Strain Name:
C57BL/6J-MtgxR5184Btlr/Mmmh
Stock Number:
042763-MU
Citation ID:
RRID:MMRRC_042763-MU
Other Names:
R5184 (G1), C57BL/6J-MtgxR5184Btlr
Major Collection:

Gene Information

Penk
Name: preproenkephalin
Synonyms: ENK, Penk, PPA, Penk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18619
HGNC: HGNC:8831
Homologene: 4528
Nfia
Name: nuclear factor I/A
Synonyms: 1110047K16Rik, NF1-A, 9430022M17Rik, NF1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18027
HGNC: HGNC:7784
Homologene: 4086
Ehmt1
Name: euchromatic histone methyltransferase 1
Synonyms: 9230102N17Rik, KMT1D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77683
Homologene: 11698
Pds5b
Name: PDS5 cohesin associated factor B
Synonyms: AS3, Aprin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100710
Homologene: 41001
Xpnpep1
Name: X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Synonyms: D230045I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 170750
Homologene: 6424
E2f2
Name: E2F transcription factor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242705
HGNC: HGNC:3114
Homologene: 48264
Usp25
Name: ubiquitin specific peptidase 25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 30940
VEGA: 16
Homologene: 8374
Flnb
Name: filamin, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Knl1
Name: kinetochore scaffold 1
Synonyms: 2310043D08Rik, 5730505K17Rik, Casc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76464
Homologene: 44890
Katnb1
Name: katanin p80 (WD40-containing) subunit B 1
Synonyms: KAT, 2410003J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74187
HGNC: HGNC:6217
Homologene: 4302
Mapre1
Name: microtubule-associated protein, RP/EB family, member 1
Synonyms: Eb1, BIM1p, D2Ertd459e, 5530600P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13589
HGNC: HGNC:6890
Homologene: 56129
Msh2
Name: mutS homolog 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17685
HGNC: HGNC:7325
Homologene: 210
Prr12
Name: proline rich 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233210
Homologene: 18957
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F32S1, D15F32S1h, D7H15F37S1, rjs, jdf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Dmtf1
Name: cyclin D binding myb-like transcription factor 1
Synonyms: Dmp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 23857
Homologene: 8017
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 5730405K23Rik, 4921511H13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207932
Homologene: 45941
Mark4
Name: MAP/microtubule affinity regulating kinase 4
Synonyms: Markl1, 2410090P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232944
Homologene: 57146
Usp10
Name: ubiquitin specific peptidase 10
Synonyms: Uchrp, 2610014N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 22224
Homologene: 31294
Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
Synonyms: cholesterol 7 alpha hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13122
HGNC: HGNC:2651
Homologene: 30987
Pole
Name: polymerase (DNA directed), epsilon
Synonyms: pol-epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18973
HGNC: HGNC:9177
Homologene: 4539
Sp3
Name: trans-acting transcription factor 3
Synonyms: D130027J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20687
Homologene: 7952
Tbc1d13
Name: TBC1 domain family, member 13
Synonyms: 2600014A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70296
Homologene: 10068
Prune2
Name: prune homolog 2
Synonyms: 6330414G02Rik, A330102H22Rik, A230083H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Celf2
Name: CUGBP, Elav-like family member 2
Synonyms: Napor-2, ETR-3, B230345P09Rik, Cugbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14007
HGNC: HGNC:2550
Homologene: 4783
Zbtb10
Name: zinc finger and BTB domain containing 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229055
Homologene: 11395
Pgap1
Name: post-GPI attachment to proteins 1
Synonyms: 5033403E17Rik, 9030223K07Rik, PGAP1, D230012E17Rik, oto
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241062
Homologene: 41605
Fgf3
Name: fibroblast growth factor 3
Synonyms: Int-P, Int-2, Fgf-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14174
HGNC: HGNC:3681
Homologene: 3841
Invs
Name: inversin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16348
Homologene: 7786
Ern2
Name: endoplasmic reticulum (ER) to nucleus signalling 2
