Strain Name:
C57BL/6J-MtgxR5107Btlr/Mmmh
Stock Number:
042695-MU
Citation ID:
RRID:MMRRC_042695-MU
Other Names:
R5107 (G1), C57BL/6J-MtgxR5107Btlr
Major Collection:

Gene Information

Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: Myhc-b, Myhcb, MYH-beta/slow, beta-MHC, B-MHC, MyHC-I, betaMHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Adgre1
Name: adhesion G protein-coupled receptor E1
Synonyms: F4/80, DD7A5-7, TM7LN3, EGF-TM7, Ly71, Emr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13733
VEGA: 17
HGNC: HGNC:3336
Homologene: 1493
Pmp22
Name: peripheral myelin protein 22
Synonyms: Gas-3, TRE002
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18858
HGNC: HGNC:9118
Homologene: 7482
Ntrk1
Name: neurotrophic tyrosine kinase, receptor, type 1
Synonyms: TrkA, Tkr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18211
HGNC: HGNC:8031
Homologene: 1898
Dgat1
Name: diacylglycerol O-acyltransferase 1
Synonyms: D15Ertd23e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13350
HGNC: HGNC:2843
Homologene: 7688
Col18a1
Name: collagen, type XVIII, alpha 1
Synonyms: endostatin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12822
HGNC: HGNC:2195
Homologene: 7673
Kcnq2
Name: potassium voltage-gated channel, subfamily Q, member 2
Synonyms: KQT2, Nmf134
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16536
HGNC: HGNC:6296
Homologene: 26174
Phf3
Name: PHD finger protein 3
Synonyms: 2310061N19Rik, AU020177
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Trim36
Name: tripartite motif-containing 36
Synonyms: D18Wsu100e, Haprin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 28105
VEGA: 18
Homologene: 10275
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Scaper
Name: S phase cyclin A-associated protein in the ER
Synonyms: D530014O03Rik, Zfp291
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244891
VEGA: 9
Homologene: 32488
Pdcd11
Name: programmed cell death 11
Synonyms: ALG-4, 1110021I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18572
VEGA: 19
Homologene: 74968
Pias1
Name: protein inhibitor of activated STAT 1
Synonyms: GBP, 2900068C24Rik, Ddxbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56469
VEGA: 9
HGNC: HGNC:2752
Homologene: 22953
Znhit1
Name: zinc finger, HIT domain containing 1
Synonyms: 2700001K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70103
Homologene: 4630
Tbc1d13
Name: TBC1 domain family, member 13
Synonyms: 2600014A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70296
Homologene: 10068
Rhou
Name: ras homolog family member U
Synonyms: 2310026M05Rik, CDC42L1, WRCH-1, mG28K, WRCH1, Arhu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69581
Homologene: 49663
Isl2
Name: insulin related protein 2 (islet 2)
Synonyms: islet 2, islet-2, 3110001N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 104360
Homologene: 10730
Tmem198b
Name: transmembrane protein 198b
Synonyms: 1110012D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 73827
Homologene: 77634
Angptl2
Name: angiopoietin-like 2
Synonyms: Arp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26360
HGNC: HGNC:490
Homologene: 22695
Ints2
Name: integrator complex subunit 2
Synonyms: 2810417D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70422
Homologene: 10801
Mettl8
Name: methyltransferase like 8
Synonyms: TIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228019
Homologene: 11706
Selenop
Name: selenoprotein P
Synonyms: D15Ucla1, selp, Se-P, Sepp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20363
Homologene: 3945
Ksr2
Name: kinase suppressor of ras 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 333050
Homologene: 45469
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Pik3c2g
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18705
HGNC: HGNC:8973
Homologene: 3362
Pde10a
Name: phosphodiesterase 10A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 23984
HGNC: HGNC:8772
Homologene: 4852
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: A530024P18Rik, 2310008C07Rik, 2310003D02Rik, mXin beta, myomaxin, Cmya3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241431
Homologene: 19388
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242274
Homologene: 10817
Vmn2r19
Name: vomeronasal 2, receptor 19
Synonyms: EG232358
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232358
Homologene: 84037
Olfr109
Name: olfactory receptor 109
Synonyms: MOR250-1, GA_x6K02T2PSCP-1914078-1915022
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258832
Homologene: 12811
Slc26a2
Name: solute carrier family 26 (sulfate transporter), member 2
Synonyms: ST-OB, Dtd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13521
Homologene: 73876
Ikzf3
Name: IKAROS family zinc finger 3
Synonyms: Aiolos, 5830411O07Rik, Zfpn1a3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22780
Homologene: 8269
Ttc23l
Name: tetratricopeptide repeat domain 23-like
Synonyms: 4930401A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75777
Homologene: 44907
Krt4
Name: keratin 4
