Strain Name:
C57BL/6J-MtgxR5116Btlr/Mmmh
Stock Number:
042704-MU
Citation ID:
RRID:MMRRC_042704-MU
Other Names:
R5116 (G1), C57BL/6J-MtgxR5116Btlr
Major Collection:

Gene Information

Adcy10
Name: adenylate cyclase 10
Synonyms: soluble adenylyl cyclase, sAC, 4930431D04Rik, Sacy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 271639
Homologene: 10188
Cdk5rap2
Name: CDK5 regulatory subunit associated protein 2
Synonyms: 2900018K03Rik, an
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 214444
Homologene: 49533
Mrpl47
Name: mitochondrial ribosomal protein L47
Synonyms: CGI-204, NCM1, 4833424P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74600
Homologene: 32475
S100a10
Name: S100 calcium binding protein A10 (calpactin)
Synonyms: Cal1l, CAL12, CLP11, 42C, p10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20194
Homologene: 2228
Itgb3
Name: integrin beta 3
Synonyms: platelet glycoprotein IIIa (GP3A), CD61
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16416
HGNC: HGNC:6156
Homologene: 55444
Pfas
Name: phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)
Synonyms: 4432409B16Rik, Sofa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237823
HGNC: HGNC:8863
Homologene: 5970
Jak1
Name: Janus kinase 1
Synonyms: C130039L05Rik, BAP004
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16451
HGNC: HGNC:6190
Homologene: 1678
Pigr
Name: polymeric immunoglobulin receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18703
HGNC: HGNC:8968
Homologene: 1984
Tnc
Name: tenascin C
Synonyms: Hxb, TN-C, TN, C130033P17Rik, tenascin-C, cytotactin, hexabrachion
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Cckbr
Name: cholecystokinin B receptor
Synonyms: CCK-B/gastrin receptor, CCK2/gastrin, CCK2R, CCKR-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12426
HGNC: HGNC:1571
Homologene: 7258
Pdlim1
Name: PDZ and LIM domain 1 (elfin)
Synonyms: mClim1, CLP36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 54132
HGNC: HGNC:2067
Homologene: 9643
Pnpla7
Name: patatin-like phospholipase domain containing 7
Synonyms: E430013P11Rik, NRE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241274
Homologene: 62431
Dnajc16
Name: DnaJ heat shock protein family (Hsp40) member C16
Synonyms: 2900037O03Rik, 4732437J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 214063
Homologene: 45414
Haus3
Name: HAUS augmin-like complex, subunit 3
Synonyms: D4S43h, D5H4S43, D5H4S43E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231123
Homologene: 75209
Akap6
Name: A kinase (PRKA) anchor protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Smarcd1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Synonyms: Baf60a, D15Kz1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 83797
VEGA: 15
Homologene: 20670
Mx1
Name: MX dynamin-like GTPase 1
Synonyms: myxovirus (influenza) resistance 1 polypeptide, Mx-1, Mx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17857
Pcdhac1
Name: protocadherin alpha subfamily C, 1
Synonyms: CNRc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 353236
HGNC: HGNC:8676
Homologene: 49561
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: PC6, SPC6, PC5A, PC5/6A, b2b585Clo, b2b1549Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Snrk
Name: SNF related kinase
Synonyms: SNRK, 2010012F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20623
Homologene: 9797
Ifi208
Name: interferon activated gene 208
Synonyms: E430029J22Rik, Pydc3, Pyr-rv1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100033459
HGNC: HGNC:5395
Homologene: 115929
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Nlrc5
Name: NLR family, CARD domain containing 5
Synonyms: AI451557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 434341
Homologene: 88935
Abcb9
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 9
Synonyms: TAPL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56325
HGNC: HGNC:50
Homologene: 10491
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Srgap1
Name: SLIT-ROBO Rho GTPase activating protein 1
Synonyms: 4930572H05Rik, Arhgap13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 117600
