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Strain Name:
C57BL/6J-MtgxR5242Btlr/Mmmh
Stock Number:
042813-MU
Citation ID:
RRID:MMRRC_042813-MU
Other Names:
R5242 (G1), C57BL/6J-MtgxR5242Btlr
Major Collection:

Strain Information

Trmt9b
Name: tRNA methyltransferase 9B
Synonyms: 6430573F11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319582
Homologene: 35306
Chrna9
Name: cholinergic receptor, nicotinic, alpha polypeptide 9
Synonyms: Acra9, 2410015I05Rik, Gm8311
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231252
Homologene: 9729
Lias
Name: lipoic acid synthetase
Synonyms: MGC7254, mLip1, 4933425M12Rik, 2900022L22Rik, 7a5ex
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 79464
Homologene: 4997
Serpina9
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
Synonyms: Centerin, 2310014L03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71907
Homologene: 23633
Atp2a2
Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Synonyms: sarco/endoplasmic reticulum Ca2+-ATPase 2, SERCA2, 9530097L16Rik, D5Wsu150e, SERCA2B, Serca2a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11938
HGNC: HGNC:812
Homologene: 80167
Ddx39a
Name: DEAD box helicase 39a
Synonyms: 2610307C23Rik, BAT1, Ddx39
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68278
Homologene: 68487
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 277939
Homologene: 19524
Rrp1b
Name: ribosomal RNA processing 1B
Synonyms: 2600005C20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72462
Homologene: 57086
Adgrl1
Name: adhesion G protein-coupled receptor L1
Synonyms: Lec2, lectomedin-2, 2900070I05Rik, Lphn1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330814
Homologene: 8951
Rps7
Name: ribosomal protein S7
Synonyms: S7, Mtu
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20115
VEGA: 12
Homologene: 107159
Ube2s
Name: ubiquitin-conjugating enzyme E2S
Synonyms: E2-EPF, 6720465F12Rik, 0910001J09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77891
Homologene: 56676
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319262
Homologene: 14127
Foxo1
Name: forkhead box O1
Synonyms: FKHR, Afxh, Fkhr1, Foxo1a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56458
HGNC: HGNC:3819
Homologene: 1527
Tsc22d2
Name: TSC22 domain family, member 2
Synonyms: 1810043J12Rik, 5530402M19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72033
Homologene: 8860
Wdr75
Name: WD repeat domain 75
Synonyms: 1300003A18Rik, 2410118I19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73674
Homologene: 32771
Stimate
Name: STIM activating enhancer
Synonyms: 1810038N08Rik, 2310014H19Rik, Tmem110
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 69179
Homologene: 7082
Cdh6
Name: cadherin 6
Synonyms: K-cadherin, cad6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12563
VEGA: 15
HGNC: HGNC:1765
Homologene: 21027
Tas2r124
Name: taste receptor, type 2, member 124
Synonyms: Tas2r24, mGR24, mt2r50, T2R24
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387351
Homologene: 87293
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Aldh6a1
Name: aldehyde dehydrogenase family 6, subfamily A1
Synonyms: 1110038I05Rik, Mmsdh
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104776
VEGA: 12
HGNC: HGNC:7179
Homologene: 4082
Ndrg2
Name: N-myc downstream regulated gene 2
Synonyms: Ndr2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 29811
VEGA: 14
Homologene: 22785
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Shmt2
Name: serine hydroxymethyltransferase 2 (mitochondrial)
Synonyms: 2700043D08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108037
VEGA: 10
Homologene: 133984
Jag2
Name: jagged 2
Synonyms: Serh, D12Ggc2e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16450
VEGA: 12
HGNC: HGNC:6189
Homologene: 1677
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330267
Homologene: 46582
Sntb1
Name: syntrophin, basic 1
Synonyms: beta1-Syntrophin, 59-1 DAP
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20649
Homologene: 9618
Smarcal1
Name: SNF2 related chromatin remodeling ATPase like 1
Synonyms: Mharp, 6030401P21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54380
Homologene: 8558
Pramel22
Name: PRAME like 22
Synonyms: Gm13088
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277668
Homologene: 129883
Usp3
Name: ubiquitin specific peptidase 3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235441
Homologene: 4766
Oasl2
Name: 2'-5' oligoadenylate synthetase-like 2
Synonyms: M1204, Mmu-OASL
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23962
