Strain Name:
C57BL/6J-MtgxR5242Btlr/Mmmh
Stock Number:
042813-MU
Citation ID:
RRID:MMRRC_042813-MU
Other Names:
R5242 (G1), C57BL/6J-MtgxR5242Btlr
Major Collection:

Gene Information

Trmt9b
Name: tRNA methyltransferase 9B
Synonyms: 6430573F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319582
Homologene: 35306
Chrna9
Name: cholinergic receptor, nicotinic, alpha polypeptide 9
Synonyms: Gm8311, Acra9, 2410015I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231252
Homologene: 9729
Lias
Name: lipoic acid synthetase
Synonyms: mLip1, 2900022L22Rik, MGC7254, 7a5ex, 4933425M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 79464
Homologene: 4997
Serpina9
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
Synonyms: Centerin, 2310014L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 71907
Homologene: 23633
Atp2a2
Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Synonyms: D5Wsu150e, SERCA2B, sarco/endoplasmic reticulum Ca2+-ATPase 2, SERCA2, Serca2a, 9530097L16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11938
HGNC: HGNC:812
Homologene: 80167
Ddx39a
Name: DEAD box helicase 39a
Synonyms: BAT1, Ddx39, 2610307C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 68278
Homologene: 68487
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 277939
Homologene: 19524
Rrp1b
Name: ribosomal RNA processing 1B
Synonyms: 2600005C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72462
Homologene: 57086
Adgrl1
Name: adhesion G protein-coupled receptor L1
Synonyms: lectomedin-2, 2900070I05Rik, Lphn1, Lec2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330814
Homologene: 8951
Rps7
Name: ribosomal protein S7
Synonyms: Mtu, S7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20115
VEGA: 12
Homologene: 107159
Ube2s
Name: ubiquitin-conjugating enzyme E2S
Synonyms: E2-EPF, 0910001J09Rik, 6720465F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77891
Homologene: 56676
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 319262
Homologene: 14127
Foxo1
Name: forkhead box O1
Synonyms: Foxo1a, Fkhr1, Afxh, FKHR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56458
HGNC: HGNC:3819
Homologene: 1527
Tsc22d2
Name: TSC22 domain family, member 2
Synonyms: 5530402M19Rik, 1810043J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72033
Homologene: 8860
Wdr75
Name: WD repeat domain 75
Synonyms: 1300003A18Rik, 2410118I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 73674
Homologene: 32771
Stimate
Name: STIM activating enhancer
Synonyms: 1810038N08Rik, Tmem110, 2310014H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 69179
Homologene: 7082
Cdh6
Name: cadherin 6
Synonyms: cad6, K-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12563
VEGA: 15
HGNC: HGNC:1765
Homologene: 21027
Tas2r124
Name: taste receptor, type 2, member 124
Synonyms: T2R24, mGR24, Tas2r24, mt2r50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387351
Homologene: 87293
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Aldh6a1
Name: aldehyde dehydrogenase family 6, subfamily A1
Synonyms: Mmsdh, 1110038I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104776
VEGA: 12
HGNC: HGNC:7179
Homologene: 4082
Ndrg2
Name: N-myc downstream regulated gene 2
Synonyms: Ndr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 29811
VEGA: 14
Homologene: 22785
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231470
Homologene: 23516
Shmt2
Name: serine hydroxymethyltransferase 2 (mitochondrial)
Synonyms: 2700043D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 108037
VEGA: 10
Homologene: 133984
Jag2
Name: jagged 2
Synonyms: Serh, D12Ggc2e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16450
VEGA: 12
HGNC: HGNC:6189
Homologene: 1677
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330267
Homologene: 46582
Sntb1
Name: syntrophin, basic 1
Synonyms: beta1-Syntrophin, 59-1 DAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20649
Homologene: 9618
Smarcal1
Name: SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
Synonyms: Mharp, 6030401P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54380
Homologene: 8558
Pramel22
Name: PRAME like 22
Synonyms: Gm13088
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 277668
Homologene: 129883
Usp3
Name: ubiquitin specific peptidase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235441
Homologene: 4766
Oasl2
Name: 2'-5' oligoadenylate synthetase-like 2
Synonyms: M1204, Mmu-OASL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 23962
Homologene: 128369
Alox5
Name: arachidonate 5-lipoxygenase
