Strain Name:
C57BL/6J-MtgxR5089Btlr/Mmmh
Stock Number:
042678-MU
Citation ID:
RRID:MMRRC_042678-MU
Other Names:
R5089 (G1), C57BL/6J-MtgxR5089Btlr
Major Collection:

Gene Information

Nfat5
Name: nuclear factor of activated T cells 5
Synonyms: nfatz, TonEBP, B130038B15Rik, OREBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 54446
HGNC: HGNC:7774
Homologene: 4811
Phf20
Name: PHD finger protein 20
Synonyms: 6820402O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228829
Homologene: 9507
Prdm5
Name: PR domain containing 5
Synonyms: 6530401I24Rik, E130112L17Rik, PFM2, 4432417F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70779
HGNC: HGNC:9349
Homologene: 10274
Fzd6
Name: frizzled class receptor 6
Synonyms: Fz6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14368
VEGA: 15
HGNC: HGNC:4044
Homologene: 2617
Ncaph2
Name: non-SMC condensin II complex, subunit H2
Synonyms: 0610010J20Rik, 2610524G04Rik, D15Ertd785e, Kleisin beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 52683
Homologene: 12045
Rangap1
Name: RAN GTPase activating protein 1
Synonyms: Fug1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19387
VEGA: 15
HGNC: HGNC:9854
Homologene: 55700
Larp1
Name: La ribonucleoprotein 1, translational regulator
Synonyms: Larp, 1810024J12Rik, 3110040D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 73158
Homologene: 9089
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: Tweek, FSA, 4932438A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229227
Homologene: 52105
Cct3
Name: chaperonin containing Tcp1, subunit 3 (gamma)
Synonyms: TriC-P5, Cctg, Tcp1-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12462
HGNC: HGNC:1616
Homologene: 4373
Prpf8
Name: pre-mRNA processing factor 8
Synonyms: DBF3/PRP8, Prp8, D11Bwg0410e, Sfprp8l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192159
Homologene: 4706
Kras
Name: Kirsten rat sarcoma viral oncogene homolog
Synonyms: Ki-ras, Kras-2, K-ras, Kras2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16653
HGNC: HGNC:6407
Homologene: 37990
Cluh
Name: clustered mitochondria (cluA/CLU1) homolog
Synonyms: 1300001I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74148
Homologene: 9063
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: nesprin-1, SYNE-1, enaptin165, A330049M09Rik, C130039F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Dhx16
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 16
Synonyms: 2410006N22Rik, DBP2, Ddx16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 69192
HGNC: HGNC:2739
Homologene: 2658
Nat10
Name: N-acetyltransferase 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 98956
Homologene: 6785
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: C530005A01Rik, 6030465E24Rik, spastic paraplegia 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 214585
Homologene: 41614
Crim1
Name: cysteine rich transmembrane BMP regulator 1 (chordin like)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 50766
VEGA: 17
HGNC: HGNC:2359
Homologene: 9510
Cdh9
Name: cadherin 9
Synonyms: T1-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12565
HGNC: HGNC:1768
Homologene: 9450
Yy1
Name: YY1 transcription factor
Synonyms: UCRBP transcription factor, delta transcription factor, NF-E1, Yin Yang 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 22632
Homologene: 2556
Smarcb1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
Synonyms: SNF5/INI1, integrase interactor 1, Baf47, Ini1, Snf5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20587
Homologene: 2310
Rae1
Name: ribonucleic acid export 1
Synonyms: MNRP41, MNRP, 41, D2Ertd342e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66679
HGNC: HGNC:9828
Homologene: 2676
Cdc123
Name: cell division cycle 123
Synonyms: G431001I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 98828
Homologene: 4394
Skor1
Name: SKI family transcriptional corepressor 1
Synonyms: C230094B15Rik, Corl1, Lbxcor1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 207667
Homologene: 18175
Pax7
Name: paired box 7
Synonyms: Pax-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18509
