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Strain Name:
C57BL/6J-MtgxR5169Btlr/Mmmh
Stock Number:
042749-MU
Citation ID:
RRID:MMRRC_042749-MU
Other Names:
R5169 (G1), C57BL/6J-MtgxR5169Btlr
Major Collection:

Strain Information

Zmpste24
Name: zinc metallopeptidase, STE24
Synonyms: A530043O15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230709
Homologene: 4277
Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Msantd3
Name: Myb/SANT-like DNA-binding domain containing 3
Synonyms: 2410046L14Rik, 2810429P03Rik, 5730528L13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66665
Homologene: 12452
Arhgef10
Name: Rho guanine nucleotide exchange factor 10
Synonyms: 6430549H08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234094
Homologene: 22827
Maco1
Name: macoilin 1
Synonyms: 9230118A01Rik, C61, 1110007C24Rik, Tmem57
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66146
Homologene: 14449
Zfp384
Name: zinc finger protein 384
Synonyms: C130073D16Rik, Ciz, Nmp4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269800
Homologene: 15849
Rc3h2
Name: ring finger and CCCH-type zinc finger domains 2
Synonyms: Rnf164, D930043C02Rik, 2900024N03Rik, 9430019J22Rik, Mnab
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319817
Homologene: 28276
Ttc27
Name: tetratricopeptide repeat domain 27
Synonyms: 2610511O17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74196
VEGA: 17
Homologene: 41191
Mtcl1
Name: microtubule crosslinking factor 1
Synonyms: t8219b25, 1110012J17Rik, Soga2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68617
Homologene: 41017
Zc3h7b
Name: zinc finger CCCH type containing 7B
Synonyms: Scrg3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20286
VEGA: 15
Homologene: 9735
Dip2b
Name: disco interacting protein 2 homolog B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239667
Homologene: 72227
Ddx54
Name: DEAD box helicase 54
Synonyms: APR-5, DP97, 2410015A15Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71990
Homologene: 5590
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: B130005I07Rik, D9Ertd809e, Dopey1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320615
Homologene: 26645
Phkb
Name: phosphorylase kinase beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102093
HGNC: HGNC:8927
Homologene: 247
Nav2
Name: neuron navigator 2
Synonyms: POMFIL2, Unc53H2, HELAD1, RAINB2, 5330421F07Rik, Rainb1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78286
Homologene: 52330
Tppp3
Name: tubulin polymerization-promoting protein family member 3
Synonyms: 2700055K07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67971
Homologene: 32659
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21819
Homologene: 2430
Cit
Name: citron
Synonyms: CRIK-SK, citron-N, citron kinase, Cit-k, C030025P15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12704
HGNC: HGNC:1985
Homologene: 21404
Acsbg2
Name: acyl-CoA synthetase bubblegum family member 2
Synonyms: Bgr
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328845
Homologene: 57133
Ms4a4d
Name: membrane-spanning 4-domains, subfamily A, member 4D
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66607
Homologene: 113790
Cdc37
Name: cell division cycle 37
Synonyms: p50Cdc37
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12539
VEGA: 9
HGNC: HGNC:1735
Homologene: 38268
Tcea3
Name: transcription elongation factor A (SII), 3
Synonyms: S-II, SII-K1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21401
Homologene: 20684
Ints7
Name: integrator complex subunit 7
Synonyms: 5930412E23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77065
Homologene: 9136
Pnpla7
Name: patatin-like phospholipase domain containing 7
Synonyms: E430013P11Rik, NRE
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241274
Homologene: 62431
Nrde2
Name: nrde-2 necessary for RNA interference, domain containing
Synonyms: 6720454P05Rik, BC002230
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217827
VEGA: 12
Homologene: 41213
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230676
Homologene: 49413
Med17
Name: mediator complex subunit 17
Synonyms: C330002H14Rik, Trap80, Crsp6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234959
VEGA: 9
HGNC: HGNC:2375
Homologene: 3151
Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
Synonyms: aldosterone receptor, Mlr, MR, mineralocorticoid receptor
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 110784
HGNC: HGNC:7979
Homologene: 121495
Milr1
