Strain Name:
C57BL/6J-MtgxR5165Btlr/Mmmh
Stock Number:
042746-MU
Citation ID:
RRID:MMRRC_042746-MU
Other Names:
R5165 (G1), C57BL/6J-MtgxR5165Btlr
Major Collection:

Gene Information

Atp1a1
Name: ATPase, Na+/K+ transporting, alpha 1 polypeptide
Synonyms: Atpa-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11928
HGNC: HGNC:799
Homologene: 564
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, DNA-PK, XRCC7, DOXNPH, dxnph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Dapp1
Name: dual adaptor for phosphotyrosine and 3-phosphoinositides 1
Synonyms: Bam32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26377
Homologene: 32138
Usp25
Name: ubiquitin specific peptidase 25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 30940
VEGA: 16
Homologene: 8374
Gstcd
Name: glutathione S-transferase, C-terminal domain containing
Synonyms: 4933434L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67553
Homologene: 11693
Fnbp4
Name: formin binding protein 4
Synonyms: FBP30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 55935
Homologene: 9087
Ralgapb
Name: Ral GTPase activating protein, beta subunit (non-catalytic)
Synonyms: B230339M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228850
Homologene: 10666
Polr1a
Name: polymerase (RNA) I polypeptide A
Synonyms: mRPA1, RPA194, 194kDa, 3010014K16Rik, Rpo1-4, 2900087K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20019
Homologene: 7033
Cep350
Name: centrosomal protein 350
Synonyms: 6430546F08Rik, 4933409L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74081
Homologene: 8879
Cyth1
Name: cytohesin 1
Synonyms: CLM1, CTH-1, Pscd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19157
HGNC: HGNC:9501
Homologene: 31262
Ccn3
Name: cellular communication network factor 3
Synonyms: C130088N23Rik, CCN3, Nov
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18133
HGNC: HGNC:7885
Homologene: 1884
Snx29
Name: sorting nexin 29
Synonyms: LOC381035, LOC385605, 4933437K13Rik, Gm11170, Rundc2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74478
Homologene: 32706
Kcnj9
Name: potassium inwardly-rectifying channel, subfamily J, member 9
Synonyms: Kir3.3, Girk3, 1700085N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16524
HGNC: HGNC:6270
Homologene: 37989
Efemp2
Name: epidermal growth factor-containing fibulin-like extracellular matrix protein 2
Synonyms: fibulin 4, MBP1, fibulin-4, 0610011K11Rik, Fbln4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 58859
HGNC: HGNC:3219
Homologene: 32339
Alas1
Name: aminolevulinic acid synthase 1
Synonyms: 5-aminolevulinate synthase, succinyl-CoA: glycine C-succinyl transferase, Alas-1, ALAS-N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11655
HGNC: HGNC:396
Homologene: 55478
Synrg
Name: synergin, gamma
Synonyms: L71-5, Ap1gbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217030
HGNC: HGNC:557
Homologene: 105680
Tomm40
Name: translocase of outer mitochondrial membrane 40
Synonyms: Tom40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 53333
Homologene: 101105
Actl6a
Name: actin-like 6A
Synonyms: Actl6, Baf53a, 2810432C06Rik, ARP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56456
Homologene: 55811
Tpcn1
Name: two pore channel 1
Synonyms: 5730403B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 252972
Homologene: 9905
Nceh1
Name: neutral cholesterol ester hydrolase 1
Synonyms: CPO-BP, mKIAA1363, B230106I24Rik, Aadacl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 320024
Homologene: 23251
Sertad4
Name: SERTA domain containing 4
Synonyms: C130018M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214791
Homologene: 10483
Gkap1
Name: G kinase anchoring protein 1
Synonyms: 42kDa, 4933400B15Rik, Gkap42, D13Ertd340e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56278
VEGA: 13
Homologene: 10515
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Kctd18