Synonyms: Ire1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26918
Homologene: 22687
Sox6
Name: SRY (sex determining region Y)-box 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20679
Homologene: 22631
Pde10a
Name: phosphodiesterase 10A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 23984
HGNC: HGNC:8772
Homologene: 4852
Pmfbp1
Name: polyamine modulated factor 1 binding protein 1
Synonyms: F77, 1700016D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56523
Homologene: 23182
Odad4
Name: outer dynein arm complex subunit 4
Synonyms: 4933404O19Rik, Ttc25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74407
Homologene: 12860
Sh3pxd2a
Name: SH3 and PX domains 2A
Synonyms: Fish, Sh3md1, Tks5, 2310014D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14218
VEGA: 19
Homologene: 7317
Arid3a
Name: AT rich interactive domain 3A (BRIGHT-like)
Synonyms: Bright, Dri1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13496
HGNC: HGNC:3031
Homologene: 124247
Fam227b
Name: family with sequence similarity 227, member B
Synonyms: 4930525F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75823
Homologene: 27384
Rskr
Name: ribosomal protein S6 kinase related
Synonyms: BC030499
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216976
Homologene: 79669
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Dcdc4, Rp1hl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 271209
VEGA: 14
Homologene: 105870
Ablim1
Name: actin-binding LIM protein 1
Synonyms: Limab1, 4833406P10Rik, abLIM-S, abLIM-M, abLIM-L, 2610209L21Rik, 9330196J19Rik, 2210411C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226251
HGNC: HGNC:78
Homologene: 40994
Lpin3
Name: lipin 3
Synonyms: 9130206L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 64899
Homologene: 84844
Gm5415
Name: predicted gene 5415
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 408191
Homologene: 130042
Nell2
Name: NEL-like 2
Synonyms: mel91, A330108N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 54003
VEGA: 15
HGNC: HGNC:7751
Homologene: 4488
Zfp108
Name: zinc finger protein 108
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 54678
Homologene: 117959
Olfr68
Name: olfactory receptor 68
Synonyms: 3'[b]2, MOR22-3, GA_x6K02T2PBJ9-6504436-6503489
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18369
Homologene: 130658
Daam2
Name: dishevelled associated activator of morphogenesis 2
Synonyms: 2310016D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76441
VEGA: 17
Homologene: 69186
Mogat2
Name: monoacylglycerol O-acyltransferase 2
Synonyms: Mgat2, DGAT2L5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233549
Homologene: 57020
Rnf19a
Name: ring finger protein 19A
Synonyms: XYbp, XY body protein, Rnf19, Dorfin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 30945
VEGA: 15
Homologene: 8501
Fxyd3
Name: FXYD domain-containing ion transport regulator 3
Synonyms: Mat8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17178
HGNC: HGNC:4027
Homologene: 4356
Barhl2
Name: BarH like homeobox 2
Synonyms: MBH1, E130309B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 104382
HGNC: HGNC:954
Homologene: 10572
Wdr35
Name: WD repeat domain 35
Synonyms: 4930459M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74682
Homologene: 10814
Carf
Name: calcium response factor
Synonyms: Als2cr8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241066
Homologene: 11689
Tcp11l1
Name: t-complex 11 like 1
Synonyms: C130096D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320554
Homologene: 41260
Klra9
Name: killer cell lectin-like receptor subfamily A, member 9
Synonyms: Ly49I, LY49I1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16640
Homologene: 110821
Tmem101
Name: transmembrane protein 101
Synonyms: 2610511E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76547
Homologene: 12649
Vmn1r17
Name: vomeronasal 1 receptor 17
Synonyms: V1rc16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171189
Homologene: 115643
Thrb
Name: thyroid hormone receptor beta
Synonyms: T3Rbeta, T3R[b], Nr1a2, TR beta, c-erbAbeta, Thrb2, Thrb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21834
Homologene: 36025
Olfr146
Name: olfactory receptor 146
Synonyms: M15, MOR171-10, GA_x6K02T2PVTD-32715386-32714466
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258742
VEGA: 9
Phtf2