Synonyms: Krt-2.4, K4, Krt2-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16682
VEGA: 15
HGNC: HGNC:6441
Homologene: 20523
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Stab1
Name: stabilin 1
Synonyms: MS-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 192187
Homologene: 9035
Sema3a
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Synonyms: SemD, semaphorin III, sema III, collapsin-1, Semad
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20346
Homologene: 31358
Wnk4
Name: WNK lysine deficient protein kinase 4
Synonyms: 2010002J11Rik, Prkwnk4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69847
Homologene: 13020
4930486L24Rik
Name: RIKEN cDNA 4930486L24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 214639
VEGA: 13
Homologene: 138410
Clpx
Name: caseinolytic mitochondrial matrix peptidase chaperone subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270166
HGNC: HGNC:2088
Homologene: 4851
Myod1
Name: myogenic differentiation 1
Synonyms: MYF3, MyoD, Myod-1, bHLHc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17927
HGNC: HGNC:7611
Homologene: 7857
Ccdc78
Name: coiled-coil domain containing 78
Synonyms: LOC381146, LOC381077
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381077
VEGA: 17
Homologene: 105408
Prob1
Name: proline rich basic protein 1
Synonyms: LOC381148, Gm1614
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 381148
Homologene: 83773
Slfn8
Name: schlafen 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276950
Homologene: 45432
Agbl5
Name: ATP/GTP binding protein-like 5
Synonyms: 9430057O19Rik, Ccp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231093
Homologene: 11053
Tex47
Name: testis expressed 47
Synonyms: 4921511H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70920
Homologene: 41723
Ubox5
Name: U box domain containing 5
Synonyms: UIP5, 1500010O06Rik, C330018L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 140629
Homologene: 8972
Atp6v1f
Name: ATPase, H+ transporting, lysosomal V1 subunit F
Synonyms: 1110004G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66144
Homologene: 3119
Dnase1l1
Name: deoxyribonuclease 1-like 1
Synonyms: G4.8, Dnl1ll, 2310005K03Rik, Dnase1ll
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 69537
HGNC: HGNC:2957
Homologene: 4896
Gm26909
Name: predicted gene, 26909
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
4930569F06Rik
Name: RIKEN cDNA 4930569F06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Igkv4-54
Name: immunoglobulin kappa chain variable 4-54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 385291
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 30,831,485 bp
  • G to A, chromosome 2 at 30,146,721 bp
  • A to T, chromosome 2 at 33,228,603 bp
  • A to G, chromosome 2 at 67,509,710 bp
  • G to T, chromosome 2 at 67,511,861 bp
  • A to T, chromosome 2 at 70,965,557 bp
  • A to G, chromosome 2 at 76,778,152 bp
  • A to G, chromosome 2 at 76,863,561 bp
  • A to G, chromosome 2 at 130,599,768 bp
  • A to T, chromosome 2 at 181,108,547 bp
  • T to A, chromosome 3 at 86,359,779 bp
  • T to C, chromosome 3 at 87,794,973 bp
  • G to A, chromosome 3 at 158,161,896 bp
  • C to T, chromosome 5 at 7,304,842 bp
  • C to A, chromosome 5 at 13,577,604 bp
  • C to A, chromosome 5 at 30,892,478 bp
  • T to G, chromosome 5 at 116,821,710 bp
  • T to C, chromosome 5 at 117,689,608 bp
  • A to G, chromosome 5 at 136,986,828 bp
  • T to A, chromosome 6 at 29,468,199 bp
  • T to C, chromosome 6 at 69,631,930 bp
  • T to A, chromosome 6 at 123,309,643 bp
  • T to C, chromosome 6 at 139,635,625 bp
  • G to T, chromosome 7 at 46,377,794 bp
  • T to A, chromosome 7 at 141,855,531 bp
  • T to C, chromosome 8 at 22,645,046 bp
  • A to T, chromosome 8 at 123,661,173 bp
  • T to C, chromosome 9 at 55,542,286 bp
  • A to G, chromosome 9 at 55,580,332 bp
  • C to A, chromosome 9 at 62,882,228 bp
  • A to G, chromosome 9 at 65,308,539 bp
  • T to C, chromosome 10 at 77,077,223 bp
  • T to C, chromosome 10 at 128,802,287 bp
  • A to G, chromosome 11 at 63,158,411 bp
  • A to C, chromosome 11 at 83,017,150 bp
  • A to G, chromosome 11 at 86,248,879 bp
  • A to G, chromosome 11 at 98,490,476 bp
  • A to G, chromosome 11 at 101,275,538 bp
  • T to C, chromosome 13 at 60,853,658 bp
  • T to A, chromosome 14 at 31,163,795 bp
  • T to A, chromosome 14 at 54,986,424 bp
  • A to G, chromosome 15 at 3,275,593 bp
  • G to T, chromosome 15 at 10,551,550 bp
  • A to G, chromosome 15 at 76,503,728 bp
  • A to T, chromosome 15 at 101,922,791 bp
  • A to G, chromosome 17 at 8,944,970 bp
  • G to A, chromosome 17 at 25,787,480 bp
  • A to G, chromosome 17 at 37,466,253 bp
  • A to G, chromosome 17 at 57,401,977 bp
  • T to C, chromosome 18 at 35,652,936 bp
  • T to C, chromosome 18 at 46,172,638 bp
  • A to G, chromosome 18 at 61,198,560 bp
  • T to A, chromosome 19 at 47,106,454 bp
  • C to T, chromosome X at 74,277,038 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5107 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042695-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.