Strain Name:
C57BL/6J-MtgxR5139Btlr/Mmmh
Stock Number:
042725-MU
Citation ID:
RRID:MMRRC_042725-MU
Other Names:
R5139 (G1), C57BL/6J-MtgxR5139Btlr
Major Collection:

Gene Information

Polr2f
Name: polymerase (RNA) II (DNA directed) polypeptide F
Synonyms: 1810060D16Rik, RNA Pol II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 69833
VEGA: 15
HGNC: HGNC:9193
Homologene: 7178
Fryl
Name: FRY like transcription coactivator
Synonyms: 2510002A14Rik, 9030227G01Rik, 2310004H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72313
Homologene: 103956
Hira
Name: histone cell cycle regulator
Synonyms: Tuple1, D16Ertd95e, Gm15797
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15260
HGNC: HGNC:4916
Homologene: 48172
Nbea
Name: neurobeachin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: Bchs, D5Ertd66e, Alfy, 2610509D04Rik, Ggtb3, Bwf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72145
Homologene: 22855
Sfswap
Name: splicing factor SWAP
Synonyms: 1190005N23Rik, Sfrs8, 6330437E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231769
Homologene: 134548
Naa15
Name: N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms: ASTBDN, mNAT1, 5730450D16Rik, tubedown, Tbdn-1, Narg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74838
Homologene: 14211
Ppp6r3
Name: protein phosphatase 6, regulatory subunit 3
Synonyms: Saps3, Pptcs3, D19Ertd703e, D19Bwg1430e, 4930528G08Rik, Pp6r3, 9130026N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 52036
VEGA: 19
HGNC: HGNC:1173
Homologene: 115911
St13
Name: suppression of tumorigenicity 13
Synonyms: 3110002K08Rik, p48, SNC6, Hsp70 interacting protein, HSPABP1, PRO0786, 1110007I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70356
Homologene: 2921
Pdcd11
Name: programmed cell death 11
Synonyms: 1110021I22Rik, ALG-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18572
VEGA: 19
Homologene: 74968
Copa
Name: coatomer protein complex subunit alpha
Synonyms: xenin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12847
HGNC: HGNC:2230
Homologene: 3218
Tesmin
Name: testis expressed metallothionein like
Synonyms: Mtl5, tesmin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 17771
HGNC: HGNC:7446
Homologene: 31275
Polg
Name: polymerase (DNA directed), gamma
Synonyms: Pol gamma, mitochondrial DNA polymerase-gamma, polymerase gamma, mitochondrial DNA polymerase gamma, Polga
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18975
HGNC: HGNC:9179
Homologene: 2016
Trf
Name: transferrin
Synonyms: HP, Tfn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22041
Homologene: 68153
Bnip3l
Name: BCL2/adenovirus E1B interacting protein 3-like
Synonyms: D14Ertd719e, Nip3L, Nix
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12177
HGNC: HGNC:1085
Homologene: 3195
Septin9
Name: septin 9
Synonyms: Sept9, MSF1, SL3-3 integration site 1, Sint1, Msf, PNUTL4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53860
HGNC: HGNC:7323
Homologene: 90949
Appl1
Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Synonyms: 2900057D21Rik, 7330406P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 72993
Homologene: 32143
Qrfprl
Name: pyroglutamylated RFamide peptide receptor like
Synonyms: C130060K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243407
Homologene: 135976
Agtpbp1
Name: ATP/GTP binding protein 1
Synonyms: 2900054O13Rik, 1700020N17Rik, Ccp1, 5730402G09Rik, 2310001G17Rik, atms, 4930445M19Rik, Nna1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67269
Homologene: 9067
Tub
Name: tubby bipartite transcription factor
Synonyms: tub, rd5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22141
Homologene: 31147
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Cmya5
Name: cardiomyopathy associated 5
Synonyms: 2310076E16Rik, 2310076E21Rik, Myospryn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Trpc3
Name: transient receptor potential cation channel, subfamily C, member 3
Synonyms: Trp3, Trcp3, Trrp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 22065
Homologene: 20708
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: Myhs-f, Myhs-f1, MyHC-IIa, MHC2A, Myhsf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Aox1
Name: aldehyde oxidase 1
Synonyms: Aox-2, Aox-1, Aox2, retinal oxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
Tshz3
Name: teashirt zinc finger family member 3
Synonyms: A630038G13Rik, teashirt3, Tsh3, Zfp537
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243931
Homologene: 10835
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 1110004P15Rik, 2310047C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Tcaf3
Name: TRPM8 channel-associated factor 3
Synonyms: Eapa2, Fam115e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 403088
Homologene: 74374
Cckar
Name: cholecystokinin A receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12425
