Strain Name:
C57BL/6J-MtgxR5157Btlr/Mmmh
Stock Number:
042739-MU
Citation ID:
RRID:MMRRC_042739-MU
Other Names:
R5157 (G1), C57BL/6J-MtgxR5157Btlr
Major Collection:

Strain Information

Ap4e1
Name: adaptor-related protein complex AP-4, epsilon 1
Synonyms: 2310033A20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108011
HGNC: HGNC:573
Homologene: 22397
Cnmd
Name: chondromodulin
Synonyms: Lect1, ChM-I, Bricd3, Chondromodulin 1, Chmd
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16840
Homologene: 5095
Satb1
Name: special AT-rich sequence binding protein 1
Synonyms: 2610306G12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20230
Homologene: 2232
Mcmbp
Name: minichromosome maintenance complex binding protein
Synonyms: 1110007A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210711
Homologene: 11749
Tbcd
Name: tubulin-specific chaperone d
Synonyms: 2310057L06Rik, A030005L14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108903
Homologene: 4368
Bicd1
Name: BICD cargo adaptor 1
Synonyms: B830009D06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12121
HGNC: HGNC:1049
Homologene: 37518
Ddb1
Name: damage specific DNA binding protein 1
Synonyms: p127-Ddb1, DNA repair protein, damage-specific DNA-binding protein, DNA repair
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13194
VEGA: 19
HGNC: HGNC:2717
Homologene: 1448
Map3k20
Name: mitogen-activated protein kinase kinase kinase 20
Synonyms: Zak, MLTKbeta, MLTKalpha, B230120H23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65964
Homologene: 32331
Plekhg5
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269608
Homologene: 10768
Golga3
Name: golgin A3
Synonyms: 5430416E01Rik, Mea-2, G1-499-14, Mea2, repro27
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269682
HGNC: HGNC:4426
Homologene: 4308
Ptprm
Name: protein tyrosine phosphatase receptor type M
Synonyms: RPTPmu
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19274
VEGA: 17
HGNC: HGNC:9675
Homologene: 37694
Smarcb1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
Synonyms: integrase interactor 1, Snf5, Ini1, Baf47, SNF5/INI1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20587
Homologene: 2310
Lsr
Name: lipolysis stimulated lipoprotein receptor
Synonyms: Lisch7, ILDR3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54135
Homologene: 9306
Pprc1
Name: peroxisome proliferative activated receptor, gamma, coactivator-related 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226169
Homologene: 9006
Abca3
Name: ATP-binding cassette, sub-family A member 3
Synonyms: ABC-C, Abc3, 1810036E22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27410
HGNC: HGNC:33
Homologene: 37437
Trappc2b
Name: trafficking protein particle complex 2B
Synonyms: 0610009B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66050
Homologene: 133292
Col24a1
Name: collagen, type XXIV, alpha 1
Synonyms: 5430404K19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71355
Homologene: 65061
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Uba7
Name: ubiquitin-like modifier activating enzyme 7
Synonyms: Ube1l, 1300004C08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74153
Homologene: 2502
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: E230025N21Rik, N-3 kinesin, Kif16a, 4831403C07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Ctsq
Name: cathepsin Q
Synonyms: 1600010J02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 104002
Homologene: 122226
Ttc23l
Name: tetratricopeptide repeat domain 23-like
Synonyms: 4930401A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75777
Homologene: 44907
Slc16a7
Name: solute carrier family 16 (monocarboxylic acid transporters), member 7
Synonyms: D630004K10Rik, MCT2, 9030411M13Rik, 4921534N07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20503
Homologene: 20990
Elmo2
Name: engulfment and cell motility 2
Synonyms: CED-12, 1190002F24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 140579
Homologene: 44338
Aox1
Name: aldehyde oxidase 1
Synonyms: Aox2, retinal oxidase, Aox-1, Aox-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
Arhgef11
Name: Rho guanine nucleotide exchange factor 11
Synonyms: PDZ-RhoGEF, Prg
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213498
Homologene: 11409
Adgb
Name: androglobin
Synonyms: 9130014G24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215772
Homologene: 100289
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320277
Homologene: 23371
Cyp2d26
Name: cytochrome P450, family 2, subfamily d, polypeptide 26
Synonyms: 1300006E06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76279
VEGA: 15
Homologene: 130660
Adap2
Name: ArfGAP with dual PH domains 2
Synonyms: Centa2, centaurin alpha 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216991
Homologene: 10179
Ehhadh
Name: enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
Synonyms: L-bifunctional enzyme, L-PBE, MFP, 1300002P22Rik, HD, MFP1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74147
HGNC: HGNC:3247
Homologene: 1486
Or5d16
Name: olfactory receptor family 5 subfamily D member 16
Synonyms: MOR174-10, GA_x6K02T2Q125-49426894-49425950, Olfr1155
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258636
Homologene: 133739
Rsad1
Name: radical S-adenosyl methionine domain containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237926
Homologene: 41252
Or14c39
Name: olfactory receptor family 14 subfamily C member 39