Homologene: 128369
Alox5
Name: arachidonate 5-lipoxygenase
Synonyms: 5-LOX, 5LO, 5LX
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11689
HGNC: HGNC:435
Homologene: 561
Or3a10
Name: olfactory receptor family 3 subfamily A member 10
Synonyms: M5, MOR255-2, GA_x6K02T2P1NL-4202012-4201065, Olfr139
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259005
Homologene: 77386
Vmn2r81
Name: vomeronasal 2, receptor 81
Synonyms: pheromone recepter, EC1-VR2, V2rf2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216144
Homologene: 83483
Cplane2
Name: ciliogenesis and planar polarity effector 2
Synonyms: LOC279260, 6330545A04Rik, b2b2827Clo, b2b2804Clo, Rsg1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76166
Homologene: 12793
G6pd2
Name: glucose-6-phosphate dehydrogenase 2
Synonyms: Gpd2, Gpd-2, G6pdx-ps1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14380
HGNC: HGNC:4057
Or51a25
Name: olfactory receptor family 51 subfamily A member 25
Synonyms: GA_x6K02T2PBJ9-5441154-5440198, MOR11-1, Olfr559
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259116
Homologene: 74124
Zfp764
Name: zinc finger protein 764
Synonyms: 8030466O12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233893
Homologene: 62158
Siae
Name: sialic acid acetylesterase
Synonyms: LSE, clone 165, Ysg2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22619
Homologene: 8001
Neurl3
Name: neuralized E3 ubiquitin protein ligase 3
Synonyms: 2010300P06Rik, Lincr
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214854
Homologene: 35002
Hoxd1
Name: homeobox D1
Synonyms: Hox-4.9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15429
HGNC: HGNC:5132
Homologene: 7772
Pnma2
Name: paraneoplastic antigen MA2
Synonyms: A830049P17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239157
HGNC: HGNC:9159
Homologene: 5249
Nudt16l1
Name: nudix hydrolase 16 like 1
Synonyms: 5330437I08Rik, 1110001K21Rik, nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1, syndesmos
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66911
VEGA: 16
Homologene: 12053
4930486I03Rik
Name: RIKEN cDNA 4930486I03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75028
Igkv12-47
Name: immunoglobulin kappa variable 12-47
Synonyms: Gm5574
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 434037
Gm10113
Name: predicted gene 10113
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 20,392,149 bp
  • G to A, chromosome 1 at 36,269,420 bp
  • T to A, chromosome 1 at 45,817,327 bp
  • T to C, chromosome 1 at 72,591,083 bp
  • A to G, chromosome 2 at 74,763,448 bp
  • T to C, chromosome 3 at 52,269,255 bp
  • T to A, chromosome 3 at 58,415,939 bp
  • T to C, chromosome 4 at 141,219,847 bp
  • A to T, chromosome 4 at 143,655,611 bp
  • A to G, chromosome 5 at 61,809,442 bp
  • A to G, chromosome 5 at 65,394,022 bp
  • A to G, chromosome 5 at 65,977,080 bp
  • T to A, chromosome 5 at 96,657,250 bp
  • A to T, chromosome 5 at 114,905,061 bp
  • A to T, chromosome 5 at 122,461,946 bp
  • G to T, chromosome 5 at 124,787,420 bp
  • A to T, chromosome 6 at 12,327,583 bp
  • A to T, chromosome 6 at 68,930,560 bp
  • T to C, chromosome 6 at 116,460,966 bp
  • T to C, chromosome 6 at 132,755,540 bp
  • C to T, chromosome 7 at 4,810,435 bp
  • G to A, chromosome 7 at 81,495,343 bp
  • T to C, chromosome 7 at 100,390,166 bp
  • C to T, chromosome 7 at 102,724,276 bp
  • T to C, chromosome 7 at 127,405,369 bp
  • A to G, chromosome 8 at 36,511,930 bp
  • A to G, chromosome 8 at 83,721,811 bp
  • T to C, chromosome 8 at 83,931,082 bp
  • C to T, chromosome 9 at 37,644,852 bp
  • C to T, chromosome 9 at 66,527,150 bp
  • T to A, chromosome 10 at 79,293,475 bp
  • C to T, chromosome 10 at 127,518,920 bp
  • A to T, chromosome 11 at 74,045,022 bp
  • C to T, chromosome 11 at 111,724,711 bp
  • T to A, chromosome 12 at 28,631,137 bp
  • A to G, chromosome 12 at 84,436,383 bp
  • C to A, chromosome 12 at 104,008,385 bp
  • C to T, chromosome 12 at 112,916,866 bp
  • T to C, chromosome 13 at 46,177,516 bp
  • T to A, chromosome 14 at 30,825,836 bp
  • A to G, chromosome 14 at 51,911,084 bp
  • C to A, chromosome 14 at 66,916,297 bp
  • A to G, chromosome 15 at 13,064,411 bp
  • C to G, chromosome 15 at 55,642,795 bp
  • C to T, chromosome 16 at 4,939,621 bp
  • T to C, chromosome 17 at 32,051,703 bp
  • C to T, chromosome 18 at 37,959,873 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5242 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042813-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.