homologene: 4745
Ripk1
Name: receptor (TNFRSF)-interacting serine-threonine kinase 1
Synonyms: Rip1, Rinp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 19766
Homologene: 2820
Prpf31
Name: pre-mRNA processing factor 31
Synonyms: 1500019O16Rik, 2810404O06Rik, RP11, PRP31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 68988
Homologene: 5980
Rnd2
Name: Rho family GTPase 2
Synonyms: Rohn, Arhn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11858
Homologene: 21123
Camkv
Name: CaM kinase-like vesicle-associated
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235604
Homologene: 56983
Nxn
Name: nucleoredoxin
Synonyms: l11Jus13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18230
Homologene: 69028
Dsg2
Name: desmoglein 2
Synonyms: D18Ertd293e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 13511
HGNC: HGNC:3049
Homologene: 1464
Selenot
Name: selenoprotein T
Synonyms: Selt, 5730408P04Rik, SelT, 2810407C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 69227
Homologene: 32304
Bicra
Name: BRD4 interacting chromatin remodeling complex associated protein
Synonyms: Gltscr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243842
HGNC: HGNC:4332
Homologene: 9250
Ice1
Name: interactor of little elongation complex ELL subunit 1
Synonyms: BC018507
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218333
VEGA: 13
Homologene: 18902
Prom2
Name: prominin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 192212
Homologene: 44536
Zic5
Name: zinc finger protein of the cerebellum 5
Synonyms: 1700049L20Rik, odd-paired related, Opr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 65100
Homologene: 11301
Pnp
Name: purine-nucleoside phosphorylase
Synonyms: Pnp1, Pnp, Np, Np-2, Np-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 18950
HGNC: HGNC:7892
Homologene: 227
Egln3
Name: egl-9 family hypoxia-inducible factor 3
Synonyms: Hif-p4h-3, SM-20, 2610021G09Rik, Phd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 112407
Homologene: 32531
Ropn1
Name: ropporin, rhophilin associated protein 1
Synonyms: RHPNAP1, ODF6, 1700008N21Rik, ropporin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 76378
Homologene: 57119
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: Fam38b, Piezo2, 9030411M15Rik, Fam38b2, 9430028L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 667742
Homologene: 49695
Ccser1
Name: coiled-coil serine rich 1
Synonyms: Fam190a, 6230405M12Rik, C130092O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232035
Homologene: 28086
Cerkl
Name: ceramide kinase-like
Synonyms: Rp26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228094
Homologene: 52396
Stard7
Name: START domain containing 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 99138
Homologene: 32463
Col4a2
Name: collagen, type IV, alpha 2
Synonyms: Col4a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 12827
HGNC: HGNC:2203
Homologene: 1390
Pcnx2
Name: pecanex homolog 2
Synonyms: E330039K12Rik, Pcnxl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Ccdc178
Name: coiled coil domain containing 178
Synonyms: 4921528I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 70950
VEGA: 18
Homologene: 12373
Phldb2
Name: pleckstrin homology like domain, family B, member 2
Synonyms: LL5beta, LL5b, C820004H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 208177
Homologene: 17100
Gpx5
Name: glutathione peroxidase 5
Synonyms: Arep
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 14780
HGNC: HGNC:4557
Homologene: 1155
Vmn2r117
Name: vomeronasal 2, receptor 117
Synonyms: EG619788, V2Rp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 619788
HGNC: null
Homologene: 86604
Klhl29
Name: kelch-like 29
Synonyms: A230106N14Rik, Kbtbd9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 208439
VEGA: 12
Homologene: 66272
Lrfn5
