Strain Name:
C57BL/6J-MtgxR5176Btlr/Mmmh
Stock Number:
042756-MU
Citation ID:
RRID:MMRRC_042756-MU
Other Names:
R5176 (G1), C57BL/6J-MtgxR5176Btlr
Major Collection:

Gene Information

Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56381
Homologene: 124461
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 0610038M01Rik, 2610510B01Rik, Dopey2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Arhgef12
Name: Rho guanine nucleotide exchange factor (GEF) 12
Synonyms: LARG, 2310014B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69632
VEGA: 9
Homologene: 9088
Nr5a2
Name: nuclear receptor subfamily 5, group A, member 2
Synonyms: Ftf, LRH-1, D1Ertd308e, UF2-H3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26424
HGNC: HGNC:7984
Homologene: 20827
Xpo1
Name: exportin 1
Synonyms: Crm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103573
Homologene: 2554
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: B130005I07Rik, D9Ertd809e, Dopey1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320615
Homologene: 26645
Akap12
Name: A kinase (PRKA) anchor protein (gravin) 12
Synonyms: SSeCKS, Tsga12, Srcs5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 83397
VEGA: 10
HGNC: HGNC:370
Homologene: 3740
Fkbp15
Name: FK506 binding protein 15
Synonyms: FKBP133, C430014M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 338355
Homologene: 28743
Cpsf6
Name: cleavage and polyadenylation specific factor 6
Synonyms: HPBRII-7, HPBRII-4, CFIM68, 4733401N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432508
Homologene: 134126
Pot1b
Name: protection of telomeres 1B
Synonyms: 2810458H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72836
VEGA: 17
Homologene: 87058
Zfp719
Name: zinc finger protein 719
Synonyms: C630016O21Rik, mszf6, 9430094P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210105
Cep135
Name: centrosomal protein 135
Synonyms: LOC381644, Cep4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381644
Homologene: 45709
Ttll4
Name: tubulin tyrosine ligase-like family, member 4
Synonyms: 4632407P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67534
Homologene: 8764
Oprd1
Name: opioid receptor, delta 1
Synonyms: DOR-1, Nbor, mDOR, DOR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18386
HGNC: HGNC:8153
Homologene: 20252
Rhou
Name: ras homolog family member U
Synonyms: 2310026M05Rik, CDC42L1, WRCH-1, mG28K, WRCH1, Arhu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69581
Homologene: 49663
Rbm48
Name: RNA binding motif protein 48
Synonyms: C030048B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269623
Homologene: 12944
Brip1
Name: BRCA1 interacting protein C-terminal helicase 1
Synonyms: BACH1, 8030460J03Rik, 3110009N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237911
Homologene: 32766
Tmeff2
Name: transmembrane protein with EGF-like and two follistatin-like domains 2
Synonyms: 4832418D20Rik, 7630402F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56363
Homologene: 9417
Steap3
Name: STEAP family member 3
Synonyms: pHyde, 1010001D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68428
Homologene: 10084
Muc19
Name: mucin 19
Synonyms: apomucin, sld
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239611
Fastkd2
Name: FAST kinase domains 2
Synonyms: 2810421I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75619
Homologene: 8957
Tmem138
Name: transmembrane protein 138
Synonyms: 1700113I01Rik, 2900055D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72982
VEGA: 19
Homologene: 9518
Itga4
Name: integrin alpha 4
Synonyms: VLA-4 receptor, alpha 4 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16401
HGNC: HGNC:6140
Homologene: 37364
Fhip2a
Name: FHF complex subunit HOOK interacting protein 2A
Synonyms: Fam160b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226252
VEGA: 19
Homologene: 28133
Trappc11
Name: trafficking protein particle complex 11
Synonyms: D030016E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 320714
Homologene: 11076
Ttc30a2
Name: tetratricopeptide repeat domain 30A2
Synonyms: OTTMUSG00000015167
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 620631
Homologene: 44342
Wdr17
Name: WD repeat domain 17
Synonyms: 3010002I12Rik, B230207L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244484
Homologene: 12460
E130309D02Rik