Name: putative homeodomain transcription factor 2
Synonyms: 9530062N20Rik, 1110054G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68770
Homologene: 10713
Snph
Name: syntaphilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241727
Homologene: 8817
Olfr298
Name: olfactory receptor 298
Synonyms: GA_x6K02T2NHDJ-9619796-9620794, MOR219-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257905
Fermt1
Name: fermitin family member 1
Synonyms: Kindlin-1, 5830467P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241639
Homologene: 9773
Kcnq5
Name: potassium voltage-gated channel, subfamily Q, member 5
Synonyms: 9230107O05Rik, D1Mgi1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226922
HGNC: HGNC:6299
Homologene: 28270
Nutm1
Name: NUT midline carcinoma, family member 1
Synonyms: Nut, BC125332
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 213765
Homologene: 18185
Ccdc90b
Name: coiled-coil domain containing 90B
Synonyms: 2310015N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66365
Homologene: 23328
Aph1a
Name: aph1 homolog A, gamma secretase subunit
Synonyms: 6530402N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 226548
Homologene: 9345
Trarg1
Name: trafficking regulator of GLUT4 (SLC2A4) 1
Synonyms: LOST1, C130069F04Rik, Tusc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237858
Homologene: 65330
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 21,402,487 bp
  • A to T, chromosome 1 at 32,545,648 bp
  • A to G, chromosome 1 at 54,481,856 bp
  • T to C, chromosome 1 at 60,108,174 bp
  • G to A, chromosome 2 at 6,664,141 bp
  • G to T, chromosome 2 at 24,877,497 bp
  • T to A, chromosome 2 at 30,142,311 bp
  • G to T, chromosome 2 at 72,970,978 bp
  • T to C, chromosome 2 at 104,699,944 bp
  • T to A, chromosome 2 at 112,249,000 bp
  • A to G, chromosome 2 at 119,069,176 bp
  • G to A, chromosome 2 at 126,116,123 bp
  • A to G, chromosome 2 at 132,941,963 bp
  • T to C, chromosome 2 at 151,594,544 bp
  • T to A, chromosome 2 at 153,758,067 bp
  • A to G, chromosome 2 at 160,897,138 bp
  • T to C, chromosome 3 at 9,264,671 bp
  • T to A, chromosome 3 at 95,895,739 bp
  • A to G, chromosome 4 at 4,134,296 bp
  • A to T, chromosome 4 at 6,271,207 bp
  • A to G, chromosome 4 at 48,283,242 bp
  • A to T, chromosome 4 at 97,783,348 bp
  • A to T, chromosome 4 at 136,184,440 bp
  • A to G, chromosome 5 at 9,126,641 bp
  • T to A, chromosome 5 at 20,813,291 bp
  • A to G, chromosome 5 at 106,457,640 bp
  • G to A, chromosome 5 at 110,294,934 bp
  • G to A, chromosome 5 at 150,805,706 bp
  • A to G, chromosome 6 at 57,360,843 bp
  • A to T, chromosome 6 at 130,188,712 bp
  • A to G, chromosome 7 at 19,447,243 bp
  • G to T, chromosome 7 at 24,260,738 bp
  • C to T, chromosome 7 at 31,070,757 bp
  • C to A, chromosome 7 at 45,046,377 bp
  • T to C, chromosome 7 at 56,122,351 bp
  • TG to T, chromosome 7 at 86,489,291 bp
  • A to G, chromosome 7 at 92,574,811 bp
  • G to T, chromosome 7 at 99,223,635 bp
  • T to C, chromosome 7 at 103,777,404 bp
  • A to G, chromosome 7 at 115,777,228 bp
  • T to C, chromosome 7 at 122,179,959 bp
  • A to G, chromosome 7 at 144,842,810 bp
  • T to A, chromosome 8 at 95,097,980 bp
  • T to C, chromosome 8 at 109,527,767 bp
  • G to A, chromosome 8 at 119,956,681 bp
  • T to A, chromosome 9 at 39,018,702 bp
  • A to G, chromosome 10 at 79,950,769 bp
  • T to A, chromosome 11 at 76,680,308 bp
  • T to C, chromosome 11 at 78,292,747 bp
  • G to T, chromosome 11 at 100,561,839 bp
  • A to G, chromosome 11 at 102,156,233 bp
  • T to C, chromosome 12 at 9,018,142 bp
  • T to A, chromosome 14 at 7,901,945 bp
  • G to T, chromosome 14 at 18,011,181 bp
  • T to C, chromosome 14 at 64,030,180 bp
  • A to G, chromosome 15 at 36,244,196 bp
  • A to G, chromosome 15 at 95,527,809 bp
  • A to G, chromosome 16 at 77,109,227 bp
  • A to T, chromosome 16 at 90,783,274 bp
  • T to C, chromosome 17 at 8,977,155 bp
  • A to G, chromosome 17 at 49,494,391 bp
  • C to A, chromosome 17 at 87,723,413 bp
  • T to C, chromosome 19 at 17,216,357 bp
  • T to C, chromosome 19 at 47,273,411 bp
  • T to C, chromosome 19 at 53,013,414 bp
  • T to A, chromosome 19 at 57,077,435 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5184 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042763-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.