Strain Name:
C57BL/6J-MtgxR5161Btlr/Mmmh
Stock Number:
042743-MU
Citation ID:
RRID:MMRRC_042743-MU
Other Names:
R5161 (G1), C57BL/6J-MtgxR5161Btlr
Major Collection:

Gene Information

Qk
Name: quaking
Synonyms: l(17)-1Wis, 1110003F05Rik, QkI, l17Wis1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 19317
VEGA: 17
Homologene: 11059
Atf2
Name: activating transcription factor 2
Synonyms: CRE-BP, D130078H02Rik, ATF-2, Creb2, mXBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 11909
HGNC: HGNC:784
Homologene: 31061
Gtf2i
Name: general transcription factor II I
Synonyms: 6030441I21Rik, TFII-I, BAP-135
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 14886
HGNC: HGNC:4659
Homologene: 7748
Ehmt1
Name: euchromatic histone methyltransferase 1
Synonyms: 9230102N17Rik, KMT1D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 77683
Homologene: 11698
Dock1
Name: dedicator of cytokinesis 1
Synonyms: D630004B07Rik, b2b3190Clo, Dock180, 9130006G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
H2afy
Name: H2A histone family, member Y
Synonyms: mH2a1, H2AF12M, macroH2A1, MACROH2A1.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 26914
HGNC: HGNC:4740
Homologene: 3598
Pmpca
Name: peptidase (mitochondrial processing) alpha
Synonyms: 4933435E07Rik, Alpha-MPP, INPP5E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 66865
Homologene: 6078
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: Eh domain, SH3 domain regulator of endocytosis 1, Intersectin-L, Ese1, Sh3p17, EHSH1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Syt3
Name: synaptotagmin III
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20981
Homologene: 9617
Gpatch2l
Name: G patch domain containing 2 like
Synonyms: 1700020O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 70373
VEGA: 12
Homologene: 9942
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235627
Homologene: 86422
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Timm23
Name: translocase of inner mitochondrial membrane 23
Synonyms: Tim23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 53600
Homologene: 9651
Ddrgk1
Name: DDRGK domain containing 1
Synonyms: 2600009E05Rik, 1110001I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 77006
Homologene: 11400
Plxna2
Name: plexin A2
Synonyms: 2810428A13Rik, PlexA2, Plxn2, OCT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Ptpn4
Name: protein tyrosine phosphatase, non-receptor type 4
Synonyms: hPTP-MEG, PTPMEG, TEP, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte), TEP/mPTPMEG, testis-enriched phosphatase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 19258
HGNC: HGNC:9656
Homologene: 2120
Rapgef3
Name: Rap guanine nucleotide exchange factor (GEF) 3
Synonyms: 2310016P22Rik, Epac1, 9330170P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223864
Homologene: 21231
Adamts13
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13
Synonyms: vWF-CP mRNA for von Willebrand factor-cleaving, LOC279028
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 279028
HGNC: HGNC:1366
Homologene: 16372
Fam20a
Name: family with sequence similarity 20, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 208659
Homologene: 9719
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 668940
Homologene: 66117
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: Nav1.2, A230052E19Rik, Scn2a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 110876
Homologene: 75001
Cass4
Name: Cas scaffolding protein family member 4
Synonyms: F730031O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 320664
Homologene: 75128
Gm10226
Name: predicted gene 10226
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380698
Homologene: 70869
Olfr305
Name: olfactory receptor 305
Synonyms: MOR219-2, GA_x6K02T2NHDJ-9744055-9745014
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258609
Homologene: 128128
Ttc23l
Name: tetratricopeptide repeat domain 23-like
Synonyms: 4930401A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 75777
Homologene: 44907
Ttc21b
Name: tetratricopeptide repeat domain 21B
Synonyms: aln, Thm1, line 158, 2410066K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 73668
Homologene: 57006
4930407I10Rik
Name: RIKEN cDNA 4930407I10 gene
Synonyms: LOC328573
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 328573
VEGA: 15
Homologene: 130065
Rbbp8
Name: retinoblastoma binding protein 8, endonuclease
Synonyms: 9930104E21Rik, CtIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225182
VEGA: 18
HGNC: HGNC:9891
Homologene: 28546
Acad11
Name: acyl-Coenzyme A dehydrogenase family, member 11
Synonyms: 5730439E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 102632
Homologene: 49896
Pde1a
Name: phosphodiesterase 1A, calmodulin-dependent
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18573
HGNC: HGNC:8774
Homologene: 21043
Pik3cg
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Synonyms: PI3Kgamma, p110gamma, PI3Kgamma, 5830428L06Rik, PI(3)Kgamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 30955
HGNC: HGNC:8978
Homologene: 68269
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: 2900083P10Rik, C230094A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237711
Homologene: 104282
1700061G19Rik
Name: RIKEN cDNA 1700061G19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 78625
Homologene: 28378
Slc5a5
Name: solute carrier family 5 (sodium iodide symporter), member 5
Synonyms: NIS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 114479
Homologene: 37311
Hyal5
Name: hyaluronoglucosaminidase 5