Name: RIKEN cDNA E130309D02 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231868
Homologene: 11445
Pdzd8
Name: PDZ domain containing 8
Synonyms: A630041P07Rik, Pdzk8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107368
VEGA: 19
Homologene: 14879
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20192
Homologene: 68151
H2-M9
Name: histocompatibility 2, M region locus 9
Synonyms: M9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14997
Homologene: 110792
Uchl4
Name: ubiquitin carboxyl-terminal esterase L4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 93841
VEGA: 9
Insr
Name: insulin receptor
Synonyms: IR, CD220, 4932439J01Rik, D630014A15Rik, IR-B, IR-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16337
HGNC: HGNC:6091
Homologene: 20090
Gm11492
Name: predicted gene 11492
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Cacna1b
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit
Synonyms: Cchn1a, alpha(1B), Cav2.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12287
HGNC: HGNC:1389
Homologene: 20184
Sik2
Name: salt inducible kinase 2
Synonyms: G630080D20Rik, Snf1lk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235344
Homologene: 22875
Cds1
Name: CDP-diacylglycerol synthase 1
Synonyms: phosphatidate cytidylyltransferase, 4833409J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74596
HGNC: HGNC:1800
Homologene: 68173
Ablim1
Name: actin-binding LIM protein 1
Synonyms: Limab1, 4833406P10Rik, abLIM-S, abLIM-M, abLIM-L, 2610209L21Rik, 9330196J19Rik, 2210411C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226251
HGNC: HGNC:78
Homologene: 40994
Olfr998
Name: olfactory receptor 998
Synonyms: GA_x6K02T2Q125-47069356-47070300, MOR175-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258428
Homologene: 74236
Dao
Name: D-amino acid oxidase
Synonyms: DAO, Dao-1, Dao1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13142
HGNC: HGNC:2671
Homologene: 37553
Ccdc69
Name: coiled-coil domain containing 69
Synonyms: 2210021E03Rik, D11Ertd461e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52570
Homologene: 77613
A530032D15Rik
Name: RIKEN cDNA A530032D15Rik gene
Synonyms: LOC381287
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381287
Homologene: 131208
Gabbr2
Name: gamma-aminobutyric acid (GABA) B receptor, 2
Synonyms: Gababr2, LOC242425, Gpr51, GB2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242425
HGNC: HGNC:4507
Homologene: 55902
Ptk2b
Name: PTK2 protein tyrosine kinase 2 beta
Synonyms: CAKbeta, Raftk, calcium-dependent tyrosine kinase, related adhesion focal tyrosine kinase, cellular adhesion kinase beta, proline-rich tyrosine kinase 2, PYK2, E430023O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19229
HGNC: HGNC:9612
Homologene: 23001
Olfr561
Name: olfactory receptor 561
Synonyms: GA_x6K02T2PBJ9-5491151-5492095, MOR14-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259096
Homologene: 133029
Cylc2
Name: cylicin, basic protein of sperm head cytoskeleton 2
Synonyms: 4930488P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74914
HGNC: HGNC:2583
Homologene: 136270
Sipa1
Name: signal-induced proliferation associated gene 1
Synonyms: SPA-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20469
VEGA: 19
Homologene: 7940
Ctif
Name: CBP80/20-dependent translation initiation factor
Synonyms: LOC269037, Gm672
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 269037
VEGA: 18
Homologene: 56682
Prss56
Name: protease, serine 56
Synonyms: 1700027L20Rik, Prss56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69453
Homologene: 79885
Rusc1
Name: RUN and SH3 domain containing 1
Synonyms: 2210403N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72296
Homologene: 75028
Panx2
Name: pannexin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 406218
HGNC: HGNC:8600
Homologene: 14155
Abca7
Name: ATP-binding cassette, sub-family A (ABC1), member 7
Synonyms: Abc51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 27403
HGNC: HGNC:37
Homologene: 22783
Vps25
Name: vacuolar protein sorting 25
Synonyms: 1110020N13Rik, D11Wsu68e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 28084
Homologene: 6303
Asb3
Name: ankyrin repeat and SOCS box-containing 3
Synonyms: 2400011J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 65257
Homologene: 9391
Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Synonyms: RIP14, FXR, HRR1, Rxrip14, Fxr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20186