Homologene: 56898
Capn3
Name: calpain 3
Synonyms: Capa-3, Capa3, Lp82, p94
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12335
HGNC: HGNC:1480
Homologene: 52
Itgad
Name: integrin, alpha D
Synonyms: Cd11d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381924
HGNC: HGNC:6146
Homologene: 56919
Adamts19
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19
Synonyms: D230034E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240322
VEGA: 18
Homologene: 15860
Adam39
Name: a disintegrin and metallopeptidase domain 39
Synonyms: 1700056P18Rik, testase 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 546055
HGNC: HGNC:199
Homologene: 128364
Zfp276
Name: zinc finger protein (C2H2 type) 276
Synonyms: D8Ertd370e, D8Ertd377e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 57247
Homologene: 10731
Cdh24
Name: cadherin-like 24
Synonyms: cadherin 14-like, EY-cadherin, 1700040A22Rik, ENSMUSG00000022188
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239096
VEGA: 14
Homologene: 56951
Pla2r1
Name: phospholipase A2 receptor 1
Synonyms: PLA2-I receptor, M-type receptor, Pla2g1br
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18779
HGNC: HGNC:9042
Homologene: 32016
Odad3
Name: outer dynein arm docking complex subunit 3
Synonyms: Ccdc151, C330001K17Rik, b2b1885Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 77609
VEGA: 9
Homologene: 16533
Tmprss11f
Name: transmembrane protease, serine 11f
Synonyms: 4732406D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243083
Homologene: 65356
Zfp932
Name: zinc finger protein 932
Synonyms: 2310001H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69504
Homologene: 137770
Kif21b
Name: kinesin family member 21B
Synonyms: N-5 kinesin, 2610511N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16565
Homologene: 56868
Alyref
Name: Aly/REF export factor
Synonyms: REF1, Refbp1, Thoc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21681
Homologene: 38099
Clip1
Name: CAP-GLY domain containing linker protein 1
Synonyms: cytoplasmic linker protein 50, Clip50, CLIP-170, 1110007I12Rik, 4631429H07Rik, Rsn, Clip 170, restin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56430
Homologene: 74455
Aldh18a1
Name: aldehyde dehydrogenase 18 family, member A1
Synonyms: 2810433K04Rik, Pycs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56454
HGNC: HGNC:9722
Homologene: 2142
Olfr1156
Name: olfactory receptor 1156
Synonyms: GA_x6K02T2Q125-49433499-49432537, MOR174-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258814
HGNC: HGNC:8351
Homologene: 72031
Fpr-rs3
Name: formyl peptide receptor, related sequence 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14290
Homologene: 130087
Olfr850
Name: olfactory receptor 850
Synonyms: GA_x6K02T2PVTD-13214162-13213224, MOR147-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258516
Homologene: 121552
Immp1l
Name: IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
Synonyms: 2610528O17Rik, 1500034J20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66541
Homologene: 41747
Ccr8
Name: chemokine (C-C motif) receptor 8
Synonyms: Cmkbr8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12776
VEGA: 9
HGNC: HGNC:1609
Homologene: 21080
Tmem19
Name: transmembrane protein 19
Synonyms: 2810428F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67226
VEGA: 10
Homologene: 10107
Cd38
Name: CD38 antigen
Synonyms: Cd38-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12494
HGNC: HGNC:1667
Homologene: 1345
Zswim9
Name: zinc finger SWIM-type containing 9
Synonyms: 6330408A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 321008
Homologene: 52386
Rab11fip5
Name: RAB11 family interacting protein 5 (class I)
Synonyms: 9130206P09Rik, RIP11, GAF1, D6Ertd32e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 52055
Homologene: 9158
Upp2
Name: uridine phosphorylase 2
Synonyms: UDRPASE2, UPASE2, UP2, 1700124F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76654
Homologene: 12654
Catsper4
Name: cation channel, sperm associated 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329954