Synonyms: MOR220-2, GA_x6K02T2NHDJ-9425121-9424195, Olfr292
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258613
Homologene: 115526
Zfp672
Name: zinc finger protein 672
Synonyms: 4930511N19Rik, 4930488P06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319475
Homologene: 23493
Kbtbd12
Name: kelch repeat and BTB (POZ) domain containing 12
Synonyms: 4833415F11Rik, 4933428M03Rik, Klhdc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74589
Homologene: 52613
Or4a27
Name: olfactory receptor family 4 subfamily A member 27
Synonyms: GA_x6K02T2Q125-50202854-50201910, MOR225-14, Olfr1197, MOR225-10P
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 433449
Homologene: 123770
Or1e26
Name: olfactory receptor family 1 subfamily E member 26
Synonyms: MOR135-3, Olfr385, GA_x6K02T2P1NL-3760313-3759375
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259025
Homologene: 133670
Msln
Name: mesothelin
Synonyms: MPF, megakaryocyte potentiating factor
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56047
VEGA: 17
HGNC: HGNC:7371
Homologene: 4249
Dzank1
Name: double zinc ribbon and ankyrin repeat domains 1
Synonyms: 2810039F03Rik, Ankrd64, 6330439K17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241688
Homologene: 10037
Upb1
Name: ureidopropionase, beta
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103149
Homologene: 9471
Igsf21
Name: immunoglobulin superfamily, member 21
Synonyms: LOC230868
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230868
Homologene: 13153
Kcnf1
Name: potassium voltage-gated channel, subfamily F, member 1
Synonyms: LOC382571
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 382571
HGNC: HGNC:6246
Homologene: 124236
Herpud1
Name: homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
Synonyms: Herp, Mifl
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 64209
Homologene: 40973
Pals1
Name: protein associated with LIN7 1, MAGUK family member
Synonyms: 3830420B02Rik, Pals1, Mpp5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56217
VEGA: 12
Homologene: 9512
Rfxap
Name: regulatory factor X-associated protein
Synonyms: 5730495K23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170767
HGNC: HGNC:9988
Homologene: 452
Crtap
Name: cartilage associated protein
Synonyms: P3h5, 5730529N23Rik, Leprel3, CASP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56693
HGNC: HGNC:2379
Homologene: 21280
Mroh9
Name: maestro heat-like repeat family member 9
Synonyms: Armc11, 4921528O07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78258
Homologene: 123521
Catspere1
Name: cation channel sperm associated auxiliary subunit epsilon 1
Synonyms: Gm7068, Catspere
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 631584
Homologene: 52161
Psma4
Name: proteasome subunit alpha 4
Synonyms: C9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26441
HGNC: HGNC:9533
Homologene: 2083
Zfp978
Name: zinc finger protein 978
Synonyms: Gm13145
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 108168963
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 58,070,063 bp
  • C to A, chromosome 1 at 163,044,121 bp
  • A to T, chromosome 1 at 177,879,782 bp
  • A to T, chromosome 2 at 72,438,214 bp
  • T to A, chromosome 2 at 87,942,888 bp
  • T to A, chromosome 2 at 88,729,548 bp
  • A to T, chromosome 2 at 120,697,861 bp
  • A to G, chromosome 2 at 127,061,695 bp
  • T to C, chromosome 2 at 144,483,412 bp
  • T to A, chromosome 2 at 165,291,707 bp
  • T to A, chromosome 3 at 54,804,517 bp
  • T to A, chromosome 3 at 87,728,510 bp
  • A to T, chromosome 3 at 88,484,107 bp
  • G to T, chromosome 3 at 145,345,951 bp
  • T to C, chromosome 4 at 140,028,067 bp
  • T to A, chromosome 4 at 147,390,980 bp
  • T to A, chromosome 4 at 152,107,865 bp
  • G to A, chromosome 5 at 110,202,671 bp
  • G to T, chromosome 6 at 73,195,634 bp
  • G to A, chromosome 6 at 88,618,133 bp
  • C to G, chromosome 6 at 149,520,414 bp
  • T to C, chromosome 7 at 30,966,040 bp
  • A to G, chromosome 7 at 86,695,232 bp
  • G to A, chromosome 7 at 128,712,735 bp
  • G to A, chromosome 8 at 94,393,847 bp
  • T to C, chromosome 9 at 54,950,818 bp
  • G to A, chromosome 9 at 107,980,047 bp
  • G to A, chromosome 9 at 114,384,792 bp
  • T to A, chromosome 10 at 10,398,966 bp
  • T to C, chromosome 10 at 75,412,804 bp
  • G to T, chromosome 10 at 75,911,794 bp
  • A to T, chromosome 10 at 125,233,464 bp
  • A to T, chromosome 11 at 51,686,066 bp
  • A to G, chromosome 11 at 58,316,851 bp
  • T to C, chromosome 11 at 73,589,723 bp
  • T to C, chromosome 11 at 80,156,946 bp
  • A to G, chromosome 11 at 94,542,601 bp
  • A to T, chromosome 11 at 121,610,027 bp
  • T to C, chromosome 12 at 17,174,741 bp
  • T to A, chromosome 12 at 78,820,815 bp
  • T to C, chromosome 13 at 61,037,099 bp
  • T to C, chromosome 14 at 79,656,686 bp
  • T to A, chromosome 15 at 9,668,791 bp
  • G to T, chromosome 15 at 10,551,550 bp
  • T to C, chromosome 15 at 82,790,989 bp
  • T to A, chromosome 16 at 21,766,511 bp
  • C to T, chromosome 17 at 24,408,122 bp
  • T to C, chromosome 17 at 25,752,983 bp
  • A to T, chromosome 17 at 51,742,074 bp
  • T to A, chromosome 17 at 66,957,097 bp
  • A to T, chromosome 19 at 10,622,364 bp
  • G to T, chromosome 19 at 46,064,758 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5157 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042739-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.