HGNC: HGNC:7967
Homologene: 3760
Apobr
Name: apolipoprotein B receptor
Synonyms: Apob-48r, Apob48r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 171504
Homologene: 26695
Rabep2
Name: rabaptin, RAB GTPase binding effector protein 2
Synonyms: 2610011A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70314
Homologene: 23489
Optc
Name: opticin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269120
HGNC: HGNC:8158
Homologene: 8652
Olfr836
Name: olfactory receptor 836
Synonyms: GA_x6K02T2PVTD-12857805-12858749, MOR152-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258557
Homologene: 115507
Mad2l1bp
Name: MAD2L1 binding protein
Synonyms: 0610009D16Rik, CMT2B, CMT2A, 2510031P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66591
VEGA: 17
Homologene: 11990
Fam187a
Name: family with sequence similarity 187, member A
Synonyms: 4933439F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66784
Homologene: 128440
Gm13991
Name: predicted gene 13991
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 433464
Marchf9
Name: membrane associated ring-CH-type finger 9
Synonyms: March9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216438
Homologene: 34705
Rnaseh2c
Name: ribonuclease H2, subunit C
Synonyms: 1500026D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 68209
Homologene: 32666
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 51,071,541 bp
  • A to G, chromosome 1 at 63,731,439 bp
  • C to A, chromosome 1 at 74,679,286 bp
  • C to T, chromosome 1 at 85,088,800 bp
  • T to C, chromosome 1 at 87,184,158 bp
  • C to T, chromosome 1 at 120,243,767 bp
  • T to C, chromosome 1 at 133,902,084 bp
  • A to T, chromosome 1 at 136,948,802 bp
  • A to T, chromosome 2 at 24,635,131 bp
  • T to C, chromosome 2 at 75,977,077 bp
  • A to G, chromosome 2 at 79,280,656 bp
  • A to C, chromosome 2 at 85,591,435 bp
  • T to C, chromosome 2 at 112,757,667 bp
  • T to A, chromosome 2 at 116,528,027 bp
  • A to G, chromosome 3 at 89,089,082 bp
  • C to A, chromosome 4 at 46,681,208 bp
  • T to C, chromosome 4 at 51,228,587 bp
  • G to T, chromosome 4 at 62,312,323 bp
  • T to C, chromosome 4 at 132,113,793 bp
  • T to C, chromosome 4 at 141,476,276 bp
  • A to C, chromosome 5 at 3,595,444 bp
  • C to A, chromosome 5 at 76,637,026 bp
  • G to T, chromosome 5 at 101,781,420 bp
  • T to C, chromosome 5 at 114,020,009 bp
  • G to T, chromosome 5 at 143,315,075 bp
  • G to T, chromosome 7 at 43,591,125 bp
  • T to A, chromosome 7 at 102,775,306 bp
  • C to A, chromosome 7 at 126,434,293 bp
  • A to G, chromosome 7 at 126,585,016 bp
  • T to A, chromosome 8 at 3,158,742 bp
  • C to A, chromosome 8 at 47,510,963 bp
  • C to T, chromosome 8 at 54,653,878 bp
  • G to T, chromosome 8 at 123,654,109 bp
  • A to T, chromosome 9 at 19,121,360 bp
  • A to T, chromosome 9 at 43,020,686 bp
  • T to C, chromosome 9 at 50,899,403 bp
  • A to T, chromosome 9 at 64,235,740 bp
  • T to A, chromosome 9 at 86,521,815 bp
  • G to T, chromosome 10 at 4,353,947 bp
  • C to A, chromosome 10 at 79,998,289 bp
  • T to A, chromosome 10 at 89,498,255 bp
  • C to A, chromosome 10 at 117,361,284 bp
  • T to C, chromosome 10 at 127,059,450 bp
  • A to G, chromosome 11 at 23,295,977 bp
  • T to A, chromosome 11 at 31,081,357 bp
  • C to T, chromosome 11 at 55,060,470 bp
  • T to C, chromosome 11 at 86,077,884 bp
  • T to A, chromosome 11 at 87,567,532 bp
  • C to A, chromosome 11 at 101,258,986 bp
  • C to T, chromosome 11 at 102,886,464 bp
  • C to T, chromosome 11 at 115,984,157 bp
  • T to C, chromosome 14 at 66,156,415 bp
  • G to T, chromosome 15 at 89,060,228 bp
  • A to G, chromosome 15 at 91,892,180 bp
  • A to G, chromosome 16 at 93,740,043 bp
  • T to C, chromosome 17 at 36,641,631 bp
  • T to A, chromosome 17 at 46,152,812 bp
  • T to A, chromosome 17 at 55,699,995 bp
  • C to T, chromosome 18 at 75,637,219 bp
  • A to G, chromosome 19 at 5,602,042 bp
  • A to G, chromosome 19 at 5,659,378 bp
  • A to T, chromosome 19 at 10,575,270 bp
  • A to G, chromosome 19 at 57,079,846 bp
  • A to G, chromosome 19 at 57,371,181 bp
  • A to G, chromosome 19 at 59,344,957 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5176 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042756-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.