Name: potassium channel tetramerisation domain containing 18
Synonyms: 4932411A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 51960
Homologene: 12710
Lrp12
Name: low density lipoprotein-related protein 12
Synonyms: C820005L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239393
Homologene: 8385
Olfr1276
Name: olfactory receptor 1276
Synonyms: GA_x6K02T2Q125-72308574-72309512, MOR245-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258390
Homologene: 133614
Kif21a
Name: kinesin family member 21A
Synonyms: N-5 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16564
VEGA: 15
Homologene: 56761
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230622
Homologene: 135888
Shank2
Name: SH3 and multiple ankyrin repeat domains 2
Synonyms: ProSAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210274
Homologene: 105965
Lrrc10
Name: leucine rich repeat containing 10
Synonyms: D330003I11Rik, Hrlrrp, Serdin1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237560
VEGA: 10
Homologene: 17154
Adam9
Name: a disintegrin and metallopeptidase domain 9 (meltrin gamma)
Synonyms: MDC9, Mltng, MDC9, Mltng
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11502
HGNC: HGNC:216
Homologene: 20824
Nkx6-3
Name: NK6 homeobox 3
Synonyms: Nkx6.3, 9130417I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74561
Homologene: 46375
Dsg1c
Name: desmoglein 1 gamma
Synonyms: Dsg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 211924
HGNC: HGNC:3048
Dmwd
Name: dystrophia myotonica-containing WD repeat motif
Synonyms: 59, DMR-N9, Dm9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13401
HGNC: HGNC:2936
Homologene: 22559
Cdhr4
Name: cadherin-related family member 4
Synonyms: D330022A01Rik, 1700021K14Rik, Cdh29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69398
Homologene: 82362
Foxred2
Name: FAD-dependent oxidoreductase domain containing 2
Synonyms: LOC239554, A430097D04Rik, D15Bwg0759e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239554
Homologene: 11800
Apc2
Name: APC regulator of WNT signaling pathway 2
Synonyms: APCL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 23805
Homologene: 4299
Slfn8
Name: schlafen 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276950
Homologene: 45432
Actg2
Name: actin, gamma 2, smooth muscle, enteric
Synonyms: SMGA, Act-4, Act4, Acta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11468
HGNC: HGNC:145
Homologene: 123845
Olfr1447
Name: olfactory receptor 1447
Synonyms: GA_x6K02T2RE5P-3231251-3230331, MOR202-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258698
Homologene: 74233
Hoxc9
Name: homeobox C9
Synonyms: Hox-3.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 15427
HGNC: HGNC:5130
Homologene: 130558
Trappc1
Name: trafficking protein particle complex 1
Synonyms: MUM2, BET5, D11Ertd172e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245828
Homologene: 41425
Lrfn5
Name: leucine rich repeat and fibronectin type III domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238205
Homologene: 17582
Olfr128
Name: olfactory receptor 128
Synonyms: GA_x6K02T2PSCP-2374126-2375048, MOR218-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 383243
Homologene: 134080
Zmynd19
Name: zinc finger, MYND domain containing 19
Synonyms: 2700064H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67187
Homologene: 12093
Asic5
Name: acid-sensing (proton-gated) ion channel family member 5
Synonyms: brain-liver-intestine amiloride-sensitive sodium channel, BLINaC, Accn5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 58170
Homologene: 41171
Smo
Name: smoothened, frizzled class receptor
Synonyms: E130215L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 319757
Homologene: 4115
Oxct1
Name: 3-oxoacid CoA transferase 1
Synonyms: 2610008O03Rik, Scot-s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67041