HGNC: HGNC:8621
Homologene: 55665
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: B930001P07Rik, 6330504P12Rik, MLSN2, melastatin 2, LTRPC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
1700019N19Rik
Name: RIKEN cDNA 1700019N19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67507
Homologene: 12147
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229003
Homologene: 14118
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Exoc7
Name: exocyst complex component 7
Synonyms: sec70, 70kDa, Exo70
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53413
Homologene: 41019
Hc
Name: hemolytic complement
Synonyms: C5a, C5, He, Hfib2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
Or4c109
Name: olfactory receptor family 4 subfamily C member 109
Synonyms: GA_x6K02T2Q125-50468705-50467770, MOR233-8, Olfr1214
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258899
Homologene: 73984
Ankhd1
Name: ankyrin repeat and KH domain containing 1
Synonyms: 1110004O12Rik, 9130019P20Rik, 4933432B13Rik, A530027J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 108857
Homologene: 87006
Ddb2
Name: damage specific DNA binding protein 2
Synonyms: p48, 2610043A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 107986
HGNC: HGNC:2718
Homologene: 83
Dthd1
Name: death domain containing 1
Synonyms: Gm17384
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100322896
Homologene: 123510
Slc51a
Name: solute carrier family 51, alpha subunit
Synonyms: OSTalpha, D630035O19Rik, Osta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 106407
Homologene: 44941
Flnc
Name: filamin C, gamma
Synonyms: Fln2, 1110055E19Rik, actin binding protein 280
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Col16a1
Name: collagen, type XVI, alpha 1
Synonyms: [a]1 (XVI) collagen, 2700007F12Rik, A530052M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 107581
HGNC: HGNC:2193
Homologene: 1397
Mpeg1
Name: macrophage expressed gene 1
Synonyms: Mpg-1, MPS1, Perforin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 17476
VEGA: 19
Homologene: 11216
Col5a1
Name: collagen, type V, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12831
HGNC: HGNC:2209
Homologene: 55434
Or2y10
Name: olfactory receptor family 2 subfamily Y member 10
Synonyms: GA_x6K02T2QP88-5871967-5871032, MOR256-66_i, Olfr1380
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 404336
Homologene: 72463
Gm1110
Name: predicted gene 1110
Synonyms: LOC382064
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382064
VEGA: 9
Homologene: 78608
Stk25
Name: serine/threonine kinase 25 (yeast)
Synonyms: Ste20-like, Ysk1, 1500019J11Rik, SOK-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 59041
Homologene: 48428
Sardh
Name: sarcosine dehydrogenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 192166
Homologene: 5149
Serpinb6b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6b
Synonyms: ovalbumin, Spi12, NK13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20708
HGNC: HGNC:8950
Homologene: 22633
Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Synonyms: Gpr49
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14160
HGNC: HGNC:4504
Homologene: 20807
Hoxc5
Name: homeobox C5
Synonyms: Hox-3.4, Hox-6.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 15424
HGNC: HGNC:5127
Homologene: 41296
Il5
Name: interleukin 5
Synonyms: Il-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16191
HGNC: HGNC:6016
Homologene: 679
Ms4a1
Name: membrane-spanning 4-domains, subfamily A, member 1
Synonyms: Ly-44, Cd20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12482
HGNC: HGNC:7315
Homologene: 7259
Crbn
Name: cereblon
Synonyms: 2610203G15Rik, 2900045O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 58799
Homologene: 9461
Adgrf2
Name: adhesion G protein-coupled receptor F2
Synonyms: PGR20, Gpr111
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 435529
Homologene: 45213
Sh2d5
Name: SH2 domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230863
Homologene: 20002
Shfl
Name: shiftless antiviral inhibitor of ribosomal frameshifting