HGNC: HGNC:1570
Homologene: 37337
Aoah
Name: acyloxyacyl hydrolase
Synonyms: 4930433E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 27052
VEGA: 13
HGNC: HGNC:548
Homologene: 1238
Olfr1131
Name: olfactory receptor 1131
Synonyms: GA_x6K02T2Q125-49133664-49134593, MOR177-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258652
Homologene: 133019
Ldhb
Name: lactate dehydrogenase B
Synonyms: H-Ldh, Ldh-2, lactate dehydrogenase-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16832
HGNC: HGNC:6541
Homologene: 55647
Synpo
Name: synaptopodin
Synonyms: 9030217H17Rik, 9330140I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 104027
Homologene: 5274
Mical1
Name: microtubule associated monooxygenase, calponin and LIM domain containing 1
Synonyms: Nical
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 171580
Homologene: 11246
Txndc16
Name: thioredoxin domain containing 16
Synonyms: 5730420B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 70561
Homologene: 18197
Pdlim7
Name: PDZ and LIM domain 7
Synonyms: 1110003B01Rik, Enigma, 2410002J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67399
Homologene: 3980
Prl8a1
Name: prolactin family 8, subfamily a, member 1
Synonyms: Plpcd, PLP-Cd, 1600017L04Rik, Prlpc4, 3830403L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 73244
2510039O18Rik
Name: RIKEN cDNA 2510039O18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77034
Homologene: 12668
Ighv3-8
Name: immunoglobulin heavy variable V3-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 780831
Cox7b2
Name: cytochrome c oxidase subunit 7B2
Synonyms: 4930503B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 78174
Homologene: 130780
Smad9
Name: SMAD family member 9
Synonyms: MADH6, SMAD8B, SMAD8A, Madh9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 55994
HGNC: HGNC:6774
Homologene: 21198
BC035947
Name: cDNA sequence BC035947
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Lce3c
Name: late cornified envelope 3C
Synonyms: Sprrl1, Eig3, 2300007B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 94060
Homologene: 137425
Zfp853
Name: zinc finger protein 853
Synonyms: LOC330230
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330230
Ccl24
Name: chemokine (C-C motif) ligand 24
Synonyms: eotaxin-2, Scya24, CKb-6, MPIF-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56221
Homologene: 2248
Igkv4-70
Name: immunoglobulin kappa chain variable 4-70
Synonyms: Gm1502, LOC385120
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 385120
Gm5215
Name: predicted gene 5215
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 383032
VEGA: 15
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 58,061,297 bp
  • T to C, chromosome 1 at 78,499,247 bp
  • C to T, chromosome 1 at 172,121,329 bp
  • C to A, chromosome 2 at 87,628,656 bp
  • A to T, chromosome 3 at 36,671,557 bp
  • T to A, chromosome 3 at 51,443,840 bp
  • T to G, chromosome 3 at 54,797,406 bp
  • T to A, chromosome 3 at 55,626,963 bp
  • G to A, chromosome 3 at 92,945,471 bp
  • T to C, chromosome 4 at 147,945,448 bp
  • T to C, chromosome 5 at 53,702,923 bp
  • A to G, chromosome 5 at 71,443,091 bp
  • A to G, chromosome 5 at 73,090,718 bp
  • A to T, chromosome 5 at 101,849,267 bp
  • T to C, chromosome 5 at 124,798,960 bp
  • T to G, chromosome 5 at 129,571,009 bp
  • C to T, chromosome 5 at 135,572,921 bp
  • T to C, chromosome 5 at 143,288,815 bp
  • A to G, chromosome 6 at 42,596,933 bp
  • A to T, chromosome 6 at 65,456,219 bp
  • G to A, chromosome 6 at 69,268,105 bp
  • A to T, chromosome 6 at 142,494,195 bp
  • C to T, chromosome 7 at 36,771,025 bp
  • T to C, chromosome 7 at 79,450,025 bp
  • T to A, chromosome 7 at 109,011,102 bp
  • C to T, chromosome 9 at 103,222,934 bp
  • T to A, chromosome 10 at 41,478,415 bp
  • T to C, chromosome 11 at 67,179,348 bp
  • A to G, chromosome 11 at 117,356,685 bp
  • T to C, chromosome 12 at 114,322,374 bp
  • T to C, chromosome 13 at 21,023,237 bp
  • T to A, chromosome 13 at 27,574,066 bp
  • A to G, chromosome 13 at 55,507,056 bp
  • A to G, chromosome 13 at 59,500,213 bp
  • A to G, chromosome 13 at 93,096,061 bp
  • A to G, chromosome 14 at 26,947,155 bp
  • A to G, chromosome 14 at 45,213,495 bp
  • A to G, chromosome 14 at 66,999,615 bp
  • C to T, chromosome 15 at 54,312,292 bp
  • C to A, chromosome 15 at 79,151,658 bp
  • G to C, chromosome 15 at 81,399,585 bp
  • T to C, chromosome 16 at 18,954,758 bp
  • C to T, chromosome 18 at 60,595,813 bp
  • A to G, chromosome 19 at 3,406,934 bp
  • A to C, chromosome 19 at 3,464,610 bp
  • A to C, chromosome 19 at 9,004,655 bp
  • C to A, chromosome 19 at 47,107,115 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5139 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042725-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.