Synonyms: 5LX, 5LO, 5-LOX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11689
HGNC: HGNC:435
Homologene: 561
Olfr139
Name: olfactory receptor 139
Synonyms: MOR255-2, M5, GA_x6K02T2P1NL-4202012-4201065
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 259005
Homologene: 77386
Vmn2r81
Name: vomeronasal 2, receptor 81
Synonyms: pheromone recepter, V2rf2, EC1-VR2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216144
Homologene: 83483
BC048679
Name: cDNA sequence BC048679
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210321
Homologene: 130364
Cplane2
Name: ciliogenesis and planar polarity effector 2
Synonyms: b2b2804Clo, LOC279260, b2b2827Clo, Rsg1, 6330545A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76166
Homologene: 12793
G6pd2
Name: glucose-6-phosphate dehydrogenase 2
Synonyms: G6pdx-ps1, Gpd2, Gpd-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14380
Olfr559
Name: olfactory receptor 559
Synonyms: MOR11-1, GA_x6K02T2PBJ9-5441154-5440198
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259116
Homologene: 74124
Zfp764
Name: zinc finger protein 764
Synonyms: 8030466O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233893
Homologene: 62158
Siae
Name: sialic acid acetylesterase
Synonyms: clone 165, Ysg2, LSE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22619
Homologene: 8001
Neurl3
Name: neuralized E3 ubiquitin protein ligase 3
Synonyms: Lincr, 2010300P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214854
Homologene: 35002
Hoxd1
Name: homeobox D1
Synonyms: Hox-4.9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15429
HGNC: HGNC:5132
Homologene: 7772
Pnma2
Name: paraneoplastic antigen MA2
Synonyms: A830049P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239157
HGNC: HGNC:9159
Homologene: 5249
Nudt16l1
Name: nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1
Synonyms: 5330437I08Rik, 1110001K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 66911
VEGA: 16
Homologene: 12053
4930486I03Rik
Name: RIKEN cDNA 4930486I03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75028
Gm11677
Name: predicted gene 11677
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 629967
Igkv12-47
Name: immunoglobulin kappa variable 12-47
Synonyms: Gm5574
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 434037
Gm10113
Name: predicted gene 10113
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 20,392,149 bp
  • G to A, chromosome 1 at 36,269,420 bp
  • T to A, chromosome 1 at 45,817,327 bp
  • T to C, chromosome 1 at 72,591,083 bp
  • A to G, chromosome 2 at 74,763,448 bp
  • T to C, chromosome 3 at 52,269,255 bp
  • T to A, chromosome 3 at 58,415,939 bp
  • T to C, chromosome 4 at 141,219,847 bp
  • A to T, chromosome 4 at 143,655,611 bp
  • A to G, chromosome 5 at 61,809,442 bp
  • A to G, chromosome 5 at 65,394,022 bp
  • A to G, chromosome 5 at 65,977,080 bp
  • T to A, chromosome 5 at 96,657,250 bp
  • A to T, chromosome 5 at 114,905,061 bp
  • A to T, chromosome 5 at 122,461,946 bp
  • G to T, chromosome 5 at 124,787,420 bp
  • A to T, chromosome 6 at 12,327,583 bp
  • A to T, chromosome 6 at 68,930,560 bp
  • T to C, chromosome 6 at 116,460,966 bp
  • T to C, chromosome 6 at 132,755,540 bp
  • C to T, chromosome 7 at 4,810,435 bp
  • G to A, chromosome 7 at 81,495,343 bp
  • T to C, chromosome 7 at 100,390,166 bp
  • C to T, chromosome 7 at 102,724,276 bp
  • T to C, chromosome 7 at 127,405,369 bp
  • A to G, chromosome 8 at 36,511,930 bp
  • A to G, chromosome 8 at 83,721,811 bp
  • T to C, chromosome 8 at 83,931,082 bp
  • C to T, chromosome 9 at 37,644,852 bp
  • C to T, chromosome 9 at 66,527,150 bp
  • T to A, chromosome 10 at 79,293,475 bp
  • C to T, chromosome 10 at 127,518,920 bp
  • A to T, chromosome 11 at 74,045,022 bp
  • C to T, chromosome 11 at 111,724,711 bp
  • T to A, chromosome 12 at 28,631,137 bp
  • A to G, chromosome 12 at 84,436,383 bp
  • C to A, chromosome 12 at 104,008,385 bp
  • C to T, chromosome 12 at 112,916,866 bp
  • T to C, chromosome 13 at 46,177,516 bp
  • T to A, chromosome 14 at 30,825,836 bp
  • A to G, chromosome 14 at 51,911,084 bp
  • C to A, chromosome 14 at 66,916,297 bp
  • A to G, chromosome 15 at 13,064,411 bp
  • C to G, chromosome 15 at 55,642,795 bp
  • C to T, chromosome 16 at 4,939,621 bp
  • T to C, chromosome 17 at 32,051,703 bp
  • C to T, chromosome 18 at 37,959,873 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5242 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042813-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.