Strain Name:
C57BL/6J-MtgxR5128Btlr/Mmmh
Stock Number:
042716-MU
Citation ID:
RRID:MMRRC_042716-MU
Other Names:
R5128 (G1), C57BL/6J-MtgxR5128Btlr
Major Collection:

Gene Information

Chrna9
Name: cholinergic receptor, nicotinic, alpha polypeptide 9
Synonyms: Acra9, 2410015I05Rik, Gm8311
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231252
Homologene: 9729
Meis1
Name: Meis homeobox 1
Synonyms: C530044H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17268
HGNC: HGNC:7000
Homologene: 86803
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20269
Homologene: 56005
Fgf1
Name: fibroblast growth factor 1
Synonyms: Fgf-1, fibroblast growth factor 1 (acidic), Fgfa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14164
HGNC: HGNC:3665
Homologene: 625
Matk
Name: megakaryocyte-associated tyrosine kinase
Synonyms: Csk homologous kinase, CHK, Ntk, HYL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17179
HGNC: HGNC:6906
Homologene: 48104
Trappc9
Name: trafficking protein particle complex 9
Synonyms: Nibp, 1810044A24Rik, 4632408O18Rik, 2900005P22Rik, TRS130
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76510
VEGA: 15
Homologene: 81931
Pafah1b1
Name: platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
Synonyms: Mdsh, LIS-1, Lis1, PAF-AH 45, Pafaha, lissencephaly-1 protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18472
HGNC: HGNC:8574
Homologene: 371
Anapc1
Name: anaphase promoting complex subunit 1
Synonyms: 2610021O03Rik, Mcpr, Apc1, tsg24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17222
Homologene: 7414
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Pip4k2b
Name: phosphatidylinositol-5-phosphate 4-kinase, type II, beta
Synonyms: c11, PI5P4Kbeta, Pip5k2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108083
HGNC: HGNC:8998
Homologene: 2634
Dcdc2a
Name: doublecortin domain containing 2a
Synonyms: RU2, Dcdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 195208
Homologene: 9483
Zfp451
Name: zinc finger protein 451
Synonyms: 4933435G09Rik, Kiaa0576-hp, 4930515K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98403
Homologene: 9188
Slc12a7
Name: solute carrier family 12, member 7
Synonyms: Kcc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20499
VEGA: 13
Homologene: 21312
Zfp597
Name: zinc finger protein 597
Synonyms: 4933407K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 71063
Homologene: 33641
Palld
Name: palladin, cytoskeletal associated protein
Synonyms: 2410003B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72333
Homologene: 75052
Esco1
Name: establishment of sister chromatid cohesion N-acetyltransferase 1
Synonyms: A930014I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 77805
Homologene: 62166
Vit
Name: vitrin
Synonyms: AKH, 1700110E08Rik, 1700052E02Rik, akhirin, 2810429K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74199
VEGA: 17
Homologene: 24942
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: B230373P09Rik, Dnahc1, E030034C22Rik, MDHC7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Ttc16
Name: tetratricopeptide repeat domain 16
Synonyms: 1200002K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 338348
Homologene: 17011
Tnn
Name: tenascin N
Synonyms: tenascin-W, Tnw
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329278
Homologene: 18634
Entpd5
Name: ectonucleoside triphosphate diphosphohydrolase 5
Synonyms: Cd39l4, NTPDase-5, ER-UDPase, NTPDase5, Pcph, mNTPase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 12499
HGNC: HGNC:3367
Homologene: 37457
Inhbc
Name: inhibin beta-C
Synonyms: activin beta-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16325
VEGA: 10
HGNC: HGNC:6068
Homologene: 21142
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: 2310047C17Rik, DY6, 1110004P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Abcc6
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 6
Synonyms: Mrp6, DCC, Dyscalc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27421
HGNC: HGNC:57
Homologene: 55559
Dgkz
Name: diacylglycerol kinase zeta
Synonyms: E130307B02Rik, mDGK[z]
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 104418
HGNC: HGNC:2857
Homologene: 37831
Mertk
Name: MER proto-oncogene tyrosine kinase
Synonyms: nmf12, Tyro 12, Nyk, Eyk, Mer
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17289
HGNC: HGNC:7027
Homologene: 4626
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: Cchra1, Cav2.3, alpha1E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Grid2
Name: glutamate receptor, ionotropic, delta 2