Synonyms: A230050P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319278
Homologene: 10165
Tbc1d12
Name: TBC1D12: TBC1 domain family, member 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 209478
VEGA: 19
Homologene: 50835
Etfa
Name: electron transferring flavoprotein, alpha polypeptide
Synonyms: 2010200I21Rik, D9Ertd394e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110842
HGNC: HGNC:3481
Homologene: 100
Lpcat2
Name: lysophosphatidylcholine acyltransferase 2
Synonyms: Aytl1, lysoPAFAT/LPCAT2, LPCAT2, Aytl1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270084
Homologene: 41201
1700030J22Rik
Name: RIKEN cDNA 1700030J22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69528
Homologene: 51842
Taco1
Name: translational activator of mitochondrially encoded cytochrome c oxidase I
Synonyms: 2310066I18Rik, Ccdc44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70207
Homologene: 39079
Gpr157
Name: G protein-coupled receptor 157
Synonyms: F730108M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269604
Homologene: 18573
Iah1
Name: isoamyl acetate-hydrolyzing esterase 1 homolog
Synonyms: 1500019E20Rik, 4833421E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 67732
VEGA: 12
Homologene: 41674
Gm7676
Name: predicted gene 7676
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 665536
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 90,794,179 bp
  • T to A, chromosome 1 at 93,624,608 bp
  • T to C, chromosome 2 at 5,805,000 bp
  • A to G, chromosome 2 at 27,239,613 bp
  • G to A, chromosome 2 at 28,018,602 bp
  • T to C, chromosome 2 at 35,024,890 bp
  • A to G, chromosome 2 at 88,988,172 bp
  • T to C, chromosome 2 at 91,211,922 bp
  • A to T, chromosome 2 at 103,757,143 bp
  • A to T, chromosome 2 at 122,114,717 bp
  • C to A, chromosome 2 at 156,302,862 bp
  • C to A, chromosome 2 at 173,012,755 bp
  • T to C, chromosome 2 at 181,235,149 bp
  • T to A, chromosome 3 at 36,987,502 bp
  • T to G, chromosome 3 at 88,300,843 bp
  • C to T, chromosome 4 at 130,079,195 bp
  • C to T, chromosome 4 at 138,259,086 bp
  • T to C, chromosome 4 at 139,830,265 bp
  • T to C, chromosome 4 at 150,102,293 bp
  • A to G, chromosome 5 at 62,849,905 bp
  • T to C, chromosome 6 at 29,447,813 bp
  • C to T, chromosome 6 at 65,856,090 bp
  • T to C, chromosome 6 at 106,781,718 bp
  • T to C, chromosome 6 at 145,225,143 bp
  • T to C, chromosome 8 at 13,896,401 bp
  • G to A, chromosome 8 at 92,879,443 bp
  • T to A, chromosome 8 at 107,351,438 bp
  • T to C, chromosome 8 at 116,971,933 bp
  • A to T, chromosome 9 at 20,868,916 bp
  • T to A, chromosome 9 at 26,882,387 bp
  • T to A, chromosome 9 at 55,488,866 bp
  • A to G, chromosome 9 at 63,145,923 bp
  • C to T, chromosome 10 at 5,405,444 bp
  • T to C, chromosome 10 at 75,915,179 bp
  • T to C, chromosome 10 at 115,478,423 bp
  • T to A, chromosome 11 at 49,564,413 bp
  • C to T, chromosome 11 at 53,721,828 bp
  • C to A, chromosome 11 at 58,047,867 bp
  • A to G, chromosome 11 at 74,660,372 bp
  • A to G, chromosome 11 at 75,509,228 bp
  • A to T, chromosome 11 at 106,069,611 bp
  • T to A, chromosome 11 at 116,290,264 bp
  • C to T, chromosome 12 at 21,323,308 bp
  • C to A, chromosome 12 at 108,793,737 bp
  • G to A, chromosome 13 at 32,978,150 bp
  • T to A, chromosome 15 at 16,778,276 bp
  • T to A, chromosome 15 at 39,007,480 bp
  • T to A, chromosome 15 at 44,591,887 bp
  • A to C, chromosome 15 at 81,710,463 bp
  • T to A, chromosome 15 at 89,355,945 bp
  • A to T, chromosome 15 at 103,014,055 bp
  • A to G, chromosome 16 at 32,477,546 bp
  • A to T, chromosome 17 at 35,884,089 bp
  • G to A, chromosome 17 at 42,710,097 bp
  • A to G, chromosome 17 at 78,374,090 bp
  • A to T, chromosome 18 at 36,624,564 bp
  • G to A, chromosome 19 at 11,258,812 bp
  • G to A, chromosome 19 at 12,462,997 bp
  • G to A, chromosome 19 at 22,766,756 bp
  • T to A, chromosome 19 at 38,916,788 bp
  • A to T, chromosome 19 at 58,786,246 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5089 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042678-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.