Name: leucine rich repeat and fibronectin type III domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238205
Homologene: 17582
Gmnc
Name: geminin coiled-coil domain containing
Synonyms: LOC385639, Gm606, LOC239789
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 239789
VEGA: 16
Homologene: 79940
Gm11568
Name: predicted gene 11568
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 432600
HGNC: null
Homologene: null
Adgrf2
Name: adhesion G protein-coupled receptor F2
Synonyms: Gpr111, PGR20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 435529
Homologene: 45213
Tll1
Name: tolloid-like
Synonyms: Tll-1, b2b2476Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 21892
Homologene: 49202
Prss27
Name: protease, serine 27
Synonyms: marapsin, CAPH2, Mpn, Pancreasin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 213171
Homologene: 23743
Tlx1
Name: T cell leukemia, homeobox 1
Synonyms: Hox11, Hox-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 21908
HGNC: HGNC:5056
Homologene: 4031
Olfr1165-ps
Name: olfactory receptor 1165, pseudogene
Synonyms: MOR174-7, GA_x6K02T2Q125-49593880-49592930
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258642
HGNC: null
Homologene: null
Rps23
Name: ribosomal protein S23
Synonyms: 2410044J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 66475
VEGA: 13
Homologene: 799
Gm13991
Name: predicted gene 13991
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 433464
HGNC: null
Homologene: null
Zmynd12
Name: zinc finger, MYND domain containing 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 332934
Homologene: 12993
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 69,501,530 bp
  • T to A, chromosome 2 at 79,393,008 bp
  • T to A, chromosome 2 at 88,101,535 bp
  • T to C, chromosome 2 at 109,295,142 bp
  • T to C, chromosome 2 at 116,527,874 bp
  • T to C, chromosome 2 at 127,295,552 bp
  • T to C, chromosome 2 at 127,531,837 bp
  • C to T, chromosome 3 at 58,585,271 bp
  • A to G, chromosome 3 at 123,290,552 bp
  • A to G, chromosome 3 at 126,942,353 bp
  • A to G, chromosome 4 at 119,444,850 bp
  • T to C, chromosome 5 at 132,258,947 bp
  • G to A, chromosome 6 at 61,311,366 bp
  • T to C, chromosome 7 at 3,634,703 bp
  • T to C, chromosome 7 at 15,975,457 bp
  • T to C, chromosome 8 at 11,443,936 bp
  • T to C, chromosome 8 at 64,093,887 bp
  • T to C, chromosome 8 at 125,752,156 bp
  • T to C, chromosome 9 at 96,571,904 bp
  • T to C, chromosome 9 at 107,945,373 bp
  • A to G, chromosome 10 at 40,436,154 bp
  • A to G, chromosome 10 at 75,721,478 bp
  • T to C, chromosome 11 at 76,261,607 bp
  • T to C, chromosome 11 at 99,858,355 bp
  • C to T, chromosome 11 at 101,468,999 bp
  • G to A, chromosome 11 at 107,656,096 bp
  • T to C, chromosome 12 at 5,093,530 bp
  • T to C, chromosome 12 at 54,181,667 bp
  • A to C, chromosome 12 at 61,843,874 bp
  • A to G, chromosome 13 at 21,288,711 bp
  • T to G, chromosome 13 at 34,017,099 bp
  • T to C, chromosome 13 at 70,604,850 bp
  • T to C, chromosome 13 at 90,923,703 bp
  • T to A, chromosome 14 at 50,951,506 bp
  • T to C, chromosome 14 at 122,459,759 bp
  • T to C, chromosome 16 at 4,323,907 bp
  • C to A, chromosome 16 at 26,965,582 bp
  • T to A, chromosome 16 at 31,856,469 bp
  • T to A, chromosome 16 at 34,666,791 bp
  • A to G, chromosome 16 at 45,777,742 bp
  • T to C, chromosome 17 at 15,726,354 bp
  • T to A, chromosome 17 at 23,460,148 bp
  • C to A, chromosome 17 at 24,044,440 bp
  • A to T, chromosome 17 at 42,710,986 bp
  • T to C, chromosome 18 at 20,596,083 bp
  • A to T, chromosome 18 at 22,067,628 bp
  • A to G, chromosome 18 at 63,024,536 bp
  • A to T, chromosome 19 at 45,156,021 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5078 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042667-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.