Strain Name:
C57BL/6J-MtgxR5167Btlr/Mmmh
Stock Number:
042747-MU
Citation ID:
RRID:MMRRC_042747-MU
Other Names:
R5167 (G1), C57BL/6J-MtgxR5167Btlr
Major Collection:

Gene Information

Esr2
Name: estrogen receptor 2 (beta)
Synonyms: ER beta, ERbeta, oestrogen receptor beta, Estrb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 13983
HGNC: HGNC:3468
Homologene: 1100
Plekha1
Name: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
Synonyms: C920009D07Rik, TAPP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 101476
Homologene: 11001
Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4930435C18Rik, 4921507G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 114873
VEGA: 9
Homologene: 79549
Polr1c
Name: polymerase (RNA) I polypeptide C
Synonyms: RPA40, Rpo1-1, 40kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 20016
Homologene: 3586
Fbxo28
Name: F-box protein 28
Synonyms: 4833428J17Rik, D1Ertd578e, Fbx28, 5730505P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 67948
Homologene: 9050
Kif13b
Name: kinesin family member 13B
Synonyms: 5330429L19Rik, N-3 kinesin, GAKIN, C130021D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16554
VEGA: 14
Homologene: 9073
Pcnt
Name: pericentrin (kendrin)
Synonyms: m275Asp, Pcnt2, m239Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 18541
VEGA: 10
Knl1
Name: kinetochore scaffold 1
Synonyms: 5730505K17Rik, 2310043D08Rik, Casc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 76464
Homologene: 44890
Ngdn
Name: neuroguidin, EIF4E binding protein
Synonyms: Ngd, neuroguidin, 1500001L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 68966
VEGA: 14
Homologene: 44286
Fubp1
Name: far upstream element (FUSE) binding protein 1
Synonyms: FBP, Fubp4, Fubp, 9530027K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 51886
HGNC: HGNC:4004
Homologene: 48253
Bcan
Name: brevican
Synonyms: Cspg7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12032
Homologene: 7244
Srp68
Name: signal recognition particle 68
Synonyms: 2610024I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217337
Homologene: 7056
Rac3
Name: Rac family small GTPase 3
Synonyms: Rac1B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 170758
HGNC: HGNC:9803
Homologene: 68433
Lypd5
Name: Ly6/Plaur domain containing 5
Synonyms: 2310011E23Rik, 2210003I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 76942
Homologene: 18797
Paxbp1
Name: PAX3 and PAX7 binding protein 1
Synonyms: Gcfc1, 1810007M14Rik, Pax3/7bp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 67367
Homologene: 9604
Rnf219
Name: ring finger protein 219
Synonyms: 2610206B13Rik, 2810449K13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 72486
VEGA: 14
Homologene: 11578
Sf3a1
Name: splicing factor 3a, subunit 1
Synonyms: 1200014H24Rik, 5930416L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67465
Homologene: 4294
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: skrr, Ryr, calcium release channel isoform 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20190
Homologene: 68069
Lig1
Name: ligase I, DNA, ATP-dependent
Synonyms: LigI, mLigI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16881
HGNC: HGNC:6598
Homologene: 197
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 26875
Homologene: 69111
Serpina12
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
Synonyms: vaspin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 68054
Homologene: 23588
Abcb1b
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1B
Synonyms: Pgy-1, Mdr1, Abcb1, Mdr1b, mdr, Pgy1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 18669
Homologene: 69084
Olfr116
Name: olfactory receptor 116
Synonyms: MOR218-2, GA_x6K02T2PSCP-2084102-2083137
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 258625
Zfp352
Name: zinc finger protein 352
Synonyms: 2czf48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 236537
Homologene: 45160
D630003M21Rik