Synonyms: tpr, GluRdelta2, B230104L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14804
HGNC: HGNC:4576
Homologene: 74399
Ctcfl
Name: CCCTC-binding factor (zinc finger protein)-like
Synonyms: OTTMUSG00000016680, Boris
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 664799
Homologene: 46476
Olfr1247
Name: olfactory receptor 1247
Synonyms: MOR231-6, GA_x6K02T2Q125-51051555-51050611
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258968
Homologene: 121536
Muc3
Name: mucin 3, intestinal
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 666339
Homologene: 141159
Nphp4
Name: nephronophthisis 4 (juvenile) homolog (human)
Synonyms: 4930564O18Rik, nmf192
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 260305
Homologene: 9024
Mtmr10
Name: myotubularin related protein 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233315
Homologene: 9822
Zdhhc1
Name: zinc finger, DHHC domain containing 1
Synonyms: 4432412D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70796
Homologene: 36891
Gm16380
Name: predicted pseudogene 16380
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100038996
VEGA: 9
Dqx1
Name: DEAQ RNA-dependent ATPase
Synonyms: 2310066E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 93838
Homologene: 14143
Olfr143
Name: olfactory receptor 143
Synonyms: K18, MOR170-6, GA_x6K02T2PVTD-31941084-31942025
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258802
Homologene: 133627
Arhgap45
Name: Rho GTPase activating protein 45
Synonyms: Hmha1, 6330406L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70719
Homologene: 69120
A26c3
Name: ANKRD26-like family C, member 3
Synonyms: 4930430A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67575
Homologene: 69410
Olfr330
Name: olfactory receptor 330
Synonyms: GA_x6K02T2NKPP-895420-896349, MOR275-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258879
Homologene: 133015
Alg5
Name: asparagine-linked glycosylation 5 (dolichyl-phosphate beta-glucosyltransferase)
Synonyms: 1500026A19Rik, 2600005J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66248
Homologene: 7060
Nlrp1c-ps
Name: NLR family, pyrin domain containing 1C, pseudogene
Synonyms: OTTMUSG00000006090, Nalp1c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 627984
Mroh9
Name: maestro heat-like repeat family member 9
Synonyms: 4921528O07Rik, Armc11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 78258
Homologene: 123521
Obox8
Name: oocyte specific homeobox 8
Synonyms: Gm5585
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 33,802,933 bp
  • A to C, chromosome 1 at 154,402,021 bp
  • A to T, chromosome 1 at 160,122,894 bp
  • C to G, chromosome 1 at 163,060,760 bp
  • T to A, chromosome 2 at 32,762,997 bp
  • T to C, chromosome 2 at 65,508,518 bp
  • A to T, chromosome 2 at 89,609,303 bp
  • A to G, chromosome 2 at 91,942,683 bp
  • G to A, chromosome 2 at 111,164,329 bp
  • A to G, chromosome 2 at 128,659,917 bp
  • C to A, chromosome 2 at 128,738,247 bp
  • T to C, chromosome 2 at 173,117,396 bp
  • T to A, chromosome 3 at 54,742,137 bp
  • T to A, chromosome 4 at 152,502,991 bp
  • A to G, chromosome 5 at 65,971,222 bp
  • A to G, chromosome 5 at 137,138,186 bp
  • G to A, chromosome 6 at 64,665,998 bp
  • T to C, chromosome 6 at 83,060,567 bp
  • A to G, chromosome 7 at 14,332,090 bp
  • A to G, chromosome 7 at 45,989,646 bp
  • C to T, chromosome 7 at 64,333,439 bp
  • T to C, chromosome 8 at 61,720,588 bp
  • T to A, chromosome 8 at 105,483,636 bp
  • T to C, chromosome 9 at 38,253,570 bp
  • C to T, chromosome 9 at 53,884,113 bp
  • A to G, chromosome 10 at 80,030,959 bp
  • A to G, chromosome 10 at 81,258,500 bp
  • A to T, chromosome 10 at 127,357,742 bp
  • G to A, chromosome 11 at 19,011,323 bp
  • A to T, chromosome 11 at 58,529,422 bp
  • G to T, chromosome 11 at 71,279,595 bp
  • A to G, chromosome 11 at 74,679,436 bp
  • A to G, chromosome 11 at 97,718,876 bp
  • A to T, chromosome 12 at 84,394,690 bp
  • C to A, chromosome 13 at 25,102,529 bp
  • G to T, chromosome 13 at 73,805,433 bp
  • T to C, chromosome 14 at 31,296,195 bp
  • A to G, chromosome 14 at 50,844,279 bp
  • A to T, chromosome 15 at 73,058,393 bp
  • G to A, chromosome 16 at 3,872,124 bp
  • T to C, chromosome 17 at 78,625,146 bp
  • A to T, chromosome 18 at 10,567,468 bp
  • C to A, chromosome 18 at 38,842,025 bp
  • T to C, chromosome 19 at 9,017,087 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5128 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042716-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.