Strain Name:
C57BL/6J-MtgxR5192Btlr/Mmmh
Stock Number:
042768-MU
Citation ID:
RRID:MMRRC_042768-MU
Other Names:
R5192 (G1), C57BL/6J-MtgxR5192Btlr
Major Collection:

Gene Information

Septin4
Name: septin 4
Synonyms: cell division control-related protein 2b, Pnutl2, Bh5, septin H5, ARTS, Sept4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18952
HGNC: HGNC:9165
Homologene: 6107
Lmna
Name: lamin A
Synonyms: lamin A/C, Dhe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16905
HGNC: HGNC:6636
Homologene: 41321
Prep
Name: prolyl endopeptidase
Synonyms: prolyl oligopeptidase, D10Wsu136e, Pop
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19072
VEGA: 10
HGNC: HGNC:9358
Homologene: 2042
T2
Name: brachyury 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21331
Homologene: 86977
Kctd4
Name: potassium channel tetramerisation domain containing 4
Synonyms: 2210017A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67516
VEGA: 14
Homologene: 36441
Vps51
Name: VPS51 GARP complex subunit
Synonyms: 3110057M17Rik, 1110014N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 68505
HGNC: HGNC:1172
Homologene: 34675
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72205
Homologene: 8125
Kat6a
Name: K(lysine) acetyltransferase 6A
Synonyms: MOZ, Zfp220, 9930021N24Rik, Myst3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244349
Homologene: 4924
Cep192
Name: centrosomal protein 192
Synonyms: D430014P18Rik, 4631422C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70799
VEGA: 18
Homologene: 73526
Myo1g
Name: myosin IG
Synonyms: E430002D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 246177
Homologene: 27996
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Zfp608
Name: zinc finger protein 608
Synonyms: 4932417D18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 269023
VEGA: 18
Homologene: 18485
Vmn2r57
Name: vomeronasal 2, receptor 57
Synonyms: EG269902
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269902
Homologene: 104832
Arhgef25
Name: Rho guanine nucleotide exchange factor (GEF) 25
Synonyms: 2410008H17Rik, GEFT, D10Ertd610e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 52666
VEGA: 10
Homologene: 32691
Slc22a30
Name: solute carrier family 22, member 30
Synonyms: C730048C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 319800
Homologene: 77136
Zfp661
Name: zinc finger protein 661
Synonyms: 2810405K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72180
Homologene: 23275
Marchf10
Name: membrane associated ring-CH-type finger 10
Synonyms: 4933417C16Rik, Rnf190, OTTMUSG00000002847, March10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 632687
Homologene: 34988
Babam1
Name: BRISC and BRCA1 A complex member 1
Synonyms: 5430437P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 68251
Homologene: 8574
Cfap43
Name: cilia and flagella associated protein 43
Synonyms: 4930428C11Rik, 4632415N18Rik, 4930463G05Rik, D19Ertd652e, Wdr96
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 100048534
Homologene: 36425
Dzip1
Name: DAZ interacting protein 1
Synonyms: 2510025K24Rik, 2810422M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66573
VEGA: 14
Homologene: 45708
Fbxw19
Name: F-box and WD-40 domain protein 19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235612
Homologene: 110776
Pif1
Name: PIF1 5'-to-3' DNA helicase
Synonyms: AI449441
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208084
Homologene: 99775
Ak8
Name: adenylate kinase 8
Synonyms: 1190002A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68870
Homologene: 17622
Gask1a
Name: golgi associated kinase 1A
Synonyms: C730027P07Rik, Fam198a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245050
VEGA: 9
Homologene: 18620
Plppr2
Name: phospholipid phosphatase related 2
Synonyms: PRG-4, BC018242, Lppr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235044
Homologene: 11229
Klrh1
Name: killer cell lectin-like receptor subfamily H, member 1
Synonyms: LOC232415, Gm156
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232415
Homologene: 16395
Olfr1
Name: olfactory receptor 1
Synonyms: MOR135-13, GA_x6K02T2P1NL-3556334-3555390, I54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258923
Homologene: 115482
Olfr906
Name: olfactory receptor 906
Synonyms: GA_x6K02T2PVTD-32194085-32195020, MOR167-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258799
VEGA: 9
Homologene: 132439
Tollip
Name: toll interacting protein
Synonyms: Toll interacting protein, 4931428G15Rik, 4930403G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 54473
Homologene: 10375
Tmtc2
Name: transmembrane and tetratricopeptide repeat containing 2
Synonyms: D330034A10Rik, 8430438D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 278279
Homologene: 25521
Ccnl1
Name: cyclin L1
Synonyms: ania-6a, 2610030E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56706
Homologene: 10541
Hsfy2
Name: heat shock transcription factor, Y-linked 2
Synonyms: 4933413G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71066
Homologene: 134090
Olfr1176
Name: olfactory receptor 1176
Synonyms: GA_x6K02T2Q125-49824309-49825256, MOR174-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258767
Gm38100
Name: predicted gene, 38100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 56,636,735 bp
  • A to G, chromosome 1 at 175,920,842 bp
  • A to G, chromosome 2 at 28,700,247 bp
  • A to G, chromosome 2 at 88,339,748 bp
  • A to G, chromosome 2 at 127,577,062 bp
  • T to C, chromosome 3 at 65,951,397 bp
  • G to A, chromosome 3 at 88,484,160 bp
  • T to C, chromosome 6 at 129,771,758 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • A to T, chromosome 7 at 41,427,939 bp
  • C to T, chromosome 7 at 141,892,117 bp
  • G to A, chromosome 8 at 22,911,713 bp
  • T to C, chromosome 8 at 71,404,253 bp
  • T to C, chromosome 9 at 21,941,132 bp
  • T to C, chromosome 9 at 38,488,805 bp
  • G to T, chromosome 9 at 65,588,092 bp
  • T to C, chromosome 9 at 109,484,428 bp
  • T to G, chromosome 9 at 121,965,661 bp
  • T to C, chromosome 10 at 45,153,111 bp
  • G to A, chromosome 10 at 105,190,177 bp
  • A to G, chromosome 10 at 127,185,109 bp
  • T to C, chromosome 11 at 6,514,816 bp
  • AGCGGTCGTAGGC to AGC, chromosome 11 at 73,395,654 bp
  • A to G, chromosome 11 at 87,583,404 bp
  • T to C, chromosome 11 at 105,371,926 bp
  • T to C, chromosome 11 at 118,034,359 bp
  • A to G, chromosome 14 at 75,962,687 bp
  • C to T, chromosome 14 at 118,911,393 bp
  • T to C, chromosome 17 at 8,413,111 bp
  • C to A, chromosome 18 at 54,898,497 bp
  • T to C, chromosome 18 at 67,835,004 bp
  • A to G, chromosome 19 at 6,070,467 bp
  • G to A, chromosome 19 at 8,344,393 bp
  • A to T, chromosome 19 at 47,825,925 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5192 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042768-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.