Strain Name:
C57BL/6J-MtgxR5284Btlr/Mmmh
Stock Number:
042841-MU
Citation ID:
RRID:MMRRC_042841-MU
Other Names:
R5284 (G1), C57BL/6J-MtgxR5284Btlr
Major Collection:

Gene Information

Ifi203
Name: interferon activated gene 203
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15950
HGNC: HGNC:5395
Homologene: 115929
Ep400
Name: E1A binding protein p400
Synonyms: p400, mDomino, 1700020J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75560
Homologene: 38779
Zfp423
Name: zinc finger protein 423
Synonyms: Roaz, ataxia1, Zfp104, Ebfaz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94187
Homologene: 9010
Phf14
Name: PHD finger protein 14
Synonyms: 1110001C23Rik, 4932409F11Rik, 5730446A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 75725
Homologene: 8775
Nup188
Name: nucleoporin 188
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227699
Homologene: 45683
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, C030045D06Rik, Depdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109294
Homologene: 23523
Dhdds
Name: dehydrodolichyl diphosphate synthase
Synonyms: 3222401G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67422
Homologene: 32615
Sacm1l
Name: SAC1 suppressor of actin mutations 1-like (yeast)
Synonyms: Sac1p, SAC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83493
VEGA: 9
Homologene: 6320
Setdb1
Name: SET domain, bifurcated 1
Synonyms: ESET, KMT1E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 84505
Homologene: 32157
Klhl7
Name: kelch-like 7
Synonyms: 2700038B03Rik, SBBI26, Klhl6, D5Ertd363e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52323
Homologene: 10317
Gabpb1
Name: GA repeat binding protein, beta 1
Synonyms: E4TF1-53, E4TF1-47, NRF2B2, NRF2B1, E4Tf1B, BABPB2, E4TF1, GABPB1-2, GABPB1-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14391
HGNC: HGNC:4074
Homologene: 7723
Ecpas
Name: Ecm29 proteasome adaptor and scaffold
Synonyms: AI314180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230249
Homologene: 6056
Gucy2c
Name: guanylate cyclase 2c
Synonyms: GC-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14917
HGNC: HGNC:4688
Homologene: 3641
Acaca
Name: acetyl-Coenzyme A carboxylase alpha
Synonyms: acetyl-CoA carboxylase, Acc1, LOC327983, Acac, A530025K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 107476
HGNC: HGNC:84
Homologene: 31015
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665775
Homologene: 45109
Crim1
Name: cysteine rich transmembrane BMP regulator 1 (chordin like)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 50766
VEGA: 17
HGNC: HGNC:2359
Homologene: 9510
Plaa
Name: phospholipase A2, activating protein
Synonyms: D4Ertd618e, Ufd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18786
HGNC: HGNC:9043
Homologene: 3138
Myo19
Name: myosin XIX
Synonyms: 1110055A02Rik, Myohd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66196
Homologene: 49819
Atad1
Name: ATPase family, AAA domain containing 1
Synonyms: 4921525H23Rik, Thorase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67979
VEGA: 19
Homologene: 5960
Cep152
Name: centrosomal protein 152
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99100
Homologene: 37159
Nav1
Name: neuron navigator 1
Synonyms: POMFIL3, 9930003A20Rik, C230080M11Rik, unc53H1, steerin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215690
Homologene: 10719
Tspan12
Name: tetraspanin 12
Synonyms: Tm4sf12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 269831
Homologene: 8212
Camkk1
Name: calcium/calmodulin-dependent protein kinase kinase 1, alpha
Synonyms: CaMKKalpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 55984
HGNC: HGNC:1469
Homologene: 10327
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: [a]4(IV), E130010M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Wdr19
Name: WD repeat domain 19
Synonyms: C330027H04Rik, D330023L08Rik, Ift144, DYF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 213081
Homologene: 11842
Egfem1
Name: EGF-like and EMI domain containing 1
Synonyms: 6130401L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 75740
Homologene: 135950
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 672511
Homologene: 45439
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668940
Homologene: 66117
Oplah
Name: 5-oxoprolinase (ATP-hydrolysing)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75475
HGNC: HGNC:8149
Homologene: 90938
Rpgrip1
Name: retinitis pigmentosa GTPase regulator interacting protein 1
Synonyms: A930002K18Rik, 4930505G06Rik, 4930401L23Rik, nmf247
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 77945
Homologene: 10679
Abcc6
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 6
Synonyms: DCC, Mrp6, Dyscalc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27421
HGNC: HGNC:57
Homologene: 55559
Tmem30a
Name: transmembrane protein 30A
Synonyms: 2010200I23Rik, D9Wsu20e, Cdc50a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69981
Homologene: 110703
Pcnx
Name: pecanex homolog
Synonyms: 3526401J03Rik, 2900024E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Tsen15
Name: tRNA splicing endonuclease subunit 15
Synonyms: 5730449L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66637
Homologene: 12002
Ubtfl1
Name: upstream binding transcription factor, RNA polymerase I-like 1
Synonyms: B020006M18Rik, Hmgpi
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 546118
Homologene: 110115
Arhgef26
Name: Rho guanine nucleotide exchange factor (GEF) 26