Name: mast cell immunoglobulin like receptor 1
Synonyms: LOC380732, Allergin-1, Gm885
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380732
Homologene: 86017
Dmpk
Name: dystrophia myotonica-protein kinase
Synonyms: DM, Dm15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13400
HGNC: HGNC:2933
Homologene: 3247
Pik3r4
Name: phosphoinositide-3-kinase regulatory subunit 4
Synonyms: Vps15, p150
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75669
HGNC: HGNC:8982
Homologene: 24678
V1rd19
Name: vomeronasal 1 receptor, D19
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404287
Homologene: 104166
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Rpl14
Name: ribosomal protein L14
Synonyms: CAG-ISL-7, CTG-B33, L14, 3100001N19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67115
VEGA: 9
Homologene: 68375
Shoc1
Name: shortage in chiasmata 1
Synonyms: LOC242489, Gm426, AI481877, Mzip2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100155
Homologene: 79783
Pcdh18
Name: protocadherin 18
Synonyms: PCDH68L
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73173
Homologene: 10389
Abcb5
Name: ATP-binding cassette, sub-family B member 5
Synonyms: 9230106F14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77706
HGNC: HGNC:46
Homologene: 83488
Itih1
Name: inter-alpha trypsin inhibitor, heavy chain 1
Synonyms: inter-alpha (globulin) inhibitor, H1 polypeptide, Intin1, Itih-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16424
HGNC: HGNC:6166
Homologene: 1667
Pcdh8
Name: protocadherin 8
Synonyms: Papc, 1700080P15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18530
HGNC: HGNC:8660
Homologene: 1943
St6galnac6
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Synonyms: ST6GalNAcVI, Siat7f
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 50935
Homologene: 8390
Ppm1d
Name: protein phosphatase 1D magnesium-dependent, delta isoform
Synonyms: Wip1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53892
HGNC: HGNC:9277
Homologene: 31185
Kctd1
Name: potassium channel tetramerisation domain containing 1
Synonyms: 4933402K10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106931
VEGA: 18
Homologene: 65999
Sh3rf2
Name: SH3 domain containing ring finger 2
Synonyms: RNF158, 9130023G24Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269016
Homologene: 17618
Slc24a3
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Synonyms: NCKX3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94249
Homologene: 41390
Lrrc8e
Name: leucine rich repeat containing 8 family, member E
Synonyms: C87354, 1810049O03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72267
Homologene: 11817
Myom3
Name: myomesin family, member 3
Synonyms: 8430427K15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242702
Homologene: 19432
Mpp4
Name: membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
Synonyms: DLG6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227157
Homologene: 23296
Masp2
Name: MBL associated serine protease 2
Synonyms: MAp19, MASP-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17175
HGNC: HGNC:6902
Homologene: 4819
Alpk1
Name: alpha-kinase 1
Synonyms: 8430410J10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71481
Homologene: 11849
Arhgap25
Name: Rho GTPase activating protein 25
Synonyms: A130039I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232201
Homologene: 45507
Pp2d1
Name: protein phosphatase 2C-like domain containing 1
Synonyms: 4921523A10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 110332
VEGA: 17
Homologene: 16981
Wdr20rt
Name: WD repeat domain 20, retrogene
Synonyms: 4921538B03Rik, 4930427E19Rik, Wdr20b
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70948
VEGA: 12
Mup-ps21
Name: major urinary protein, pseudogene 21
Synonyms: Gm12555
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 546832
Ncoa4-ps
Name: nuclear receptor coactivator 4, pseudogene
Synonyms: Gm6768
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 627557
VEGA: 12
Rragc
Name: Ras-related GTP binding C
Synonyms: YGR163W, TIB929, Gtr2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54170
Homologene: 39141
Sytl3
Name: synaptotagmin-like 3
Synonyms: Slp3-a, Slp3-b, Slp3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 83672
Homologene: 12855
Psg29
Name: pregnancy-specific beta-1-glycoprotein 29
Synonyms: cea17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 114872
Homologene: 83380
Spi1
Name: Spi-1 proto-oncogene
