Strain Name:
C57BL/6J-MtgxR5105Btlr/Mmmh
Stock Number:
042693-MU
Citation ID:
RRID:MMRRC_042693-MU
Other Names:
R5105 (G1), C57BL/6J-MtgxR5105Btlr
Major Collection:

Gene Information

Col1a1
Name: collagen, type I, alpha 1
Synonyms: Col1a-1, Mov-13, Cola-1, Cola1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12842
HGNC: HGNC:2197
Homologene: 73874
Sparcl1
Name: SPARC-like 1
Synonyms: Sc1, hevin, mast9, Ecm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13602
Homologene: 3438
Lhx3
Name: LIM homeobox protein 3
Synonyms: P-LIM, mLim-3, Lim3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16871
HGNC: HGNC:6595
Homologene: 7814
Zmym6
Name: zinc finger, MYM-type 6
Synonyms: D4Wsu24e, 9330177P20Rik, Zfp258
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100177
Homologene: 5186
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: 2610509D04Rik, Ggtb3, D5Ertd66e, Bwf1, Bchs, Alfy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72145
Homologene: 22855
Rlf
Name: rearranged L-myc fusion sequence
Synonyms: 9230110M18Rik, MommeD8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109263
Homologene: 8243
Tmem87b
Name: transmembrane protein 87B
Synonyms: 2810431I02Rik, 2610301K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72477
Homologene: 69513
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21, 2610202A04Rik, D16Ium21e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 22129
Homologene: 2487
Eif4b
Name: eukaryotic translation initiation factor 4B
Synonyms: 2310046H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75705
VEGA: 15
HGNC: HGNC:3285
Homologene: 83162
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: MAP1C, dynein heavy chain, retrograde transport, Dnec1, Loa, 9930018I23Rik, Dnchc1, Swl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Dlx6
Name: distal-less homeobox 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13396
HGNC: HGNC:2919
Homologene: 87855
Ccdc92
Name: coiled-coil domain containing 92
Synonyms: D5Bwg0834e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 215707
Homologene: 11848
Camsap1
Name: calmodulin regulated spectrin-associated protein 1
Synonyms: PRO2405, 9530003A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227634
Homologene: 19202
Cep135
Name: centrosomal protein 135
Synonyms: LOC381644, Cep4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381644
Homologene: 45709
Trpv4
Name: transient receptor potential cation channel, subfamily V, member 4
Synonyms: VR-OAC, Trp12, 0610033B08Rik, OTRPC4, VROAC, VRL-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 63873
Homologene: 11003
Kank4
Name: KN motif and ankyrin repeat domains 4
Synonyms: Ankrd38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242553
Homologene: 18244
Ppp3cb
Name: protein phosphatase 3, catalytic subunit, beta isoform
Synonyms: PP2BA beta, Calnb, CnAbeta, 1110063J16Rik, Cnab
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19056
HGNC: HGNC:9315
Homologene: 56429
Lrrc47
Name: leucine rich repeat containing 47
Synonyms: 2900010D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72946
Homologene: 10795
Shisa2
Name: shisa family member 2
Synonyms: 9430059P22Rik, shisa, mShisa, Tmem46, MAd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219134
VEGA: 14
Homologene: 17078
Cep192
Name: centrosomal protein 192
Synonyms: D430014P18Rik, 4631422C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70799
VEGA: 18
Homologene: 73526
A830010M20Rik
Name: RIKEN cDNA A830010M20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231570
VEGA: 5
Homologene: 128318
Gpx3
Name: glutathione peroxidase 3
Synonyms: GPx, plasma GPx, extracellular GPx, EGPx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14778
HGNC: HGNC:4555
Homologene: 20480
Gnao1
Name: guanine nucleotide binding protein, alpha O
Synonyms: Go alpha, alphaO, Galphao
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14681
HGNC: HGNC:4389
Homologene: 39203
Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
Synonyms: mtrp6, Trrp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22068
VEGA: 9
Homologene: 37944
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Sorcs1
Name: sortilin-related VPS10 domain containing receptor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 58178
Homologene: 10967
Siglec1
Name: sialic acid binding Ig-like lectin 1, sialoadhesin
Synonyms: CD169, Siglec-1, Sn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20612
Homologene: 124458
Kdm5d
Name: lysine (K)-specific demethylase 5D
Synonyms: Smcy, Jarid1d, HY
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 20592
Homologene: 55838
Pkdrej
Name: polycystin (PKD) family receptor for egg jelly
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18766
VEGA: 15
HGNC: HGNC:9015
Homologene: 4427
Olfr974
Name: olfactory receptor 974
Synonyms: GA_x6K02T2PVTD-33640290-33641222, MOR171-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 259111
VEGA: 9
Homologene: 133680
Flt1
Name: FMS-like tyrosine kinase 1
Synonyms: vascular endothelial growth factor receptor-1, VEGFR-1, VEGFR1, Flt-1, sFlt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14254
HGNC: HGNC:3763
Homologene: 134179
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Dclk1
Name: doublecortin-like kinase 1