Synonyms: 8430436L14Rik, 4631416L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 622434
Homologene: 9204
Slco6b1
Name: solute carrier organic anion transporter family, member 6b1
Synonyms: 1700022M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67854
Homologene: 12199
Bank1
Name: B cell scaffold protein with ankyrin repeats 1
Synonyms: A530094C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242248
Homologene: 9926
Ehhadh
Name: enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
Synonyms: HD, MFP, L-bifunctional enzyme, L-PBE, 1300002P22Rik, MFP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74147
HGNC: HGNC:3247
Homologene: 1486
Smg8
Name: smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)
Synonyms: 1200011M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74133
Homologene: 32393
Cactin
Name: cactin, spliceosome C complex subunit
Synonyms: 2510012J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70312
VEGA: 10
Homologene: 69553
Skint8
Name: selection and upkeep of intraepithelial T cells 8
Synonyms: OTTMUSG00000009475
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 639774
Homologene: 106613
Gba2
Name: glucosidase beta 2
Synonyms: bile acid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230101
Homologene: 10859
Prpf18
Name: pre-mRNA processing factor 18
Synonyms: 2810441A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67229
Homologene: 2726
Trpc4
Name: transient receptor potential cation channel, subfamily C, member 4
Synonyms: CCE1, Trp4, STRPC4, Trrp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 22066
Homologene: 22955
Asic5
Name: acid-sensing (proton-gated) ion channel family member 5
Synonyms: brain-liver-intestine amiloride-sensitive sodium channel, BLINaC, Accn5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 58170
Homologene: 41171
Erg
Name: ETS transcription factor
Synonyms: D030036I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13876
HGNC: HGNC:3446
Homologene: 15848
Fastkd1
Name: FAST kinase domains 1
Synonyms: 5330408N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320720
Homologene: 36420
Dcun1d4
Name: DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100737
Homologene: 22867
Olfr212
Name: olfactory receptor 212
Synonyms: GA_x54KRFPKN04-58149882-58150865, MOR119-4, 4931403F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258019
Homologene: 74186
Krtap12-1
Name: keratin associated protein 12-1
Synonyms: D10Jhu14e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16694
VEGA: 10
Homologene: 135687
Ubiad1
Name: UbiA prenyltransferase domain containing 1
Synonyms: Tere1, 1200002M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71707
Homologene: 8336
Kcnk13
Name: potassium channel, subfamily K, member 13
Synonyms: LOC380778, LOC381712, F730021E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217826
HGNC: HGNC:6275
Homologene: 69351
Mup11
Name: major urinary protein 11
Synonyms: Gm12549
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100039028
Homologene: 74304
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 11,266,090 bp
  • C to T, chromosome 1 at 82,493,591 bp
  • C to A, chromosome 1 at 96,921,937 bp
  • C to T, chromosome 1 at 135,449,963 bp
  • A to G, chromosome 1 at 152,371,873 bp
  • C to T, chromosome 1 at 173,928,708 bp
  • G to A, chromosome 2 at 4,645,670 bp
  • A to T, chromosome 2 at 30,330,635 bp
  • T to C, chromosome 2 at 69,712,188 bp
  • A to G, chromosome 2 at 125,580,021 bp
  • T to C, chromosome 2 at 126,652,357 bp
  • A to G, chromosome 2 at 155,632,314 bp
  • A to G, chromosome 3 at 29,650,787 bp
  • T to A, chromosome 3 at 54,279,947 bp
  • T to C, chromosome 3 at 62,419,631 bp
  • C to T, chromosome 3 at 82,008,523 bp
  • G to T, chromosome 3 at 95,327,570 bp
  • T to C, chromosome 3 at 136,064,154 bp
  • T to A, chromosome 4 at 43,569,327 bp
  • C to T, chromosome 4 at 58,836,172 bp
  • T to A, chromosome 4 at 60,659,769 bp
  • T to C, chromosome 4 at 94,569,637 bp
  • C to A, chromosome 4 at 111,950,193 bp
  • A to G, chromosome 4 at 133,980,212 bp
  • G to A, chromosome 4 at 148,436,498 bp
  • A to G, chromosome 5 at 24,159,617 bp
  • G to A, chromosome 5 at 41,820,467 bp
  • C to T, chromosome 5 at 65,225,409 bp
  • T to C, chromosome 5 at 73,522,682 bp
  • A to G, chromosome 5 at 110,668,124 bp
  • C to A, chromosome 6 at 11,997,120 bp
  • G to T, chromosome 6 at 21,835,467 bp
  • T to A, chromosome 6 at 116,516,552 bp
  • A to G, chromosome 6 at 136,763,043 bp
  • T to A, chromosome 7 at 45,981,059 bp
  • C to T, chromosome 8 at 87,781,677 bp
  • A to T, chromosome 9 at 18,409,445 bp
  • C to T, chromosome 9 at 79,777,323 bp
  • T to C, chromosome 9 at 123,586,420 bp
  • G to T, chromosome 10 at 77,720,965 bp
  • A to G, chromosome 10 at 81,323,762 bp
  • A to G, chromosome 11 at 73,037,555 bp
  • T to A, chromosome 11 at 84,130,163 bp
  • T to A, chromosome 11 at 84,885,272 bp
  • G to A, chromosome 11 at 87,080,311 bp
  • A to G, chromosome 11 at 119,458,866 bp
  • A to T, chromosome 12 at 81,919,029 bp
  • A to C, chromosome 12 at 100,061,289 bp
  • A to G, chromosome 14 at 52,149,276 bp
  • A to T, chromosome 15 at 76,306,559 bp
  • T to C, chromosome 16 at 21,763,344 bp
  • C to T, chromosome 16 at 95,459,243 bp
  • A to T, chromosome 17 at 78,313,266 bp
  • T to C, chromosome 19 at 32,687,271 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5284 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042841-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.