Synonyms: Spi-1, Sfpi-1, Tfpu.1, PU.1, Dis-1, Tcfpu1, Sfpi1, spleen focus forming virus (SFFV) proviral integration oncogene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20375
Homologene: 2346
Trmt5
Name: TRM5 tRNA methyltransferase 5
Synonyms: 2610027O18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76357
VEGA: 12
Homologene: 6096
Srgn
Name: serglycin
Synonyms: Sgc, Prg1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19073
HGNC: HGNC:9361
Homologene: 137238
Timm8a2
Name: translocase of inner mitochondrial membrane 8A2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 223262
Homologene: 86868
Alyreffm2
Name: Aly/REF export factor family member 2
Synonyms: Gm6489
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 624262
Spata31d1b
Name: spermatogenesis associated 31 subfamily D, member 1B
Synonyms: Fam75d1b, Gm4934
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238662
VEGA: 13
Igkv4-80
Name: immunoglobulin kappa variable 4-80
Synonyms: Gm16729
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 545848
Mgam2-ps
Name: maltase-glucoamylase 2, pseudogene
Synonyms: Gm7254
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 638904
Gm17023
Name: predicted gene 17023
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Trav2
Name: T cell receptor alpha variable 2
Synonyms: ENSMUSG00000072561
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100042372
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 31,287,429 bp
  • T to C, chromosome 1 at 59,130,097 bp
  • T to C, chromosome 1 at 191,613,090 bp
  • A to T, chromosome 2 at 25,050,309 bp
  • A to G, chromosome 2 at 32,614,845 bp
  • A to T, chromosome 2 at 37,405,312 bp
  • A to T, chromosome 2 at 91,115,083 bp
  • C to T, chromosome 2 at 112,670,660 bp
  • G to A, chromosome 2 at 145,640,264 bp
  • T to C, chromosome 3 at 49,755,966 bp
  • A to T, chromosome 3 at 127,671,101 bp
  • T to C, chromosome 4 at 48,560,935 bp
  • T to A, chromosome 4 at 59,059,618 bp
  • A to T, chromosome 4 at 62,030,705 bp
  • T to C, chromosome 4 at 118,389,830 bp
  • A to T, chromosome 4 at 121,068,717 bp
  • A to G, chromosome 4 at 123,935,664 bp
  • T to C, chromosome 4 at 134,828,463 bp
  • T to C, chromosome 4 at 135,775,578 bp
  • A to T, chromosome 4 at 136,264,870 bp
  • T to C, chromosome 4 at 148,606,114 bp
  • T to A, chromosome 5 at 115,987,685 bp
  • C to A, chromosome 5 at 120,623,263 bp
  • A to T, chromosome 6 at 40,797,918 bp
  • A to C, chromosome 6 at 69,016,665 bp
  • A to T, chromosome 6 at 87,463,270 bp
  • G to T, chromosome 6 at 125,031,864 bp
  • C to T, chromosome 7 at 17,211,653 bp
  • C to G, chromosome 7 at 19,088,019 bp
  • A to G, chromosome 7 at 24,003,784 bp
  • G to T, chromosome 7 at 46,298,148 bp
  • C to T, chromosome 7 at 49,548,483 bp
  • A to G, chromosome 8 at 4,234,329 bp
  • A to G, chromosome 8 at 13,079,632 bp
  • A to G, chromosome 8 at 14,930,051 bp
  • A to T, chromosome 8 at 76,909,037 bp
  • A to G, chromosome 8 at 85,896,491 bp
  • G to C, chromosome 8 at 105,467,869 bp
  • A to T, chromosome 9 at 15,277,604 bp
  • T to A, chromosome 9 at 21,141,117 bp
  • T to C, chromosome 9 at 86,533,021 bp
  • T to C, chromosome 9 at 105,678,161 bp
  • T to A, chromosome 9 at 120,572,188 bp
  • C to A, chromosome 10 at 62,495,087 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • C to T, chromosome 11 at 85,332,370 bp
  • C to T, chromosome 11 at 106,754,928 bp
  • A to T, chromosome 12 at 65,227,410 bp
  • T to C, chromosome 12 at 73,282,721 bp
  • A to G, chromosome 12 at 100,129,293 bp
  • A to T, chromosome 12 at 118,877,817 bp
  • C to A, chromosome 12 at 119,261,650 bp
  • T to C, chromosome 13 at 59,716,495 bp
  • A to T, chromosome 14 at 30,933,446 bp
  • G to A, chromosome 14 at 52,567,302 bp
  • G to A, chromosome 14 at 79,767,655 bp
  • T to A, chromosome 14 at 122,034,726 bp
  • T to A, chromosome 15 at 66,678,780 bp
  • A to T, chromosome 15 at 81,773,314 bp
  • T to C, chromosome 15 at 100,205,113 bp
  • A to T, chromosome 17 at 6,715,546 bp
  • C to A, chromosome 17 at 53,507,902 bp
  • T to C, chromosome 17 at 56,849,913 bp
  • T to C, chromosome 17 at 66,343,823 bp
  • T to A, chromosome 17 at 74,747,695 bp
  • T to C, chromosome 18 at 15,062,765 bp
  • A to G, chromosome 18 at 42,153,061 bp
  • C to T, chromosome 19 at 11,557,976 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5169 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042749-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.