Homologene: 18638
Slc35f1
Name: solute carrier family 35, member F1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215085
Homologene: 33552
Nde1
Name: nudE neurodevelopment protein 1
Synonyms: 2810027M15Rik, mNudE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67203
Homologene: 32354
Olfr885
Name: olfactory receptor 885
Synonyms: GA_x6K02T2PVTD-31740639-31741568, MOR162-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 257885
Homologene: 79400
Olfr603
Name: olfactory receptor 603
Synonyms: GA_x6K02T2PBJ9-6096387-6095449, GA_x6K02T2PBJ9-6092550-6092362, MOR32-2, MOR32-14_i, Olfr604
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259073
Homologene: 121535
Olfr803
Name: olfactory receptor 803
Synonyms: GA_x6K02T2PULF-11370664-11369738, MOR111-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258547
Homologene: 105153
H1f4
Name: H1.4 linker histone, cluster member
Synonyms: H1s-4, H1e, H1var2, H1-4, H1f4, Hist1h1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 50709
HGNC: HGNC:4718
Homologene: 137314
Trem3
Name: triggering receptor expressed on myeloid cells 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 58218
VEGA: 17
Homologene: 87012
Gm6189
Name: predicted gene 6189
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 620899
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 80,383,973 bp
  • T to A, chromosome 1 at 130,849,031 bp
  • A to G, chromosome 1 at 136,152,783 bp
  • C to A, chromosome 1 at 165,519,500 bp
  • A to G, chromosome 1 at 173,677,983 bp
  • G to T, chromosome 2 at 25,021,970 bp
  • A to G, chromosome 2 at 58,771,542 bp
  • A to C, chromosome 2 at 60,448,906 bp
  • G to A, chromosome 2 at 87,949,529 bp
  • G to A, chromosome 2 at 105,965,295 bp
  • G to T, chromosome 2 at 120,485,292 bp
  • A to G, chromosome 3 at 32,733,601 bp
  • A to G, chromosome 3 at 93,560,940 bp
  • A to G, chromosome 4 at 63,967,215 bp
  • G to T, chromosome 4 at 70,307,238 bp
  • A to G, chromosome 4 at 101,155,113 bp
  • A to T, chromosome 4 at 134,226,680 bp
  • A to T, chromosome 4 at 141,767,969 bp
  • G to T, chromosome 5 at 34,167,539 bp
  • T to C, chromosome 5 at 43,868,962 bp
  • T to C, chromosome 5 at 86,539,696 bp
  • T to A, chromosome 5 at 110,009,376 bp
  • C to T, chromosome 5 at 123,630,707 bp
  • T to C, chromosome 5 at 124,078,867 bp
  • C to T, chromosome 6 at 85,348,807 bp
  • G to A, chromosome 7 at 13,277,319 bp
  • T to C, chromosome 7 at 46,273,767 bp
  • G to A, chromosome 7 at 103,383,864 bp
  • T to A, chromosome 7 at 105,433,655 bp
  • C to A, chromosome 7 at 128,203,893 bp
  • G to T, chromosome 8 at 40,825,001 bp
  • T to C, chromosome 8 at 94,481,860 bp
  • A to G, chromosome 8 at 123,264,977 bp
  • A to G, chromosome 9 at 19,477,798 bp
  • A to G, chromosome 9 at 21,990,128 bp
  • T to C, chromosome 9 at 38,061,338 bp
  • T to C, chromosome 9 at 120,094,029 bp
  • A to G, chromosome 9 at 122,160,330 bp
  • A to T, chromosome 10 at 27,118,560 bp
  • T to C, chromosome 10 at 53,021,895 bp
  • A to T, chromosome 10 at 115,343,746 bp
  • A to G, chromosome 10 at 121,792,379 bp
  • A to G, chromosome 10 at 129,691,397 bp
  • T to C, chromosome 11 at 68,990,990 bp
  • T to C, chromosome 11 at 104,641,077 bp
  • G to T, chromosome 11 at 120,597,728 bp
  • A to G, chromosome 12 at 53,141,515 bp
  • A to T, chromosome 12 at 84,809,737 bp
  • A to G, chromosome 13 at 23,622,287 bp
  • T to C, chromosome 14 at 54,636,413 bp
  • C to T, chromosome 15 at 99,702,488 bp
  • T to A, chromosome 16 at 14,183,487 bp
  • T to G, chromosome 16 at 97,457,479 bp
  • A to G, chromosome 17 at 20,624,300 bp
  • T to C, chromosome 17 at 48,249,552 bp
  • G to A, chromosome 18 at 37,091,447 bp
  • T to C, chromosome 18 at 58,902,994 bp
  • G to A, chromosome 19 at 17,463,434 bp
  • G to A, chromosome 19 at 40,222,612 bp
  • A to G, chromosome 19 at 40,553,505 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5116 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042704-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.