Synonyms: CPG16, DCLK, 1700113D08Rik, 2810480F11Rik, Dcl, Click-I, Dcamkl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13175
HGNC: HGNC:2700
Homologene: 130530
Ddhd1
Name: DDHD domain containing 1
Synonyms: 9630061G18Rik, 4921528E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 114874
Homologene: 35221
Psd3
Name: pleckstrin and Sec7 domain containing 3
Synonyms: 4931420C21Rik, EFA6D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234353
Homologene: 87257
Grin2b
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Synonyms: NMDAR2B, NR2B, Nmdar2b, GluRepsilon2, GluN2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14812
HGNC: HGNC:4586
Homologene: 646
Fscb
Name: fibrous sheath CABYR binding protein
Synonyms: EG623046
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 623046
VEGA: 12
Homologene: 136275
Stxbp5l
Name: syntaxin binding protein 5-like
Synonyms: t2md1, LLGL4, A830015P08Rik, insulin level locus 1, tomosyn-2, T2dm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207227
Homologene: 18173
Vmn2r59
Name: vomeronasal 2, receptor 59
Synonyms: EG628444
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 628444
Homologene: 129683
Tcaf3
Name: TRPM8 channel-associated factor 3
Synonyms: Eapa2, Fam115e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 403088
Homologene: 74374
Matn2
Name: matrilin 2
Synonyms: Crtm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17181
VEGA: 15
HGNC: HGNC:6908
Homologene: 20538
Scaf11
Name: SR-related CTD-associated factor 11
Synonyms: 1110061H03Rik, SRRP129, CASP11, SIP1, 2610510E10Rik, Sfrs2ip, Srsf2ip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72193
VEGA: 15
Homologene: 37957
Large1
Name: LARGE xylosyl- and glucuronyltransferase 1
Synonyms: fg, BPFD#36, froggy, enr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16795
HGNC: HGNC:6511
Homologene: 7810
Olfr357
Name: olfactory receptor 357
Synonyms: GA_x6K02T2NLDC-33688556-33689482, MOR138-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258616
HGNC: HGNC:8223
Homologene: 17320
Olfr135
Name: olfactory receptor 135
Synonyms: GA_x6K02T2PSCP-2656648-2657586, MOR256-48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258329
Homologene: 110603
Myo18b
Name: myosin XVIIIb
Synonyms: 4932408L24Rik, 4933411E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74376
Homologene: 53435
Lrriq4
Name: leucine-rich repeats and IQ motif containing 4
Synonyms: 4930558O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68307
Homologene: 12260
Cyp4a12b
Name: cytochrome P450, family 4, subfamily a, polypeptide 12B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13118
Homologene: 134044
Zfp184
Name: zinc finger protein 184 (Kruppel-like)
Synonyms: 4930500C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 193452
Homologene: 113602
Olfr524
Name: olfactory receptor 524
Synonyms: GA_x6K02T2PBJ9-42354580-42353624, MOR103-14P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258055
Homologene: 79347
Gm13734
Name: predicted gene 13734
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 90,798,140 bp
  • A to G, chromosome 2 at 25,940,929 bp
  • TCCTACGGGCCGGCCC to TCC, chromosome 2 at 26,201,423 bp
  • G to A, chromosome 2 at 36,997,457 bp
  • A to G, chromosome 2 at 87,136,210 bp
  • T to C, chromosome 2 at 128,831,589 bp
  • T to A, chromosome 2 at 131,080,400 bp
  • T to C, chromosome 3 at 30,650,483 bp
  • T to G, chromosome 3 at 55,255,939 bp
  • A to T, chromosome 4 at 98,779,159 bp
  • T to C, chromosome 4 at 115,433,761 bp
  • G to A, chromosome 4 at 121,150,367 bp
  • A to G, chromosome 4 at 127,123,758 bp
  • A to G, chromosome 4 at 154,012,216 bp
  • T to C, chromosome 5 at 76,594,092 bp
  • A to G, chromosome 5 at 101,855,549 bp
  • C to T, chromosome 5 at 104,085,763 bp
  • T to G, chromosome 5 at 107,510,471 bp
  • T to A, chromosome 5 at 112,840,778 bp
  • T to A, chromosome 5 at 114,626,920 bp
  • A to G, chromosome 5 at 124,811,482 bp
  • G to A, chromosome 5 at 124,835,794 bp
  • C to T, chromosome 5 at 147,699,882 bp
  • AGG to AG, chromosome 6 at 6,865,180 bp
  • A to G, chromosome 6 at 42,591,325 bp
  • T to A, chromosome 6 at 135,732,441 bp
  • T to A, chromosome 7 at 42,047,105 bp
  • A to G, chromosome 7 at 140,202,549 bp
  • A to G, chromosome 8 at 67,964,116 bp
  • A to T, chromosome 8 at 72,852,244 bp
  • A to G, chromosome 8 at 93,944,239 bp
  • T to A, chromosome 9 at 8,649,470 bp
  • T to C, chromosome 9 at 39,942,398 bp
  • A to T, chromosome 11 at 54,907,154 bp
  • G to T, chromosome 11 at 94,942,385 bp
  • T to C, chromosome 12 at 64,473,336 bp
  • T to A, chromosome 12 at 110,617,932 bp
  • A to G, chromosome 13 at 21,959,629 bp
  • A to G, chromosome 14 at 20,509,422 bp
  • A to T, chromosome 14 at 45,657,407 bp
  • A to T, chromosome 14 at 59,629,814 bp
  • A to G, chromosome 15 at 34,355,668 bp
  • T to C, chromosome 15 at 85,816,384 bp
  • T to C, chromosome 15 at 96,420,432 bp
  • T to C, chromosome 15 at 102,084,196 bp
  • C to A, chromosome 16 at 37,142,372 bp
  • A to T, chromosome 16 at 94,466,934 bp
  • A to C, chromosome 17 at 38,208,317 bp
  • T to A, chromosome 18 at 67,866,541 bp
  • A to T, chromosome 19 at 50,225,141 bp
  • A to G, chromosome Y at 941,752 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5105 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042693-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.