HGNC: HGNC:8527
Homologene: 377
Cplx2
Name: complexin 2
Synonyms: 921-L, Gm34843
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 12890
HGNC: HGNC:2310
Homologene: 38212
Ifi203-ps
Name: interferon activated gene 203, pseudogene
Synonyms: Gm16340
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100504287
HGNC: HGNC:5395
Homologene: 115929
Olfr1388
Name: olfactory receptor 1388
Synonyms: GA_x6K02T2QP88-5991012-5990077, MOR256-28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258459
Homologene: 74258
Cx3cl1
Name: chemokine (C-X3-C motif) ligand 1
Synonyms: fractalkine, CX3C, neurotactin, D8Bwg0439e, Scyd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20312
Homologene: 2251
Mettl11b
Name: methyltransferase like 11B
Synonyms: LOC240879
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240879
Homologene: 28168
Igkv4-80
Name: immunoglobulin kappa variable 4-80
Synonyms: Gm16729
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545848
Pcdhga3
Name: protocadherin gamma subfamily A, 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93711
HGNC: HGNC:8701
Homologene: 75100
Gm4454
Name: predicted gene 4454
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100043467
Homologene: 45597
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 57,959,236 bp
  • A to G, chromosome 1 at 155,928,368 bp
  • A to G, chromosome 1 at 163,722,523 bp
  • A to T, chromosome 1 at 172,323,157 bp
  • G to A, chromosome 1 at 173,776,565 bp
  • A to T, chromosome 1 at 192,846,822 bp
  • T to A, chromosome 2 at 24,958,189 bp
  • T to A, chromosome 2 at 76,776,556 bp
  • C to G, chromosome 2 at 90,777,657 bp
  • T to A, chromosome 2 at 111,257,223 bp
  • A to G, chromosome 2 at 158,465,912 bp
  • G to A, chromosome 3 at 27,241,528 bp
  • G to A, chromosome 3 at 32,720,208 bp
  • A to G, chromosome 3 at 81,999,591 bp
  • A to G, chromosome 3 at 101,581,789 bp
  • A to C, chromosome 3 at 133,084,679 bp
  • T to C, chromosome 3 at 137,939,215 bp
  • A to T, chromosome 4 at 112,865,668 bp
  • T to C, chromosome 5 at 120,557,945 bp
  • T to A, chromosome 6 at 29,736,078 bp
  • A to C, chromosome 6 at 69,016,665 bp
  • T to G, chromosome 6 at 71,967,925 bp
  • T to A, chromosome 6 at 83,526,832 bp
  • G to A, chromosome 7 at 19,078,035 bp
  • A to G, chromosome 7 at 19,713,667 bp
  • T to C, chromosome 7 at 38,567,405 bp
  • T to A, chromosome 7 at 144,409,636 bp
  • T to A, chromosome 8 at 23,153,743 bp
  • A to T, chromosome 8 at 24,967,174 bp
  • T to C, chromosome 8 at 94,779,876 bp
  • T to C, chromosome 9 at 106,241,255 bp
  • T to C, chromosome 9 at 107,997,630 bp
  • A to G, chromosome 10 at 80,315,850 bp
  • A to T, chromosome 10 at 117,046,060 bp
  • A to G, chromosome 11 at 49,444,376 bp
  • A to G, chromosome 11 at 69,324,234 bp
  • A to T, chromosome 11 at 83,017,127 bp
  • T to C, chromosome 11 at 83,990,935 bp
  • T to C, chromosome 11 at 118,169,082 bp
  • T to C, chromosome 12 at 61,839,624 bp
  • A to G, chromosome 13 at 54,378,976 bp
  • A to G, chromosome 13 at 58,263,196 bp
  • A to T, chromosome 15 at 4,053,769 bp
  • A to G, chromosome 15 at 39,872,461 bp
  • A to G, chromosome 15 at 54,749,189 bp
  • A to G, chromosome 15 at 77,956,012 bp
  • A to T, chromosome 15 at 90,956,376 bp
  • T to A, chromosome 15 at 102,984,000 bp
  • T to A, chromosome 16 at 11,420,775 bp
  • T to A, chromosome 16 at 15,678,272 bp
  • T to A, chromosome 16 at 77,076,405 bp
  • A to G, chromosome 17 at 37,924,361 bp
  • A to G, chromosome 18 at 20,277,023 bp
  • A to G, chromosome 18 at 37,675,670 bp
  • T to C, chromosome 19 at 5,475,411 bp
  • T to C, chromosome 19 at 9,015,665 bp
  • A to T, chromosome 19 at 12,901,200 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5165 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042746-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.