Name: RIKEN cDNA D630003M21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228846
Homologene: 18598
Lbp
Name: lipopolysaccharide binding protein
Synonyms: Bpifd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16803
HGNC: HGNC:6517
Homologene: 3055
Spdl1
Name: spindle apparatus coiled-coil protein 1
Synonyms: 2810049B11Rik, 1700018I02Rik, 2600001J17Rik, Ccdc99
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 70385
Homologene: 9837
Lvrn
Name: laeverin
Synonyms: Aqpep, 4833403I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 74574
VEGA: 18
Homologene: 51352
Rgl2
Name: ral guanine nucleotide dissociation stimulator-like 2
Synonyms: Rgt2, Rlf, KE1.5, Rab2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 19732
HGNC: HGNC:9769
Homologene: 3494
Nudt7
Name: nudix (nucleoside diphosphate linked moiety X)-type motif 7
Synonyms: 2210404C19Rik, 1300007B24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 67528
HGNC: HGNC:8054
Homologene: 41564
Glis1
Name: GLIS family zinc finger 1
Synonyms: GliH1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230587
Homologene: 77390
Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms: E130207I19Rik, NEDL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 94253
VEGA: 13
Homologene: 9004
Olfr1472
Name: olfactory receptor 1472
Synonyms: GA_x6K02T2RE5P-3787124-3786180, MOR202-16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258685
Homologene: 77370
Ly9
Name: lymphocyte antigen 9
Synonyms: Lgp100, CD229, SLAMF3, T100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 17085
HGNC: HGNC:6730
Homologene: 1759
Olfr1307
Name: olfactory receptor 1307
Synonyms: GA_x6K02T2Q125-72988111-72987173, MOR245-19P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 257956
Homologene: 128383
Cldn23
Name: claudin 23
Synonyms: 2310014B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 71908
Homologene: 12421
Calm3
Name: calmodulin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12315
HGNC: HGNC:1449
Homologene: 116117
Gm7258
Name: predicted gene 7258
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 639030
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 171,605,205 bp
  • T to C, chromosome 1 at 182,317,993 bp
  • A to T, chromosome 2 at 111,945,102 bp
  • A to G, chromosome 2 at 119,070,031 bp
  • A to G, chromosome 2 at 158,205,745 bp
  • A to G, chromosome 2 at 158,308,730 bp
  • G to T, chromosome 3 at 87,994,207 bp
  • T to C, chromosome 3 at 152,221,352 bp
  • A to G, chromosome 4 at 90,224,216 bp
  • G to A, chromosome 4 at 107,634,694 bp
  • T to A, chromosome 5 at 8,812,656 bp
  • T to C, chromosome 5 at 14,678,626 bp
  • T to A, chromosome 7 at 13,311,058 bp
  • T to C, chromosome 7 at 16,917,701 bp
  • T to C, chromosome 7 at 24,352,464 bp
  • T to C, chromosome 7 at 29,067,693 bp
  • T to C, chromosome 7 at 128,596,067 bp
  • G to A, chromosome 7 at 130,885,449 bp
  • C to T, chromosome 8 at 35,826,320 bp
  • C to A, chromosome 8 at 114,151,827 bp
  • T to C, chromosome 9 at 45,717,432 bp
  • G to T, chromosome 10 at 76,420,424 bp
  • T to C, chromosome 11 at 4,177,456 bp
  • G to T, chromosome 11 at 34,813,360 bp
  • C to A, chromosome 11 at 116,265,474 bp
  • A to G, chromosome 11 at 120,722,595 bp
  • T to C, chromosome 12 at 76,123,274 bp
  • A to T, chromosome 12 at 104,037,920 bp
  • C to T, chromosome 13 at 14,285,657 bp
  • C to T, chromosome 14 at 55,022,199 bp
  • T to C, chromosome 14 at 64,772,935 bp
  • A to G, chromosome 14 at 104,478,787 bp
  • A to G, chromosome 16 at 91,022,667 bp
  • C to T, chromosome 17 at 33,935,974 bp
  • C to A, chromosome 17 at 37,623,751 bp
  • G to T, chromosome 17 at 46,247,709 bp
  • T to A, chromosome 18 at 46,880,747 bp
  • T to A, chromosome 19 at 13,454,377 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5167 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042747-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.