Synonyms: 4933439A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 74468
Homologene: 50610
0610040J01Rik
Name: RIKEN cDNA 0610040J01 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 76261
Homologene: 49537
Itpripl1
Name: inositol 1,4,5-triphosphate receptor interacting protein-like 1
Synonyms: 1700041B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 73338
Homologene: 77641
Spata2l
Name: spermatogenesis associated 2-like
Synonyms: 2610039E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 78779
Homologene: 32729
Apopt1
Name: apoptogenic, mitochondrial 1
Synonyms: Apop-1, 2810002N01Rik, 1700081D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 68020
Homologene: 12225
Zer1
Name: zyg-11 related, cell cycle regulator
Synonyms: Zyg11bl, C230075L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227693
Homologene: 4621
Vmn1r15
Name: vomeronasal 1 receptor 15
Synonyms: V1rc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 113863
Homologene: 123826
P2ry2
Name: purinergic receptor P2Y, G-protein coupled 2
Synonyms: P2Y2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18442
HGNC: HGNC:8541
Homologene: 1927
Vxn
Name: vexin
Synonyms: 3110035E14Rik, R75066
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 76982
Homologene: 17666
Dipk1b
Name: divergent protein kinase domain 1B
Synonyms: Fam69b, PIP49, B230317C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 56279
Homologene: 10516
Olfr1436
Name: olfactory receptor 1436
Synonyms: GA_x6K02T2RE5P-2634596-2633658, MOR214-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258682
Homologene: 83129
Fbxl8
Name: F-box and leucine-rich repeat protein 8
Synonyms: FBL8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 50788
Homologene: 9279
Tmem191c
Name: transmembrane protein 191C
Synonyms: D16Bwg1494e, MNCb-4137, 4933405M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224019
Homologene: 131221
Usp17ld
Name: ubiquitin specific peptidase 17-like D
Synonyms: Dub2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 384701
Homologene: 131315
Gm2075
Name: predicted gene 2075
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 100039162
VEGA: 12
Krt88
Name: keratin 88
Synonyms: 1700011A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 66322
VEGA: 15
Homologene: 11945
Pate10
Name: prostate and testis expressed 10
Synonyms: Gm17677
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 100312949
Homologene: 130079
Gm20997
Name: predicted gene, 20997
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
Ighv5-9-1
Name: immunoglobulin heavy variable 5-9-1
Synonyms: Gm16886
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 641178
Gm21994
Name: predicted gene 21994
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
Ctsd
Name: cathepsin D
Synonyms: CD, CatD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13033
HGNC: HGNC:2529
Homologene: 55616
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 9,622,677 bp
  • C to T, chromosome 1 at 119,707,863 bp
  • A to G, chromosome 1 at 194,751,404 bp
  • T to C, chromosome 2 at 24,858,195 bp
  • T to C, chromosome 2 at 26,395,171 bp
  • C to T, chromosome 2 at 26,636,248 bp
  • G to A, chromosome 2 at 26,993,008 bp
  • C to T, chromosome 2 at 30,108,239 bp
  • A to G, chromosome 2 at 65,764,591 bp
  • A to G, chromosome 2 at 66,229,023 bp
  • A to C, chromosome 2 at 73,829,790 bp
  • T to C, chromosome 2 at 79,878,144 bp
  • A to C, chromosome 2 at 127,141,857 bp
  • A to T, chromosome 2 at 130,663,376 bp
  • A to T, chromosome 2 at 150,255,215 bp
  • G to C, chromosome 2 at 155,632,373 bp
  • C to A, chromosome 2 at 172,432,324 bp
  • G to T, chromosome 5 at 63,898,001 bp
  • C to T, chromosome 5 at 134,263,731 bp
  • A to T, chromosome 6 at 24,891,603 bp
  • T to C, chromosome 6 at 57,258,512 bp
  • A to T, chromosome 6 at 130,482,905 bp
  • C to A, chromosome 7 at 44,396,015 bp
  • T to C, chromosome 7 at 86,364,338 bp
  • A to T, chromosome 7 at 100,998,929 bp
  • A to T, chromosome 7 at 103,250,372 bp
  • G to A, chromosome 7 at 134,734,062 bp
  • A to T, chromosome 7 at 142,377,144 bp
  • A to G, chromosome 8 at 44,952,512 bp
  • A to C, chromosome 8 at 70,888,848 bp
  • A to T, chromosome 8 at 105,268,906 bp
  • A to G, chromosome 8 at 123,235,549 bp
  • T to A, chromosome 9 at 35,741,588 bp
  • T to C, chromosome 9 at 104,124,028 bp
  • G to T, chromosome 9 at 110,629,868 bp
  • A to G, chromosome 11 at 30,024,467 bp
  • T to C, chromosome 11 at 59,028,604 bp
  • A to G, chromosome 11 at 59,064,310 bp
  • C to T, chromosome 11 at 109,673,370 bp
  • C to T, chromosome 12 at 32,204,978 bp
  • G to T, chromosome 12 at 86,267,176 bp
  • T to A, chromosome 12 at 88,012,117 bp
  • C to A, chromosome 12 at 111,722,774 bp
  • T to C, chromosome 12 at 113,736,157 bp
  • T to C, chromosome 13 at 56,089,781 bp
  • G to A, chromosome 14 at 32,193,925 bp
  • G to T, chromosome 15 at 10,551,550 bp
  • G to T, chromosome 15 at 82,063,341 bp
  • A to G, chromosome 15 at 97,757,725 bp
  • T to A, chromosome 15 at 101,450,468 bp
  • T to C, chromosome 16 at 17,276,879 bp
  • G to A, chromosome 16 at 32,762,521 bp
  • G to A, chromosome 16 at 91,908,838 bp
  • A to T, chromosome 17 at 10,215,490 bp
  • A to C, chromosome 17 at 21,691,927 bp
  • A to T, chromosome 17 at 56,882,888 bp
  • T to G, chromosome 18 at 11,722,114 bp
  • A to T, chromosome 19 at 12,298,789 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5161 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042743-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.